{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:04:58Z","timestamp":1791914698795,"version":"4.3.4"},"reference-count":19,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Several randomized studies have compared the effect of deep brain stimulation (DBS) of the subthalamic nucleus with the best medical treatment in large groups of patients. Important outcome measures differ between studies. Two such major studies, the life-quality study of the German Competence Network for Parkinson\u2019s disease (LQ study) and the US Veterans Affairs\/National Institute of Neurological Disorders and Stroke trial (VA\/NINDS trial), were compared here in order to understand their differences in outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Unless otherwise noted, analyses were based on those subjects in each study who received a DBS implant (LQ study 76 patients, VA\/NINDS trial 140 patients) and who had data for the measurement under consideration (i.e., no imputations for missing data), referred to hereafter as the \u201cas-treated completers\u201d (LQ 69 patients, VA\/NINDS 125 patients). Data were prepared and analyzed by biostatisticians at the US Department of Veterans Affairs Cooperative Studies Program Coordinating Center, the Coordinating Center for Clinical Trials Marburg, and Medtronic, under the direction of two authors (G.D. and K.A.F.). Data were extracted from the respective databases into SAS data sets and analyzed using SAS software. Analyses were based on the 6-month follow-up data from both studies because this was the endpoint for the LQ study.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Pre-DBS baseline demographics differed significantly between the studies, including greater levodopa responsiveness (LDR) in the LQ study population than in the VA\/NINDS group. After DBS, LQ subjects demonstrated greater improvement in motor function (Unified Parkinson\u2019s Disease Rating Scale, Motor Examination [UPDRS-III]), activities of daily living (ADLs), and complications of therapy. Medication reduction and improvements in life quality other than ADLs were not significantly different between LQ and VA\/NINDS subjects. When the two populations were compared according to pre-DBS LDR, the \u201cfull responders\u201d to levodopa (\u2265 50% improvement on UPDRS-III with medication) in the two studies showed no significant difference in motor improvement with DBS (LQ 18.5 \u00b1 12.0\u2013point improvement on UPDRS-III vs VA\/NINDS 17.7 \u00b1 15.6\u2013point improvement, p = 0.755). Among levodopa full responders, ADLs improved slightly more in the LQ group, but scores on other UPDRS subscales and the Parkinson\u2019s Disease Questionnaire-39 were not significantly different between the two studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>This comparison suggests that patient selection criteria, especially preoperative LDR, are the most important source of differences in motor outcomes and quality of life between the two studies.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2018.12.jns182042","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T19:59:58Z","timestamp":1554839998000},"page":"1376-1384","source":"Crossref","is-referenced-by-count":25,"title":["Comparing two randomized deep brain stimulation trials for Parkinson\u2019s disease"],"prefix":"10.3171","volume":"132","author":[{"given":"G\u00fcnther","family":"Deuschl","sequence":"first","affiliation":[{"name":"Department of Neurology, Universit\u00e4tsklinikum Schleswig-Holstein, Kiel Campus, Christian-Albrechts-University Kiel, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth A.","family":"Follett","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, University of Nebraska Medical Center;"},{"name":"VA Medical Center, Omaha, Nebraska;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs Cooperative Studies Program Coordinating Center, Edward Hines Jr. VA Hospital, Hines, Illinois;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joern","family":"Rau","sequence":"additional","affiliation":[{"name":"The Coordinating Center for Clinical Trials, Philipps University, Marburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances M.","family":"Weaver","sequence":"additional","affiliation":[{"name":"Center of Innovation for Complex Chronic Health Care, Edward Hines Jr. VA Hospital, Hines, Illinois;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Paschen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Universit\u00e4tsklinikum Schleswig-Holstein, Kiel Campus, Christian-Albrechts-University Kiel, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Steigerwald","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital and Julius-Maximilian-University, Wuerzburg, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Tonder","sequence":"additional","affiliation":[{"name":"Medtronic, Inc., Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Stoker","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital and Julius-Maximilian-University, Wuerzburg, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenic J.","family":"Reda","sequence":"additional","affiliation":[{"name":"Department of Veterans Affairs Cooperative Studies Program Coordinating Center, Edward Hines Jr. VA Hospital, Hines, Illinois;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1212\/WNL.59.6.932","article-title":"Predictors of effective bilateral subthalamic nucleus stimulation for PD","volume":"59","author":"Charles PD","year":"2002","unstructured":"Charles PD, Van Blercom N, Krack P, Lee SL, Xie J, Besson G, : Predictors of effective bilateral subthalamic nucleus stimulation for PD. 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