{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:50:01Z","timestamp":1783486201221,"version":"3.55.0"},"reference-count":27,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Giant posterior circulation aneurysms (GPCirAs) usually cause substantial mass effect on the brainstem, which may lead to neurological deficits. So far, there has been no systematic investigation of factors associated with such deficits in GPCirA. The authors aim to examine the risk factors for cranial nerve deficit (CND), motor deficit, and disability in patients with GPCirA.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Using MR images obtained in 30 patients with unruptured GPCirA, the authors examined GPCirA volume, presence of hydrocephalus or partial thrombosis (PT) of the aneurysm, and the degree of brainstem displacement measured by the distance between the McRae line and the tip of the GPCirA (\u2206MT). They evaluated associations between these factors and neurological deficits.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Thirty GPCirAs in 30 patients were included. The prevalence of CNDs was 50%. Patients with CNDs significantly differed from those without CNDs in terms of age (mean 51.0 years [SD 15.0 years] vs 69.0 years [SD 21.0 years], p = 0.01) and in \u2206MT (median 50.7 mm [IQR 39.2\u201353.9 mm] vs 39.0 mm [IQR 32.3\u201345.9 mm], p = 0.02). The prevalence of motor deficits was 33.3%. Patients with motor deficits showed a larger \u2206MT (median 50.5 mm [IQR 40.8\u201354.6 mm]) compared with those without (\u2206MT: median 39.1 mm [IQR 32.8\u201350.5 mm], p = 0.04). GPCirA volume was larger in patients with poor modified Rankin Scale (mRS) scores (median 14.9 cm<jats:sup>3<\/jats:sup> [IQR 8.6\u201318.7 cm<jats:sup>3<\/jats:sup>]) than in those with mRS scores of 0\u20132 (median 6.8 cm<jats:sup>3<\/jats:sup> [IQR 4.4\u201311.7 cm<jats:sup>3<\/jats:sup>], p = 0.03). After adjusting for patient age and the occurrence of hydrocephalus or PT, the authors found that higher degrees of disability were significantly associated with aneurysm volume (OR 1.13, 95% CI 1.0\u20131.3; p = 0.04), but not with \u2206MT. The occurrence of CND or motor deficit was not associated with any of the examined variables. There was no correlation between GPCirA volume and \u2206MT (r<jats:sub>s<\/jats:sub> = 0.01, p = 0.96). The prevalence of neurological deficits did not differ between GPCirA at the basilar apex, the basilar trunk, the vertebrobasilar junction, or the vertebral artery.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In this study, the neurological condition of the patients was associated only with GPCirA volume and not with the degree of brainstem displacement, the occurrence of PT or hydrocephalus, or the exact location of the GPCirA. These findings highlight the clinical relevance of GPCirA volume and suggest that factors such as brainstem displacement or PT should play less of a role when finding arguments for or against treatment of GPCirA.<\/jats:p><jats:p>Clinical trial registration no.: NCT02066493 (clinicaltrials.gov)<\/jats:p><\/jats:sec>","DOI":"10.3171\/2018.4.jns172343","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T13:59:46Z","timestamp":1533909586000},"page":"403-409","source":"Crossref","is-referenced-by-count":14,"title":["Giant intracranial aneurysms of the posterior circulation and their relation to the brainstem: analysis of risk factors for neurological deficits"],"prefix":"10.3171","volume":"131","author":[{"given":"Pavlina","family":"Lenga","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Charit\u00e9-Universitaetsmedizin Berlin;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Hohaus","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, BG Hospital Bergmannstrost, Halle;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bujung","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hannover Medical School, Hannover;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adisa","family":"Kursumovic","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Interventional Neuroradiology, DONAUISAR Klinikum Deggendorf, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolai","family":"Maldaner","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital of Zurich;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Karl","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital of Zurich;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Bijlenga","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Geneva;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"R\u00fcfenacht","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Clinic Hirslanden, Zurich, Switzerland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils O.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Medical Center, Hamburg Eppendorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vajkoczy","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Charit\u00e9-Universitaetsmedizin Berlin;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Dengler","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Charit\u00e9-Universitaetsmedizin Berlin;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3171\/2013.8.JNS13535","article-title":"True petroclival meningiomas: results of surgical management","volume":"120","author":"Almefty R","year":"2014","unstructured":"Almefty R, Dunn IF, Pravdenkova S, Abolfotoh M, Al-Mefty O: True petroclival meningiomas: results of surgical management. 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