{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T06:27:51Z","timestamp":1772951271632,"version":"3.50.1"},"reference-count":16,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>Astroblastoma is a rare tumor that is thought to occur exclusively in the cerebrum. To the authors\u2019 knowledge, no cases of spinal cord astroblastoma have been reported. A 20-year-old woman presented with numbness in her legs. MRI demonstrated a 2-cm intramedullary enhancing lesion in the spinal cord at the T-1 level. The patient declined to undergo resection of the tumor because she was able to walk unassisted; however, she returned for surgery 1 month later because she had developed paraplegia with bladder and rectal dysfunction, and MRI showed enlargement of the tumor. Intraoperatively, the border between the tumor and normal tissue was poorly defined. Biopsy samples were obtained for histopathological examinations, and a diagnosis of astroblastoma with a Ki-67 index of 5% was made. Considering the rapid tumor growth on MRI and remarkable deterioration in her symptoms, the patient was treated with a combination of radiation therapy, temozolomide (TMZ), and bevacizumab. After completion of the combined treatment, she was able to move her toes, and oral TMZ and bevacizumab injections were continued. Six months later, definite tumor shrinkage was identified on MRI, and the patient was able to stand up from a wheelchair without assistance and walk by herself. No therapeutic regimens for residual astroblastoma are established; however, in this case the authors\u2019 therapeutic strategy was successful in treating the spinal cord astroblastoma.<\/jats:p>","DOI":"10.3171\/2017.9.spine161302","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T15:02:28Z","timestamp":1520002948000},"page":"642-646","source":"Crossref","is-referenced-by-count":14,"title":["Primary spinal cord astroblastoma: case report"],"prefix":"10.3171","volume":"28","author":[{"given":"Shoko Merrit","family":"Yamada","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Tomita","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichiro","family":"Shibui","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikiko","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Diagnostic Pathology, Teikyo University Mizonokuchi Hospital, Kawasaki, Kanagawa;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Kawamoto","sequence":"additional","affiliation":[{"name":"Diagnostic Pathology, Teikyo University Mizonokuchi Hospital, Kawasaki, Kanagawa;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumihito","family":"Nobusawa","sequence":"additional","affiliation":[{"name":"Department of Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Gunma; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Hirato","sequence":"additional","affiliation":[{"name":"Department of Pathology, Gunma University Hospital, Maebashi, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"WHO Classification of Tumours of the Central Nervous System","first-page":"121","article-title":"Astroblastoma","author":"Aldape KD","year":"2016","unstructured":"Aldape KD, Rosenblum MK, Brat DJ: Astroblastoma, in Louis DN, Ohgaki H, Wiestler OD,  (eds): WHO Classification of Tumours of the Central Nervous System. 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