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To place the laser probe for LITT, however, stereotaxy is required\u2014which classically involves head fixation with cranial pins. This creates a relative minimum age limit of 2 years old because it demands a mature skull and fused cranial sutures. A novel technique is presented for the application of MRgLITT in a 6-month-old infant for the treatment of epilepsy associated with TSC. To the authors\u2019 knowledge this is the youngest patient treated with laser ablation. The authors used a frameless navigation technique with a miniframe tripod system and intraoperative reference points. This technique expands the application of MRgLITT to younger patients, which may lead to safer surgical interventions and improved outcomes for these children.<\/jats:p>","DOI":"10.3171\/2018.6.peds1828","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T13:56:21Z","timestamp":1538142981000},"page":"92-97","source":"Crossref","is-referenced-by-count":24,"title":["MRI-guided laser interstitial thermal therapy in an infant with tuberous sclerosis: technical case report"],"prefix":"10.3171","volume":"23","author":[{"given":"Kristopher G.","family":"Hooten","sequence":"first","affiliation":[{"name":"Department of Neurosurgery,"},{"name":"Department of Neurosurgery, University of Florida, Gainesville, Florida"},{"name":"Tuberous Sclerosis Complex Clinic, Duke University, Durham, North Carolina; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Werner","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology,"},{"name":"Tuberous Sclerosis Complex Clinic, Duke University, Durham, North Carolina; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad A.","family":"Mikati","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology,"},{"name":"Tuberous Sclerosis Complex Clinic, Duke University, Durham, North Carolina; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie R.","family":"Muh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery,"},{"name":"Tuberous Sclerosis Complex Clinic, Duke University, Durham, North Carolina; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00006123-199707000-00004","article-title":"Surgical and neurological complications in a series of 708 epilepsy surgery procedures","volume":"41","author":"Behrens E","year":"1997","unstructured":"Behrens E, Schramm J, Zentner J, K\u00f6nig R: Surgical and neurological complications in a series of 708 epilepsy surgery procedures. 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