{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:39:13Z","timestamp":1790343553454,"version":"4.1.0"},"reference-count":40,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>The authors conducted a study to test if the cortical brain tissue levels of soluble amyloid beta (A\u03b2) reflect the propensity of cortical A\u03b2 aggregate formation and may be an additional factor predicting surgical outcome following idiopathic normal pressure hydrocephalus (iNPH) treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Highly selective ELISAs (enzyme-linked immunosorbent assays) were used to quantify soluble A\u03b240, A\u03b242, and neurotoxic A\u03b2 oligomers\/protofibrils, associated with A\u03b2 aggregation, in cortical biopsy samples obtained in patients with iNPH (n = 20), sampled during ventriculoperitoneal (VP) shunt surgery. Patients underwent pre- and postoperative (3-month) clinical assessment with a modified iNPH scale. The preoperative CSF biomarkers and the levels of soluble and insoluble A\u03b2 species in cortical biopsy samples were analyzed for their association with a favorable outcome following the VP shunt procedure, defined as a \u2265 5-point increase in the iNPH scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The brain tissue levels of A\u03b242 were negatively correlated with CSF A\u03b242 (Spearman\u2019s r = \u22120.53, p &lt; 0.05). The A\u03b240, A\u03b242, and A\u03b2 oligomer\/protofibril levels in cortical biopsy samples were higher in patients with insoluble cortical A\u03b2 aggregates (p &lt; 0.05). The preoperative CSF A\u03b242 levels were similar in patients responding (n = 11) and not responding (n = 9) to VP shunt treatment at 3 months postsurgery. In contrast, the presence of cortical A\u03b2 aggregates and high brain tissue A\u03b242 levels were associated with a poor outcome following VP shunt treatment (p &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Brain tissue measurements of soluble A\u03b2 species are feasible. Since high A\u03b242 levels in cortical biopsy samples obtained in patients with iNPH indicated a poor surgical outcome, tissue levels of A\u03b2 species may be associated with the clinical response to shunt treatment.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2017.7.jns171005","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T14:59:33Z","timestamp":1516373973000},"page":"121-129","source":"Crossref","is-referenced-by-count":34,"title":["Brain tissue A\u03b242 levels are linked to shunt response in idiopathic normal pressure hydrocephalus"],"prefix":"10.3171","volume":"130","author":[{"given":"Sami","family":"Abu Hamdeh","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Section of Neurosurgery, Uppsala University;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Virhammar","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Neurology, Uppsala University Hospital, Uppsala University;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dag","family":"Sehlin","sequence":"additional","affiliation":[{"name":"Department of Public Health and Caring Sciences\/Geriatrics, Uppsala University; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Alafuzoff","sequence":"additional","affiliation":[{"name":"Department of Pathology, Uppsala University Hospital, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina Giuliana","family":"Cesarini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Section of Neurosurgery, Uppsala University;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Marklund","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Section of Neurosurgery, Uppsala University;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Science","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1126\/science.1161591","article-title":"Amyloid-\u03b2 dynamics correlate with neurological status in the injured human brain","volume":"321","author":"Brody DL","year":"2008","unstructured":"Brody DL, Magnoni S, Schwetye KE, Spinner ML, Esparza TJ, Stocchetti N, : Amyloid-\u03b2 dynamics correlate with neurological status in the injured human brain. Science 321:1221\u20131224, 200810.1126\/science.116159118755980"},{"issue":"3","key":"b2","series-title":"Neurosurg Focus","doi-asserted-by":"publisher","first-page":"E6","DOI":"10.3171\/2016.6.FOCUS16189","article-title":"Revisiting secondary normal pressure hydrocephalus: does it exist? A review","volume":"41","author":"Daou B","year":"2016","unstructured":"Daou B, Klinge P, Tjoumakaris S, Rosenwasser RH, Jabbour P: Revisiting secondary normal pressure hydrocephalus: does it exist? A review. Neurosurg Focus 41(3):E6, 20162758131810.3171\/2016.6.FOCUS16189"},{"key":"b3","series-title":"J Neuropathol Exp Neurol","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1097\/NEN.0000000000000191","article-title":"Correlations between mini-mental state examination score, cerebrospinal fluid biomarkers, and pathology observed in brain biopsies of patients with normal-pressure hydrocephalus","volume":"74","author":"Elobeid A","year":"2015","unstructured":"Elobeid A, Laurell K, Cesarini KG, Alafuzoff I: Correlations between mini-mental state examination score, cerebrospinal fluid biomarkers, and pathology observed in brain biopsies of patients with normal-pressure hydrocephalus. J Neuropathol Exp Neurol 74:470\u2013479, 201510.1097\/NEN.000000000000019125868149"},{"key":"b4","series-title":"J Neuropathol Exp Neurol","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1093\/jnen\/nlw002","article-title":"Altered proteins in the aging brain","volume":"75","author":"Elobeid A","year":"2016","unstructured":"Elobeid A, Libard S, Leino M, Popova SN, Alafuzoff I: Altered proteins in the aging brain. J Neuropathol Exp Neurol 75:316\u2013325, 20162697908210.1093\/jnen\/nlw002"},{"key":"b5","series-title":"Arch Neurol Psychiatry","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1001\/archneurpsyc.1942.02290060069004","article-title":"AN encephalographic ratio for estimating ventricular enlargement and cerebral atrophy","volume":"47","author":"Evans WAJr","year":"1942","unstructured":"Evans WAJr: AN encephalographic ratio for estimating ventricular enlargement and cerebral atrophy. Arch Neurol Psychiatry 47:931\u2013937, 194210.1001\/archneurpsyc.1942.02290060069004"},{"key":"b6","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1136\/jnnp.68.6.778","article-title":"Alzheimer\u2019s disease comorbidity in normal pressure hydrocephalus: prevalence and shunt response","volume":"68","author":"Golomb J","year":"2000","unstructured":"Golomb J, Wisoff J, Miller DC, Boksay I, Kluger A, Weiner H, : Alzheimer\u2019s disease comorbidity in normal pressure hydrocephalus: prevalence and shunt response. J Neurol Neurosurg Psychiatry 68:778\u2013781, 20001081170610.1136\/jnnp.68.6.778"},{"key":"b7","series-title":"Science","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy J","year":"2002","unstructured":"Hardy J, Selkoe DJ: The amyloid hypothesis of Alzheimer\u2019s disease: progress and problems on the road to therapeutics. Science 297:353\u2013356, 20021213077310.1126\/science.1072994"},{"key":"b8","series-title":"Acta Neurol Scand","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1111\/j.1600-0404.2012.01677.x","article-title":"A new scale for assessment of severity and outcome in iNPH","volume":"126","author":"Hellstr\u00f6m P","year":"2012","unstructured":"Hellstr\u00f6m P, Klinge P, Tans J, Wikkels\u00f8 C: A new scale for assessment of severity and outcome in iNPH. Acta Neurol Scand 126:229\u2013237, 20122258762410.1111\/j.1600-0404.2012.01677.x"},{"key":"b9","series-title":"Svensk Neuropsykologi","first-page":"12","article-title":"Stroop, the bewildering effect","volume":"13","author":"Hellstr\u00f6m P","year":"2001","unstructured":"Hellstr\u00f6m P, Scharin M: Stroop, the bewildering effect. Svensk Neuropsykologi 13:12\u201315, 2001 (Swedish)"},{"key":"b10","series-title":"J Alzheimers Dis","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3233\/JAD-142862","article-title":"Amyloid-\u03b2 and tau dynamics in human brain interstitial fluid in patients with suspected normal pressure hydrocephalus","volume":"46","author":"Herukka SK","year":"2015","unstructured":"Herukka SK, Rummukainen J, Ihalainen J, von Und Zu Fraunberg M, Koivisto AM, Nerg O, : Amyloid-\u03b2 and tau dynamics in human brain interstitial fluid in patients with suspected normal pressure hydrocephalus. J Alzheimers Dis 46:261\u2013269, 20152572040610.3233\/JAD-142862"},{"key":"b11","series-title":"J Neurosci","doi-asserted-by":"publisher","first-page":"15861","DOI":"10.1523\/JNEUROSCI.3272-11.2011","article-title":"Dynamic analysis of amyloid \u03b2-protein in behaving mice reveals opposing changes in ISF versus parenchymal A\u03b2 during age-related plaque formation","volume":"31","author":"Hong S","year":"2011","unstructured":"Hong S, Quintero-Monzon O, Ostaszewski BL, Podlisny DR, Cavanaugh WT, Yang T, : Dynamic analysis of amyloid \u03b2-protein in behaving mice reveals opposing changes in ISF versus parenchymal A\u03b2 during age-related plaque formation. J Neurosci 31:15861\u201315869, 201110.1523\/JNEUROSCI.3272-11.201122049429"},{"key":"b12","series-title":"Brain","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1093\/brain\/awn016","article-title":"Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer\u2019s disease","volume":"131","author":"Ikonomovic MD","year":"2008","unstructured":"Ikonomovic MD, Klunk WE, Abrahamson EE, Mathis CA, Price JC, Tsopelas ND, : Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer\u2019s disease. Brain 131:1630\u20131645, 200810.1093\/brain\/awn016"},{"key":"b13","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1212\/WNL.0b013e31828c2fda","article-title":"Idiopathic normal-pressure hydrocephalus: pathophysiology and diagnosis by CSF biomarkers","volume":"80","author":"Jeppsson A","year":"2013","unstructured":"Jeppsson A, Zetterberg H, Blennow K, Wikkels\u00f8 C: Idiopathic normal-pressure hydrocephalus: pathophysiology and diagnosis by CSF biomarkers. Neurology 80:1385\u20131392, 201310.1212\/WNL.0b013e31828c2fda23486875"},{"key":"b14","series-title":"J Neurol Sci","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.jns.2016.08.040","article-title":"Association between high biomarker probability of Alzheimer\u2019s disease and improvement of clinical outcomes after shunt surgery in patients with idiopathic normal pressure hydrocephalus","volume":"369","author":"Kazui H","year":"2016","unstructured":"Kazui H, Kanemoto H, Yoshiyama K, Kishima H, Suzuki Y, Sato S, : Association between high biomarker probability of Alzheimer\u2019s disease and improvement of clinical outcomes after shunt surgery in patients with idiopathic normal pressure hydrocephalus. J Neurol Sci 369:236\u2013241, 201610.1016\/j.jns.2016.08.04027653897"},{"key":"b15","series-title":"Lancet Neurol","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/S1474-4422(15)00046-0","article-title":"Lumboperitoneal shunt surgery for idiopathic normal pressure hydrocephalus (SINPHONI-2): an open-label randomised trial","volume":"14","author":"Kazui H","year":"2015","unstructured":"Kazui H, Miyajima M, Mori E, Ishikawa M: Lumboperitoneal shunt surgery for idiopathic normal pressure hydrocephalus (SINPHONI-2): an open-label randomised trial. Lancet Neurol 14:585\u2013594, 20152593424210.1016\/S1474-4422(15)00046-0"},{"key":"b16","series-title":"Acta Neurol Scand","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/j.1600-0404.2012.01676.x","article-title":"One-year outcome in the European multicentre study on iNPH","volume":"126","author":"Klinge P","year":"2012","unstructured":"Klinge P, Hellstr\u00f6m P, Tans J, Wikkels\u00f8 C: One-year outcome in the European multicentre study on iNPH. Acta Neurol Scand 126:145\u2013153, 201210.1111\/j.1600-0404.2012.01676.x22571428"},{"key":"b17","series-title":"Arch Neurol","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1001\/archneur.65.10.noc80013","article-title":"Assessment of \u03b2-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11-labeled Pittsburgh Compound B","volume":"65","author":"Leinonen V","year":"2008","unstructured":"Leinonen V, Alafuzoff I, Aalto S, Suotunen T, Savolainen S, N\u00e5gren K, : Assessment of \u03b2-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11-labeled Pittsburgh Compound B. Arch Neurol 65:1304\u20131309, 200810.1001\/archneur.65.10.noc80013"},{"key":"b18","series-title":"Neuropathol Appl Neurobiol","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/j.1365-2990.2011.01195.x","article-title":"Post-mortem findings in 10 patients with presumed normal-pressure hydrocephalus and review of the literature","volume":"38","author":"Leinonen V","year":"2012","unstructured":"Leinonen V, Koivisto AM, Savolainen S, Rummukainen J, Sutela A, Vanninen R, : Post-mortem findings in 10 patients with presumed normal-pressure hydrocephalus and review of the literature. Neuropathol Appl Neurobiol 38:72\u201386, 201210.1111\/j.1365-2990.2011.01195.x21696417"},{"key":"b19","series-title":"Eur J Neurol","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1111\/ene.12102","article-title":"Positron emission tomography with [18F]flutemetamol and [11C]PiB for in vivo detection of cerebral cortical amyloid in normal pressure hydrocephalus patients","volume":"20","author":"Leinonen V","year":"2013","unstructured":"Leinonen V, Rinne JO, Virtanen KA, Eskola O, Rummukainen J, Huttunen J, : Positron emission tomography with [18F]flutemetamol and [11C]PiB for in vivo detection of cerebral cortical amyloid in normal pressure hydrocephalus patients. Eur J Neurol 20:1043\u20131052, 201310.1111\/ene.1210223398333"},{"key":"b20","series-title":"World Neurosurg","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.1016\/j.wneu.2015.07.005","article-title":"Epidemiology of idiopathic normal pressure hydrocephalus: a systematic review of the literature","volume":"84","author":"Mart\u00edn-L\u00e1ez R","year":"2015","unstructured":"Mart\u00edn-L\u00e1ez R, Caballero-Arzapalo H, L\u00f3pez-Men\u00e9ndez LA, Arango-Lasprilla JC, V\u00e1zquez-Barquero A: Epidemiology of idiopathic normal pressure hydrocephalus: a systematic review of the literature. World Neurosurg 84:2002\u20132009, 201510.1016\/j.wneu.2015.07.00526183137"},{"key":"b21","series-title":"J Neurol Sci","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.jns.2016.01.028","article-title":"CSF tap test\u2014obsolete or appropriate test for predicting shunt responsiveness? A systemic review","volume":"362","author":"Mihalj M","year":"2016","unstructured":"Mihalj M, Doli\u0107 K, Koli\u0107 K, Ledenko V: CSF tap test\u2014obsolete or appropriate test for predicting shunt responsiveness? A systemic review. J Neurol Sci 362:78\u201384, 201610.1016\/j.jns.2016.01.02826944123"},{"key":"b22","series-title":"Neurol Med Chir (Tokyo)","doi-asserted-by":"publisher","first-page":"775","DOI":"10.2176\/nmc.52.775","article-title":"Guidelines for management of idiopathic normal pressure hydrocephalus","volume":"52","author":"Mori E","year":"2012","unstructured":"Mori E, Ishikawa M, Kato T, Kazui H, Miyake H, Miyajima M, : Guidelines for management of idiopathic normal pressure hydrocephalus: second edition. Neurol Med Chir (Tokyo) 52:775\u2013809, 20122318307410.2176\/nmc.52.775"},{"key":"b23","series-title":"PLoS One","doi-asserted-by":"publisher","first-page":"e0119973","DOI":"10.1371\/journal.pone.0119973","article-title":"Impact of cerebrospinal fluid shunting for idiopathic normal pressure hydrocephalus on the amyloid cascade","volume":"10","author":"Moriya M","year":"2015","unstructured":"Moriya M, Miyajima M, Nakajima M, Ogino I, Arai H: Impact of cerebrospinal fluid shunting for idiopathic normal pressure hydrocephalus on the amyloid cascade. PLoS One 10:e0119973, 201510.1371\/journal.pone.011997325821958"},{"key":"b24","series-title":"J Neurol Sci","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.jns.2015.07.001","article-title":"Cerebrospinal fluid biomarkers for prognosis of long-term cognitive treatment outcomes in patients with idiopathic normal pressure hydrocephalus","volume":"357","author":"Nakajima M","year":"2015","unstructured":"Nakajima M, Miyajima M, Ogino I, Akiba C, Sugano H, Hara T, : Cerebrospinal fluid biomarkers for prognosis of long-term cognitive treatment outcomes in patients with idiopathic normal pressure hydrocephalus. J Neurol Sci 357:88\u201395, 20152616915810.1016\/j.jns.2015.07.001"},{"key":"b25","series-title":"J Nucl Med","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.2967\/jnumed.109.063305","article-title":"Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer disease","volume":"50","author":"Nelissen N","year":"2009","unstructured":"Nelissen N, Van Laere K, Thurfjell L, Owenius R, Vandenbulcke M, Koole M, : Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer disease. J Nucl Med 50:1251\u20131259, 200910.2967\/jnumed.109.06330519617318"},{"key":"b26","series-title":"J Surg Res","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.jss.2014.03.075","article-title":"Shunting for hydrocephalus: analysis of techniques and failure patterns","volume":"191","author":"Nigim F","year":"2014","unstructured":"Nigim F, Critchlow JF, Schneider BE, Chen C, Kasper EM: Shunting for hydrocephalus: analysis of techniques and failure patterns. J Surg Res 191:140\u2013147, 20142478732410.1016\/j.jss.2014.03.075"},{"key":"b27","series-title":"Fluids Barriers CNS","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/2045-8118-9-7","article-title":"Phosphorylated tau\/amyloid beta 1-42 ratio in ventricular cerebrospinal fluid reflects outcome in idiopathic normal pressure hydrocephalus","volume":"9","author":"Patel S","year":"2012","unstructured":"Patel S, Lee EB, Xie SX, Law A, Jackson EM, Arnold SE, : Phosphorylated tau\/amyloid beta 1-42 ratio in ventricular cerebrospinal fluid reflects outcome in idiopathic normal pressure hydrocephalus. Fluids Barriers CNS 9:7, 20122244446110.1186\/2045-8118-9-7"},{"key":"b28","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"382","DOI":"10.3171\/2015.2.JNS142318","article-title":"Concurrent Alzheimer\u2019s pathology in patients with clinical normal pressure hydrocephalus: correlation of high-volume lumbar puncture results, cortical brain biopsies, and outcomes","volume":"124","author":"Pomeraniec IJ","year":"2016","unstructured":"Pomeraniec IJ, Bond AE, Lopes MB, Jane JA Sr: Concurrent Alzheimer\u2019s pathology in patients with clinical normal pressure hydrocephalus: correlation of high-volume lumbar puncture results, cortical brain biopsies, and outcomes. J Neurosurg 124:382\u2013388, 201610.3171\/2015.2.JNS14231826339853"},{"issue":"3 Suppl","key":"b29","series-title":"Neurosurgery","first-page":"S4","article-title":"Diagnosing idiopathic normal-pressure hydrocephalus","volume":"57","author":"Relkin N","year":"2005","unstructured":"Relkin N, Marmarou A, Klinge P, Bergsneider M, Black PM: Diagnosing idiopathic normal-pressure hydrocephalus. Neurosurgery 57 (3 Suppl):S4\u2013S16, ii\u2013v, 2005"},{"key":"b30","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s00701-002-0936-3","article-title":"Five-year outcome of normal pressure hydrocephalus with or without a shunt: predictive value of the clinical signs, neuropsychological evaluation and infusion test","volume":"144","author":"Savolainen S","year":"2002","unstructured":"Savolainen S, Hurskainen H, Palj\u00e4rvi L, Alafuzoff I, Vapalahti M: Five-year outcome of normal pressure hydrocephalus with or without a shunt: predictive value of the clinical signs, neuropsychological evaluation and infusion test. Acta Neurochir (Wien) 144:515\u2013523, 200210.1007\/s00701-002-0936-312111484"},{"key":"b31","series-title":"PLoS One","doi-asserted-by":"publisher","first-page":"e32014","DOI":"10.1371\/journal.pone.0032014","article-title":"Large aggregates are the major soluble A\u03b2 species in AD brain fractionated with density gradient ultracentrifugation","volume":"7","author":"Sehlin D","year":"2012","unstructured":"Sehlin D, Englund H, Simu B, Karlsson M, Ingelsson M, Nikolajeff F, : Large aggregates are the major soluble A\u03b2 species in AD brain fractionated with density gradient ultracentrifugation. PLoS One 7:e32014, 201210.1371\/journal.pone.003201422355408"},{"key":"b32","series-title":"Nat Commun","doi-asserted-by":"publisher","first-page":"10759","DOI":"10.1038\/ncomms10759","article-title":"Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer\u2019s disease","volume":"7","author":"Sehlin D","year":"2016","unstructured":"Sehlin D, Fang XT, Cato L, Antoni G, Lannfelt L, Syv\u00e4nen S: Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer\u2019s disease. Nat Commun 7:10759, 201610.1038\/ncomms1075926892305"},{"key":"b33","series-title":"J Alzheimers Dis","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.3233\/JAD-2010-100609","article-title":"Interference from heterophilic antibodies in amyloid-\u03b2 oligomer ELISAs","volume":"21","author":"Sehlin D","year":"2010","unstructured":"Sehlin D, S\u00f6llvander S, Paulie S, Brundin R, Ingelsson M, Lannfelt L, : Interference from heterophilic antibodies in amyloid-\u03b2 oligomer ELISAs. J Alzheimers Dis 21:1295\u20131301, 201010.3233\/JAD-2010-10060921504116"},{"key":"b34","series-title":"Lancet Neurol","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/S1474-4422(03)00487-3","article-title":"Alzheimer\u2019s disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesis","volume":"2","author":"Silverberg GD","year":"2003","unstructured":"Silverberg GD, Mayo M, Saul T, Rubenstein E, McGuire D: Alzheimer\u2019s disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesis. Lancet Neurol 2:506\u2013511, 20031287843910.1016\/S1474-4422(03)00487-3"},{"key":"b35","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1002\/ana.20524","article-title":"Amyloid-\u03b2 oligomers are inefficiently measured by enzyme-linked immunosorbent assay","volume":"58","author":"Stenh C","year":"2005","unstructured":"Stenh C, Englund H, Lord A, Johansson AS, Almeida CG, Gellerfors P, : Amyloid-\u03b2 oligomers are inefficiently measured by enzyme-linked immunosorbent assay. Ann Neurol 58:147\u2013150, 20051598401210.1002\/ana.20524"},{"key":"b36","series-title":"Br J Neurosurg","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1080\/02688697.2016.1229749","article-title":"Incidence and outcome of surgery for adult hydrocephalus patients in Sweden","volume":"31","author":"Sundstrom N","year":"2017","unstructured":"Sundstrom N, Malm J, Laurell K, Lundin F, Kahlon B, Cesarini KG, : Incidence and outcome of surgery for adult hydrocephalus patients in Sweden. Br J Neurosurg 31:21\u201327, 201710.1080\/02688697.2016.122974927619731"},{"key":"b37","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3171\/2011.2.JNS101316","article-title":"Use of cerebrospinal fluid amyloid-\u03b2 and total tau protein to predict favorable surgical outcomes in patients with idiopathic normal pressure hydrocephalus","volume":"115","author":"Tarnaris A","year":"2011","unstructured":"Tarnaris A, Toma AK, Chapman MD, Keir G, Kitchen ND, Watkins LD: Use of cerebrospinal fluid amyloid-\u03b2 and total tau protein to predict favorable surgical outcomes in patients with idiopathic normal pressure hydrocephalus. J Neurosurg 115:145\u2013150, 201110.3171\/2011.2.JNS10131621438653"},{"key":"b38","series-title":"J Alzheimers Dis","doi-asserted-by":"publisher","first-page":"575","DOI":"10.3233\/JAD-140741","article-title":"The murine version of BAN2401 (mAb158) selectively reduces amyloid-\u03b2 protofibrils in brain and cerebrospinal fluid of tg-ArcSwe mice","volume":"43","author":"Tucker S","year":"2015","unstructured":"Tucker S, M\u00f6ller C, Tegerstedt K, Lord A, Laudon H, Sj\u00f6dahl J, : The murine version of BAN2401 (mAb158) selectively reduces amyloid-\u03b2 protofibrils in brain and cerebrospinal fluid of tg-ArcSwe mice. J Alzheimers Dis 43:575\u2013588, 201510.3233\/JAD-14074125096615"},{"key":"b39","series-title":"Acta Neuropathol","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00401-008-0457-0","article-title":"Lymphatic drainage of the brain and the pathophysiology of neurological disease","volume":"117","author":"Weller RO","year":"2009","unstructured":"Weller RO, Djuanda E, Yow HY, Carare RO: Lymphatic drainage of the brain and the pathophysiology of neurological disease. Acta Neuropathol 117:1\u201314, 200910.1007\/s00401-008-0457-019002474"},{"key":"b40","series-title":"Arch Neurol","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1001\/archneurol.2011.153","article-title":"Association between in vivo fluorine 18-labeled flutemetamol amyloid positron emission tomography imaging and in vivo cerebral cortical histopathology","volume":"68","author":"Wolk DA","year":"2011","unstructured":"Wolk DA, Grachev ID, Buckley C, Kazi H, Grady MS, Trojanowski JQ, : Association between in vivo fluorine 18-labeled flutemetamol amyloid positron emission tomography imaging and in vivo cerebral cortical histopathology. Arch Neurol 68:1398\u20131403, 201110.1001\/archneurol.2011.15321747004"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/130\/1\/article-p121.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/130\/1\/article-p121.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/130\/1\/article-p121.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T07:07:41Z","timestamp":1679814461000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/130\/1\/article-p121.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":40,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/2017.7.jns171005","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1]]}}}