{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T14:48:28Z","timestamp":1781275708423,"version":"3.54.1"},"reference-count":48,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>Fifty years before a report on the complete bitemporal lobectomy syndrome in primates, known as the Kl\u00fcver-Bucy syndrome, was published, 2 talented investigators working at the University College in London, England\u2014neurologist Sanger Brown and physiologist Edward Sch\u00e4fer\u2014also made this discovery. The title of their work was \u201cAn investigation into the functions of the occipital and temporal lobes of the monkey\u2019s brain,\u201d and it involved excisional brain surgery in 12 monkeys. They were particularly interested in the then-disputed primary cortical locations relating to vision and hearing. However, following extensive bilateral temporal lobe excisions in 2 monkeys, they noted peculiar behavior including apparent loss of memory and intelligence resembling \u201cidiocy.\u201d These investigators recognized most of the behavioral findings that later came to be known as the Kl\u00fcver-Bucy syndrome. However, they were working within the late-19th-century framework of cerebral cortical localizations of basic motor and sensory functions.<\/jats:p>\n                  <jats:p>Details of the Brown and Sch\u00e4fer study and a glimpse of the neurological thinking of that period is presented. In the decades following the pivotal work of Kl\u00fcver and Bucy in the late 1930s, in which they used a more advanced neurosurgical technique, tools of behavioral observations, and analysis of brain sections after euthanasia, investigators have elaborated the full components of the clinical syndrome and the extent of their resections.<\/jats:p>\n                  <jats:p>Other neuroscientists sought to isolate and determine the specific temporal neocortical, medial temporal, and deep limbic structures responsible for various visual and complex behavioral deficits. No doubt, Kl\u00fcver and Bucy\u2019s contribution led to a great expansion in attention given to the limbic system\u2019s role in action, perception, emotion, and affect\u2014a tide that continues to the present time.<\/jats:p>","DOI":"10.3171\/2017.6.focus17265","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T03:36:47Z","timestamp":1504237007000},"page":"E2","source":"Crossref","is-referenced-by-count":6,"title":["Sanger Brown and Edward Sch\u00e4fer before Heinrich Kl\u00fcver and Paul Bucy: their observations on bilateral temporal lobe ablations"],"prefix":"10.3171","volume":"43","author":[{"given":"Prasad S. S. V.","family":"Vannemreddy","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Illinois at Chicago, Illinois; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James L.","family":"Stone","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, NYU Langone Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Comp Physiol Psychol","first-page":"961","article-title":"Syndrome produced by lesions of the amygdala in monkeys (Macaca mulatta)","volume":"95","author":"Aggleton JP","year":"1981","unstructured":"Aggleton JP, Passingham RE: Syndrome produced by lesions of the amygdala in monkeys (Macaca mulatta). 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