{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T01:01:39Z","timestamp":1780794099505,"version":"3.54.1"},"reference-count":37,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Spinal instability or neurological impairment caused by spinal brown tumors (BTs) with end-stage renal disease (ESRD) is an acute condition that needs urgent surgery. There is not much published information on BTs of the mobile spine given the rarity of the disease, and the literature shows inconsistent treatment options and ambiguous follow-up information. The aim of the present study was to elucidate the clinical features, anesthesia management, and surgical treatment for this rare disease through long-term follow-up observations.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Clinical, laboratory, radiological, and perioperative data on 6 consecutive patients with spinal BTs who had been admitted to the authors\u2019 institution between 2010 and 2016 were retrospectively reviewed. The literature on spinal BT with secondary hyperparathyroidism was also reviewed. Summaries of the clinical features and anesthesia management are provided.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The mean age of the 6 patients was 45.5 years (range 35\u201362 years). Lesions were located in the cervical segment (2 cases) and thoracic segment (4 cases). Localized pain was the most common complaint, and pathological fracture occurred in 5 patients. Elevation of serum alkaline phosphate (AKP) and parathyroid hormone (PTH) was a common phenomenon. Four patients underwent circumferential resection and 2 underwent laminectomy, with parathyroidectomy performed in all patients. The anesthesia process was uneventful for all patients. The mean follow-up was 33 months (range 26\u201340 months). No spinal lesion progression occurred in any patient. The Karnofsky Performance Status score improved to 80\u201390 by 3 months after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Although uncommon, spinal BTs should be a diagnostic consideration in patients with ESRD. The thoracic spine is the most frequently affected site. ESRD is not a contraindication for surgery; with the assistance of experienced anesthesiologists, urgent surgery is the preferred option to alleviate neurological impairment and restore spinal stability.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2018.12.spine181044","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T20:03:12Z","timestamp":1554840192000},"page":"850-857","source":"Crossref","is-referenced-by-count":2,"title":["Urgent surgery for spinal instability or neurological impairment caused by spinal brown tumors occurring in the context of end-stage renal disease"],"prefix":"10.3171","volume":"30","author":[{"given":"Qi","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Orthopedic Oncology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Oncology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Oncology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Lan","sequence":"additional","affiliation":[{"name":"Medical Center of Military Unit 32151, Xingtai, Hebei, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Oncology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tielong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Oncology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghai","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Oncology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Oncology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianru","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Oncology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Int Urol Nephrol","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1007\/s11255-012-0123-2","article-title":"Multiple brown tumors causing spinal cord compression in association with secondary hyperparathyroidism","volume":"45","author":"Ara\u00fajo SM","year":"2013","unstructured":"Ara\u00fajo SM, Bruin VM, Nunes AS, Pereira EN, Mota AC, Ribeiro MZ, : Multiple brown tumors causing spinal cord compression in association with secondary hyperparathyroidism. 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