{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:08:01Z","timestamp":1789877281243,"version":"4.0.1"},"reference-count":38,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>The authors aimed to describe the natural history of ventriculostomy-related infections (VRIs) under appropriate treatment and to assess risk factors for poor outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>All patients older than 18 years in whom an external ventricular drain (EVD) had been implanted and who had developed a VRI requiring treatment were included in this retrospective study. D0 was defined as the first day of antibiotic administration. Clinical and biological parameters were compared each day beginning with D1 and ending with D10 to those of D0. The authors defined D0 in a control group as the day a CSF culture came back positive, without any sign of infection. The authors then searched for poor prognostic factors in the VRI group.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Among 567 patients requiring an EVD between January 2007 and October 2017, 39 developed a VRI. Most were monomicrobial infections, and 47 microbes were responsible (45% were gram-positive cocci). Clinical parameters differed significantly from the control group during the first 2 days and then returned to baseline. The CSF parameters differed significantly from the control group for a longer period, returning to baseline after 5 days. CSF sterilization occurred in a median time of 2 days. An intrathecal route or EVD exchange was not associated with a poor outcome. No clinical or biological parameter between D3 and D5 was linked to outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Clinical status improved faster than CSF parameters (before and after D5, respectively). Some CSF parameters remained abnormal until D10. Body temperature and microbiological cultures normalized faster than other parameters.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2018.6.jns18853","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:13:27Z","timestamp":1551226407000},"page":"1052-1061","source":"Crossref","is-referenced-by-count":7,"title":["Natural history of ventriculostomy-related infection under appropriate treatment and risk factors of poor outcome: a retrospective study"],"prefix":"10.3171","volume":"131","author":[{"given":"Roman","family":"Mounier","sequence":"first","affiliation":[{"name":"Departments of Anesthesia and Surgical Intensive Care,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Birnbaum","sequence":"additional","affiliation":[{"name":"Departments of Anesthesia and Surgical Intensive Care,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Cook","sequence":"additional","affiliation":[{"name":"Departments of Anesthesia and Surgical Intensive Care,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul-Henri","family":"Jost","sequence":"additional","affiliation":[{"name":"Departments of Anesthesia and Surgical Intensive Care,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Martin","sequence":"additional","affiliation":[{"name":"Departments of Anesthesia and Surgical Intensive Care,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bouziane","family":"A\u00eft-Mamar","sequence":"additional","affiliation":[{"name":"Departments of Anesthesia and Surgical Intensive Care,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biba","family":"Nebbad","sequence":"additional","affiliation":[{"name":"Microbiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Couffin","sequence":"additional","affiliation":[{"name":"Departments of Anesthesia and Surgical Intensive Care,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Tomberli","sequence":"additional","affiliation":[{"name":"Departments of Anesthesia and Surgical Intensive Care,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryad","family":"Djedid","sequence":"additional","affiliation":[{"name":"Neurosurgery, Henri Mondor University Hospital of Paris, Paris XII School of Medicine, Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Dhonneur","sequence":"additional","affiliation":[{"name":"Departments of Anesthesia and Surgical Intensive Care,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lobo","sequence":"additional","affiliation":[{"name":"Departments of Anesthesia and Surgical Intensive Care,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1136\/jnnp.52.5.605","article-title":"Prevention of hydrocephalus shunt catheter colonisation in vitro by impregnation with antimicrobials","volume":"52","author":"Bayston R","year":"1989","unstructured":"Bayston R, Grove N, Siegel J, Lawellin D, Barsham S: Prevention of hydrocephalus shunt catheter colonisation in vitro by impregnation with antimicrobials. 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