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These imaging findings were correlated with neuro-ophthalmological results to assess the utility of ultra\u2013high-field MRI for objective evaluation of damage to the anterior and posterior visual pathways.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Probabilistic tractography employing 7-T DWI was used to reconstruct the optic tracts and radiations in 18 patients with adenomas and in 16 healthy volunteers. Optic chiasm compression was found in 66.7% of the patients and visual defects in 61.1%. Diffusion indices were calculated along the projections and correlated with tumor volumes and results from neuro-ophthalmological examinations. Primary visual cortical thicknesses were also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Fractional anisotropy was reduced by 21.9% in the optic tracts (p &lt; 0.001) and 17.7% in the optic radiations (p &lt; 0.001) in patients with adenomas. Patients showed an 8.5% increase in mean diffusivity of optic radiations compared with healthy controls (p &lt; 0.001). Primary visual cortical thickness was reduced in adenoma patients. Diffusion indices of the visual pathway showed significant correlations with neuro-ophthalmological examination findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Imaging-based quantification of secondary neuronal damage from adenomas strongly correlated with neuro-ophthalmological findings. Diffusion characteristics enabled by ultra\u2013high-field DWI may allow preoperative characterization of visual pathway damage in patients with chiasmatic compression and may inform prognosis for vision recoverability.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2018.9.jns182022","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:15:25Z","timestamp":1551226525000},"page":"333-342","source":"Crossref","is-referenced-by-count":18,"title":["Quantitative assessment of secondary white matter injury in the visual pathway by pituitary adenomas: a multimodal study at 7-Tesla MRI"],"prefix":"10.3171","volume":"132","author":[{"given":"John W.","family":"Rutland","sequence":"first","affiliation":[{"name":"Translational and Molecular Imaging Institute and"},{"name":"Neurosurgery, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Padormo","sequence":"additional","affiliation":[{"name":"Translational and Molecular Imaging Institute and"},{"name":"Guy\u2019s and St. Thomas\u2019 NHS Foundation Trust, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindi K.","family":"Yim","sequence":"additional","affiliation":[{"name":"Departments of Ophthalmology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Yao","sequence":"additional","affiliation":[{"name":"Neurosurgery, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Arrighi-Allisan","sequence":"additional","affiliation":[{"name":"Neurosurgery, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuang-Han","family":"Huang","sequence":"additional","affiliation":[{"name":"Translational and Molecular Imaging Institute and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Mo","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Population Health Science and Policy, Mount Sinai Hospital, New York, New York; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Chelnis","sequence":"additional","affiliation":[{"name":"Departments of Ophthalmology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley N.","family":"Delman","sequence":"additional","affiliation":[{"name":"Radiology, Icahn School of Medicine at Mount Sinai, New York; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj K.","family":"Shrivastava","sequence":"additional","affiliation":[{"name":"Neurosurgery, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priti","family":"Balchandani","sequence":"additional","affiliation":[{"name":"Translational and Molecular Imaging Institute and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Ann Endocrinol (Paris)","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.ando.2015.04.006","article-title":"Neuro-ophthalmologic exploration in non-functioning pituitary adenoma","volume":"76","author":"Abouaf L","year":"2015","unstructured":"Abouaf L, Vighetto A, Lebas M: Neuro-ophthalmologic exploration in non-functioning pituitary adenoma. 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