{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:47:07Z","timestamp":1767919627170,"version":"3.49.0"},"reference-count":24,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Endovascular treatment in children, especially neonates, can be more challenging than analogous procedures in adults. This study aimed to describe the clinical and radiological findings, type and timing of endovascular treatment, and early outcomes in children who present with neurovascular malformations, who are treated with embolization, and who weigh less than 5 kg.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors carried out a retrospective review of all consecutively treated children weighing less than 5 kg with neurovascular arteriovenous malformations (AVMs) at a single institution over a 10-year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Fifty-two patients were included in the study. Thirty-eight had a vein of Galen aneurysmal malformation, 3 a pial AVM, 6 a pial arteriovenous fistula, and 5 a dural sinus malformation. The endovascular treatment goals were control of cardiac failure or hydrocephalus in cases of nonhemorrhagic malformations or to prevent new bleeding in cases of previous hemorrhage. A hemorrhagic complication occurred in 12 procedures and an ischemic complication in 2. Both complication types were correlated with the age of the infant (age cutoff at 3 months) (p = of 0.015 and 0.049, respectively). No correlation was found with the weight of the infant or the duration of the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The embolization of AVMs in these patients prevented adverse cardiac effects, hydrovenous disorders, and rebleeding. The risk of major cerebral complications seems mainly correlated with age, with a threshold at 3 months. A multidisciplinary team involved in the treatment of these children may help to improve treatment success and management.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2018.11.peds1865","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:52:05Z","timestamp":1551228725000},"page":"597-605","source":"Crossref","is-referenced-by-count":6,"title":["Embolization of cerebral arteriovenous shunts in infants weighing less than 5 kg"],"prefix":"10.3171","volume":"23","author":[{"given":"Francesco","family":"Puccinelli","sequence":"first","affiliation":[{"name":"Neuroradiologie Interventionnelle, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minh Ngoc Thien Kim","family":"Tran Dong","sequence":"additional","affiliation":[{"name":"Referral Centre for Neurovascular Disease in Children, Service de Neuroradiologie, H\u00f4pital Bic\u00eatre;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Iacobucci","sequence":"additional","affiliation":[{"name":"Service de Neuroradiologie, H\u00f4pital Bic\u00eatre;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Xavier","family":"Mazoit","sequence":"additional","affiliation":[{"name":"Anesth\u00e9sie P\u00e9diatrique, H\u00f4pital Bic\u00eatre; Laboratoire d\u2019Anesth\u00e9sie UMR788 \u201cNeuroprotection, R\u00e9g\u00e9n\u00e9ration des Axones et de la My\u00e9line,\u201d Universit\u00e9 Paris-Sud, Facult\u00e9 de M\u00e9decine du Kremlin-Bic\u00eatre; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Durand","sequence":"additional","affiliation":[{"name":"R\u00e9animation P\u00e9diatrique, H\u00f4pital Bic\u00eatre, Le Kremlin Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Tissieres","sequence":"additional","affiliation":[{"name":"R\u00e9animation P\u00e9diatrique, H\u00f4pital Bic\u00eatre, Le Kremlin Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Saliou","sequence":"additional","affiliation":[{"name":"Neuroradiologie Interventionnelle, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland;"},{"name":"Service de Neuroradiologie, H\u00f4pital Bic\u00eatre;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Interv Neuroradiol","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1177\/159101990300900413","article-title":"Dural sinus malformations (DSM) with giant lakes, in neonates and infants. Review of 30 consecutive cases","volume":"9","author":"Barbosa M","year":"2003","unstructured":"Barbosa M, Mahadevan J, Weon YC, Yoshida Y, Ozanne A, Rodesch G, : Dural sinus malformations (DSM) with giant lakes, in neonates and infants. Review of 30 consecutive cases. Interv Neuroradiol 9:407\u2013424, 200310.1177\/15910199030090041320591322"},{"key":"b2","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1227\/NEU.0b013e3182417be3","article-title":"Vein of Galen malformations in neonates: new management paradigms for improving outcomes","volume":"70","author":"Berenstein A","year":"2012","unstructured":"Berenstein A, Fifi JT, Niimi Y, Presti S, Ortiz R, Ghatan S, : Vein of Galen malformations in neonates: new management paradigms for improving outcomes. Neurosurgery 70:1207\u20131214, 201210.1227\/NEU.0b013e3182417be322089754"},{"key":"b3","series-title":"J Appl Physiol (1985)","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1152\/japplphysiol.00143.2006","article-title":"Plasticity in the nucleus tractus solitarius and its influence on lung and airway reflexes","volume":"101","author":"Bonham AC","year":"2006","unstructured":"Bonham AC, Chen CY, Sekizawa S, Joad JP: Plasticity in the nucleus tractus solitarius and its influence on lung and airway reflexes. J Appl Physiol (1985) 101:322\u2013327, 200610.1152\/japplphysiol.00143.200616484366"},{"key":"b4","series-title":"Pulm Pharmacol Ther","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.pupt.2004.09.008","article-title":"Plasticity of central mechanisms for cough","volume":"17","author":"Bonham AC","year":"2004","unstructured":"Bonham AC, Sekizawa SI, Joad JP: Plasticity of central mechanisms for cough. Pulm Pharmacol Ther 17:453\u2013470, 20041556409110.1016\/j.pupt.2004.09.008"},{"key":"b5","series-title":"AJNR Am J Neuroradiol","doi-asserted-by":"publisher","first-page":"2308","DOI":"10.3174\/ajnr.A5403","article-title":"Endovascular treatment of vein of Galen malformations: a systematic review and meta-analysis","volume":"38","author":"Brinjikji W","year":"2017","unstructured":"Brinjikji W, Krings T, Murad MH, Rouchaud A, Meila D: Endovascular treatment of vein of Galen malformations: a systematic review and meta-analysis. AJNR Am J Neuroradiol 38:2308\u20132314, 201710.3174\/ajnr.A540328982789"},{"issue":"Suppl 4","key":"b6","series-title":"Environ Health Perspect","first-page":"567","article-title":"Inflammation-induced plasticity of the afferent innervation of the airways","volume":"109","author":"Carr MJ","year":"2001","unstructured":"Carr MJ, Undem BJ: Inflammation-induced plasticity of the afferent innervation of the airways. Environ Health Perspect 109 (Suppl 4):567\u2013571, 200111544165"},{"key":"b7","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s00381-009-0959-7","article-title":"Predicting factors for the follow-up outcome and management decisions in vein of Galen aneurysmal malformations","volume":"26","author":"Geibprasert S","year":"2010","unstructured":"Geibprasert S, Krings T, Armstrong D, terBrugge KG, Raybaud CA: Predicting factors for the follow-up outcome and management decisions in vein of Galen aneurysmal malformations. Childs Nerv Syst 26:35\u201346, 201010.1007\/s00381-009-0959-719662427"},{"key":"b8","series-title":"Arch Ophthalmol","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1001\/archophthalmol.2011.5","article-title":"Intra-arterial chemotherapy for the management of retinoblastoma: four-year experience","volume":"129","author":"Gobin YP","year":"2011","unstructured":"Gobin YP, Dunkel IJ, Marr BP, Brodie SE, Abramson DH: Intra-arterial chemotherapy for the management of retinoblastoma: four-year experience. Arch Ophthalmol 129:732\u2013737, 201110.1001\/archophthalmol.2011.521320950"},{"key":"b9","series-title":"World Neurosurg","doi-asserted-by":"publisher","first-page":"e837","DOI":"10.1016\/j.wneu.2018.01.172","article-title":"Multimodality management of vein of Galen malformations\u2014an institutional experience","volume":"112","author":"Hosmann A","year":"2018","unstructured":"Hosmann A, El-Garci A, Gatterbauer B, Bavinzski G, Knosp E, Gruber A: Multimodality management of vein of Galen malformations\u2014an institutional experience. World Neurosurg 112:e837\u2013e847, 201810.1016\/j.wneu.2018.01.172"},{"key":"b10","series-title":"Respir Physiol","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S0034-5687(01)00234-1","article-title":"On reflexes from the nasal mucous membrane on respiration and circulation","volume":"127","author":"Kratschmer F","year":"2001","unstructured":"Kratschmer F: On reflexes from the nasal mucous membrane on respiration and circulation. Respir Physiol 127:93\u2013104, 200110.1016\/S0034-5687(01)00234-1"},{"key":"b11","series-title":"J Appl Physiol (1985)","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1152\/japplphysiol.00252.2006","article-title":"Central pathways of pulmonary and lower airway vagal afferents","volume":"101","author":"Kubin L","year":"2006","unstructured":"Kubin L, Alheid GF, Zuperku EJ, McCrimmon DR: Central pathways of pulmonary and lower airway vagal afferents. J Appl Physiol (1985) 101:618\u2013627, 200610.1152\/japplphysiol.00252.200616645192"},{"key":"b12","series-title":"Neuroradiology","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1007\/BF00588224","article-title":"Deep venous drainage in great cerebral vein (vein of Galen) absence and malformations","volume":"33","author":"Lasjaunias P","year":"1991","unstructured":"Lasjaunias P, Garcia-Monaco R, Rodesch G, Terbrugge K: Deep venous drainage in great cerebral vein (vein of Galen) absence and malformations. Neuroradiology 33:234\u2013238, 199110.1007\/BF005882241881541"},{"key":"b13","series-title":"Surgical Neuroangiography. Vol. 3: Clinical and Interventional Aspects in Children","first-page":"992","author":"Lasjaunias P","year":"2007","unstructured":"Lasjaunias P, ter Brugge KG, Berenstein A: Surgical Neuroangiography. Vol. 3: Clinical and Interventional Aspects in Children. Heidelberg: Springer, 2007, p 992"},{"issue":"5 Suppl 3","key":"b14","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"S184","DOI":"10.1227\/01.NEU.0000237445.39514.16","article-title":"The management of vein of Galen aneurysmal malformations","volume":"59","author":"Lasjaunias PL","unstructured":"Lasjaunias PL, Chng SM, Sachet M, Alvarez H, Rodesch G, Garcia-Monaco R: The management of vein of Galen aneurysmal malformations. Neurosurgery 59 (5 Suppl 3):S184\u2013S194, S3\u2013S13, 200610.1227\/01.NEU.0000237445.39514.16"},{"key":"b15","series-title":"Brain Res","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/0006-8993(76)90101-3","article-title":"Carotid baroreceptor and chemoreceptor inputs onto single medullary neurones","volume":"107","author":"Lipski J","year":"1976","unstructured":"Lipski J, McAllen RM, Trzebski A: Carotid baroreceptor and chemoreceptor inputs onto single medullary neurones. Brain Res 107:132\u2013136, 197610.1016\/0006-8993(76)90101-31268716"},{"key":"b16","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"344","DOI":"10.3171\/2013.6.PEDS13110","article-title":"An institutional series and literature review of pial arteriovenous fistulas in the pediatric population: clinical article","volume":"12","author":"Madsen PJ","year":"2013","unstructured":"Madsen PJ, Lang SS, Pisapia JM, Storm PB, Hurst RW, Heuer GG: An institutional series and literature review of pial arteriovenous fistulas in the pediatric population: clinical article. J Neurosurg Pediatr 12:344\u2013350, 201310.3171\/2013.6.PEDS1311023909618"},{"key":"b17","series-title":"Bull Int Acad Polon Sci Lett","first-page":"1","article-title":"Entwicklung der Sinus durae matris und der Hirnvenen des Menschen","volume":"Suppl","author":"Markowski J","year":"1922","unstructured":"Markowski J: Entwicklung der Sinus durae matris und der Hirnvenen des Menschen. Bull Int Acad Polon Sci Lett Suppl:1\u2013269, 1922"},{"key":"b18","series-title":"Arch Dis Child","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1136\/adc.2009.177584","article-title":"Management and outcome of vein of Galen malformation","volume":"95","author":"McSweeney N","year":"2010","unstructured":"McSweeney N, Brew S, Bhate S, Cox T, Roebuck DJ, Ganesan V: Management and outcome of vein of Galen malformation. Arch Dis Child 95:903\u2013909, 201010.1136\/adc.2009.17758420605862"},{"key":"b19","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1007\/s00701-016-2836-y","article-title":"Hydrocephalus in vein of Galen malformation: etiologies and therapeutic management implications","volume":"158","author":"Meila D","year":"2016","unstructured":"Meila D, Grieb D, Melber K, Jacobs C, Maslehaty H, Petridis A, : Hydrocephalus in vein of Galen malformation: etiologies and therapeutic management implications. Acta Neurochir (Wien) 158:1279\u20131284, 201610.1007\/s00701-016-2836-y27173099"},{"key":"b20","series-title":"Neuroradiology","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s00234-011-0860-4","article-title":"Vein of Galen aneurysmal malformation: combined transvenous and transarterial method using a \u201ckissing microcatheter technique\u201d","volume":"54","author":"Meila D","year":"2012","unstructured":"Meila D, Hannak R, Feldkamp A, Schlunz-Hendann M, Mangold A, Jacobs C, : Vein of Galen aneurysmal malformation: combined transvenous and transarterial method using a \u201ckissing microcatheter technique\u201d. Neuroradiology 54:51\u201359, 201210.1007\/s00234-011-0860-421455720"},{"key":"b21","series-title":"J Neuroradiol","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.neurad.2007.04.005","article-title":"[Pediatric neurovascular malformations: vein of Galen arteriovenous malformations (VGAM), pial arteriovenous malformations (pial AVM), dural sinus malformations (DSM).]","volume":"34","author":"Ozanne A","year":"2007","unstructured":"Ozanne A, Alvarez H, Krings T, Lasjaunias P: [Pediatric neurovascular malformations: vein of Galen arteriovenous malformations (VGAM), pial arteriovenous malformations (pial AVM), dural sinus malformations (DSM).] J Neuroradiol 34:145\u2013166, 2007 (Fr)1760274510.1016\/j.neurad.2007.04.005"},{"key":"b22","series-title":"Eur J Paediatr Neurol","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.ejpn.2014.07.007","article-title":"Cerebral venous thrombosis after embolization of pediatric AVM with jugular bulb stenosis or occlusion: management and prevention","volume":"18","author":"Puccinelli F","year":"2014","unstructured":"Puccinelli F, Deiva K, Bellesme C, Durand P, Chevret L, Husson B, : Cerebral venous thrombosis after embolization of pediatric AVM with jugular bulb stenosis or occlusion: management and prevention. Eur J Paediatr Neurol 18:766\u2013773, 20142513094010.1016\/j.ejpn.2014.07.007"},{"key":"b23","series-title":"J Neurophysiol","doi-asserted-by":"publisher","first-page":"2644","DOI":"10.1152\/jn.1996.76.4.2644","article-title":"Simultaneous encoding of carotid sinus pressure and dP\/dt by NTS target neurons of myelinated baroreceptors","volume":"76","author":"Rogers RF","year":"1996","unstructured":"Rogers RF, Rose WC, Schwaber JS: Simultaneous encoding of carotid sinus pressure and dP\/dt by NTS target neurons of myelinated baroreceptors. J Neurophysiol 76:2644\u20132660, 1996889963510.1152\/jn.1996.76.4.2644"},{"key":"b24","series-title":"Arch Dis Child Fetal Neonatal Ed","doi-asserted-by":"publisher","first-page":"F119","DOI":"10.1136\/fn.85.2.F119","article-title":"Percutaneous femoral arterial and venous catheterisation during neonatal intensive care","volume":"85","author":"Wardle SP","year":"2001","unstructured":"Wardle SP, Kelsall AW, Yoxall CW, Subhedar NV: Percutaneous femoral arterial and venous catheterisation during neonatal intensive care. Arch Dis Child Fetal Neonatal Ed 85:F119\u2013F122, 200110.1136\/fn.85.2.F119"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/23\/5\/article-p597.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/23\/5\/article-p597.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/23\/5\/article-p597.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T13:31:09Z","timestamp":1681565469000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/23\/5\/article-p597.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":24,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/2018.11.peds1865","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5]]}}}