{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:02:42Z","timestamp":1787025762917,"version":"build-2736575974"},"reference-count":20,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6]]},"abstract":"\n OBJECTIVE<\/jats:title>\n In addition to craniocerebral disproportion, other factors, such as Chiari malformation type I, obstructive sleep apnea, and venous outflow obstruction, are considered to have a role in the occurrence of intracranial hypertension in craniosynostosis. This pilot study examined cerebral venous flow velocity to better characterize the complex intracranial venous physiology of craniosynostosis.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n \n The authors performed a prospective cohort study of craniosynostosis patients (n = 34) referred to a single national (tertiary) craniofacial unit. Controls (n = 28) consisted of children who were referred to the unit\u2019s outpatient clinic and did not have craniosynostosis. Transfontanelle ultrasound scans with venous Doppler flow velocity assessment were performed at the first outpatient clinic visit and after each surgery, if applicable. Mean venous blood flow velocities of the internal cerebral vein (ICV\n v<\/jats:sub>\n ) and the superior sagittal sinus (SSS\n v<\/jats:sub>\n ) were recorded and blood flow waveform was scored.\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n Preoperatively, SSS\n v<\/jats:sub>\n was decreased in craniosynostosis patients compared with controls (7.57 vs 11.31 cm\/sec, p = 0.009). ICV\n v<\/jats:sub>\n did not differ significantly between patients and controls. Postoperatively, SSS\n v<\/jats:sub>\n increased significantly (7.99 vs 10.66 cm\/sec, p = 0.023). Blood flow waveform analyses did not differ significantly between patients and controls.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n \n Premature closure of cranial sutures was associated with decreased SSS\n v<\/jats:sub>\n but not ICV\n v<\/jats:sub>\n ; indicating an effect on the superficial rather than deep venous drainage. Further Doppler ultrasound studies are needed to test the hypothesis that at an early stage of craniosynostosis pathology SSS\n v<\/jats:sub>\n , but not pulsatility, is abnormal, and that abnormality in both SSS\n v<\/jats:sub>\n and the superficial venous waveform reflect a more advanced stage of evolution in suture closure.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2018.1.peds17480","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T09:55:42Z","timestamp":1523008542000},"page":"626-631","source":"Crossref","is-referenced-by-count":14,"title":["Pilot study of intracranial venous physiology in craniosynostosis"],"prefix":"10.3171","volume":"21","author":[{"given":"Martijn J.","family":"Cornelissen","sequence":"first","affiliation":[{"name":"Departments of Plastic and Reconstructive Surgery and Hand Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robbin","family":"de Goederen","sequence":"additional","affiliation":[{"name":"Departments of Plastic and Reconstructive Surgery and Hand Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Doerga","sequence":"additional","affiliation":[{"name":"Departments of Plastic and Reconstructive Surgery and Hand Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Cuperus","sequence":"additional","affiliation":[{"name":"Departments of Plastic and Reconstructive Surgery and Hand Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Lise","family":"van Veelen","sequence":"additional","affiliation":[{"name":"Neurosurgery, Sophia Children\u2019s Hospital, Erasmus MC, University Medical Center, Rotterdam;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Lequin","sequence":"additional","affiliation":[{"name":"Department of Radiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Govaert","sequence":"additional","affiliation":[{"name":"Neonatology Division, Department of Pediatrics, Koningin Paola Children\u2019s Hospital, Antwerp, Belgium; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene M. 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