{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:39:16Z","timestamp":1788212356077,"version":"build-2803163510"},"reference-count":134,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>Vagus nerve stimulation (VNS) is increasingly considered for the treatment of intractable epilepsy and holds potential for the management of a variety of neuropsychiatric conditions. The emergence of the field of connectomics and the introduction of large-scale modeling of neural networks has helped elucidate the underlying neurobiology of VNS, which may be variably expressed in patient populations and related to responsiveness to stimulation. In this report, the authors outline current data on the underlying neural circuitry believed to be implicated in VNS responsiveness in what the authors term the \u201cvagus afferent network.\u201d The emerging role of biomarkers to predict treatment effect is further discussed and important avenues for future work are highlighted.<\/jats:p>","DOI":"10.3171\/2018.6.focus18216","type":"journal-article","created":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T03:36:56Z","timestamp":1535773016000},"page":"E2","source":"Crossref","is-referenced-by-count":133,"title":["The vagus afferent network: emerging role in translational connectomics"],"prefix":"10.3171","volume":"45","author":[{"given":"Laureen D.","family":"Hachem","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, University of Toronto;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simeon M.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Hospital for Sick Children, Toronto; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George M.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, University of Toronto;"},{"name":"Division of Neurosurgery, Hospital for Sick Children, Program in Neuroscience and Mental Health, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Am J Psychiatry","first-page":"640","article-title":"A 5-year observational study of patients with treatment-resistant depression treated with vagus nerve stimulation or treatment as usual: comparison of response, remission, and suicidality","volume":"174","author":"Aaronson ST","year":"2017","unstructured":"Aaronson ST, Sears P, Ruvuna F, Bunker M, Conway CR, Dougherty DD, : A 5-year observational study of patients with treatment-resistant depression treated with vagus nerve stimulation or treatment as usual: comparison of response, remission, and suicidality. 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