{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:53:27Z","timestamp":1790790807176,"version":"4.1.0"},"reference-count":184,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Contrary to common psychosurgical practice in the 1950s, Dr. Jean Talairach had the intuition, based on clinical experience, that the brain connectome and neuroplasticity had a role to play in psychosurgery. Due to the remarkable progress of pharmacology at that time and to the technical limits of neurosurgery, these concepts were not put into practice. Currently, these concepts are being confirmed by modern techniques such as neuroimaging and computational neurosciences, and could pave the way for therapeutic innovation in psychiatry.<\/jats:p>\n                  <jats:p>Psychosurgery commonly uses a localizationist approach, based on the idea that a lesion to a specific area is responsible for a deficit opposite to its function. To psychosurgeons such as Walter Freeman, who performed extensive lesions causing apparently inevitable deficit, Talairach answered with clinical data: complex psychic functions cannot be described that simply, because the same lesion does not provoke the same deficit in different patients. Moreover, cognitive impairment did not always follow efficacious psychosurgery. Talairach suggested that selectively destructing part of a network could open the door to a new organization, and that early psychotherapy could encourage this psychoplasticity. Talairach did not have the opportunity to put these concepts into practice in psychiatric diseases because of the sudden availability of neuroleptics, but connectomics and neuroplasticity gave rise to major advances in intraparenchymal neurosurgery, from epilepsy to low-grade glioma. In psychiatry, alongside long-standing theories implicating focal lesions and diffuse pathological processes, neuroimaging techniques are currently being developed. In mentally healthy individuals, combining diffusion tensor imaging with functional MRI, magnetoencephalography, and electroencephalography allows the determination of a comprehensive map of neural connections in the brain on many spatial scales, the so-called connectome. Ultimately, global neurocomputational models could predict physiological activity, behavior, and subjective feeling, and describe neuropsychiatric disorders.<\/jats:p>\n                  <jats:p>Connectomic studies comparing psychiatric patients with controls have already confirmed the early intuitions of Talairach. As a striking example, massive dysconnectivity has been found in schizophrenia, leading some authors to propose a \u201cdysconnection hypothesis.\u201d Alterations of the connectome have also been demonstrated in obsessive-compulsive disorder and depression. Furthermore, normalization of the functional dysconnectivity has been observed following clinical improvement in several therapeutic interventions, from psychotherapy to pharmacological treatments. Provided that mental disorders result from abnormal structural or functional wiring, targeted psychosurgery would require that one be able: 1) to identify the pathological network involved in a given patient; 2) to use neurostimulation to safely create a reversible and durable alteration, mimicking a lesion, in a network compatible with neuroplasticity; and 3) to predict which functional lesion would result in adapted neuronal plasticity and\/or to guide neuronal plasticity to promote recovery. All these conditions, already suggested by Talairach, could now be achievable considering modern biomarkers and surgical progress.<\/jats:p>","DOI":"10.3171\/2017.6.focus17251","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T03:36:47Z","timestamp":1504237007000},"page":"E11","source":"Crossref","is-referenced-by-count":14,"title":["Neuroplasticity and the brain connectome: what can Jean Talairach\u2019s reflections bring to modern psychosurgery?"],"prefix":"10.3171","volume":"43","author":[{"given":"Pierre","family":"Bourdillon","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Neurology and Neurosurgery Hospital Pierre Wertheimer, Hospices Civils de Lyon;"},{"name":"Inserm U1127, CNRS U7225, Universit\u00e9 Pierre et Marie Curie (UPMC-Paris 6), Paris;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Apra","sequence":"additional","affiliation":[{"name":"Sorbonne Universities, Universit\u00e9 Pierre et Marie Curie, Paris;"},{"name":"Inserm U1127, CNRS U7225, Universit\u00e9 Pierre et Marie Curie (UPMC-Paris 6), Paris;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"L\u00e9v\u00eaque","sequence":"additional","affiliation":[{"name":"Beauregard Hospital, Marseille;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Vinckier","sequence":"additional","affiliation":[{"name":"Inserm U1127, CNRS U7225, Universit\u00e9 Pierre et Marie Curie (UPMC-Paris 6), Paris;"},{"name":"Department of Psychiatry, Service Hospitalo-Universitaire, Centre Hospitalier Sainte-Anne, Paris;"},{"name":"INSERM, Laboratoire de Physiopathologie des Maladies Psychiatriques, Centre de Psychiatrie et Neurosciences, UMR S894, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Geriatr Psychiatry Neurol","first-page":"33","article-title":"A review of longitudinal electroconvulsive therapy: neuroimaging investigations","volume":"27","author":"Abbott CC","year":"2014","unstructured":"Abbott CC, Gallegos P, Rediske N, Lemke NT, Quinn DK: A review of longitudinal electroconvulsive therapy: neuroimaging investigations. J Geriatr Psychiatry Neurol 27:33\u201346, 2014"},{"key":"b2","series-title":"Neuropsychopharmacology","first-page":"1210","article-title":"Ketamine treatment and global brain connectivity in major depression","volume":"42","author":"Abdallah CG","year":"2017","unstructured":"Abdallah CG, Averill LA, Collins KA, Geha P, Schwartz J, Averill C, : Ketamine treatment and global brain connectivity in major depression. Neuropsychopharmacology 42:1210\u20131219, 2017"},{"key":"b3","series-title":"Brain Struct Funct","first-page":"1983","article-title":"The left inferior fronto-occipital fasciculus subserves language semantics: a multilevel lesion study","volume":"220","author":"Almairac F","year":"2015","unstructured":"Almairac F, Herbet G, Moritz-Gasser S, de Champfleur NM, Duffau H: The left inferior fronto-occipital fasciculus subserves language semantics: a multilevel lesion study. Brain Struct Funct 220:1983\u20131995, 2015"},{"key":"b4","series-title":"J Affect Disord","first-page":"175","article-title":"Graph-theoretical analysis of resting-state fMRI in pediatric obsessive-compulsive disorder","volume":"193","author":"Armstrong CC","year":"2016","unstructured":"Armstrong CC, Moody TD, Feusner JD, McCracken JT, Chang S, Levitt JG, : Graph-theoretical analysis of resting-state fMRI in pediatric obsessive-compulsive disorder. J Affect Disord 193:175\u2013184, 2016"},{"key":"b5","series-title":"Med Contemp","first-page":"61","article-title":"[A clinical and psychological study of patients in leucotomized Hospital J\u00falio de Matos.]","volume":"67","year":"1949","unstructured":"Barahona Fernandes HJ: [A clinical and psychological study of patients in leucotomized Hospital J\u00falio de Matos.] Med Contemp 67:61\u201366, 1949 (Portuguese)"},{"key":"b6","series-title":"J Med (Oporto)","first-page":"496","article-title":"[Clinical study on the psychological and leucotomy.]","volume":"12","year":"1948","unstructured":"Barahona Fernandes HJ: [Clinical study on the psychological and leucotomy.] J Med (Oporto) 12:496, 1948 (Portuguese)"},{"key":"b7","series-title":"Curr Opin Neurol","first-page":"340","article-title":"Human brain networks in health and disease","volume":"22","author":"Bassett DS","year":"2009","unstructured":"Bassett DS, Bullmore ET: Human brain networks in health and disease. Curr Opin Neurol 22:340\u2013347, 2009"},{"key":"b8","series-title":"Neurology","first-page":"1319","article-title":"Improvements in memory function following anterior temporal lobe resection for epilepsy","volume":"71","author":"Baxendale S","year":"2008","unstructured":"Baxendale S, Thompson PJ, Duncan JS: Improvements in memory function following anterior temporal lobe resection for epilepsy. Neurology 71:1319\u20131325, 2008"},{"key":"b9","series-title":"Bull la Soci\u00e9t\u00e9 d\u2019Anthropologie","first-page":"200","article-title":"Localisations des fonctions c\u00e9r\u00e9brales. Si\u00e8ge de la facult\u00e9 du langage articul\u00e9","volume":"4","author":"Broca P","year":"1863","unstructured":"Broca P: Localisations des fonctions c\u00e9r\u00e9brales. Si\u00e8ge de la facult\u00e9 du langage articul\u00e9. Bull la Soci\u00e9t\u00e9 d\u2019Anthropologie 4:200\u2013208, 1863"},{"key":"b10","series-title":"Nat Rev Neurosci","first-page":"186","article-title":"Complex brain networks: graph theoretical analysis of structural and functional systems","volume":"10","author":"Bullmore E","year":"2009","unstructured":"Bullmore E, Sporns O: Complex brain networks: graph theoretical analysis of structural and functional systems. Nat Rev Neurosci 10:186\u2013198, 2009"},{"key":"b11","series-title":"Nat Rev Neurosci","first-page":"336","article-title":"The economy of brain network organization","volume":"13","author":"Bullmore E","year":"2012","unstructured":"Bullmore E, Sporns O: The economy of brain network organization. Nat Rev Neurosci 13:336\u2013349, 2012"},{"key":"b12","series-title":"Brain Stimulat","first-page":"65","article-title":"Modulation of limbic and prefrontal connectivity by electroconvulsive therapy in treatment-resistant depression: a preliminary study","volume":"9","author":"Cano M","year":"2016","unstructured":"Cano M, Cardoner N, Urretavizcaya M, Mart\u00ednez-Zalaca\u00edn I, Goldberg X, Via E, : Modulation of limbic and prefrontal connectivity by electroconvulsive therapy in treatment-resistant depression: a preliminary study. Brain Stimulat 9:65\u201371, 2016"},{"key":"b13","series-title":"Ann Neurol","first-page":"8","article-title":"Perisylvian language networks of the human brain","volume":"57","author":"Catani M","year":"2005","unstructured":"Catani M, Jones DK, ffytche DH: Perisylvian language networks of the human brain. Ann Neurol 57:8\u201316, 2005"},{"key":"b14","series-title":"Rev Neurol (Paris)","first-page":"3","article-title":"[Follow-up of 78 cases of psychosurgery a year after the operation.]","volume":"89","author":"David M","year":"1953","unstructured":"David M, Sauguet J, Hecaen H, Talairach J: [Follow-up of 78 cases of psychosurgery a year after the operation.] Rev Neurol (Paris) 89:3\u201321, 1953"},{"key":"b15","series-title":"Neurosurgery","first-page":"1709","article-title":"Brain hodotopy: from esoteric concept to practical surgical applications","volume":"68","author":"De Benedictis A","year":"2011","unstructured":"De Benedictis A, Duffau H: Brain hodotopy: from esoteric concept to practical surgical applications. Neurosurgery 68:1709\u20131723, 2011"},{"key":"b16","series-title":"J Clin Oncol","first-page":"2559","article-title":"Impact of intraoperative stimulation brain mapping on glioma surgery outcome: a meta-analysis","volume":"30","author":"De Witt Hamer PC","year":"2012","unstructured":"De Witt Hamer PC, Robles SG, Zwinderman AH, Duffau H, Berger MS: Impact of intraoperative stimulation brain mapping on glioma surgery outcome: a meta-analysis. J Clin Oncol 30:2559\u20132565, 2012"},{"key":"b17","series-title":"Neuron","first-page":"892","article-title":"Great expectations: using whole-brain computational connectomics for understanding neuropsychiatric disorders","volume":"84","author":"Deco G","year":"2014","unstructured":"Deco G, Kringelbach ML: Great expectations: using whole-brain computational connectomics for understanding neuropsychiatric disorders. Neuron 84:892\u2013905, 2014"},{"key":"b18","series-title":"Ann Med Psychol (Paris)","first-page":"112","article-title":"[Therapeutic use in psychiatry of phenothiazine of central elective action (4560 RP).]","volume":"110","author":"Delay J","year":"1952","unstructured":"Delay J, Deniker P, Harl JM: [Therapeutic use in psychiatry of phenothiazine of central elective action (4560 RP).] Ann Med Psychol (Paris) 110:112\u2013117, 1952 (Fr)"},{"key":"b19","series-title":"Brain","first-page":"898","article-title":"Contrasting acute and slow-growing lesions: a new door to brain plasticity","volume":"130","author":"Desmurget M","year":"2007","unstructured":"Desmurget M, Bonnetblanc F, Duffau H: Contrasting acute and slow-growing lesions: a new door to brain plasticity. Brain 130:898\u2013914, 2007"},{"key":"b20","series-title":"Psychiatry Res","first-page":"53","article-title":"Short-term group cognitive behavior therapy contributes to recovery from mild depression: evidence from functional and structural MRI","volume":"251","author":"Du X","year":"2016","unstructured":"Du X, Mao Y, Ran Q, Zhang Q, Luo Q, Qiu J: Short-term group cognitive behavior therapy contributes to recovery from mild depression: evidence from functional and structural MRI. Psychiatry Res 251:53\u201359, 2016"},{"key":"b21","series-title":"Curr Behav Neurosci Rep","first-page":"70","article-title":"Network-guided transcranial magnetic stimulation for depression","volume":"4","author":"Dubin MJ","year":"2017","unstructured":"Dubin MJ, Liston C, Avissar MA, Ilieva I, Gunning FM: Network-guided transcranial magnetic stimulation for depression. Curr Behav Neurosci Rep 4:70\u201377, 2017"},{"key":"b22","series-title":"Eur J Surg Oncol","first-page":"1261","article-title":"Awake mapping of the brain connectome in glioma surgery: concept is stronger than technology","volume":"41","author":"Duffau H","year":"2015","unstructured":"Duffau H: Awake mapping of the brain connectome in glioma surgery: concept is stronger than technology. Eur J Surg Oncol 41:1261\u20131263, 2015"},{"key":"b23","series-title":"J Clin Neurosci","first-page":"885","article-title":"Brain plasticity: from pathophysiological mechanisms to therapeutic applications","volume":"13","author":"Duffau H","year":"2006","unstructured":"Duffau H: Brain plasticity: from pathophysiological mechanisms to therapeutic applications. J Clin Neurosci 13:885\u2013897, 2006"},{"key":"b24","series-title":"Nat Rev Neurol","first-page":"255","article-title":"Stimulation mapping of white matter tracts to study brain functional connectivity","volume":"11","author":"Duffau H","year":"2015","unstructured":"Duffau H: Stimulation mapping of white matter tracts to study brain functional connectivity. Nat Rev Neurol 11:255\u2013265, 2015"},{"key":"b25","series-title":"J Neurol","first-page":"382","article-title":"Is the left uncinate fasciculus essential for language? A cerebral stimulation study","volume":"256","author":"Duffau H","year":"2009","unstructured":"Duffau H, Gatignol P, Moritz-Gasser S, Mandonnet E: Is the left uncinate fasciculus essential for language? A cerebral stimulation study. J Neurol 256:382\u2013389, 2009"},{"key":"b26","series-title":"Brain Lang","first-page":"1","article-title":"A re-examination of neural basis of language processing: proposal of a dynamic hodotopical model from data provided by brain stimulation mapping during picture naming","volume":"131","author":"Duffau H","year":"2014","unstructured":"Duffau H, Moritz-Gasser S, Mandonnet E: A re-examination of neural basis of language processing: proposal of a dynamic hodotopical model from data provided by brain stimulation mapping during picture naming. Brain Lang 131:1\u201310, 2014"},{"key":"b27","series-title":"J Neurol Neurosurg Psychiatry","first-page":"492","article-title":"White matter functional connectivity as an additional landmark for dominant temporal lobectomy","volume":"79","author":"Duffau H","year":"2008","unstructured":"Duffau H, Thiebaut de Schotten M, Mandonnet E: White matter functional connectivity as an additional landmark for dominant temporal lobectomy. J Neurol Neurosurg Psychiatry 79:492\u2013495, 2008"},{"key":"b28","series-title":"G Psichiatr Neuropatol","first-page":"291","article-title":"[Bases for an organic-dynamic concept of psychiatry.]","volume":"79","author":"Ey H","year":"1951","unstructured":"Ey H: [Bases for an organic-dynamic concept of psychiatry.] G Psichiatr Neuropatol 79:291\u2013311, 1951 (Italian)"},{"key":"b29","series-title":"Dia Med","first-page":"1075","article-title":"Concepci\u00f3n organo-dinamista de la psiquiatr\u00e4a en una perspectiva neo-jacksoniana","volume":"20","author":"Ey H","year":"1948","unstructured":"Ey H: Concepci\u00f3n organo-dinamista de la psiquiatr\u00e4a en una perspectiva neo-jacksoniana. Dia Med 20:1075\u20131078, 1948"},{"key":"b30","series-title":"Bleuler. Ann Med Psychol (Paris)","first-page":"272","article-title":"Les principes de Jackson et la psychopathologie d\u2019E","volume":"104","author":"Ey H","year":"1946","unstructured":"Ey H: Les principes de Jackson et la psychopathologie d\u2019E. Bleuler. Ann Med Psychol (Paris) 104:272, 1946"},{"key":"b31","series-title":"Nat Neurosci","first-page":"386","article-title":"Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder","volume":"16","author":"Figee M","year":"2013","unstructured":"Figee M, Luigjes J, Smolders R, Valencia-Alfonso CE, van Wingen G, de Kwaasteniet B, : Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder. Nat Neurosci 16:386\u2013387, 2013"},{"key":"b32","series-title":"Nat Neurosci","first-page":"1664","article-title":"Functional connectome fingerprinting: identifying individuals using patterns of brain connectivity","volume":"18","author":"Finn ES","year":"2015","unstructured":"Finn ES, Shen X, Scheinost D, Rosenberg MD, Huang J, Chun MM, : Functional connectome fingerprinting: identifying individuals using patterns of brain connectivity. Nat Neurosci 18:1664\u20131671, 2015"},{"key":"b33","article-title":"De la phr\u00e9nologie et des \u00e9tudes vraies sur le cerveau","author":"Flourens P","year":"1863","unstructured":"Flourens P: De la phr\u00e9nologie et des \u00e9tudes vraies sur le cerveau. Paris: Garnier fr\u00e9res, 1863"},{"key":"b34","series-title":"Eur Neuropsychopharmacol","first-page":"733","article-title":"Connectomics: a new paradigm for understanding brain disease","volume":"25","author":"Fornito A","year":"2015","unstructured":"Fornito A, Bullmore ET: Connectomics: a new paradigm for understanding brain disease. Eur Neuropsychopharmacol 25:733\u2013748, 2015"},{"key":"b35","series-title":"Neuroimage","first-page":"2296","article-title":"Schizophrenia, neuroimaging and connectomics","volume":"62","author":"Fornito A","year":"2012","unstructured":"Fornito A, Zalesky A, Pantelis C, Bullmore ET: Schizophrenia, neuroimaging and connectomics. Neuroimage 62:2296\u20132314, 2012"},{"key":"b36","series-title":"Proc Natl Acad Sci U S A","first-page":"E4367","article-title":"Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases","volume":"111","author":"Fox MD","year":"2014","unstructured":"Fox MD, Buckner RL, Liu H, Chakravarty MM, Lozano AM, Pascual-Leone A: Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases. Proc Natl Acad Sci U S A 111:E4367\u2013E4375, 2014"},{"key":"b37","series-title":"Med J Aust","first-page":"83","article-title":"Psychology and some applications","volume":"2","author":"Freeman W","year":"1946","unstructured":"Freeman W: Psychology and some applications. Med J Aust 2:83\u201386, 1946"},{"key":"b38","series-title":"Am J Med Sci","first-page":"1","article-title":"Prefrontal lobotomy; survey of 331 cases","volume":"211","author":"Freeman W","year":"1946","unstructured":"Freeman W, Watts JW: Prefrontal lobotomy; survey of 331 cases. Am J Med Sci 211:1\u20138, 1946"},{"key":"b39","series-title":"Prog Neurol Psychiatry","first-page":"409","article-title":"Psychosurgery","volume":"3","author":"Freeman W","year":"1948","unstructured":"Freeman W, Watts JW: Psychosurgery. Prog Neurol Psychiatry 3:409\u2013420, 1948"},{"key":"b40","series-title":"Schizophr Res","first-page":"83","article-title":"The dysconnection hypothesis (2016).","volume":"176","author":"Friston K","year":"2016","unstructured":"Friston K, Brown HR, Siemerkus J, Stephan KE: The dysconnection hypothesis (2016). Schizophr Res 176:83\u201394, 2016"},{"key":"b41","series-title":"Clin Neurosci","first-page":"89","article-title":"Schizophrenia: a disconnection syndrome?","volume":"3","author":"Friston KJ","year":"1995","unstructured":"Friston KJ, Frith CD: Schizophrenia: a disconnection syndrome? Clin Neurosci 3:89\u201397, 1995"},{"key":"b42","series-title":"Biol Psychiatry","first-page":"223","article-title":"Depression, neuroimaging and connectomics: a selective overview","volume":"77","author":"Gong Q","year":"2015","unstructured":"Gong Q, He Y: Depression, neuroimaging and connectomics: a selective overview. Biol Psychiatry 77:223\u2013235, 2015"},{"key":"b43","series-title":"Hum Brain Mapp","first-page":"5617","article-title":"Decreased limbic and increased fronto-parietal connectivity in unmedicated patients with obsessive-compulsive disorder","volume":"35","author":"G\u00f6ttlich M","year":"2014","unstructured":"G\u00f6ttlich M, Kr\u00e4mer UM, Kordon A, Hohagen F, Zurowski B: Decreased limbic and increased fronto-parietal connectivity in unmedicated patients with obsessive-compulsive disorder. Hum Brain Mapp 35:5617\u20135632, 2014"},{"key":"b44","series-title":"Neuropsychopharmacology","first-page":"317","article-title":"Invasive circuitry-based neurotherapeutics: stereotactic ablation and deep brain stimulation for OCD","volume":"35","author":"Greenberg BD","year":"2010","unstructured":"Greenberg BD, Rauch SL, Haber SN: Invasive circuitry-based neurotherapeutics: stereotactic ablation and deep brain stimulation for OCD. Neuropsychopharmacology 35:317\u2013336, 2010"},{"key":"b45","series-title":"Front Hum Neurosci","first-page":"582","article-title":"Changes in brain connectivity related to the treatment of depression measured through fMRI: a systematic review","volume":"9","author":"Gudayol-Ferr\u00e9 E","year":"2015","unstructured":"Gudayol-Ferr\u00e9 E, Per\u00f3-Cebollero M, Gonz\u00e1lez-Garrido AA, Gu\u00e0rdia-Olmos J: Changes in brain connectivity related to the treatment of depression measured through fMRI: a systematic review. Front Hum Neurosci 9:582, 2015"},{"key":"b46","series-title":"PLoS Biol","first-page":"e159","article-title":"Mapping the structural core of human cerebral cortex","volume":"6","author":"Hagmann P","year":"2008","unstructured":"Hagmann P, Cammoun L, Gigandet X, Meuli R, Honey CJ, Wedeen VJ, : Mapping the structural core of human cerebral cortex. PLoS Biol 6:e159, 2008"},{"key":"b47","series-title":"Nat Biotechnol","first-page":"40","article-title":"Clinical development success rates for investigational drugs","volume":"32","author":"Hay M","year":"2014","unstructured":"Hay M, Thomas DW, Craighead JL, Economides C, Rosenthal J: Clinical development success rates for investigational drugs. Nat Biotechnol 32:40\u201351, 2014"},{"key":"b48","series-title":"Front Integr Neurosci","first-page":"15","article-title":"\u201cConnectomic surgery\u201d: diffusion tensor imaging (DTI) tractography as a targeting modality for surgical modulation of neural networks","volume":"6","author":"Henderson JM","year":"2012","unstructured":"Henderson JM: \u201cConnectomic surgery\u201d: diffusion tensor imaging (DTI) tractography as a targeting modality for surgical modulation of neural networks. Front Integr Neurosci 6:15, 2012"},{"key":"b49","series-title":"Proc Natl Acad Sci U S A","first-page":"10240","article-title":"Network structure of cerebral cortex shapes functional connectivity on multiple time scales","volume":"104","author":"Honey CJ","year":"2007","unstructured":"Honey CJ, K\u00f6tter R, Breakspear M, Sporns O: Network structure of cerebral cortex shapes functional connectivity on multiple time scales. Proc Natl Acad Sci U S A 104:10240\u201310245, 2007"},{"key":"b50","series-title":"Hum Brain Mapp","first-page":"802","article-title":"Dynamical consequences of lesions in cortical networks","volume":"29","author":"Honey CJ","year":"2008","unstructured":"Honey CJ, Sporns O: Dynamical consequences of lesions in cortical networks. Hum Brain Mapp 29:802\u2013809, 2008"},{"key":"b51","series-title":"Neuroimage","first-page":"992","article-title":"Evidence for potentials and limitations of brain plasticity using an atlas of functional resectability of WHO grade II gliomas: towards a \u201cminimal common brain\u201d","volume":"56","author":"Ius T","year":"2011","unstructured":"Ius T, Angelini E, Thiebaut de Schotten M, Mandonnet E, Duffau H: Evidence for potentials and limitations of brain plasticity using an atlas of functional resectability of WHO grade II gliomas: towards a \u201cminimal common brain\u201d. Neuroimage 56:992\u20131000, 2011"},{"key":"b52","series-title":"Neuropsychologia","first-page":"1716","article-title":"Solving the paradox of the equipotential and modular brain: a neurocomputational model of stroke vs. slow-growing glioma","volume":"48","author":"Keidel JL","year":"2010","unstructured":"Keidel JL, Welbourne SR, Lambon Ralph MA: Solving the paradox of the equipotential and modular brain: a neurocomputational model of stroke vs. slow-growing glioma. Neuropsychologia 48:1716\u20131724, 2010"},{"key":"b53","series-title":"Nat Rev Drug Discov","first-page":"815","article-title":"Two decades of new drug development for central nervous system disorders","volume":"14","author":"Kesselheim AS","year":"2015","unstructured":"Kesselheim AS, Hwang TJ, Franklin JM: Two decades of new drug development for central nervous system disorders. Nat Rev Drug Discov 14:815\u2013816, 2015"},{"key":"b54","series-title":"Brain Struct Funct","first-page":"3399","article-title":"Role of fronto-striatal tract and frontal aslant tract in movement and speech: an axonal mapping study","volume":"220","author":"Kinoshita M","year":"2015","unstructured":"Kinoshita M, de Champfleur NM, Deverdun J, Moritz-Gasser S, Herbet G, Duffau H: Role of fronto-striatal tract and frontal aslant tract in movement and speech: an axonal mapping study. Brain Struct Funct 220:3399\u20133412, 2015"},{"key":"b55","article-title":"Gehirnpathologie Vornehmlich auf Grund der Kriegserfahrungen","author":"Kleist K","year":"1934","unstructured":"Kleist K: Gehirnpathologie Vornehmlich auf Grund der Kriegserfahrungen. Leipzig: Barth, 1934"},{"key":"b56","series-title":"Monatsschr Psychiatr Neurol","first-page":"853","article-title":"Gehirnpathologische und lokalisatorische Ergebnisse \u00fcber H\u00f6rst\u00f6rungen, Ger\u00e4uschtaubheiten und Amusien","volume":"68","author":"Kleist K","year":"1928","unstructured":"Kleist K: Gehirnpathologische und lokalisatorische Ergebnisse \u00fcber H\u00f6rst\u00f6rungen, Ger\u00e4uschtaubheiten und Amusien. Monatsschr Psychiatr Neurol 68:853\u2013860, 1928"},{"key":"b57","series-title":"Biol Psychiatry","first-page":"567","article-title":"Abnormal structural networks characterize major depressive disorder: a connectome analysis","volume":"76","author":"Korgaonkar MS","year":"2014","unstructured":"Korgaonkar MS, Fornito A, Williams LM, Grieve SM: Abnormal structural networks characterize major depressive disorder: a connectome analysis. Biol Psychiatry 76:567\u2013574, 2014"},{"key":"b58","series-title":"Front Integr Neurosci","first-page":"8","article-title":"Balancing the brain: resting state networks and deep brain stimulation","volume":"5","author":"Kringelbach ML","year":"2011","unstructured":"Kringelbach ML, Green AL, Aziz TZ: Balancing the brain: resting state networks and deep brain stimulation. Front Integr Neurosci 5:8, 2011"},{"key":"b59","series-title":"Neurosci Biobehav Rev","first-page":"286","article-title":"Small-world human brain networks: Perspectives and challenges","volume":"77","author":"Liao X","year":"2017","unstructured":"Liao X, Vasilakos AV, He Y: Small-world human brain networks: Perspectives and challenges. Neurosci Biobehav Rev 77:286\u2013300, 2017"},{"key":"b60","series-title":"J Neurol","first-page":"858","article-title":"William Macewen [1848\u20131924]","volume":"257","author":"Macmillan M","year":"2010","unstructured":"Macmillan M: William Macewen [1848\u20131924]. J Neurol 257:858\u2013859, 2010"},{"key":"b61","series-title":"Cereb Cortex","first-page":"854","article-title":"Segmentation of subcomponents within the superior longitudinal fascicle in humans: a quantitative, in vivo, DT-MRI study","volume":"15","author":"Makris N","year":"2005","unstructured":"Makris N, Kennedy DN, McInerney S, Sorensen AG, Wang R, Caviness VS Jr, : Segmentation of subcomponents within the superior longitudinal fascicle in humans: a quantitative, in vivo, DT-MRI study. Cereb Cortex 15:854\u2013869, 2005"},{"key":"b62","series-title":"J Clin Invest","first-page":"717","article-title":"Targeted electrode-based modulation of neural circuits for depression","volume":"119","author":"Mayberg HS","year":"2009","unstructured":"Mayberg HS: Targeted electrode-based modulation of neural circuits for depression. J Clin Invest 119:717\u2013725, 2009"},{"key":"b63","series-title":"Science","first-page":"502","article-title":"Is pharma running out of brainy ideas?","volume":"329","author":"Miller G","year":"2010","unstructured":"Miller G: Is pharma running out of brainy ideas? Science 329:502\u2013504, 2010"},{"key":"b64","series-title":"J Psychopharmacol","first-page":"133","article-title":"Schizophrenia: is the concept disintegrating?","volume":"1","author":"Murray RM","year":"1987","unstructured":"Murray RM, Foerster A: Schizophrenia: is the concept disintegrating? J Psychopharmacol 1:133\u2013139, 1987"},{"key":"b65","series-title":"World Neurosurg","first-page":"603","article-title":"Surgical approaches in psychiatry: a survey of the world literature on psychosurgery","volume":"97","author":"Neumaier F","year":"2017","unstructured":"Neumaier F, Paterno M, Alpdogan S, Tevoufouet EE, Schneider T, Hescheler J, : Surgical approaches in psychiatry: a survey of the world literature on psychosurgery. World Neurosurg 97:603\u2013634, 634.e1\u2013634.e8, 2017"},{"key":"b66","series-title":"Proc Natl Acad Sci U S A","first-page":"5464","article-title":"Electroconvulsive therapy reduces frontal cortical connectivity in severe depressive disorder","volume":"109","author":"Perrin JS","year":"2012","unstructured":"Perrin JS, Merz S, Bennett DM, Currie J, Steele DJ, Reid IC, : Electroconvulsive therapy reduces frontal cortical connectivity in severe depressive disorder. Proc Natl Acad Sci U S A 109:5464\u20135468, 2012"},{"key":"b67","series-title":"Neurosci Biobehav Rev","first-page":"1110","article-title":"Dysconnectivity in schizophrenia: where are we now?","volume":"35","author":"Pettersson-Yeo W","year":"2011","unstructured":"Pettersson-Yeo W, Allen P, Benetti S, McGuire P, Mechelli A: Dysconnectivity in schizophrenia: where are we now? Neurosci Biobehav Rev 35:1110\u20131124, 2011"},{"key":"b68","series-title":"Neurosci Biobehav Rev","first-page":"2856","article-title":"Brain circuitries of obsessive compulsive disorder: a systematic review and meta-analysis of diffusion tensor imaging studies","volume":"37","author":"Piras F","year":"2013","unstructured":"Piras F, Piras F, Caltagirone C, Spalletta G: Brain circuitries of obsessive compulsive disorder: a systematic review and meta-analysis of diffusion tensor imaging studies. Neurosci Biobehav Rev 37:2856\u20132877, 2013"},{"key":"b69","series-title":"Transl Psychiatry","first-page":"e882","article-title":"Connectomics-based structural network alterations in obsessive-compulsive disorder","volume":"6","author":"Reess TJ","year":"2016","unstructured":"Reess TJ, Rus OG, Schmidt R, de Reus MA, Zaudig M, Wagner G, : Connectomics-based structural network alterations in obsessive-compulsive disorder. Transl Psychiatry 6:e882, 2016"},{"key":"b70","series-title":"Neuroimage","first-page":"202","article-title":"Dynamic causal modelling of brain-behaviour relationships","volume":"117","author":"Rigoux L","year":"2015","unstructured":"Rigoux L, Daunizeau J: Dynamic causal modelling of brain-behaviour relationships. Neuroimage 117:202\u2013221, 2015"},{"key":"b71","series-title":"Mol Psychiatry","article-title":"A connectomic approach for subcallosal cingulate deep brain stimulation surgery: prospective targeting in treatment-resistant depression","author":"Riva-Posse P","unstructured":"Riva-Posse P, Choi KS, Holtzheimer PE, Crowell AL, Garlow SJ, Rajendra JK, : A connectomic approach for subcallosal cingulate deep brain stimulation surgery: prospective targeting in treatment-resistant depression. Mol Psychiatry [epub ahead of print], 2017"},{"key":"b72","series-title":"Biol Psychiatry","first-page":"963","article-title":"Defining critical white matter pathways mediating successful subcallosal cingulate deep brain stimulation for treatment-resistant depression","volume":"76","author":"Riva-Posse P","year":"2014","unstructured":"Riva-Posse P, Choi KS, Holtzheimer PE, McIntyre CC, Gross RE, Chaturvedi A, : Defining critical white matter pathways mediating successful subcallosal cingulate deep brain stimulation for treatment-resistant depression. Biol Psychiatry 76:963\u2013969, 2014"},{"key":"b73","series-title":"Neuropathol Appl Neurobiol","first-page":"3","article-title":"Notes from the graveyard: neuropathology and schizophrenia","volume":"16","author":"Roberts GW","year":"1990","unstructured":"Roberts GW, Bruton CJ: Notes from the graveyard: neuropathology and schizophrenia. Neuropathol Appl Neurobiol 16:3\u201316, 1990"},{"key":"b74","series-title":"J Neurosci","first-page":"6263","article-title":"Emerging evidence of connectomic abnormalities in schizophrenia","volume":"31","author":"Rubinov M","year":"2011","unstructured":"Rubinov M, Bassett DS: Emerging evidence of connectomic abnormalities in schizophrenia. J Neurosci 31:6263\u20136265, 2011"},{"key":"b75","series-title":"N Engl J Med","first-page":"18","article-title":"Functional outcome after language mapping for glioma resection","volume":"358","author":"Sanai N","year":"2008","unstructured":"Sanai N, Mirzadeh Z, Berger MS: Functional outcome after language mapping for glioma resection. N Engl J Med 358:18\u201327, 2008"},{"key":"b76","series-title":"Nat Rev Drug Discov","first-page":"19","article-title":"A comprehensive map of molecular drug targets","volume":"16","author":"Santos R","year":"2017","unstructured":"Santos R, Ursu O, Gaulton A, Bento AP, Donadi RS, Bologa CG, : A comprehensive map of molecular drug targets. Nat Rev Drug Discov 16:19\u201334, 2017"},{"key":"b77","series-title":"Biol Psychiatry","first-page":"606","article-title":"The effects of pharmacological treatment on functional brain connectome in obsessive-compulsive disorder","volume":"75","author":"Shin DJ","year":"2014","unstructured":"Shin DJ, Jung WH, He Y, Wang J, Shim G, Byun MS, : The effects of pharmacological treatment on functional brain connectome in obsessive-compulsive disorder. Biol Psychiatry 75:606\u2013614, 2014"},{"key":"b78","series-title":"Nat Neurosci","first-page":"652","article-title":"Contributions and challenges for network models in cognitive neuroscience","volume":"17","author":"Sporns O","year":"2014","unstructured":"Sporns O: Contributions and challenges for network models in cognitive neuroscience. Nat Neurosci 17:652\u2013660, 2014"},{"key":"b79","series-title":"PLOS Comput Biol","first-page":"e42","article-title":"The human connectome: a structural description of the human brain","volume":"1","author":"Sporns O","year":"2005","unstructured":"Sporns O, Tononi G, K\u00f6tter R: The human connectome: a structural description of the human brain. PLOS Comput Biol 1:e42, 2005"},{"issue":"Pt B","key":"b80","series-title":"Neuroimage","first-page":"180","article-title":"Computational neuroimaging strategies for single patient predictions","volume":"145","author":"Stephan KE","year":"2017","unstructured":"Stephan KE, Schlagenhauf F, Huys QJM, Raman S, Aponte EA, Brodersen KH, : Computational neuroimaging strategies for single patient predictions. Neuroimage 145 (Pt B):180\u2013199, 2017"},{"key":"b81","series-title":"Rev Neurol (Paris)","first-page":"554","article-title":"[Anatomic-physiological reflections on psychosurgery.]","volume":"87","author":"Talairach J","year":"1952","unstructured":"Talairach J: [Anatomic-physiological reflections on psychosurgery.] Rev Neurol (Paris) 87:554\u2013557, 1952 (Fr)"},{"key":"b82","series-title":"Rev Neurol (Paris)","first-page":"352","article-title":"[Destruction of the anterior ventral thalamic nucleus in the treatment of mental diseases.]","volume":"87","author":"Talairach J","year":"1952","unstructured":"Talairach J: [Destruction of the anterior ventral thalamic nucleus in the treatment of mental diseases.] Rev Neurol (Paris) 87:352\u2013357, 1952 (Fr)"},{"key":"b83","series-title":"Confin Neurol","first-page":"328","article-title":"Functional stereotaxic exploration of epilepsy","volume":"22","author":"Talairach J","year":"1962","unstructured":"Talairach J, Bancaud J, Bonis A, Szikla G, Tournoux P: Functional stereotaxic exploration of epilepsy. Confin Neurol 22:328\u2013331, 1962"},{"key":"b84","series-title":"Stereotact Funct Neurosurg","first-page":"282","article-title":"Integrating diffusion tensor imaging-based tractography into deep brain stimulation surgery: a review of the literature","volume":"92","author":"Torres CV","year":"2014","unstructured":"Torres CV, Manzanares R, Sola RG: Integrating diffusion tensor imaging-based tractography into deep brain stimulation surgery: a review of the literature. Stereotact Funct Neurosurg 92:282\u2013290, 2014"},{"key":"b85","series-title":"Biol Psychiatry","first-page":"749","article-title":"The Wernicke-Kleist-Leonhard school of psychiatry","volume":"34","author":"Ungvari GS","year":"1993","unstructured":"Ungvari GS: The Wernicke-Kleist-Leonhard school of psychiatry. Biol Psychiatry 34:749\u2013752, 1993"},{"key":"b86","series-title":"JAMA Psychiatry","first-page":"783","article-title":"Abnormal rich club organization and functional brain dynamics in schizophrenia","volume":"70","author":"van den Heuvel MP","year":"2013","unstructured":"van den Heuvel MP, Sporns O, Collin G, Scheewe T, Mandl RCW, Cahn W, : Abnormal rich club organization and functional brain dynamics in schizophrenia. JAMA Psychiatry 70:783\u2013792, 2013"},{"key":"b87","series-title":"PLoS One","first-page":"e86496","article-title":"Neural plasticity in human brain connectivity: the effects of long term deep brain stimulation of the subthalamic nucleus in Parkinson\u2019s disease","volume":"9","author":"van Hartevelt TJ","year":"2014","unstructured":"van Hartevelt TJ, Cabral J, Deco G, M\u00f8ller A, Green AL, Aziz TZ, : Neural plasticity in human brain connectivity: the effects of long term deep brain stimulation of the subthalamic nucleus in Parkinson\u2019s disease. PLoS One 9:e86496, 2014"},{"key":"b88","series-title":"J Neurosurg","first-page":"1181","article-title":"Recovery of functional connectivity of the sensorimotor network after surgery for diffuse low-grade gliomas involving the supplementary motor area","volume":"126","author":"Vassal M","year":"2017","unstructured":"Vassal M, Charroud C, Deverdun J, Le Bars E, Molino F, Bonnetblanc F, : Recovery of functional connectivity of the sensorimotor network after surgery for diffuse low-grade gliomas involving the supplementary motor area. J Neurosurg 126:1181\u20131190, 2017"},{"key":"b89","series-title":"South Med Surg","first-page":"241","article-title":"Prefrontal lobotomy; factors influencing prognosis","volume":"108","author":"Watts JW","year":"1946","unstructured":"Watts JW, Freeman W: Prefrontal lobotomy; factors influencing prognosis. South Med Surg 108:241\u2013247, 1946"},{"key":"b90","series-title":"Front Hum Neurosci","first-page":"653","article-title":"A review of structural neuroimaging in schizophrenia: from connectivity to connectomics","volume":"8","author":"Wheeler AL","year":"2014","unstructured":"Wheeler AL, Voineskos AN: A review of structural neuroimaging in schizophrenia: from connectivity to connectomics. Front Hum Neurosci 8:653, 2014"},{"key":"b91","series-title":"J Affect Disord","first-page":"610","article-title":"Cognitive behavioral therapy changes functional connectivity between medial prefrontal and anterior cingulate cortices","volume":"208","author":"Yoshimura S","year":"2017","unstructured":"Yoshimura S, Okamoto Y, Matsunaga M, Onoda K, Okada G, Kunisato Y, : Cognitive behavioral therapy changes functional connectivity between medial prefrontal and anterior cingulate cortices. J Affect Disord 208:610\u2013614, 2017"},{"key":"b92","series-title":"Neural Plast 2015","first-page":"271674","article-title":"Reorganization of anatomical connectome following electroconvulsive therapy in major depressive disorder","author":"Zeng J","year":"2015","unstructured":"Zeng J, Luo Q, Du L, Liao W, Li Y, Liu H, : Reorganization of anatomical connectome following electroconvulsive therapy in major depressive disorder. Neural Plast 2015:271674, 2015"},{"key":"b1","series-title":"J Geriatr Psychiatry Neurol","first-page":"33","article-title":"A review of longitudinal electroconvulsive therapy: neuroimaging investigations","volume":"27","author":"Abbott CC","year":"2014","unstructured":"Abbott CC, Gallegos P, Rediske N, Lemke NT, Quinn DK: A review of longitudinal electroconvulsive therapy: neuroimaging investigations. J Geriatr Psychiatry Neurol 27:33\u201346, 2014"},{"key":"b2","series-title":"Neuropsychopharmacology","first-page":"1210","article-title":"Ketamine treatment and global brain connectivity in major depression","volume":"42","author":"Abdallah CG","year":"2017","unstructured":"Abdallah CG, Averill LA, Collins KA, Geha P, Schwartz J, Averill C, : Ketamine treatment and global brain connectivity in major depression. Neuropsychopharmacology 42:1210\u20131219, 2017"},{"key":"b3","series-title":"Brain Struct Funct","first-page":"1983","article-title":"The left inferior fronto-occipital fasciculus subserves language semantics: a multilevel lesion study","volume":"220","author":"Almairac F","year":"2015","unstructured":"Almairac F, Herbet G, Moritz-Gasser S, de Champfleur NM, Duffau H: The left inferior fronto-occipital fasciculus subserves language semantics: a multilevel lesion study. Brain Struct Funct 220:1983\u20131995, 2015"},{"key":"b4","series-title":"J Affect Disord","first-page":"175","article-title":"Graph-theoretical analysis of resting-state fMRI in pediatric obsessive-compulsive disorder","volume":"193","author":"Armstrong CC","year":"2016","unstructured":"Armstrong CC, Moody TD, Feusner JD, McCracken JT, Chang S, Levitt JG, : Graph-theoretical analysis of resting-state fMRI in pediatric obsessive-compulsive disorder. J Affect Disord 193:175\u2013184, 2016"},{"key":"b5","series-title":"Med Contemp","first-page":"61","article-title":"[A clinical and psychological study of patients in leucotomized Hospital J\u00falio de Matos.]","volume":"67","year":"1949","unstructured":"Barahona Fernandes HJ: [A clinical and psychological study of patients in leucotomized Hospital J\u00falio de Matos.] Med Contemp 67:61\u201366, 1949 (Portuguese)"},{"key":"b6","series-title":"J Med (Oporto)","first-page":"496","article-title":"[Clinical study on the psychological and leucotomy.]","volume":"12","year":"1948","unstructured":"Barahona Fernandes HJ: [Clinical study on the psychological and leucotomy.] J Med (Oporto) 12:496, 1948 (Portuguese)"},{"key":"b7","series-title":"Curr Opin Neurol","first-page":"340","article-title":"Human brain networks in health and disease","volume":"22","author":"Bassett DS","year":"2009","unstructured":"Bassett DS, Bullmore ET: Human brain networks in health and disease. Curr Opin Neurol 22:340\u2013347, 2009"},{"key":"b8","series-title":"Neurology","first-page":"1319","article-title":"Improvements in memory function following anterior temporal lobe resection for epilepsy","volume":"71","author":"Baxendale S","year":"2008","unstructured":"Baxendale S, Thompson PJ, Duncan JS: Improvements in memory function following anterior temporal lobe resection for epilepsy. Neurology 71:1319\u20131325, 2008"},{"key":"b9","series-title":"Bull la Soci\u00e9t\u00e9 d\u2019Anthropologie","first-page":"200","article-title":"Localisations des fonctions c\u00e9r\u00e9brales. Si\u00e8ge de la facult\u00e9 du langage articul\u00e9","volume":"4","author":"Broca P","year":"1863","unstructured":"Broca P: Localisations des fonctions c\u00e9r\u00e9brales. Si\u00e8ge de la facult\u00e9 du langage articul\u00e9. Bull la Soci\u00e9t\u00e9 d\u2019Anthropologie 4:200\u2013208, 1863"},{"key":"b10","series-title":"Nat Rev Neurosci","first-page":"186","article-title":"Complex brain networks: graph theoretical analysis of structural and functional systems","volume":"10","author":"Bullmore E","year":"2009","unstructured":"Bullmore E, Sporns O: Complex brain networks: graph theoretical analysis of structural and functional systems. Nat Rev Neurosci 10:186\u2013198, 2009"},{"key":"b11","series-title":"Nat Rev Neurosci","first-page":"336","article-title":"The economy of brain network organization","volume":"13","author":"Bullmore E","year":"2012","unstructured":"Bullmore E, Sporns O: The economy of brain network organization. Nat Rev Neurosci 13:336\u2013349, 2012"},{"key":"b12","series-title":"Brain Stimulat","first-page":"65","article-title":"Modulation of limbic and prefrontal connectivity by electroconvulsive therapy in treatment-resistant depression: a preliminary study","volume":"9","author":"Cano M","year":"2016","unstructured":"Cano M, Cardoner N, Urretavizcaya M, Mart\u00ednez-Zalaca\u00edn I, Goldberg X, Via E, : Modulation of limbic and prefrontal connectivity by electroconvulsive therapy in treatment-resistant depression: a preliminary study. Brain Stimulat 9:65\u201371, 2016"},{"key":"b13","series-title":"Ann Neurol","first-page":"8","article-title":"Perisylvian language networks of the human brain","volume":"57","author":"Catani M","year":"2005","unstructured":"Catani M, Jones DK, ffytche DH: Perisylvian language networks of the human brain. Ann Neurol 57:8\u201316, 2005"},{"key":"b14","series-title":"Rev Neurol (Paris)","first-page":"3","article-title":"[Follow-up of 78 cases of psychosurgery a year after the operation.]","volume":"89","author":"David M","year":"1953","unstructured":"David M, Sauguet J, Hecaen H, Talairach J: [Follow-up of 78 cases of psychosurgery a year after the operation.] Rev Neurol (Paris) 89:3\u201321, 1953"},{"key":"b15","series-title":"Neurosurgery","first-page":"1709","article-title":"Brain hodotopy: from esoteric concept to practical surgical applications","volume":"68","author":"De Benedictis A","year":"2011","unstructured":"De Benedictis A, Duffau H: Brain hodotopy: from esoteric concept to practical surgical applications. Neurosurgery 68:1709\u20131723, 2011"},{"key":"b16","series-title":"J Clin Oncol","first-page":"2559","article-title":"Impact of intraoperative stimulation brain mapping on glioma surgery outcome: a meta-analysis","volume":"30","author":"De Witt Hamer PC","year":"2012","unstructured":"De Witt Hamer PC, Robles SG, Zwinderman AH, Duffau H, Berger MS: Impact of intraoperative stimulation brain mapping on glioma surgery outcome: a meta-analysis. J Clin Oncol 30:2559\u20132565, 2012"},{"key":"b17","series-title":"Neuron","first-page":"892","article-title":"Great expectations: using whole-brain computational connectomics for understanding neuropsychiatric disorders","volume":"84","author":"Deco G","year":"2014","unstructured":"Deco G, Kringelbach ML: Great expectations: using whole-brain computational connectomics for understanding neuropsychiatric disorders. Neuron 84:892\u2013905, 2014"},{"key":"b18","series-title":"Ann Med Psychol (Paris)","first-page":"112","article-title":"[Therapeutic use in psychiatry of phenothiazine of central elective action (4560 RP).]","volume":"110","author":"Delay J","year":"1952","unstructured":"Delay J, Deniker P, Harl JM: [Therapeutic use in psychiatry of phenothiazine of central elective action (4560 RP).] Ann Med Psychol (Paris) 110:112\u2013117, 1952 (Fr)"},{"key":"b19","series-title":"Brain","first-page":"898","article-title":"Contrasting acute and slow-growing lesions: a new door to brain plasticity","volume":"130","author":"Desmurget M","year":"2007","unstructured":"Desmurget M, Bonnetblanc F, Duffau H: Contrasting acute and slow-growing lesions: a new door to brain plasticity. Brain 130:898\u2013914, 2007"},{"key":"b20","series-title":"Psychiatry Res","first-page":"53","article-title":"Short-term group cognitive behavior therapy contributes to recovery from mild depression: evidence from functional and structural MRI","volume":"251","author":"Du X","year":"2016","unstructured":"Du X, Mao Y, Ran Q, Zhang Q, Luo Q, Qiu J: Short-term group cognitive behavior therapy contributes to recovery from mild depression: evidence from functional and structural MRI. Psychiatry Res 251:53\u201359, 2016"},{"key":"b21","series-title":"Curr Behav Neurosci Rep","first-page":"70","article-title":"Network-guided transcranial magnetic stimulation for depression","volume":"4","author":"Dubin MJ","year":"2017","unstructured":"Dubin MJ, Liston C, Avissar MA, Ilieva I, Gunning FM: Network-guided transcranial magnetic stimulation for depression. Curr Behav Neurosci Rep 4:70\u201377, 2017"},{"key":"b22","series-title":"Eur J Surg Oncol","first-page":"1261","article-title":"Awake mapping of the brain connectome in glioma surgery: concept is stronger than technology","volume":"41","author":"Duffau H","year":"2015","unstructured":"Duffau H: Awake mapping of the brain connectome in glioma surgery: concept is stronger than technology. Eur J Surg Oncol 41:1261\u20131263, 2015"},{"key":"b23","series-title":"J Clin Neurosci","first-page":"885","article-title":"Brain plasticity: from pathophysiological mechanisms to therapeutic applications","volume":"13","author":"Duffau H","year":"2006","unstructured":"Duffau H: Brain plasticity: from pathophysiological mechanisms to therapeutic applications. J Clin Neurosci 13:885\u2013897, 2006"},{"key":"b24","series-title":"Nat Rev Neurol","first-page":"255","article-title":"Stimulation mapping of white matter tracts to study brain functional connectivity","volume":"11","author":"Duffau H","year":"2015","unstructured":"Duffau H: Stimulation mapping of white matter tracts to study brain functional connectivity. Nat Rev Neurol 11:255\u2013265, 2015"},{"key":"b25","series-title":"J Neurol","first-page":"382","article-title":"Is the left uncinate fasciculus essential for language? A cerebral stimulation study","volume":"256","author":"Duffau H","year":"2009","unstructured":"Duffau H, Gatignol P, Moritz-Gasser S, Mandonnet E: Is the left uncinate fasciculus essential for language? A cerebral stimulation study. J Neurol 256:382\u2013389, 2009"},{"key":"b26","series-title":"Brain Lang","first-page":"1","article-title":"A re-examination of neural basis of language processing: proposal of a dynamic hodotopical model from data provided by brain stimulation mapping during picture naming","volume":"131","author":"Duffau H","year":"2014","unstructured":"Duffau H, Moritz-Gasser S, Mandonnet E: A re-examination of neural basis of language processing: proposal of a dynamic hodotopical model from data provided by brain stimulation mapping during picture naming. Brain Lang 131:1\u201310, 2014"},{"key":"b27","series-title":"J Neurol Neurosurg Psychiatry","first-page":"492","article-title":"White matter functional connectivity as an additional landmark for dominant temporal lobectomy","volume":"79","author":"Duffau H","year":"2008","unstructured":"Duffau H, Thiebaut de Schotten M, Mandonnet E: White matter functional connectivity as an additional landmark for dominant temporal lobectomy. J Neurol Neurosurg Psychiatry 79:492\u2013495, 2008"},{"key":"b28","series-title":"G Psichiatr Neuropatol","first-page":"291","article-title":"[Bases for an organic-dynamic concept of psychiatry.]","volume":"79","author":"Ey H","year":"1951","unstructured":"Ey H: [Bases for an organic-dynamic concept of psychiatry.] G Psichiatr Neuropatol 79:291\u2013311, 1951 (Italian)"},{"key":"b29","series-title":"Dia Med","first-page":"1075","article-title":"Concepci\u00f3n organo-dinamista de la psiquiatr\u00e4a en una perspectiva neo-jacksoniana","volume":"20","author":"Ey H","year":"1948","unstructured":"Ey H: Concepci\u00f3n organo-dinamista de la psiquiatr\u00e4a en una perspectiva neo-jacksoniana. Dia Med 20:1075\u20131078, 1948"},{"key":"b30","series-title":"Bleuler. Ann Med Psychol (Paris)","first-page":"272","article-title":"Les principes de Jackson et la psychopathologie d\u2019E","volume":"104","author":"Ey H","year":"1946","unstructured":"Ey H: Les principes de Jackson et la psychopathologie d\u2019E. Bleuler. Ann Med Psychol (Paris) 104:272, 1946"},{"key":"b31","series-title":"Nat Neurosci","first-page":"386","article-title":"Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder","volume":"16","author":"Figee M","year":"2013","unstructured":"Figee M, Luigjes J, Smolders R, Valencia-Alfonso CE, van Wingen G, de Kwaasteniet B, : Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder. Nat Neurosci 16:386\u2013387, 2013"},{"key":"b32","series-title":"Nat Neurosci","first-page":"1664","article-title":"Functional connectome fingerprinting: identifying individuals using patterns of brain connectivity","volume":"18","author":"Finn ES","year":"2015","unstructured":"Finn ES, Shen X, Scheinost D, Rosenberg MD, Huang J, Chun MM, : Functional connectome fingerprinting: identifying individuals using patterns of brain connectivity. Nat Neurosci 18:1664\u20131671, 2015"},{"key":"b33","article-title":"De la phr\u00e9nologie et des \u00e9tudes vraies sur le cerveau","author":"Flourens P","year":"1863","unstructured":"Flourens P: De la phr\u00e9nologie et des \u00e9tudes vraies sur le cerveau. Paris: Garnier fr\u00e9res, 1863"},{"key":"b34","series-title":"Eur Neuropsychopharmacol","first-page":"733","article-title":"Connectomics: a new paradigm for understanding brain disease","volume":"25","author":"Fornito A","year":"2015","unstructured":"Fornito A, Bullmore ET: Connectomics: a new paradigm for understanding brain disease. Eur Neuropsychopharmacol 25:733\u2013748, 2015"},{"key":"b35","series-title":"Neuroimage","first-page":"2296","article-title":"Schizophrenia, neuroimaging and connectomics","volume":"62","author":"Fornito A","year":"2012","unstructured":"Fornito A, Zalesky A, Pantelis C, Bullmore ET: Schizophrenia, neuroimaging and connectomics. Neuroimage 62:2296\u20132314, 2012"},{"key":"b36","series-title":"Proc Natl Acad Sci U S A","first-page":"E4367","article-title":"Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases","volume":"111","author":"Fox MD","year":"2014","unstructured":"Fox MD, Buckner RL, Liu H, Chakravarty MM, Lozano AM, Pascual-Leone A: Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases. Proc Natl Acad Sci U S A 111:E4367\u2013E4375, 2014"},{"key":"b37","series-title":"Med J Aust","first-page":"83","article-title":"Psychology and some applications","volume":"2","author":"Freeman W","year":"1946","unstructured":"Freeman W: Psychology and some applications. Med J Aust 2:83\u201386, 1946"},{"key":"b38","series-title":"Am J Med Sci","first-page":"1","article-title":"Prefrontal lobotomy; survey of 331 cases","volume":"211","author":"Freeman W","year":"1946","unstructured":"Freeman W, Watts JW: Prefrontal lobotomy; survey of 331 cases. Am J Med Sci 211:1\u20138, 1946"},{"key":"b39","series-title":"Prog Neurol Psychiatry","first-page":"409","article-title":"Psychosurgery","volume":"3","author":"Freeman W","year":"1948","unstructured":"Freeman W, Watts JW: Psychosurgery. Prog Neurol Psychiatry 3:409\u2013420, 1948"},{"key":"b40","series-title":"Schizophr Res","first-page":"83","article-title":"The dysconnection hypothesis (2016).","volume":"176","author":"Friston K","year":"2016","unstructured":"Friston K, Brown HR, Siemerkus J, Stephan KE: The dysconnection hypothesis (2016). Schizophr Res 176:83\u201394, 2016"},{"key":"b41","series-title":"Clin Neurosci","first-page":"89","article-title":"Schizophrenia: a disconnection syndrome?","volume":"3","author":"Friston KJ","year":"1995","unstructured":"Friston KJ, Frith CD: Schizophrenia: a disconnection syndrome? Clin Neurosci 3:89\u201397, 1995"},{"key":"b42","series-title":"Biol Psychiatry","first-page":"223","article-title":"Depression, neuroimaging and connectomics: a selective overview","volume":"77","author":"Gong Q","year":"2015","unstructured":"Gong Q, He Y: Depression, neuroimaging and connectomics: a selective overview. Biol Psychiatry 77:223\u2013235, 2015"},{"key":"b43","series-title":"Hum Brain Mapp","first-page":"5617","article-title":"Decreased limbic and increased fronto-parietal connectivity in unmedicated patients with obsessive-compulsive disorder","volume":"35","author":"G\u00f6ttlich M","year":"2014","unstructured":"G\u00f6ttlich M, Kr\u00e4mer UM, Kordon A, Hohagen F, Zurowski B: Decreased limbic and increased fronto-parietal connectivity in unmedicated patients with obsessive-compulsive disorder. Hum Brain Mapp 35:5617\u20135632, 2014"},{"key":"b44","series-title":"Neuropsychopharmacology","first-page":"317","article-title":"Invasive circuitry-based neurotherapeutics: stereotactic ablation and deep brain stimulation for OCD","volume":"35","author":"Greenberg BD","year":"2010","unstructured":"Greenberg BD, Rauch SL, Haber SN: Invasive circuitry-based neurotherapeutics: stereotactic ablation and deep brain stimulation for OCD. Neuropsychopharmacology 35:317\u2013336, 2010"},{"key":"b45","series-title":"Front Hum Neurosci","first-page":"582","article-title":"Changes in brain connectivity related to the treatment of depression measured through fMRI: a systematic review","volume":"9","author":"Gudayol-Ferr\u00e9 E","year":"2015","unstructured":"Gudayol-Ferr\u00e9 E, Per\u00f3-Cebollero M, Gonz\u00e1lez-Garrido AA, Gu\u00e0rdia-Olmos J: Changes in brain connectivity related to the treatment of depression measured through fMRI: a systematic review. Front Hum Neurosci 9:582, 2015"},{"key":"b46","series-title":"PLoS Biol","first-page":"e159","article-title":"Mapping the structural core of human cerebral cortex","volume":"6","author":"Hagmann P","year":"2008","unstructured":"Hagmann P, Cammoun L, Gigandet X, Meuli R, Honey CJ, Wedeen VJ, : Mapping the structural core of human cerebral cortex. PLoS Biol 6:e159, 2008"},{"key":"b47","series-title":"Nat Biotechnol","first-page":"40","article-title":"Clinical development success rates for investigational drugs","volume":"32","author":"Hay M","year":"2014","unstructured":"Hay M, Thomas DW, Craighead JL, Economides C, Rosenthal J: Clinical development success rates for investigational drugs. Nat Biotechnol 32:40\u201351, 2014"},{"key":"b48","series-title":"Front Integr Neurosci","first-page":"15","article-title":"\u201cConnectomic surgery\u201d: diffusion tensor imaging (DTI) tractography as a targeting modality for surgical modulation of neural networks","volume":"6","author":"Henderson JM","year":"2012","unstructured":"Henderson JM: \u201cConnectomic surgery\u201d: diffusion tensor imaging (DTI) tractography as a targeting modality for surgical modulation of neural networks. Front Integr Neurosci 6:15, 2012"},{"key":"b49","series-title":"Proc Natl Acad Sci U S A","first-page":"10240","article-title":"Network structure of cerebral cortex shapes functional connectivity on multiple time scales","volume":"104","author":"Honey CJ","year":"2007","unstructured":"Honey CJ, K\u00f6tter R, Breakspear M, Sporns O: Network structure of cerebral cortex shapes functional connectivity on multiple time scales. Proc Natl Acad Sci U S A 104:10240\u201310245, 2007"},{"key":"b50","series-title":"Hum Brain Mapp","first-page":"802","article-title":"Dynamical consequences of lesions in cortical networks","volume":"29","author":"Honey CJ","year":"2008","unstructured":"Honey CJ, Sporns O: Dynamical consequences of lesions in cortical networks. Hum Brain Mapp 29:802\u2013809, 2008"},{"key":"b51","series-title":"Neuroimage","first-page":"992","article-title":"Evidence for potentials and limitations of brain plasticity using an atlas of functional resectability of WHO grade II gliomas: towards a \u201cminimal common brain\u201d","volume":"56","author":"Ius T","year":"2011","unstructured":"Ius T, Angelini E, Thiebaut de Schotten M, Mandonnet E, Duffau H: Evidence for potentials and limitations of brain plasticity using an atlas of functional resectability of WHO grade II gliomas: towards a \u201cminimal common brain\u201d. Neuroimage 56:992\u20131000, 2011"},{"key":"b52","series-title":"Neuropsychologia","first-page":"1716","article-title":"Solving the paradox of the equipotential and modular brain: a neurocomputational model of stroke vs. slow-growing glioma","volume":"48","author":"Keidel JL","year":"2010","unstructured":"Keidel JL, Welbourne SR, Lambon Ralph MA: Solving the paradox of the equipotential and modular brain: a neurocomputational model of stroke vs. slow-growing glioma. Neuropsychologia 48:1716\u20131724, 2010"},{"key":"b53","series-title":"Nat Rev Drug Discov","first-page":"815","article-title":"Two decades of new drug development for central nervous system disorders","volume":"14","author":"Kesselheim AS","year":"2015","unstructured":"Kesselheim AS, Hwang TJ, Franklin JM: Two decades of new drug development for central nervous system disorders. Nat Rev Drug Discov 14:815\u2013816, 2015"},{"key":"b54","series-title":"Brain Struct Funct","first-page":"3399","article-title":"Role of fronto-striatal tract and frontal aslant tract in movement and speech: an axonal mapping study","volume":"220","author":"Kinoshita M","year":"2015","unstructured":"Kinoshita M, de Champfleur NM, Deverdun J, Moritz-Gasser S, Herbet G, Duffau H: Role of fronto-striatal tract and frontal aslant tract in movement and speech: an axonal mapping study. Brain Struct Funct 220:3399\u20133412, 2015"},{"key":"b55","article-title":"Gehirnpathologie Vornehmlich auf Grund der Kriegserfahrungen","author":"Kleist K","year":"1934","unstructured":"Kleist K: Gehirnpathologie Vornehmlich auf Grund der Kriegserfahrungen. Leipzig: Barth, 1934"},{"key":"b56","series-title":"Monatsschr Psychiatr Neurol","first-page":"853","article-title":"Gehirnpathologische und lokalisatorische Ergebnisse \u00fcber H\u00f6rst\u00f6rungen, Ger\u00e4uschtaubheiten und Amusien","volume":"68","author":"Kleist K","year":"1928","unstructured":"Kleist K: Gehirnpathologische und lokalisatorische Ergebnisse \u00fcber H\u00f6rst\u00f6rungen, Ger\u00e4uschtaubheiten und Amusien. Monatsschr Psychiatr Neurol 68:853\u2013860, 1928"},{"key":"b57","series-title":"Biol Psychiatry","first-page":"567","article-title":"Abnormal structural networks characterize major depressive disorder: a connectome analysis","volume":"76","author":"Korgaonkar MS","year":"2014","unstructured":"Korgaonkar MS, Fornito A, Williams LM, Grieve SM: Abnormal structural networks characterize major depressive disorder: a connectome analysis. Biol Psychiatry 76:567\u2013574, 2014"},{"key":"b58","series-title":"Front Integr Neurosci","first-page":"8","article-title":"Balancing the brain: resting state networks and deep brain stimulation","volume":"5","author":"Kringelbach ML","year":"2011","unstructured":"Kringelbach ML, Green AL, Aziz TZ: Balancing the brain: resting state networks and deep brain stimulation. Front Integr Neurosci 5:8, 2011"},{"key":"b59","series-title":"Neurosci Biobehav Rev","first-page":"286","article-title":"Small-world human brain networks: Perspectives and challenges","volume":"77","author":"Liao X","year":"2017","unstructured":"Liao X, Vasilakos AV, He Y: Small-world human brain networks: Perspectives and challenges. Neurosci Biobehav Rev 77:286\u2013300, 2017"},{"key":"b60","series-title":"J Neurol","first-page":"858","article-title":"William Macewen [1848\u20131924]","volume":"257","author":"Macmillan M","year":"2010","unstructured":"Macmillan M: William Macewen [1848\u20131924]. J Neurol 257:858\u2013859, 2010"},{"key":"b61","series-title":"Cereb Cortex","first-page":"854","article-title":"Segmentation of subcomponents within the superior longitudinal fascicle in humans: a quantitative, in vivo, DT-MRI study","volume":"15","author":"Makris N","year":"2005","unstructured":"Makris N, Kennedy DN, McInerney S, Sorensen AG, Wang R, Caviness VS Jr, : Segmentation of subcomponents within the superior longitudinal fascicle in humans: a quantitative, in vivo, DT-MRI study. Cereb Cortex 15:854\u2013869, 2005"},{"key":"b62","series-title":"J Clin Invest","first-page":"717","article-title":"Targeted electrode-based modulation of neural circuits for depression","volume":"119","author":"Mayberg HS","year":"2009","unstructured":"Mayberg HS: Targeted electrode-based modulation of neural circuits for depression. J Clin Invest 119:717\u2013725, 2009"},{"key":"b63","series-title":"Science","first-page":"502","article-title":"Is pharma running out of brainy ideas?","volume":"329","author":"Miller G","year":"2010","unstructured":"Miller G: Is pharma running out of brainy ideas? Science 329:502\u2013504, 2010"},{"key":"b64","series-title":"J Psychopharmacol","first-page":"133","article-title":"Schizophrenia: is the concept disintegrating?","volume":"1","author":"Murray RM","year":"1987","unstructured":"Murray RM, Foerster A: Schizophrenia: is the concept disintegrating? J Psychopharmacol 1:133\u2013139, 1987"},{"key":"b65","series-title":"World Neurosurg","first-page":"603","article-title":"Surgical approaches in psychiatry: a survey of the world literature on psychosurgery","volume":"97","author":"Neumaier F","year":"2017","unstructured":"Neumaier F, Paterno M, Alpdogan S, Tevoufouet EE, Schneider T, Hescheler J, : Surgical approaches in psychiatry: a survey of the world literature on psychosurgery. World Neurosurg 97:603\u2013634, 634.e1\u2013634.e8, 2017"},{"key":"b66","series-title":"Proc Natl Acad Sci U S A","first-page":"5464","article-title":"Electroconvulsive therapy reduces frontal cortical connectivity in severe depressive disorder","volume":"109","author":"Perrin JS","year":"2012","unstructured":"Perrin JS, Merz S, Bennett DM, Currie J, Steele DJ, Reid IC, : Electroconvulsive therapy reduces frontal cortical connectivity in severe depressive disorder. Proc Natl Acad Sci U S A 109:5464\u20135468, 2012"},{"key":"b67","series-title":"Neurosci Biobehav Rev","first-page":"1110","article-title":"Dysconnectivity in schizophrenia: where are we now?","volume":"35","author":"Pettersson-Yeo W","year":"2011","unstructured":"Pettersson-Yeo W, Allen P, Benetti S, McGuire P, Mechelli A: Dysconnectivity in schizophrenia: where are we now? Neurosci Biobehav Rev 35:1110\u20131124, 2011"},{"key":"b68","series-title":"Neurosci Biobehav Rev","first-page":"2856","article-title":"Brain circuitries of obsessive compulsive disorder: a systematic review and meta-analysis of diffusion tensor imaging studies","volume":"37","author":"Piras F","year":"2013","unstructured":"Piras F, Piras F, Caltagirone C, Spalletta G: Brain circuitries of obsessive compulsive disorder: a systematic review and meta-analysis of diffusion tensor imaging studies. Neurosci Biobehav Rev 37:2856\u20132877, 2013"},{"key":"b69","series-title":"Transl Psychiatry","first-page":"e882","article-title":"Connectomics-based structural network alterations in obsessive-compulsive disorder","volume":"6","author":"Reess TJ","year":"2016","unstructured":"Reess TJ, Rus OG, Schmidt R, de Reus MA, Zaudig M, Wagner G, : Connectomics-based structural network alterations in obsessive-compulsive disorder. Transl Psychiatry 6:e882, 2016"},{"key":"b70","series-title":"Neuroimage","first-page":"202","article-title":"Dynamic causal modelling of brain-behaviour relationships","volume":"117","author":"Rigoux L","year":"2015","unstructured":"Rigoux L, Daunizeau J: Dynamic causal modelling of brain-behaviour relationships. Neuroimage 117:202\u2013221, 2015"},{"key":"b71","series-title":"Mol Psychiatry","article-title":"A connectomic approach for subcallosal cingulate deep brain stimulation surgery: prospective targeting in treatment-resistant depression","author":"Riva-Posse P","unstructured":"Riva-Posse P, Choi KS, Holtzheimer PE, Crowell AL, Garlow SJ, Rajendra JK, : A connectomic approach for subcallosal cingulate deep brain stimulation surgery: prospective targeting in treatment-resistant depression. Mol Psychiatry [epub ahead of print], 2017"},{"key":"b72","series-title":"Biol Psychiatry","first-page":"963","article-title":"Defining critical white matter pathways mediating successful subcallosal cingulate deep brain stimulation for treatment-resistant depression","volume":"76","author":"Riva-Posse P","year":"2014","unstructured":"Riva-Posse P, Choi KS, Holtzheimer PE, McIntyre CC, Gross RE, Chaturvedi A, : Defining critical white matter pathways mediating successful subcallosal cingulate deep brain stimulation for treatment-resistant depression. Biol Psychiatry 76:963\u2013969, 2014"},{"key":"b73","series-title":"Neuropathol Appl Neurobiol","first-page":"3","article-title":"Notes from the graveyard: neuropathology and schizophrenia","volume":"16","author":"Roberts GW","year":"1990","unstructured":"Roberts GW, Bruton CJ: Notes from the graveyard: neuropathology and schizophrenia. Neuropathol Appl Neurobiol 16:3\u201316, 1990"},{"key":"b74","series-title":"J Neurosci","first-page":"6263","article-title":"Emerging evidence of connectomic abnormalities in schizophrenia","volume":"31","author":"Rubinov M","year":"2011","unstructured":"Rubinov M, Bassett DS: Emerging evidence of connectomic abnormalities in schizophrenia. J Neurosci 31:6263\u20136265, 2011"},{"key":"b75","series-title":"N Engl J Med","first-page":"18","article-title":"Functional outcome after language mapping for glioma resection","volume":"358","author":"Sanai N","year":"2008","unstructured":"Sanai N, Mirzadeh Z, Berger MS: Functional outcome after language mapping for glioma resection. N Engl J Med 358:18\u201327, 2008"},{"key":"b76","series-title":"Nat Rev Drug Discov","first-page":"19","article-title":"A comprehensive map of molecular drug targets","volume":"16","author":"Santos R","year":"2017","unstructured":"Santos R, Ursu O, Gaulton A, Bento AP, Donadi RS, Bologa CG, : A comprehensive map of molecular drug targets. Nat Rev Drug Discov 16:19\u201334, 2017"},{"key":"b77","series-title":"Biol Psychiatry","first-page":"606","article-title":"The effects of pharmacological treatment on functional brain connectome in obsessive-compulsive disorder","volume":"75","author":"Shin DJ","year":"2014","unstructured":"Shin DJ, Jung WH, He Y, Wang J, Shim G, Byun MS, : The effects of pharmacological treatment on functional brain connectome in obsessive-compulsive disorder. Biol Psychiatry 75:606\u2013614, 2014"},{"key":"b78","series-title":"Nat Neurosci","first-page":"652","article-title":"Contributions and challenges for network models in cognitive neuroscience","volume":"17","author":"Sporns O","year":"2014","unstructured":"Sporns O: Contributions and challenges for network models in cognitive neuroscience. Nat Neurosci 17:652\u2013660, 2014"},{"key":"b79","series-title":"PLOS Comput Biol","first-page":"e42","article-title":"The human connectome: a structural description of the human brain","volume":"1","author":"Sporns O","year":"2005","unstructured":"Sporns O, Tononi G, K\u00f6tter R: The human connectome: a structural description of the human brain. PLOS Comput Biol 1:e42, 2005"},{"issue":"Pt B","key":"b80","series-title":"Neuroimage","first-page":"180","article-title":"Computational neuroimaging strategies for single patient predictions","volume":"145","author":"Stephan KE","year":"2017","unstructured":"Stephan KE, Schlagenhauf F, Huys QJM, Raman S, Aponte EA, Brodersen KH, : Computational neuroimaging strategies for single patient predictions. Neuroimage 145 (Pt B):180\u2013199, 2017"},{"key":"b81","series-title":"Rev Neurol (Paris)","first-page":"554","article-title":"[Anatomic-physiological reflections on psychosurgery.]","volume":"87","author":"Talairach J","year":"1952","unstructured":"Talairach J: [Anatomic-physiological reflections on psychosurgery.] Rev Neurol (Paris) 87:554\u2013557, 1952 (Fr)"},{"key":"b82","series-title":"Rev Neurol (Paris)","first-page":"352","article-title":"[Destruction of the anterior ventral thalamic nucleus in the treatment of mental diseases.]","volume":"87","author":"Talairach J","year":"1952","unstructured":"Talairach J: [Destruction of the anterior ventral thalamic nucleus in the treatment of mental diseases.] Rev Neurol (Paris) 87:352\u2013357, 1952 (Fr)"},{"key":"b83","series-title":"Confin Neurol","first-page":"328","article-title":"Functional stereotaxic exploration of epilepsy","volume":"22","author":"Talairach J","year":"1962","unstructured":"Talairach J, Bancaud J, Bonis A, Szikla G, Tournoux P: Functional stereotaxic exploration of epilepsy. Confin Neurol 22:328\u2013331, 1962"},{"key":"b84","series-title":"Stereotact Funct Neurosurg","first-page":"282","article-title":"Integrating diffusion tensor imaging-based tractography into deep brain stimulation surgery: a review of the literature","volume":"92","author":"Torres CV","year":"2014","unstructured":"Torres CV, Manzanares R, Sola RG: Integrating diffusion tensor imaging-based tractography into deep brain stimulation surgery: a review of the literature. Stereotact Funct Neurosurg 92:282\u2013290, 2014"},{"key":"b85","series-title":"Biol Psychiatry","first-page":"749","article-title":"The Wernicke-Kleist-Leonhard school of psychiatry","volume":"34","author":"Ungvari GS","year":"1993","unstructured":"Ungvari GS: The Wernicke-Kleist-Leonhard school of psychiatry. Biol Psychiatry 34:749\u2013752, 1993"},{"key":"b86","series-title":"JAMA Psychiatry","first-page":"783","article-title":"Abnormal rich club organization and functional brain dynamics in schizophrenia","volume":"70","author":"van den Heuvel MP","year":"2013","unstructured":"van den Heuvel MP, Sporns O, Collin G, Scheewe T, Mandl RCW, Cahn W, : Abnormal rich club organization and functional brain dynamics in schizophrenia. JAMA Psychiatry 70:783\u2013792, 2013"},{"key":"b87","series-title":"PLoS One","first-page":"e86496","article-title":"Neural plasticity in human brain connectivity: the effects of long term deep brain stimulation of the subthalamic nucleus in Parkinson\u2019s disease","volume":"9","author":"van Hartevelt TJ","year":"2014","unstructured":"van Hartevelt TJ, Cabral J, Deco G, M\u00f8ller A, Green AL, Aziz TZ, : Neural plasticity in human brain connectivity: the effects of long term deep brain stimulation of the subthalamic nucleus in Parkinson\u2019s disease. PLoS One 9:e86496, 2014"},{"key":"b88","series-title":"J Neurosurg","first-page":"1181","article-title":"Recovery of functional connectivity of the sensorimotor network after surgery for diffuse low-grade gliomas involving the supplementary motor area","volume":"126","author":"Vassal M","year":"2017","unstructured":"Vassal M, Charroud C, Deverdun J, Le Bars E, Molino F, Bonnetblanc F, : Recovery of functional connectivity of the sensorimotor network after surgery for diffuse low-grade gliomas involving the supplementary motor area. J Neurosurg 126:1181\u20131190, 2017"},{"key":"b89","series-title":"South Med Surg","first-page":"241","article-title":"Prefrontal lobotomy; factors influencing prognosis","volume":"108","author":"Watts JW","year":"1946","unstructured":"Watts JW, Freeman W: Prefrontal lobotomy; factors influencing prognosis. South Med Surg 108:241\u2013247, 1946"},{"key":"b90","series-title":"Front Hum Neurosci","first-page":"653","article-title":"A review of structural neuroimaging in schizophrenia: from connectivity to connectomics","volume":"8","author":"Wheeler AL","year":"2014","unstructured":"Wheeler AL, Voineskos AN: A review of structural neuroimaging in schizophrenia: from connectivity to connectomics. Front Hum Neurosci 8:653, 2014"},{"key":"b91","series-title":"J Affect Disord","first-page":"610","article-title":"Cognitive behavioral therapy changes functional connectivity between medial prefrontal and anterior cingulate cortices","volume":"208","author":"Yoshimura S","year":"2017","unstructured":"Yoshimura S, Okamoto Y, Matsunaga M, Onoda K, Okada G, Kunisato Y, : Cognitive behavioral therapy changes functional connectivity between medial prefrontal and anterior cingulate cortices. J Affect Disord 208:610\u2013614, 2017"},{"key":"b92","series-title":"Neural Plast 2015","first-page":"271674","article-title":"Reorganization of anatomical connectome following electroconvulsive therapy in major depressive disorder","author":"Zeng J","year":"2015","unstructured":"Zeng J, Luo Q, Du L, Liao W, Li Y, Liu H, : Reorganization of anatomical connectome following electroconvulsive therapy in major depressive disorder. 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