{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:22:20Z","timestamp":1778872940202,"version":"3.51.4"},"reference-count":16,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11]]},"abstract":"OBJECTIVE<\/jats:title>Retrospective studies have reported that the local application of vancomycin (VCM) powder into the operative field decreases the incidence of surgical site infection (SSI) in thoracic and\/or lumbar fusion. Authors of the present study prospectively evaluated the effects of VCM in patients undergoing thoracic and\/or lumbar fusion.<\/jats:p><\/jats:sec>METHODS<\/jats:title>In this randomized double-blind trial, 230 patients undergoing thoracic and\/or lumbar fusion were randomly assigned to the local administration of VCM (interventional group, 1 g) or ampicillin (AMP; control group, 1 g) into the surgical field. The primary outcome was SSI results within 1 year of surgery.<\/jats:p><\/jats:sec>RESULTS<\/jats:title>The trial was prematurely stopped according to predetermined rules. The results showed one superficial infection (0.9%, Staphylococcus aureus<\/jats:italic>) and one deep infection (0.9%, S. aureus<\/jats:italic>) in the VCM group and two superficial infections (1.8%, Staphylococcus epidermidis<\/jats:italic> and culture negative) and one deep infection (0.9%, methicillin-resistant S. aureus<\/jats:italic>) in the AMP group. No significant differences in infection rates were observed between the groups (p = 0.8).<\/jats:p><\/jats:sec>CONCLUSIONS<\/jats:title>This double-blind randomized controlled trial demonstrated that the local application of VCM or AMP powder into the operative field in short thoracic and\/or lumbar fusion procedures resulted in a similar incidence of SSI.<\/jats:p>\u25a0 CLASSIFICATION OF EVIDENCE<\/jats:bold> Type of question: therapeutic; study design: randomized controlled trial; evidence: class III.<\/jats:p>Clinical trial registration no.: UMIN000009377 (umin.ac.jp\/ctr)<\/jats:p><\/jats:sec>","DOI":"10.3171\/2018.3.spine171111","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T14:01:27Z","timestamp":1533909687000},"page":"553-559","source":"Crossref","is-referenced-by-count":33,"title":["A double-blind randomized controlled trial of the local application of vancomycin versus ampicillin powder into the operative field for thoracic and\/or lumbar fusions"],"prefix":"10.3171","volume":"29","author":[{"given":"Mikinobu","family":"Takeuchi","sequence":"first","affiliation":[{"name":"Spine Center;"},{"name":"Departments of Neurological Surgery and"},{"name":"Department of Spine Surgery, Aichi Spine Hospital, Inuyama, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norimitsu","family":"Wakao","sequence":"additional","affiliation":[{"name":"Spine Center;"},{"name":"Orthopedics Surgery; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Spine Center;"},{"name":"Orthopedics Surgery; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuhiko","family":"Hirasawa","sequence":"additional","affiliation":[{"name":"Spine Center;"},{"name":"Orthopedics Surgery; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Murotani","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, Clinical Research Center, Aichi Medical University Hospital, Nagakute; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Takayasu","sequence":"additional","affiliation":[{"name":"Spine Center;"},{"name":"Departments of Neurological Surgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Spinal Disord","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1097\/00002517-199508040-00003","article-title":"Treatment of postoperative wound infections following spinal fusion with instrumentation","volume":"8","author":"Abbey DM","year":"1995","unstructured":"Abbey DM, Turner DM, Warson JS, Wirt TC, Scalley RD: Treatment of postoperative wound infections following spinal fusion with instrumentation. 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