{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T20:16:18Z","timestamp":1769717778503,"version":"3.49.0"},"reference-count":34,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Endothelial colony-forming cells (ECFCs) isolated from pediatric patients with moyamoya disease (MMD) have demonstrated decreased numbers and defective functioning in in vitro experiments. However, the function of ECFCs has not been evaluated using in vivo animal models. In this study, the authors compared normal and MMD ECFCs using a chronic cerebral hypoperfusion (CCH) rat model.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A CCH rat model was made via ligation of the bilateral common carotid arteries (2-vessel occlusion [2-VO]). The rats were divided into three experimental groups: vehicle-treated (n = 8), normal ECFC-treated (n = 8), and MMD ECFC-treated (n = 8). ECFCs were injected into the cisterna magna. A laser Doppler flowmeter was used to evaluate cerebral blood flow, and a radial arm maze test was used to examine cognitive function. Neuropathological examinations of the hippocampus and agranular cortex were performed using hematoxylin and eosin and Luxol fast blue staining in addition to immunofluorescence with CD31, von Willebrand factor, NeuN, myelin basic protein, glial fibrillary acidic protein, and cleaved caspase-3 antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The normal ECFC-treated group exhibited improvement in the restoration of cerebral perfusion and in behavior compared with the vehicle-treated and MMD ECFC-treated groups at the 12-week follow-up after the 2-VO surgery. The normal ECFC-treated group showed a greater amount of neovasculogenesis and neurogenesis, with less apoptosis, than the other groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>These results support the impaired functional recovery of MMD ECFCs compared with normal ECFCs in a CCH rat model. This in vivo study suggests the functional role of ECFCs in the pathogenesis of MMD.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2018.8.peds1883","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T23:50:52Z","timestamp":1542325852000},"page":"204-213","source":"Crossref","is-referenced-by-count":21,"title":["Impaired functional recovery of endothelial colony-forming cells from moyamoya disease in a chronic cerebral hypoperfusion rat model"],"prefix":"10.3171","volume":"23","author":[{"given":"Seung Ah","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children\u2019s Hospital;"},{"name":"Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangjoon","family":"Chong","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children\u2019s Hospital;"},{"name":"Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pil Ae","family":"Kwak","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children\u2019s Hospital;"},{"name":"Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youn Joo","family":"Moon","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children\u2019s Hospital;"},{"name":"Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anshika","family":"Jangra","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children\u2019s Hospital;"},{"name":"Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hoon","family":"Phi","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children\u2019s Hospital;"},{"name":"Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Yeoun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children\u2019s Hospital;"},{"name":"Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine;"},{"name":"Department of Anatomy, Seoul National University College of Medicine; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Hye","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pathology, Seoul National University Hospital, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Ki","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, Pediatric Clinical Neuroscience Center, Seoul National University Children\u2019s Hospital;"},{"name":"Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Neuroreport","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1097\/00001756-199801050-00033","article-title":"Chronic cerebral hypoperfusion elicits neuronal apoptosis and behavioral impairment","volume":"9","author":"Bennett SA","year":"1998","unstructured":"Bennett SA, Tenniswood M, Chen JH, Davidson CM, Keyes MT, Fortin T, : Chronic cerebral hypoperfusion elicits neuronal apoptosis and behavioral impairment. Neuroreport 9:161\u2013166, 199810.1097\/00001756-199801050-000339592069"},{"key":"b2","series-title":"Exp Mol Pathol","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.yexmp.2010.11.005","article-title":"Transplantation of SNAP-treated adipose tissue-derived stem cells improves cardiac function and induces neovascularization after myocardium infarct in rats","volume":"90","author":"Berardi GR","year":"2011","unstructured":"Berardi GR, Rebelatto CK, Tavares HF, Ingberman M, Shigunov P, Barchiki F, : Transplantation of SNAP-treated adipose tissue-derived stem cells improves cardiac function and induces neovascularization after myocardium infarct in rats. Exp Mol Pathol 90:149\u2013156, 20112111172810.1016\/j.yexmp.2010.11.005"},{"key":"b3","series-title":"Brain Res Bull","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.brainresbull.2011.10.006","article-title":"Chronic brain hypoperfusion causes early glial activation and neuronal death, and subsequent long-term memory impairment","volume":"87","author":"Cechetti F","year":"2012","unstructured":"Cechetti F, Pagnussat AS, Worm PV, Elsner VR, Ben J, da Costa MS, : Chronic brain hypoperfusion causes early glial activation and neuronal death, and subsequent long-term memory impairment. Brain Res Bull 87:109\u2013116, 201210.1016\/j.brainresbull.2011.10.00622040859"},{"key":"b4","series-title":"Stem Cells Dev","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1089\/scd.2015.0324","article-title":"Preclinical biosafety evaluation of genetically modified human adipose tissue-derived mesenchymal stem cells for clinical applications to brainstem glioma","volume":"25","author":"Choi SA","year":"2016","unstructured":"Choi SA, Yun JW, Joo KM, Lee JY, Kwak PA, Lee YE, : Preclinical biosafety evaluation of genetically modified human adipose tissue-derived mesenchymal stem cells for clinical applications to brainstem glioma. Stem Cells Dev 25:897\u2013908, 201610.1089\/scd.2015.032427151205"},{"key":"b5","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/BF00300793","article-title":"Attempts to induce immune-mediated cerebral arterial injury for an experimental model of moyamoya disease","volume":"8","author":"Ezura M","year":"1992","unstructured":"Ezura M, Fujiwara S, Nose M, Yoshimoto T, Kyogoku M: Attempts to induce immune-mediated cerebral arterial injury for an experimental model of moyamoya disease. Childs Nerv Syst 8:263\u2013267, 199210.1007\/BF003007931394265"},{"key":"b6","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1002\/ana.21919","article-title":"Endothelial progenitor cell transplantation improves long-term stroke outcome in mice","volume":"67","author":"Fan Y","year":"2010","unstructured":"Fan Y, Shen F, Frenzel T, Zhu W, Ye J, Liu J, : Endothelial progenitor cell transplantation improves long-term stroke outcome in mice. Ann Neurol 67:488\u2013497, 20102043758410.1002\/ana.21919"},{"key":"b7","series-title":"Brain Res Brain Res Rev","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.brainresrev.2007.01.003","article-title":"Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases","volume":"54","author":"Farkas E","year":"2007","unstructured":"Farkas E, Luiten PG, Bari F: Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases. Brain Res Brain Res Rev 54:162\u2013180, 200710.1016\/j.brainresrev.2007.01.003"},{"key":"b8","series-title":"Neurobiol Aging","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1016\/j.neurobiolaging.2009.10.002","article-title":"Effects of early aging and cerebral hypoperfusion on spreading depression in rats","volume":"32","author":"Farkas E","year":"2011","unstructured":"Farkas E, Obrenovitch TP, Instit\u00f3ris \u00c1, Bari F: Effects of early aging and cerebral hypoperfusion on spreading depression in rats. Neurobiol Aging 32:1707\u20131715, 201110.1016\/j.neurobiolaging.2009.10.00219883954"},{"key":"b9","series-title":"Exp Neurol","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.expneurol.2015.01.005","article-title":"Fullerenols and glucosamine fullerenes reduce infarct volume and cerebral inflammation after ischemic stroke in normotensive and hypertensive rats","volume":"265","author":"Fluri F","year":"2015","unstructured":"Fluri F, Gr\u00fcnstein D, Cam E, Ungethuem U, Hatz F, Sch\u00e4fer J, : Fullerenols and glucosamine fullerenes reduce infarct volume and cerebral inflammation after ischemic stroke in normotensive and hypertensive rats. Exp Neurol 265:142\u2013151, 20152562585110.1016\/j.expneurol.2015.01.005"},{"issue":"Suppl","key":"b10","series-title":"Neuropathology","first-page":"S61","article-title":"Moyamoya disease","volume":"20","author":"Fukui M","year":"2000","unstructured":"Fukui M, Kono S, Sueishi K, Ikezaki K: Moyamoya disease. Neuropathology 20 Suppl:S61\u2013S64, 2000"},{"key":"b11","series-title":"J Cereb Blood Flow Metab","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1038\/jcbfm.2014.78","article-title":"Endothelial progenitor cells augment collateralization and hemodynamic rescue in a model of chronic cerebral ischemia","volume":"34","author":"Hecht N","year":"2014","unstructured":"Hecht N, Schneider UC, Czabanka M, Vinci M, Hatzopoulos AK, Vajkoczy P, : Endothelial progenitor cells augment collateralization and hemodynamic rescue in a model of chronic cerebral ischemia. J Cereb Blood Flow Metab 34:1297\u20131305, 201410.1038\/jcbfm.2014.78"},{"key":"b12","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"679","DOI":"10.3171\/2016.8.JNS16366","article-title":"Combined gene therapy with vascular endothelial growth factor plus apelin in a chronic cerebral hypoperfusion model in rats","volume":"127","author":"Hiramatsu M","year":"2017","unstructured":"Hiramatsu M, Hishikawa T, Tokunaga K, Kidoya H, Nishihiro S, Haruma J, : Combined gene therapy with vascular endothelial growth factor plus apelin in a chronic cerebral hypoperfusion model in rats. J Neurosurg 127:679\u2013686, 201710.3171\/2016.8.JNS16366"},{"key":"b13","series-title":"Neurol Med Chir (Tokyo)","doi-asserted-by":"publisher","first-page":"267","DOI":"10.2176\/nmc.52.267","article-title":"Review of past research and current concepts on the etiology of moyamoya disease","volume":"52","author":"Houkin K","year":"2012","unstructured":"Houkin K, Ito M, Sugiyama T, Shichinohe H, Nakayama N, Kazumata K, : Review of past research and current concepts on the etiology of moyamoya disease. Neurol Med Chir (Tokyo) 52:267\u2013277, 201210.2176\/nmc.52.26722688062"},{"key":"b14","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1161\/01.STR.15.5.873","article-title":"Intelligence in children with moyamoya disease: evaluation after surgical treatments with special reference to changes in cerebral blood flow","volume":"15","author":"Ishii R","year":"1984","unstructured":"Ishii R, Takeuchi S, Ibayashi K, Tanaka R: Intelligence in children with moyamoya disease: evaluation after surgical treatments with special reference to changes in cerebral blood flow. Stroke 15:873\u2013877, 198410.1161\/01.STR.15.5.8736474539"},{"key":"b15","series-title":"J Cereb Blood Flow Metab","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1038\/jcbfm.2008.67","article-title":"Circulating endothelial progenitor cells as a pathogenetic marker of moyamoya disease","volume":"28","author":"Jung KH","year":"2008","unstructured":"Jung KH, Chu K, Lee ST, Park HK, Kim DH, Kim JH, : Circulating endothelial progenitor cells as a pathogenetic marker of moyamoya disease. J Cereb Blood Flow Metab 28:1795\u20131803, 200810.1038\/jcbfm.2008.6718612318"},{"key":"b16","series-title":"J Hum Genet","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/jhg.2010.132","article-title":"A genome-wide association study identifies RNF213 as the first moyamoya disease gene","volume":"56","author":"Kamada F","year":"2011","unstructured":"Kamada F, Aoki Y, Narisawa A, Abe Y, Komatsuzaki S, Kikuchi A, : A genome-wide association study identifies RNF213 as the first moyamoya disease gene. J Hum Genet 56:34\u201340, 201110.1038\/jhg.2010.13221048783"},{"key":"b17","series-title":"Acta Med Okayama","first-page":"143","article-title":"Attempt to establish an experimental animal model of moyamoya disease using immuno-embolic material\u2014histological changes of the arterial wall resulting from immunological reaction in cats","volume":"57","author":"Kamata I","year":"2003","unstructured":"Kamata I, Terai Y, Ohmoto T: Attempt to establish an experimental animal model of moyamoya disease using immuno-embolic material\u2014histological changes of the arterial wall resulting from immunological reaction in cats. Acta Med Okayama 57:143\u2013150, 200312908012"},{"key":"b18","series-title":"No Shinkei Geka","first-page":"251","article-title":"[The experimental study on causal genesis of moyamoya disease\u2014correlation with immunological reaction and sympathetic nerve influence for vascular changes (author\u2019s transl).]","volume":"10","author":"Kasai N","year":"1982","unstructured":"Kasai N, Fujiwara S, Kodama N, Yonemitsu T, Suzuki J: [The experimental study on causal genesis of moyamoya disease\u2014correlation with immunological reaction and sympathetic nerve influence for vascular changes (author\u2019s transl).] No Shinkei Geka 10:251\u2013261, 1982 (Jpn)"},{"key":"b19","series-title":"J Neurosci Res","first-page":"510","article-title":"Decreased level and defective function of circulating endothelial progenitor cells in children with moyamoya disease","volume":"88","author":"Kim JH","year":"2010","unstructured":"Kim JH, Jung JH, Phi JH, Kang HS, Kim JE, Chae JH, : Decreased level and defective function of circulating endothelial progenitor cells in children with moyamoya disease. J Neurosci Res 88:510\u2013518, 201019774676"},{"key":"b20","series-title":"J Am Heart Assoc","doi-asserted-by":"publisher","first-page":"e002146","DOI":"10.1161\/JAHA.115.002146","article-title":"Biochemical and functional characterization of RNF213 (mysterin) R4810K, a susceptibility mutation of moyamoya disease, in angiogenesis in vitro and in vivo","volume":"4","author":"Kobayashi H","year":"2015","unstructured":"Kobayashi H, Matsuda Y, Hitomi T, Okuda H, Shioi H, Matsuda T, : Biochemical and functional characterization of RNF213 (mysterin) R4810K, a susceptibility mutation of moyamoya disease, in angiogenesis in vitro and in vivo. J Am Heart Assoc 4:e002146, 20152612654710.1161\/JAHA.115.002146"},{"key":"b21","series-title":"Arterioscler Thromb Vasc Biol","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1161\/ATVBAHA.115.305363","article-title":"Deregulation of retinaldehyde dehydrogenase 2 leads to defective angiogenic function of endothelial colony-forming cells in pediatric moyamoya disease","volume":"35","author":"Lee JY","year":"2015","unstructured":"Lee JY, Moon YJ, Lee HO, Park AK, Choi SA, Wang KC, : Deregulation of retinaldehyde dehydrogenase 2 leads to defective angiogenic function of endothelial colony-forming cells in pediatric moyamoya disease. Arterioscler Thromb Vasc Biol 35:1670\u20131677, 201510.1161\/ATVBAHA.115.30536326023078"},{"key":"b22","series-title":"Stem Cell Rev","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1007\/s12015-010-9157-y","article-title":"Transplanted late outgrowth endothelial progenitor cells as cell therapy product for stroke","volume":"7","author":"Moubarik C","year":"2011","unstructured":"Moubarik C, Guillet B, Youssef B, Codaccioni JL, Piercecchi MD, Sabatier F, : Transplanted late outgrowth endothelial progenitor cells as cell therapy product for stroke. Stem Cell Rev 7:208\u2013220, 20112052675410.1007\/s12015-010-9157-y"},{"key":"b23","series-title":"Brain Res","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/0006-8993(94)01436-L","article-title":"Neuronal damage and decrease of central acetylcholine level following permanent occlusion of bilateral common carotid arteries in rat","volume":"673","author":"Ni JW","year":"1995","unstructured":"Ni JW, Matsumoto K, Li HB, Murakami Y, Watanabe H: Neuronal damage and decrease of central acetylcholine level following permanent occlusion of bilateral common carotid arteries in rat. Brain Res 673:290\u2013296, 1995760644310.1016\/0006-8993(94)01436-L"},{"key":"b24","series-title":"Neurol Res","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1179\/1743132813Y.0000000235","article-title":"Therapeutic benefit of a combined strategy using erythropoietin and endothelial progenitor cells after transient focal cerebral ischemia in rats","volume":"35","author":"Pellegrini L","year":"2013","unstructured":"Pellegrini L, Bennis Y, Guillet B, Velly L, Garrigue P, Sabatier F, : Therapeutic benefit of a combined strategy using erythropoietin and endothelial progenitor cells after transient focal cerebral ischemia in rats. Neurol Res 35:937\u2013947, 20132381623510.1179\/1743132813Y.0000000235"},{"key":"b25","series-title":"PLoS One","doi-asserted-by":"publisher","first-page":"e0169714","DOI":"10.1371\/journal.pone.0169714","article-title":"Chemokine ligand 5 (CCL5) derived from endothelial colony-forming cells (ECFCs) mediates recruitment of smooth muscle progenitor cells (SPCs) toward critical vascular locations in moyamoya disease","volume":"12","author":"Phi JH","year":"2017","unstructured":"Phi JH, Suzuki N, Moon YJ, Park AK, Wang KC, Lee JY, : Chemokine ligand 5 (CCL5) derived from endothelial colony-forming cells (ECFCs) mediates recruitment of smooth muscle progenitor cells (SPCs) toward critical vascular locations in moyamoya disease. PLoS One 12:e0169714, 201710.1371\/journal.pone.016971428072843"},{"key":"b26","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1161\/STROKEAHA.108.529420","article-title":"Increased levels of circulating endothelial progenitor cells in patients with moyamoya disease","volume":"40","author":"Rafat N","year":"2009","unstructured":"Rafat N, Beck GCh, Pe\u00f1a-Tapia PG, Schmiedek P, Vajkoczy P: Increased levels of circulating endothelial progenitor cells in patients with moyamoya disease. Stroke 40:432\u2013438, 20091909598810.1161\/STROKEAHA.108.529420"},{"key":"b27","series-title":"Brain Res","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.brainres.2008.01.020","article-title":"Prenatal opiate exposure impairs radial arm maze performance and reduces levels of BDNF precursor following training","volume":"1198","author":"Schrott LM","year":"2008","unstructured":"Schrott LM, Franklin L, Serrano PA: Prenatal opiate exposure impairs radial arm maze performance and reduces levels of BDNF precursor following training. Brain Res 1198:132\u2013140, 20081826250010.1016\/j.brainres.2008.01.020"},{"key":"b28","series-title":"Front Behav Neurosci","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3389\/fnbeh.2013.00038","article-title":"Robust training attenuates TBI-induced deficits in reference and working memory on the radial 8-arm maze","volume":"7","author":"Sebastian V","year":"2013","unstructured":"Sebastian V, Diallo A, Ling DS, Serrano PA: Robust training attenuates TBI-induced deficits in reference and working memory on the radial 8-arm maze. Front Behav Neurosci 7:38, 20132365360010.3389\/fnbeh.2013.00038"},{"key":"b29","series-title":"J Thromb Haemost","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1111\/j.1538-7836.2008.02918.x","article-title":"Circulating endothelial cells: from bench to clinical practice","volume":"6","author":"Shantsila E","year":"2008","unstructured":"Shantsila E, Blann AD, Lip GY: Circulating endothelial cells: from bench to clinical practice. J Thromb Haemost 6:865\u2013868, 200810.1111\/j.1538-7836.2008.02918.x18221356"},{"key":"b30","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"N11","DOI":"10.1227\/01.neu.0000351423.30085.9d","article-title":"Endothelial progenitor cells in moyamoya disease","volume":"64","author":"Sherma AK","year":"2009","unstructured":"Sherma AK, Bendok BR: Endothelial progenitor cells in moyamoya disease. Neurosurgery 64:N11, 20091940413110.1227\/01.neu.0000351423.30085.9d"},{"key":"b31","series-title":"Acta Physiol (Oxf)","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1111\/apha.12205","article-title":"Contribution of calpain to myoglobin efflux from cardiomyocytes during ischaemia and after reperfusion in anaesthetized rats","volume":"210","author":"Sonobe T","year":"2014","unstructured":"Sonobe T, Akiyama T, Du CK, Zhan DY, Shirai M: Contribution of calpain to myoglobin efflux from cardiomyocytes during ischaemia and after reperfusion in anaesthetized rats. Acta Physiol (Oxf) 210:823\u2013831, 201410.1111\/apha.1220524256333"},{"key":"b32","series-title":"Methods Mol Biol","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/978-1-4939-0320-7_20","article-title":"Laser Doppler flowmetry to measure changes in cerebral blood flow","volume":"1135","author":"Sutherland BA","year":"2014","unstructured":"Sutherland BA, Rabie T, Buchan AM: Laser Doppler flowmetry to measure changes in cerebral blood flow. Methods Mol Biol 1135:237\u2013248, 201410.1007\/978-1-4939-0320-7_2024510869"},{"key":"b33","series-title":"Acta Neuropathol","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/s00401-007-0300-z","article-title":"Lack of interferon-beta leads to accelerated remyelination in a toxic model of central nervous system demyelination","volume":"114","author":"Trebst C","year":"2007","unstructured":"Trebst C, Heine S, Lienenklaus S, Lindner M, Baumg\u00e4rtner W, Weiss S, : Lack of interferon-beta leads to accelerated remyelination in a toxic model of central nervous system demyelination. Acta Neuropathol 114:587\u2013596, 200710.1007\/s00401-007-0300-z"},{"key":"b34","series-title":"Stem Cell Res (Amst)","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.scr.2011.06.003","article-title":"Reduction of infarct size by intravenous injection of uncultured adipose derived stromal cells in a rat model is dependent on the time point of application","volume":"7","author":"van Dijk A","year":"2011","unstructured":"van Dijk A, Naaijkens BA, Jurgens WJ, Nalliah K, Sairras S, van der Pijl RJ, : Reduction of infarct size by intravenous injection of uncultured adipose derived stromal cells in a rat model is dependent on the time point of application. Stem Cell Res (Amst) 7:219\u2013229, 201110.1016\/j.scr.2011.06.003"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/23\/2\/article-p204.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/23\/2\/article-p204.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/23\/2\/article-p204.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T13:29:07Z","timestamp":1681565347000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/23\/2\/article-p204.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":34,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3171\/2018.8.peds1883","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2]]}}}