{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T17:36:56Z","timestamp":1776447416579,"version":"3.51.2"},"reference-count":20,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>The aim of this paper was to evaluate the association between intracranial vessel wall MRI enhancement characteristics and the development of angiographic vasospasm in endovascularly treated aneurysm patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Consecutive cases of both ruptured and unruptured intracranial aneurysms that were treated endovascularly, followed by intracranial vessel wall MRI in the immediate postoperative period, were included. Two raters blinded to clinical data and follow-up imaging independently evaluated for the presence, pattern, and intensity of wall enhancement. Development of angiographic vasospasm was independently evaluated. Delayed cerebral ischemia; cerebral infarct; procedural details; and presence and grade of subarachnoid, parenchymal, and intraventricular hemorrhage were evaluated. Statistical associations were determined on a per\u2013vessel segment and per-patient basis.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Twenty-nine patients with 30 treated aneurysms (8 unruptured and 22 ruptured) were included in this study. Interobserver agreement was substantial for the presence of enhancement (\u03ba = 0.67) and nearly perfect for distribution (\u03ba = 0.87) and intensity (\u03ba = 0.84) of wall enhancement. Patients with ruptured aneurysms had a significantly greater number of enhancing segments than those with unruptured aneurysms (29.9% vs 7.2%; OR 5.5, 95% CI 2.2\u201313.7). For ruptured cases, wall enhancement was significantly associated with subsequent angiographic vasospasm while controlling for grade of hemorrhage (adjusted OR 3.9, 95% CI 1.7\u20139.4). Vessel segments affected by balloon, stent, or flow-diverter use demonstrated greater enhancement than those not affected (OR 22.7, 95% CI 5.3\u201397.2 for ruptured; and OR 12.9, 95% CI 3.3\u201349.8 for unruptured).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Vessel wall enhancement after endovascular treatment of ruptured aneurysms is associated with subsequent angiographic vasospasm.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2018.4.jns172829","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T14:20:29Z","timestamp":1537539629000},"page":"859-867","source":"Crossref","is-referenced-by-count":21,"title":["Vessel wall MRI characteristics of endovascularly treated aneurysms: association with angiographic vasospasm"],"prefix":"10.3171","volume":"131","author":[{"given":"Mahmud","family":"Mossa-Basha","sequence":"first","affiliation":[{"name":"Departments of Radiology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thien J.","family":"Huynh","sequence":"additional","affiliation":[{"name":"Departments of Radiology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel S.","family":"Hippe","sequence":"additional","affiliation":[{"name":"Departments of Radiology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Fata","sequence":"additional","affiliation":[{"name":"Departments of Radiology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan P.","family":"Morton","sequence":"additional","affiliation":[{"name":"Neurosurgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Levitt","sequence":"additional","affiliation":[{"name":"Departments of Radiology,"},{"name":"Neurosurgery, and"},{"name":"Mechanical Engineering, University of Washington, Seattle, Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Stroke","first-page":"2506","article-title":"Early vasospasm on admission angiography in patients with aneurysmal subarachnoid hemorrhage is a predictor for in-hospital complications and poor outcome","volume":"35","author":"Baldwin ME","year":"2004","unstructured":"Baldwin ME, Macdonald RL, Huo D, Novakovic RL, Goldenberg FD, Frank JI, : Early vasospasm on admission angiography in patients with aneurysmal subarachnoid hemorrhage is a predictor for in-hospital complications and poor outcome. Stroke 35:2506\u20132511, 2004 (Erratum in Stroke 36:175, 2005)"},{"key":"b2","series-title":"Stroke","first-page":"1711","article-title":"Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"43","author":"Connolly ES Jr","year":"2012","unstructured":"Connolly ES Jr, Rabinstein AA, Carhuapoma JR, Derdeyn CP, Dion J, Higashida RT, : Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association. Stroke 43:1711\u20131737, 2012"},{"key":"b3","series-title":"Clin Neuroradiol","first-page":"175","article-title":"High-resolution vessel wall magnetic resonance imaging in angiogram-negative non-perimesencephalic subarachnoid hemorrhage","volume":"27","author":"Coutinho JM","year":"2017","unstructured":"Coutinho JM, Sacho RH, Schaafsma JD, Agid R, Krings T, Radovanovic I, : High-resolution vessel wall magnetic resonance imaging in angiogram-negative non-perimesencephalic subarachnoid hemorrhage. Clin Neuroradiol 27:175\u2013183, 2017"},{"key":"b4","series-title":"Stroke","first-page":"919","article-title":"Angiographic vasospasm is strongly correlated with cerebral infarction after subarachnoid hemorrhage","volume":"42","author":"Crowley RW","year":"2011","unstructured":"Crowley RW, Medel R, Dumont AS, Ilodigwe D, Kassell NF, Mayer SA, : Angiographic vasospasm is strongly correlated with cerebral infarction after subarachnoid hemorrhage. Stroke 42:919\u2013923, 2011"},{"key":"b5","series-title":"Case Rep Radiol","first-page":"356582","article-title":"Nonstenotic culprit plaque: the utility of high-resolution vessel wall MRI of intracranial vessels after ischemic stroke","volume":"2015","author":"de Havenon A","year":"2015","unstructured":"de Havenon A, Yuan C, Tirschwell D, Hatsukami T, Anzai Y, Becker K, : Nonstenotic culprit plaque: the utility of high-resolution vessel wall MRI of intracranial vessels after ischemic stroke. Case Rep Radiol 2015:356582, 2015"},{"key":"b6","series-title":"Stroke","article-title":"Magnetic resonance imaging of plaque morphology, burden, and distribution in patients with symptomatic middle cerebral artery stenosis","volume":"47","author":"Dieleman N","year":"1797\u20131802","unstructured":"Dieleman N, Yang W, Abrigo JM, Chu WC, van der Kolk AG, Siero JC, : Magnetic resonance imaging of plaque morphology, burden, and distribution in patients with symptomatic middle cerebral artery stenosis. Stroke 47:1797\u20131802, 2016"},{"key":"b7","series-title":"Neurosurgery","first-page":"736","article-title":"Arterial wall changes in cerebral vasospasm","volume":"25","author":"Findlay JM","year":"1989","unstructured":"Findlay JM, Weir BK, Kanamaru K, Espinosa F: Arterial wall changes in cerebral vasospasm. Neurosurgery 25:736\u2013746, 1989"},{"key":"b8","series-title":"Neurosurgery","first-page":"21","article-title":"Prediction of symptomatic vasospasm after subarachnoid hemorrhage: the modified fisher scale","volume":"59","author":"Frontera JA","year":"2006","unstructured":"Frontera JA, Claassen J, Schmidt JM, Wartenberg KE, Temes R, Connolly ES Jr, : Prediction of symptomatic vasospasm after subarachnoid hemorrhage: the modified fisher scale. Neurosurgery 59:21\u201327, 2006"},{"key":"b9","series-title":"World Neurosurg","first-page":"56","article-title":"Risk factors for cerebral vasospasm following aneurysmal subarachnoid hemorrhage: a review of the literature","volume":"85","author":"Inagawa T","year":"2016","unstructured":"Inagawa T: Risk factors for cerebral vasospasm following aneurysmal subarachnoid hemorrhage: a review of the literature. World Neurosurg 85:56\u201376, 2016"},{"key":"b10","series-title":"Nat Rev Neurol","first-page":"44","article-title":"Delayed neurological deterioration after subarachnoid haemorrhage","volume":"10","author":"Macdonald RL","year":"2014","unstructured":"Macdonald RL: Delayed neurological deterioration after subarachnoid haemorrhage. Nat Rev Neurol 10:44\u201358, 2014"},{"key":"b11","series-title":"AJNR Am J Neuroradiol","first-page":"218","article-title":"Intracranial vessel wall MRI: principles and expert consensus recommendations of the American Society of Neuroradiology","volume":"38","author":"Mandell DM","year":"2017","unstructured":"Mandell DM, Mossa-Basha M, Qiao Y, Hess CP, Hui F, Matouk C, : Intracranial vessel wall MRI: principles and expert consensus recommendations of the American Society of Neuroradiology. AJNR Am J Neuroradiol 38:218\u2013229, 2017"},{"key":"b12","series-title":"J Neurointerv Surg","first-page":"1154","article-title":"Vessel wall imaging for intracranial vascular disease evaluation","volume":"8","author":"Mossa-Basha M","year":"2016","unstructured":"Mossa-Basha M, Alexander M, Gaddikeri S, Yuan C, Gandhi D: Vessel wall imaging for intracranial vascular disease evaluation. J Neurointerv Surg 8:1154\u20131159, 2016"},{"key":"b13","series-title":"Stroke","first-page":"1782","article-title":"Added value of vessel wall magnetic resonance imaging in the differentiation of moyamoya vasculopathies in a non-Asian cohort","volume":"47","author":"Mossa-Basha M","year":"2016","unstructured":"Mossa-Basha M, de Havenon A, Becker KJ, Hallam DK, Levitt MR, Cohen WA, : Added value of vessel wall magnetic resonance imaging in the differentiation of moyamoya vasculopathies in a non-Asian cohort. Stroke 47:1782\u20131788, 2016"},{"key":"b14","series-title":"Stroke","first-page":"1567","article-title":"Multicontrast high-resolution vessel wall magnetic resonance imaging and its value in differentiating intracranial vasculopathic processes","volume":"46","author":"Mossa-Basha M","year":"2015","unstructured":"Mossa-Basha M, Hwang WD, De Havenon A, Hippe D, Balu N, Becker KJ, : Multicontrast high-resolution vessel wall magnetic resonance imaging and its value in differentiating intracranial vasculopathic processes. Stroke 46:1567\u20131573, 2015"},{"key":"b15","series-title":"Stroke","first-page":"3026","article-title":"Added value of vessel wall magnetic resonance imaging for differentiation of nonocclusive intracranial vasculopathies","volume":"48","author":"Mossa-Basha M","year":"2017","unstructured":"Mossa-Basha M, Shibata DK, Hallam DK, de Havenon A, Hippe DS, Becker KJ, : Added value of vessel wall magnetic resonance imaging for differentiation of nonocclusive intracranial vasculopathies. Stroke 48:3026\u20133033, 2017"},{"key":"b16","series-title":"Stroke","first-page":"2330","article-title":"Vessel wall magnetic resonance imaging in acute ischemic stroke: effects of embolism and mechanical thrombectomy on the arterial wall","volume":"45","author":"Power S","year":"2014","unstructured":"Power S, Matouk C, Casaubon LK, Silver FL, Krings T, Mikulis DJ, : Vessel wall magnetic resonance imaging in acute ischemic stroke: effects of embolism and mechanical thrombectomy on the arterial wall. Stroke 45:2330\u20132334, 2014"},{"key":"b17","series-title":"J Neurosurg","first-page":"255","article-title":"Clot volume and clearance rate as independent predictors of vasospasm after aneurysmal subarachnoid hemorrhage","volume":"101","author":"Reilly C","year":"2004","unstructured":"Reilly C, Amidei C, Tolentino J, Jahromi BS, Macdonald RL: Clot volume and clearance rate as independent predictors of vasospasm after aneurysmal subarachnoid hemorrhage. J Neurosurg 101:255\u2013261, 2004"},{"key":"b18","series-title":"AJNR Am J Neuroradiol","first-page":"643","article-title":"A standardized method for measuring intracranial arterial stenosis","volume":"21","author":"Samuels OB","year":"2000","unstructured":"Samuels OB, Joseph GJ, Lynn MJ, Smith HA, Chimowitz MI: A standardized method for measuring intracranial arterial stenosis. AJNR Am J Neuroradiol 21:643\u2013646, 2000"},{"key":"b19","series-title":"Stroke","first-page":"2391","article-title":"Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group","volume":"41","author":"Vergouwen MD","year":"2010","unstructured":"Vergouwen MD, Vermeulen M, van Gijn J, Rinkel GJ, Wijdicks EF, Muizelaar JP, : Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group. Stroke 41:2391\u20132395, 2010"},{"key":"b20","series-title":"CNS Neurosci Ther","first-page":"364","article-title":"Intracranial artery atherosclerosis and lumen dilation in cerebral small-vessel diseases: a high-resolution MRI study","volume":"20","author":"Xu WH","year":"2014","unstructured":"Xu WH, Li ML, Niu JW, Feng F, Jin ZY, Gao S: Intracranial artery atherosclerosis and lumen dilation in cerebral small-vessel diseases: a high-resolution MRI study. CNS Neurosci Ther 20:364\u2013367, 2014"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/131\/3\/article-p859.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/131\/3\/article-p859.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/131\/3\/article-p859.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T03:49:32Z","timestamp":1742701772000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/131\/3\/article-p859.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":20,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3171\/2018.4.jns172829","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9]]}}}