{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:02:42Z","timestamp":1787025762951,"version":"build-2736575974"},"reference-count":40,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Deep brain stimulation (DBS) of the posterior subthalamic area (PSA) is an alternative to thalamic DBS for the treatment of essential tremor (ET). The dentato-rubro-thalamic tract (DRTT) has recently been proposed as the anatomical substrate underlying effective stimulation. For clinical purposes, depiction of the DRTT mainly depends on diffusion tensor imaging (DTI)\u2013based tractography, which has some drawbacks. The objective of this study was to present an accurate targeting strategy for DBS of the PSA based on anatomical landmarks visible on MRI and to evaluate clinical effectiveness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The authors performed a retrospective cohort study of a prospective series of 11 ET patients undergoing bilateral DBS of the PSA. The subthalamic nucleus and red nucleus served as anatomical landmarks to define the target point within the adjacent PSA on 3-T T2-weighted MRI. Stimulating contact (SC) positions with reference to the midcommissural point were analyzed and projected onto the stereotactic atlas of Morel. Postoperative outcome assessment after 6 and 12 months was based on change in Tremor Rating Scale (TRS) scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Actual target position corresponded to the intended target based on anatomical landmarks depicted on MRI. The total TRS score was reduced (improved) from 47.2 \u00b1 15.7 to 21.3 \u00b1 10.7 (p &lt; 0.001). No severe complication occurred. The mean SC position projected onto the PSA at the margin of the cerebellothalamic fascicle and the zona incerta.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Targeting of the PSA based on anatomical landmarks representable on MRI is reliable and leads to accurate lead placement as well as good long-term clinical outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2018.4.jns18373","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T17:53:43Z","timestamp":1542304423000},"page":"820-827","source":"Crossref","is-referenced-by-count":29,"title":["Targeting the posterior subthalamic area for essential tremor: proposal for MRI-based anatomical landmarks"],"prefix":"10.3171","volume":"131","author":[{"given":"Andreas","family":"Nowacki","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Debove","sequence":"additional","affiliation":[{"name":"Neurology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Rossi","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine Ai","family":"Schlaeppi","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Petermann","sequence":"additional","affiliation":[{"name":"Neurology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Wiest","sequence":"additional","affiliation":[{"name":"Diagnostic and Interventional Neuroradiology, Inselspital, University Hospital Bern, and University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sch\u00fcpbach","sequence":"additional","affiliation":[{"name":"Neurology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Pollo","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Magn Reson Imaging","first-page":"773","article-title":"A theoretical study of the effect of experimental noise on the measurement of anisotropy in diffusion imaging","volume":"16","author":"Bastin ME","year":"1998","unstructured":"Bastin ME, Armitage PA, Marshall I: A theoretical study of the effect of experimental noise on the measurement of anisotropy in diffusion imaging. Magn Reson Imaging 16:773\u2013785, 1998"},{"key":"b2","series-title":"J Neurosurg","first-page":"615","article-title":"Bilateral subthalamic stimulation for Parkinson\u2019s disease by using three-dimensional stereotactic magnetic resonance imaging and electrophysiological guidance","volume":"92","author":"Bejjani BP","year":"2000","unstructured":"Bejjani BP, Dormont D, Pidoux B, Yelnik J, Damier P, Arnulf I, : Bilateral subthalamic stimulation for Parkinson\u2019s disease by using three-dimensional stereotactic magnetic resonance imaging and electrophysiological guidance. J Neurosurg 92:615\u2013625, 2000"},{"issue":"Suppl 3","key":"b3","series-title":"Mov Disord","first-page":"119","article-title":"Long-term electrical inhibition of deep brain targets in movement disorders","volume":"13","author":"Benabid AL","year":"1998","unstructured":"Benabid AL, Benazzouz A, Hoffmann D, Limousin P, Krack P, Pollak P: Long-term electrical inhibition of deep brain targets in movement disorders. Mov Disord 13 (Suppl 3):119\u2013125, 1998"},{"key":"b4","series-title":"J Neurosurg","first-page":"203","article-title":"Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders","volume":"84","author":"Benabid AL","year":"1996","unstructured":"Benabid AL, Pollak P, Gao D, Hoffmann D, Limousin P, Gay E, : Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders. J Neurosurg 84:203\u2013214, 1996"},{"key":"b5","series-title":"Mov Disord","first-page":"1350","article-title":"Deep brain stimulation in the posterior subthalamic area in the treatment of essential tremor","volume":"25","author":"Blomstedt P","year":"2010","unstructured":"Blomstedt P, Sandvik U, Tisch S: Deep brain stimulation in the posterior subthalamic area in the treatment of essential tremor. Mov Disord 25:1350\u20131356, 2010"},{"key":"b6","series-title":"Clin Neurophysiol","first-page":"447","article-title":"Sources and effects of electrode impedance during deep brain stimulation","volume":"117","author":"Butson CR","year":"2006","unstructured":"Butson CR, Maks CB, McIntyre CC: Sources and effects of electrode impedance during deep brain stimulation. Clin Neurophysiol 117:447\u2013454, 2006"},{"key":"b7","series-title":"Neurosurgery","first-page":"347","article-title":"Bilateral electrical stimulation of prelemniscal radiations in the treatment of advanced Parkinson\u2019s disease","volume":"62","author":"Carrillo-Ruiz JD","year":"2008","unstructured":"Carrillo-Ruiz JD, Velasco F, Jim\u00e8nez F, Castro G, Velasco AL, Hern\u00e1ndez JA, : Bilateral electrical stimulation of prelemniscal radiations in the treatment of advanced Parkinson\u2019s disease. Neurosurgery 62:347\u2013359, 2008"},{"key":"b8","series-title":"Acta Neurochir (Wien)","first-page":"1579","article-title":"A role of diffusion tensor imaging fiber tracking in deep brain stimulation surgery: DBS of the dentato-rubro-thalamic tract (drt) for the treatment of therapy-refractory tremor","volume":"153","author":"Coenen VA","year":"2011","unstructured":"Coenen VA, Allert N, M\u00e4dler B: A role of diffusion tensor imaging fiber tracking in deep brain stimulation surgery: DBS of the dentato-rubro-thalamic tract (drt) for the treatment of therapy-refractory tremor. Acta Neurochir (Wien) 153:1579\u20131585, 2011"},{"key":"b9","series-title":"Neurosurgery","first-page":"657","article-title":"Modulation of the cerebello-thalamo-cortical network in thalamic deep brain stimulation for tremor: a diffusion tensor imaging study","volume":"75","author":"Coenen VA","year":"2014","unstructured":"Coenen VA, Allert N, Paus S, Kronenb\u00fcrger M, Urbach H, M\u00e4dler B: Modulation of the cerebello-thalamo-cortical network in thalamic deep brain stimulation for tremor: a diffusion tensor imaging study. Neurosurgery 75:657\u2013670, 2014"},{"issue":"Suppl 3","key":"b10","series-title":"Mov Disord","first-page":"2","article-title":"Consensus statement of the Movement Disorder Society on tremor","volume":"13","author":"Deuschl G","year":"1998","unstructured":"Deuschl G, Bain P, Brin M: Consensus statement of the Movement Disorder Society on tremor. Mov Disord 13 (Suppl 3):2\u201323, 1998"},{"key":"b11","series-title":"Neuromodulation","first-page":"429","article-title":"Deep brain stimulation of the dentato-rubro-thalamic tract: outcomes of direct targeting for tremor","volume":"20","author":"Fenoy AJ","year":"2017","unstructured":"Fenoy AJ, Schiess MC: Deep brain stimulation of the dentato-rubro-thalamic tract: outcomes of direct targeting for tremor. Neuromodulation 20:429\u2013436, 2017"},{"key":"b12","series-title":"Stereotact Funct Neurosurg","first-page":"243","article-title":"Deep brain stimulation for tremor: is there a common structure?","volume":"95","author":"Fiechter M","year":"2017","unstructured":"Fiechter M, Nowacki A, Oertel MF, Fichtner J, Debove I, Lachenmayer ML, : Deep brain stimulation for tremor: is there a common structure? Stereotact Funct Neurosurg 95:243\u2013250, 2017"},{"key":"b13","series-title":"Brain Struct Funct","first-page":"443","article-title":"Human pallidothalamic and cerebellothalamic tracts: anatomical basis for functional stereotactic neurosurgery","volume":"212","author":"Gallay MN","year":"2008","unstructured":"Gallay MN, Jeanmonod D, Liu J, Morel A: Human pallidothalamic and cerebellothalamic tracts: anatomical basis for functional stereotactic neurosurgery. Brain Struct Funct 212:443\u2013463, 2008"},{"key":"b14","series-title":"Stereotact Funct Neurosurg","first-page":"208","article-title":"Tolerance and tremor rebound following long-term chronic thalamic stimulation for Parkinsonian and essential tremor","volume":"72","author":"Hariz MI","year":"1999","unstructured":"Hariz MI, Shamsgovara P, Johansson F, Hariz G, Fodstad H: Tolerance and tremor rebound following long-term chronic thalamic stimulation for Parkinsonian and essential tremor. Stereotact Funct Neurosurg 72:208\u2013218, 1999"},{"key":"b15","series-title":"Introduction to Stereotaxic Operations With an Atlas of the Human Brain","first-page":"230","article-title":"Anatomy of the thalamus","author":"Hassler R","year":"1959","unstructured":"Hassler R: Anatomy of the thalamus, in Schaltenbrand G, Bailey P (eds): Introduction to Stereotaxic Operations With an Atlas of the Human Brain. Stuttgart: Thieme, 1959, pp 230\u2013290"},{"key":"b16","series-title":"Science","first-page":"130","article-title":"Functional dynamics of GABAergic inhibition in the thalamus","volume":"278","author":"Kim U","year":"1997","unstructured":"Kim U, Sanchez-Vives MV, McCormick DA: Functional dynamics of GABAergic inhibition in the thalamus. Science 278:130\u2013134, 1997"},{"key":"b17","series-title":"Neurology","first-page":"114","article-title":"Deep brain stimulation of subthalamic area for severe proximal tremor","volume":"55","author":"Kitagawa M","year":"2000","unstructured":"Kitagawa M, Murata J, Kikuchi S, Sawamura Y, Saito H, Sasaki H, : Deep brain stimulation of subthalamic area for severe proximal tremor. Neurology 55:114\u2013116, 2000"},{"key":"b18","series-title":"J Comp Neurol","first-page":"544","article-title":"Patterns of connections between zona incerta and brainstem in rats","volume":"396","author":"Kolmac CI","year":"1998","unstructured":"Kolmac CI, Power BD, Mitrofanis J: Patterns of connections between zona incerta and brainstem in rats. J Comp Neurol 396:544\u2013555, 1998"},{"key":"b19","series-title":"J Neurol Neurosurg Psychiatry","first-page":"289","article-title":"Multicentre European study of thalamic stimulation in parkinsonian and essential tremor","volume":"66","author":"Limousin P","year":"1999","unstructured":"Limousin P, Speelman JD, Gielen F, Janssens M: Multicentre European study of thalamic stimulation in parkinsonian and essential tremor. J Neurol Neurosurg Psychiatry 66:289\u2013296, 1999"},{"key":"b20","series-title":"Arch Med Res","first-page":"266","article-title":"Vim thalamic stimulation for tremor","volume":"31","author":"Lozano AM","year":"2000","unstructured":"Lozano AM: Vim thalamic stimulation for tremor. Arch Med Res 31:266\u2013269, 2000"},{"key":"b21","series-title":"Biophys J","first-page":"878","article-title":"Excitation of central nervous system neurons by nonuniform electric fields","volume":"76","author":"McIntyre CC","year":"1999","unstructured":"McIntyre CC, Grill WM: Excitation of central nervous system neurons by nonuniform electric fields. Biophys J 76:878\u2013888, 1999"},{"key":"b22","series-title":"Clin Neurophysiol","first-page":"589","article-title":"Electric field and stimulating influence generated by deep brain stimulation of the subthalamic nucleus","volume":"115","author":"McIntyre CC","year":"2004","unstructured":"McIntyre CC, Mori S, Sherman DL, Thakor NV, Vitek JL: Electric field and stimulating influence generated by deep brain stimulation of the subthalamic nucleus. Clin Neurophysiol 115:589\u2013595, 2004"},{"key":"b23","series-title":"Neuroscience","first-page":"1","article-title":"Some certainty for the \u201czone of uncertainty\u201d? Exploring the function of the zona incerta","volume":"130","author":"Mitrofanis J","year":"2005","unstructured":"Mitrofanis J: Some certainty for the \u201czone of uncertainty\u201d? Exploring the function of the zona incerta. Neuroscience 130:1\u201315, 2005"},{"key":"b24","series-title":"Brain Struct Funct","first-page":"3487","article-title":"Dentatorubrothalamic tract localization with postmortem MR diffusion tractography compared to histological 3D reconstruction","volume":"221","author":"Mollink J","year":"2016","unstructured":"Mollink J, van Baarsen KM, Dederen PJ, Foxley S, Miller KL, Jbabdi S, : Dentatorubrothalamic tract localization with postmortem MR diffusion tractography compared to histological 3D reconstruction. Brain Struct Funct 221:3487\u20133501, 2016"},{"key":"b25","series-title":"Neuron","first-page":"527","article-title":"Principles of diffusion tensor imaging and its applications to basic neuroscience research","volume":"51","author":"Mori S","year":"2006","unstructured":"Mori S, Zhang J: Principles of diffusion tensor imaging and its applications to basic neuroscience research. Neuron 51:527\u2013539, 2006"},{"key":"b26","series-title":"J Neurosurg","first-page":"708","article-title":"Electrical stimulation of the posterior subthalamic area for the treatment of intractable proximal tremor","volume":"99","author":"Murata J","year":"2003","unstructured":"Murata J, Kitagawa M, Uesugi H, Saito H, Iwasaki Y, Kikuchi S, : Electrical stimulation of the posterior subthalamic area for the treatment of intractable proximal tremor. J Neurosurg 99:708\u2013715, 2003"},{"key":"b27","series-title":"Oper Neurosurg (Hagerstown)","first-page":"66","article-title":"Targeting accuracy of the subthalamic nucleus in deep brain stimulation surgery: comparison between 3 T T2-weighted magnetic resonance imaging and microelectrode recording results","volume":"15","author":"Nowacki A","year":"2018","unstructured":"Nowacki A, Debove I, Fiechter M, Rossi F, Oertel MF, Wiest R, : Targeting accuracy of the subthalamic nucleus in deep brain stimulation surgery: comparison between 3 T T2-weighted magnetic resonance imaging and microelectrode recording results. Oper Neurosurg (Hagerstown) 15:66\u201371, 2018"},{"key":"b28","series-title":"PLoS One","first-page":"e0137868","article-title":"Using MDEFT MRI sequences to target the GPi in DBS surgery","volume":"10","author":"Nowacki A","year":"2015","unstructured":"Nowacki A, Fiechter M, Fichtner J, Debove I, Lachenmayer L, Sch\u00fcpbach M, : Using MDEFT MRI sequences to target the GPi in DBS surgery. PLoS One 10:e0137868, 2015"},{"key":"b29","series-title":"Neurology","first-page":"1447","article-title":"Bilateral thalamic stimulation for the treatment of essential tremor","volume":"53","author":"Pahwa R","year":"1999","unstructured":"Pahwa R, Lyons KL, Wilkinson SB, Carpenter MA, Tr\u00f6ster AI, Searl JP, : Bilateral thalamic stimulation for the treatment of essential tremor. Neurology 53:1447\u20131450, 1999"},{"key":"b30","series-title":"Zentralbl Neurochir","first-page":"71","article-title":"Electrode implantation for deep brain stimulation in dystonia: a fast spin-echo inversion-recovery sequence technique for direct stereotactic targeting of the GPI","volume":"69","author":"Pinsker MO","year":"2008","unstructured":"Pinsker MO, Volkmann J, Falk D, Herzog J, Alfke K, Steigerwald F, : Electrode implantation for deep brain stimulation in dystonia: a fast spin-echo inversion-recovery sequence technique for direct stereotactic targeting of the GPI. Zentralbl Neurochir 69:71\u201375, 2008"},{"key":"b31","series-title":"J Neurol Neurosurg Psychiatry","first-page":"899","article-title":"Bilateral caudal zona incerta nucleus stimulation for essential tremor: outcome and quality of life","volume":"82","author":"Plaha P","year":"2011","unstructured":"Plaha P, Javed S, Agombar D, O\u2019 Farrell G, Khan S, Whone A, : Bilateral caudal zona incerta nucleus stimulation for essential tremor: outcome and quality of life. J Neurol Neurosurg Psychiatry 82:899\u2013904, 2011"},{"key":"b32","series-title":"J Neurol Neurosurg Psychiatry","first-page":"504","article-title":"Bilateral stimulation of the caudal zona incerta nucleus for tremor control","volume":"79","author":"Plaha P","year":"2008","unstructured":"Plaha P, Khan S, Gill SS: Bilateral stimulation of the caudal zona incerta nucleus for tremor control. J Neurol Neurosurg Psychiatry 79:504\u2013513, 2008"},{"key":"b33","series-title":"J Neurosurg","first-page":"48","article-title":"Stimulation of the subthalamic region for essential tremor","volume":"101","author":"Plaha P","year":"2004","unstructured":"Plaha P, Patel NK, Gill SS: Stimulation of the subthalamic region for essential tremor. J Neurosurg 101:48\u201354, 2004Pubmed Partial stitle stitle Volume Page"},{"key":"b34","series-title":"J Comp Neurol","first-page":"33","article-title":"Ultrastructure of afferents from the zona incerta to the posterior and parafascicular thalamic nuclei of rats","volume":"451","author":"Power BD","year":"2002","unstructured":"Power BD, Mitrofanis J: Ultrastructure of afferents from the zona incerta to the posterior and parafascicular thalamic nuclei of rats. J Comp Neurol 451:33\u201344, 2002"},{"key":"b35","series-title":"J Comp Neurol","first-page":"480","article-title":"Afferents to the zona incerta in the rat: a combined retrograde and anterograde study","volume":"241","author":"Roger M","year":"1985","unstructured":"Roger M, Cadusseau J: Afferents to the zona incerta in the rat: a combined retrograde and anterograde study. J Comp Neurol 241:480\u2013492, 1985"},{"key":"b36","series-title":"Mov Disord","first-page":"1217","article-title":"Tractography-based ventral intermediate nucleus targeting: novel methodology and intraoperative validation","volume":"31","author":"Sammartino F","year":"2016","unstructured":"Sammartino F, Krishna V, King NK, Lozano AM, Schwartz ML, Huang Y, : Tractography-based ventral intermediate nucleus targeting: novel methodology and intraoperative validation. Mov Disord 31:1217\u20131225, 2016"},{"key":"b37","series-title":"Neuromodulation","first-page":"105","article-title":"Deep brain stimulation for essential tremor: targeting the dentato-rubro-thalamic tract?","volume":"18","author":"Schlaier J","year":"2015","unstructured":"Schlaier J, Anthofer J, Steib K, Fellner C, Rothenfusser E, Brawanski A, : Deep brain stimulation for essential tremor: targeting the dentato-rubro-thalamic tract? Neuromodulation 18:105\u2013112, 2015"},{"key":"b38","series-title":"Mov Disord","first-page":"833","article-title":"Assessment of interrater and intrarater reliability of the Fahn-Tolosa-Marin Tremor Rating Scale in essential tremor","volume":"22","author":"Stacy MA","year":"2007","unstructured":"Stacy MA, Elble RJ, Ondo WG, Wu SC, Hulihan J: Assessment of interrater and intrarater reliability of the Fahn-Tolosa-Marin Tremor Rating Scale in essential tremor. Mov Disord 22:833\u2013838, 2007"},{"key":"b39","series-title":"Neurochirurgie","first-page":"105","article-title":"[Trials in thalamic surgery.]","volume":"6","author":"Wertheimer P","year":"1960","unstructured":"Wertheimer P, Lapras C, Levy A: [Trials in thalamic surgery.] Neurochirurgie 6:105\u2013112, 1960 (Fr)"},{"key":"b40","series-title":"Brain","first-page":"141","article-title":"Localization of the motor hand area to a knob on the precentral gyrus. A new landmark","volume":"120","author":"Yousry TA","year":"1997","unstructured":"Yousry TA, Schmid UD, Alkadhi H, Schmidt D, Peraud A, Buettner A, : Localization of the motor hand area to a knob on the precentral gyrus. A new landmark. 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