{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T13:09:23Z","timestamp":1762607363980},"reference-count":14,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:p>The use of methotrexate (MTX) to treat rheumatoid arthritis (RA) is increasing. Recently, MTX-associated lymphoproliferative disorder (MTX-LPD) has been frequently reported as lymphoma occurring during MTX therapy. The authors report their experience with a relatively rare case of MTX-LPD presenting in the lumbar spine. The patient, a 73-year-old woman who experienced low-back pain while receiving MTX therapy for RA, was suspected of having developed MTX-LPD based on her medical history, images of the L1 vertebra, and transpedicular biopsy results. One week after discontinuing MTX, the patient\u2019s low-back pain reportedly improved. The woman was diagnosed with MTX-LPD based on histopathological findings. MTX discontinuation alone coincided with spontaneous tumor regression. Because MTX-LPD can occur in tissues other than lymph nodes, such as in bones and joints, it is a disease that should be considered when diagnosing spinal tumors in patients receiving MTX therapy.<\/jats:p>","DOI":"10.3171\/2018.4.spine1860","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T14:01:39Z","timestamp":1535724099000},"page":"545-548","source":"Crossref","is-referenced-by-count":7,"title":["Methotrexate-related lymphoproliferative disorder of the lumbar spine origin presenting with severe low-back pain: case report"],"prefix":"10.3171","volume":"29","author":[{"given":"Naoya","family":"Kikuchi","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Ibaraki Seinan Medical Center Hospital, Sashima, Ibaraki; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Uesugi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Ibaraki Seinan Medical Center Hospital, Sashima, Ibaraki; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Koda","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Ibaraki Seinan Medical Center Hospital, Sashima, Ibaraki; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Ibaraki Seinan Medical Center Hospital, Sashima, Ibaraki; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Kono","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Ibaraki Seinan Medical Center Hospital, Sashima, Ibaraki; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruka","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Ibaraki Seinan Medical Center Hospital, Sashima, Ibaraki; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Rheumatol","first-page":"1741","article-title":"Lymphoma developing in a patient with rheumatoid arthritis taking low dose weekly methotrexate","volume":"18","author":"Ellman MH","year":"1991","unstructured":"Ellman MH, Hurwitz H, Thomas C, Kozloff M: Lymphoma developing in a patient with rheumatoid arthritis taking low dose weekly methotrexate. 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