{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:52:58Z","timestamp":1784559178629,"version":"3.55.0"},"reference-count":56,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,11]]},"abstract":"\n OBJECTIVE<\/jats:title>\n The majority of neurosurgeons administer antiepileptic drugs (AEDs) prophylactically for supratentorial tumor resection without clear evidence to support this practice. The putative benefit of perioperative seizure prophylaxis must be weighed against the risks of adverse effects and drug interactions in patients without a history of seizures. Consequently, the authors conducted a systematic review of prospective randomized controlled trials (RCTs) that have evaluated the efficacy of perioperative seizure prophylaxis among patients without a history of seizures.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n Five databases (PubMed\/MEDLINE, Cochrane Central Register of Controlled Trials, CINAHL\/Academic Search Complete, Web of Science, and ScienceDirect) were searched for RCTs published before May 2017 and investigating perioperative seizure prophylaxis in brain tumor resection. Of the 496 unique research articles identified, 4 were selected for inclusion in this review.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n This systematic review revealed a weighted average seizure rate of 10.65% for the control groups. There was no significant difference in seizure rates among the groups that received seizure prophylaxis and those that did not. Further, this expected incidence of new-onset postoperative seizures would require a total of 1258 patients to enroll in a RCT, as determined by a Farrington-Manning noninferiority test performed at the 0.05 level using a noninferiority difference of 5%.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n According to a systematic review of major RCTs, the administration of prophylactic AEDs after brain tumor resection shows no significant reduction in the incidence of seizures compared with that in controls. A large multicenter randomized clinical trial would be required to assess whether perioperative seizure prophylaxis provides benefit for patients undergoing brain tumor resection.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2017.8.focus17442","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T03:37:00Z","timestamp":1509507420000},"page":"E18","source":"Crossref","is-referenced-by-count":35,"title":["A systematic review of perioperative seizure prophylaxis during brain tumor resection: the case for a multicenter randomized clinical trial"],"prefix":"10.3171","volume":"43","author":[{"given":"Vyshak","family":"Chandra","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Virginia Commonwealth University Health System, Medical College of Virginia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew K.","family":"Rock","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Virginia Commonwealth University Health System, Medical College of Virginia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Opalak","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Virginia Commonwealth University Health System, Medical College of Virginia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel M.","family":"Stary","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Virginia Commonwealth University Health System, Medical College of Virginia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam P.","family":"Sima","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Virginia Commonwealth University, Richmond, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Carr","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Virginia Commonwealth University Health System, Medical College of Virginia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael A.","family":"Vega","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Virginia Commonwealth University Health System, Medical College of Virginia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Broaddus","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Virginia Commonwealth University Health System, Medical College of Virginia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neurol Neurosurg Psychiatry","first-page":"474","article-title":"Comparative double blind clinical trial of phenytoin and sodium valproate as anticonvulsant prophylaxis after craniotomy: efficacy, tolerability, and cognitive effects","volume":"67","author":"Beenen LF","year":"1999","unstructured":"Beenen LF, Lindeboom J, Kasteleijn-Nolst Trenit\u00e9 DG, Heimans JJ, Snoek FJ, Touw DJ, : Comparative double blind clinical trial of phenytoin and sodium valproate as anticonvulsant prophylaxis after craniotomy: efficacy, tolerability, and cognitive effects. 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Mayo Clin Proc 79:1489\u20131494, 2004"},{"key":"b25","series-title":"Epilepsia","first-page":"515","article-title":"Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials","volume":"42","author":"Temkin NR","year":"2001","unstructured":"Temkin NR: Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials. Epilepsia 42:515\u2013524, 2001"},{"key":"b26","series-title":"Anesth Analg","first-page":"1625","article-title":"The analgesic effect of gabapentin as a prophylactic anticonvulsant drug on postcraniotomy pain: a prospective randomized study","volume":"109","author":"T\u00fcre H","year":"2009","unstructured":"T\u00fcre H, Sayin M, Karlikaya G, Bingol CA, Aykac B, T\u00fcre U: The analgesic effect of gabapentin as a prophylactic anticonvulsant drug on postcraniotomy pain: a prospective randomized study. Anesth Analg 109:1625\u20131631, 2009"},{"key":"b27","series-title":"J Neurosurg","first-page":"873","article-title":"A prospective randomized trial of perioperative seizure prophylaxis in patients with intraparenchymal brain tumors","volume":"118","author":"Wu AS","year":"2013","unstructured":"Wu AS, Trinh VT, Suki D, Graham S, Forman A, Weinberg JS, : A prospective randomized trial of perioperative seizure prophylaxis in patients with intraparenchymal brain tumors. J Neurosurg 118:873\u2013883, 2013"},{"key":"b28","series-title":"Tehran Univ Med J","first-page":"548","article-title":"Comparing \u2018remifentanil-propofol\u2019 and \u2018fentanyl-propofol\u2019 in patients undergoing craniotomy for supratentorial space-occupying lesions","volume":"70","author":"Zadeghan SY","year":"2012","unstructured":"Zadeghan SY, Sajedi P, Khalili GR: Comparing \u2018remifentanil-propofol\u2019 and \u2018fentanyl-propofol\u2019 in patients undergoing craniotomy for supratentorial space-occupying lesions. 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