{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:56:36Z","timestamp":1792842996940,"version":"4.5.0"},"reference-count":35,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Cranial base development plays a large role in anterior and vertical maxillary growth through 7 years of age, and the effect of early endonasal cranial base surgery on midface growth is unknown. The authors present their experience with pediatric endoscopic endonasal surgery (EES) and long-term midface growth.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This is a retrospective review of cases where EES was performed from 2000 to 2016. Patients who underwent their first EES of the skull base before age 7 (prior to cranial suture fusion) and had a complete set of pre- and postoperative imaging studies (CT or MRI) with at least 1 year of follow-up were included. A radiologist performed measurements (sella-nasion [S-N] distance and angles between the sella, nasion, and the most concave points of the anterior maxilla [A point] or anterior mandibular synthesis [B point], the SNA, SNB, and ANB angles), which were compared to age- and sex-matched Bolton standards. A Z-score test was used; significance was set at p &lt; 0.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The early surgery group had 11 patients, with an average follow-up of 5 years; the late surgery group had 33 patients. Most tumors were benign; 1 patient with a panclival arteriovenous malformation was a significant outlier for all measurements. Comparing the measurements obtained in the early surgery group to Bolton standard norms, the authors found no significant difference in postoperative SNA (p = 0.10), SNB (p = 0.14), or ANB (0.67) angles. The S-N distance was reduced both pre- and postoperatively (SD 1.5, p = 0.01 and p = 0.009). Sex had no significant effect. Compared to patients who had surgery after the age of 7 years, the early surgery group demonstrated no significant difference in pre- to postoperative changes with regard to S-N distance (p = 0.87), SNA angle (p = 0.89), or ANB angle (p = 0.14). Lesion type (craniopharyngioma, angiofibroma, and other types) had no significant effect in either age group.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Though our cohort of patients with skull base lesions demonstrated some abnormal measurements in the maxillary-mandibular relationship before their operation, their postoperative cephalometrics fell within the normal range and showed no significant difference from those of patients who underwent operations at an older age. Therefore, there appears to be no evidence of impact of endoscopic endonasal skull base surgery on craniofacial development within the growth period studied.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2018.8.peds18183","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:52:05Z","timestamp":1551228725000},"page":"523-530","source":"Crossref","is-referenced-by-count":35,"title":["Long-term impact of pediatric endoscopic endonasal skull base surgery on midface growth"],"prefix":"10.3171","volume":"23","author":[{"given":"Wendy","family":"Chen","sequence":"first","affiliation":[{"name":"Departments of Plastic Surgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Gardner","sequence":"additional","affiliation":[{"name":"Neurosurgery,"},{"name":"Neurosurgery, Children\u2019s Hospital of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barton F.","family":"Branstetter","sequence":"additional","affiliation":[{"name":"Radiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Dun","family":"Liu","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue Fang","family":"Chang","sequence":"additional","affiliation":[{"name":"Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl H.","family":"Snyderman","sequence":"additional","affiliation":[{"name":"Otolaryngology, University of Pittsburgh Medical Center;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse A.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Departments of Plastic Surgery,"},{"name":"Departments of Plastic Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth C.","family":"Tyler-Kabara","sequence":"additional","affiliation":[{"name":"Neurosurgery,"},{"name":"Neurosurgery, Children\u2019s Hospital of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay A.","family":"Schuster","sequence":"additional","affiliation":[{"name":"Departments of Plastic Surgery,"},{"name":"Departments of Plastic Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1007\/s00381-012-1866-x","article-title":"Endoscopic endonasal resection of sinonasal and skull base malignancies in children: feasibility and outcomes","volume":"28","author":"AlQahtani A","year":"2012","unstructured":"AlQahtani A, Turri-Zanoni M, Dallan I, Battaglia P, Castelnuovo P: Endoscopic endonasal resection of sinonasal and skull base malignancies in children: feasibility and outcomes. 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