{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:56:13Z","timestamp":1792515373096,"version":"4.5.0"},"reference-count":32,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Microvascular decompression (MVD) is commonly used in the treatment of trigeminal neuralgia (TN) with positive clinical outcomes. Fully endoscopic MVD (E-MVD) has been proposed as an effective minimally invasive alternative, but a comparative review of the two approaches has not been conducted. The authors performed a meta-analysis of studies, comparing patient outcome rates and complications for the open versus the endoscopic technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The PubMed\/MEDLINE and Ovid databases were searched for studies published from database inception to 2017. The search terms used included, but were not limited to, \u201copen microvascular decompression,\u201d \u201cmicrovascular decompression for trigeminal neuralgia,\u201d and \u201cendoscopic decompression for trigeminal neuralgia.\u201d Criteria for inclusion of studies in the meta-analysis were established as follows: adult patients, clinical studies with \u2265 10 patients (excluding case studies to obtain a higher volume of outcome rates), utilization of open MVD or E-MVD to treat TN, craniotomy and retrosigmoid incision, English-language studies, and articles that listed pain relief outcomes (complete, very good, partial, or absent), recurrence rate (number of patients), and complications (paresis, hearing loss, CSF leakage, cerebellar damage, infection, death). Relevant references from the chosen articles were also included.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>From a larger pool of 1039 studies, 23 articles were selected for review: 13 on traditional MVD and 10 on E-MVD. The total number of patients was 6749, of which 5783 patients (and 5802 procedures) had undergone MVD and 993 patients (and procedures) had undergone E-MVD. Analyzed data included postoperative pain relief outcome (complete or good pain relief vs partial or no pain relief), and rates of recurrence and complications including facial paralysis, weakness, or paresis; hearing loss; auditory and facial nerve damage; cerebrospinal fluid leakage; infection; cerebellar damage; and death.<\/jats:p><jats:p>Good pain relief was achieved in 81% of MVD patients and 88% of E-MVD patients, with a mean recurrence rate of 14% and 9%, respectively. Average rates of reported complications were statistically lower in E-MVD than in MVD approaches, including facial paresis or weakness, hearing loss, cerebellar damage, infection, and death, whereas cerebrospinal fluid leakage was similar. The overall incidence of complications was 19% for MVD and 8% for E-MVD.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The reviewed literature revealed similar clinical outcomes with respect to pain relief for MVD and E-MVD. The recurrence rate was lower in E-MVD studies, though not significantly so, and the incidence of complications, notably facial paresis and hearing loss, were statistically higher for MVD than for E-MVD. Based on these results, the use of endoscopy to perform MVD for TN appears to offer at least as good a surgical outcome as the more commonly used open MVD, with the possible added advantages of having a shorter operative time, smaller craniotomy, and lower recurrence rates. The authors advise caution in interpreting these data given the asymmetry in the sample size between the two groups and the relative novelty of the E-MVD approach.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2018.6.jns172690","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:13:18Z","timestamp":1551226398000},"page":"1532-1540","source":"Crossref","is-referenced-by-count":39,"title":["Endoscopic versus open microvascular decompression for trigeminal neuralgia: a systematic review and comparative meta-analysis"],"prefix":"10.3171","volume":"131","author":[{"given":"Nirmeen","family":"Zagzoog","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Attar","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Hamilton General Hospital, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radwan","family":"Takroni","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazen B.","family":"Alotaibi","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kesh","family":"Reddy","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Otol Neurotol","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1097\/MAO.0b013e318184601a","article-title":"Endoscopic vascular decompression","volume":"29","author":"Artz GJ","year":"2008","unstructured":"Artz GJ, Hux FJ, Larouere MJ, Bojrab DI, Babu S, Pieper DR: Endoscopic vascular decompression. 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