{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T11:33:31Z","timestamp":1792928011391,"version":"4.5.0"},"reference-count":18,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Long-term follow-up results of the treatment of unruptured intracranial aneurysms (UIAs) by means of coil embolization remain unclear. The aim of this study was to analyze the frequency of rupture, retreatment, stroke, and death in patients with coiled UIAs who were followed for up to 20 years at multiple stroke centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors retrospectively analyzed data from cases in which patients underwent coil embolization between 1995 and 2004 at 4 stroke centers. In collecting the late (\u2265 1 year) follow-up data, postal questionnaires were used to assess whether patients had experienced rupture or retreatment of a coiled aneurysm or any stroke or had died.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Overall, 184 patients with 188 UIAs were included. The median follow-up period was 12 years (interquartile range 11\u201313 years, maximum 20 years). A total of 152 UIAs (81%) were followed for more than 10 years. The incidence of rupture was 2 in 2122 aneurysm-years (annual rupture rate 0.09%). Nine of the 188 patients with coiled UIAs (4.8%) underwent additional treatment. In 5 of these 9 cases, the first retreatment was performed more than 5 years after the initial treatment. Large aneurysms were significantly more likely to require retreatment. Nine strokes occurred over the 2122 aneurysm-years. Seventeen patients died in this cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>This study demonstrates a low risk of rupture of coiled UIAs with long-term follow-up periods of up to 20 years. This suggests that coiling of UIAs could prevent rupture for a long period of time. However, large aneurysms might need to be followed for a longer time.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2017.6.jns17174","type":"journal-article","created":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T14:59:43Z","timestamp":1515164383000},"page":"1492-1498","source":"Crossref","is-referenced-by-count":25,"title":["Long-term outcomes of coil embolization of unruptured intracranial aneurysms"],"prefix":"10.3171","volume":"129","author":[{"given":"Masaomi","family":"Koyanagi","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, National Hospital Organization Himeji Medical Center, Himeji;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotoshi","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kobe City Medical Center General Hospital, Kobe;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsu","family":"Satow","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Cerebral and Cardiovascular Center, Suita; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumichi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Takenobu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsushige","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kokura Memorial Hospital, Kokura, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun C.","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Cerebral and Cardiovascular Center, Suita; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Nakahara","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kokura Memorial Hospital, Kokura, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kobe City Medical Center General Hospital, Kobe;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"AJNR Am J Neuroradiol","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.3174\/ajnr.A2453","article-title":"Better outcomes with treatment by coiling relative to clipping of unruptured intracranial aneurysms in the United States, 2001\u20132008","volume":"32","author":"Brinjikji W","year":"2011","unstructured":"Brinjikji W, Rabinstein AA, Nasr DM, Lanzino G, Kallmes DF, Cloft HJ: Better outcomes with treatment by coiling relative to clipping of unruptured intracranial aneurysms in the United States, 2001\u20132008. 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