{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T01:03:39Z","timestamp":1793754219682,"version":"4.6.1"},"reference-count":19,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>Musician\u2019s dystonia (MD) is a type of focal hand dystonia that develops only while playing musical instruments and interferes with skilled and fine movements. Lesioning of the ventro-oral (Vo) nucleus of the thalamus (Vo-thalamotomy) using radiofrequency can cause dramatic improvement in MD symptoms. Focused ultrasound (FUS) can make intracranial focal lesions without an incision. The authors used MRI-guided FUS (MRgFUS) to create a lesion on the Vo nucleus to treat a patient with MD. Tubiana\u2019s MD scale (TMDS) was used to evaluate the condition of musical play ranging from 1 to 5 (1: worst, 5: best). The patient was a 35-year-old right-handed man with involuntary flexion of the right second, third, and fourth fingers, which occurred while playing a classical guitar. Immediately after therapeutic sonications of FUS Vo-thalamotomy, there was dramatic improvement in the MD symptoms. The TMDS scores before; at 0 and 1 week after; and at 1, 3, 6, and 12 months after MRgFUS Vo-thalamotomy were 1, 4, 4, 5, 5, 5, and 5, respectively. No complications were observed. Focused ultrasound Vo-thalamotomy can be an effective treatment for MD.<\/jats:p>","DOI":"10.3171\/2018.5.jns173125","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T14:20:29Z","timestamp":1537539629000},"page":"384-386","source":"Crossref","is-referenced-by-count":36,"title":["A single case of MRI-guided focused ultrasound ventro-oral thalamotomy for musician\u2019s dystonia"],"prefix":"10.3171","volume":"131","author":[{"given":"Shiro","family":"Horisawa","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Tokyo Women\u2019s Medical University, Tokyo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shin-Yurigaoka General Hospital, Kawasaki; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tokyo Women\u2019s Medical University, Tokyo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Hori","sequence":"additional","affiliation":[{"name":"Faculty of Advanced Techno-Surgery, Institute of Advanced Biomedical Engineering & Science, Graduate School of Medicine, Tokyo Women\u2019s Medical University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatake","family":"Sumi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tokyo Women\u2019s Medical University, Tokyo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Konishi","sequence":"additional","affiliation":[{"name":"Faculty of Advanced Techno-Surgery, Institute of Advanced Biomedical Engineering & Science, Graduate School of Medicine, Tokyo Women\u2019s Medical University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaomi","family":"Taira","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Tokyo Women\u2019s Medical University, Tokyo;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Med Probl Perform Art","doi-asserted-by":"publisher","first-page":"3","DOI":"10.21091\/mppa.2010.1002","article-title":"Focal dystonia in musicians: phenomenology, pathophysiology, triggering factors, and treatment","volume":"25","author":"Altenm\u00fcller E","year":"2010","unstructured":"Altenm\u00fcller E, Jabusch HC: Focal dystonia in musicians: phenomenology, pathophysiology, triggering factors, and treatment. Med Probl Perform Art 25:3\u20139, 201010.21091\/mppa.2010.100220795373"},{"key":"b2","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1002\/ana.25126","article-title":"A prospective trial of magnetic resonance-guided focused ultrasound thalamotomy for essential tremor: results at the 2-year follow-up","volume":"83","author":"Chang JW","year":"2018","unstructured":"Chang JW, Park CK, Lipsman N, Schwartz ML, Ghanouni P, Henderson JM, : A prospective trial of magnetic resonance-guided focused ultrasound thalamotomy for essential tremor: results at the 2-year follow-up. Ann Neurol 83:107\u2013114, 201810.1002\/ana.2512629265546"},{"key":"b3","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1056\/NEJMoa1600159","article-title":"A randomized trial of focused ultrasound thalamotomy for essential tremor","volume":"375","author":"Elias WJ","year":"2016","unstructured":"Elias WJ, Lipsman N, Ondo WG, Ghanouni P, Kim YG, Lee W, : A randomized trial of focused ultrasound thalamotomy for essential tremor. N Engl J Med 375:730\u2013739, 20162755730110.1056\/NEJMoa1600159"},{"key":"b4","series-title":"Adv Neurol","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1212\/WNL.50.5_Suppl_5.S1","article-title":"Classification of dystonia","volume":"78","author":"Fahn S","year":"1998","unstructured":"Fahn S, Bressman SB, Marsden CD: Classification of dystonia. Adv Neurol 78:1\u201310, 1998975089710.1212\/WNL.50.5_Suppl_5.S1"},{"key":"b5","series-title":"Mov Disord","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1002\/mds.1135","article-title":"Abolition of postapoplectic hemichorea by Vo-complex thalamotomy: long-term follow-up study","volume":"16","author":"Goto S","year":"2001","unstructured":"Goto S, Kunitoku N, Hamasaki T, Nishikawa S, Ushio Y: Abolition of postapoplectic hemichorea by Vo-complex thalamotomy: long-term follow-up study. Mov Disord 16:771\u2013774, 200110.1002\/mds.113511481712"},{"key":"b6","series-title":"Eur J Neurol","doi-asserted-by":"publisher","first-page":"e71","DOI":"10.1111\/ene.13379","article-title":"Thalamotomy for paroxysmal kinesigenic dyskinesias in a multiplex family","volume":"24","author":"Horisawa S","year":"2017","unstructured":"Horisawa S, Sumi M, Akagawa H, Kawamata T, Taira T: Thalamotomy for paroxysmal kinesigenic dyskinesias in a multiplex family. Eur J Neurol 24:e71\u2013e72, 201710.1111\/ene.13379"},{"key":"b7","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1002\/ana.23877","article-title":"Long-term improvement of musician\u2019s dystonia after stereotactic ventro-oral thalamotomy","volume":"74","author":"Horisawa S","year":"2013","unstructured":"Horisawa S, Taira T, Goto S, Ochiai T, Nakajima T: Long-term improvement of musician\u2019s dystonia after stereotactic ventro-oral thalamotomy. Ann Neurol 74:648\u2013654, 201310.1002\/ana.2387723463596"},{"key":"b8","series-title":"Mov Disord","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1002\/mds.26726","article-title":"Gamma Knife ventro-oral thalamotomy for musician\u2019s dystonia","volume":"32","author":"Horisawa S","year":"2017","unstructured":"Horisawa S, Tamura N, Hayashi M, Matsuoka A, Hanada T, Kawamata T, : Gamma Knife ventro-oral thalamotomy for musician\u2019s dystonia. Mov Disord 32:89\u201390, 201710.1002\/mds.2672627431379"},{"key":"b9","series-title":"Mov Disord","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1002\/mds.20631","article-title":"Focal dystonia in musicians: treatment strategies and long-term outcome in 144 patients","volume":"20","author":"Jabusch HC","year":"2005","unstructured":"Jabusch HC, Zschucke D, Schmidt A, Schuele S, Altenm\u00fcller E: Focal dystonia in musicians: treatment strategies and long-term outcome in 144 patients. Mov Disord 20:1623\u20131626, 20051607823710.1002\/mds.20631"},{"key":"b10","series-title":"Arch Neurol","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1001\/archneurol.2010.69","article-title":"Gamma knife thalamotomy for disabling tremor: a blinded evaluation","volume":"67","author":"Lim SY","year":"2010","unstructured":"Lim SY, Hodaie M, Fallis M, Poon YY, Mazzella F, Moro E: Gamma knife thalamotomy for disabling tremor: a blinded evaluation. Arch Neurol 67:584\u2013588, 201010.1001\/archneurol.2010.6920457958"},{"key":"b11","series-title":"J Ther Ultrasound","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/2050-5736-2-11","article-title":"First experience with MR-guided focused ultrasound in the treatment of Parkinson\u2019s disease","volume":"2","author":"Magara A","year":"2014","unstructured":"Magara A, B\u00fchler R, Moser D, Kowalski M, Pourtehrani P, Jeanmonod D: First experience with MR-guided focused ultrasound in the treatment of Parkinson\u2019s disease. J Ther Ultrasound 2:11, 20142551286910.1186\/2050-5736-2-11"},{"key":"b12","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1227\/NEU.0b013e3182350893","article-title":"Gamma knife thalamotomy for Parkinson disease and essential tremor: a prospective multicenter study","volume":"70","author":"Ohye C","year":"2012","unstructured":"Ohye C, Higuchi Y, Shibazaki T, Hashimoto T, Koyama T, Hirai T, : Gamma knife thalamotomy for Parkinson disease and essential tremor: a prospective multicenter study. Neurosurgery 70:526\u2013536, 20122190426710.1227\/NEU.0b013e3182350893"},{"issue":"5 Suppl","key":"b13","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"600","DOI":"10.3171\/jns.2002.97.supplement_5.0600","article-title":"Thalamic lesions produced by gamma thalamotomy for movement disorders","volume":"97","author":"Ohye C","year":"2002","unstructured":"Ohye C, Shibazaki T, Zhang J, Andou Y: Thalamic lesions produced by gamma thalamotomy for movement disorders. J Neurosurg 97 (5 Suppl):600\u2013606, 20021250710410.3171\/jns.2002.97.supplement_5.0600"},{"key":"b14","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1212\/01.WNL.0000149768.36634.92","article-title":"Botulinum toxin injections in the treatment of musician\u2019s dystonia","volume":"64","author":"Schuele S","year":"2005","unstructured":"Schuele S, Jabusch HC, Lederman RJ, Altenm\u00fcller E: Botulinum toxin injections in the treatment of musician\u2019s dystonia. Neurology 64:341\u2013343, 20051566843610.1212\/01.WNL.0000149768.36634.92"},{"key":"b15","series-title":"Mov Disord","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/mds.10647","article-title":"Long-term outcome of focal dystonia in string instrumentalists","volume":"19","author":"Schuele S","year":"2004","unstructured":"Schuele S, Lederman RJ: Long-term outcome of focal dystonia in string instrumentalists. Mov Disord 19:43\u201348, 20041474335910.1002\/mds.10647"},{"key":"b16","series-title":"Stereotact Funct Neurosurg","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1159\/000075165","article-title":"Stereotactic ventrooralis thalamotomy for task-specific focal hand dystonia (writer\u2019s cramp)","volume":"80","author":"Taira T","year":"2003","unstructured":"Taira T, Hori T: Stereotactic ventrooralis thalamotomy for task-specific focal hand dystonia (writer\u2019s cramp). Stereotact Funct Neurosurg 80:88\u201391, 200310.1159\/00007516514745214"},{"key":"b17","series-title":"Hand Clin","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S0749-0712(02)00099-9","article-title":"Musician\u2019s focal dystonia","volume":"19","author":"Tubiana R","year":"2003","unstructured":"Tubiana R: Musician\u2019s focal dystonia. Hand Clin 19:303\u2013308, vii, 20031285267210.1016\/S0749-0712(02)00099-9"},{"key":"b18","series-title":"Parkinsonism Relat Disord","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.parkreldis.2013.08.009","article-title":"Musician\u2019s dystonia in pianists: long-term evaluation of retraining and other therapies","volume":"20","author":"van Vugt FT","year":"2014","unstructured":"van Vugt FT, Boullet L, Jabusch HC, Altenm\u00fcller E: Musician\u2019s dystonia in pianists: long-term evaluation of retraining and other therapies. Parkinsonism Relat Disord 20:8\u201312, 20142405501310.1016\/j.parkreldis.2013.08.009"},{"key":"b19","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.3171\/2009.10.JNS09332","article-title":"Gamma Knife thalamotomy for treatment of essential tremor: long-term results","volume":"112","author":"Young RF","year":"2010","unstructured":"Young RF, Li F, Vermeulen S, Meier R: Gamma Knife thalamotomy for treatment of essential tremor: long-term results. J Neurosurg 112:1311\u20131317, 201010.3171\/2009.10.JNS0933219895197"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/131\/2\/article-p384.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/131\/2\/article-p384.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/131\/2\/article-p384.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T04:11:06Z","timestamp":1742703066000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/131\/2\/article-p384.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":19,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3171\/2018.5.jns173125","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8]]}}}