{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:26:44Z","timestamp":1791617204094,"version":"4.3.4"},"reference-count":40,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>The method of artificial disc replacement (ADR) has been developed as an alternative treatment to fusion surgery after decompression for cervical degenerative disc disease (DDD) with radiculopathy. Preserving the motion of ADR devices aims to prevent immobilization side effects such as adjacent-segment pathology (ASP). However, long-term follow-up evaluations using MRI are needed to investigate if this intent is achieved.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors performed a randomized controlled trial with 153 patients (mean age 47 years) undergoing surgery for cervical radiculopathy. Eighty-three patients received an ADR and 70 patients underwent fusion surgery. Outcomes after 5 years were assessed using patient-reported outcome measures using the Neck Disability Index (NDI) score as the primary outcome; motion preservation and heterotopic ossification by radiography; ASP by MRI; and secondary surgical procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Scores on the NDI were approximately halved in both groups: the mean score after 5 years was 36 (95% confidence interval [CI] 31\u201341) in the ADR group and 32 (95% CI 27\u201338) in the fusion group (p = 0.48). There were no other significant differences between the groups in six other patient-related outcome measures. Fifty-four percent of the patients in the ADR group preserved motion at the operated cervical level and 25% of the ADRs were spontaneously fused. Seventeen ADR patients (21%) and 7 fusion patients (10%) underwent secondary surgery (p = 0.11), with 5 patients in each group due to clinical ASP.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In patients with cervical DDD and radiculopathy decompression as well as ADR, surgery did not result in better clinical or radiological outcomes after 5 years compared with decompression and fusion surgery.<\/jats:p><jats:p>Clinical trial registration no.: 44347115 (ISRCTN).<\/jats:p><\/jats:sec>","DOI":"10.3171\/2018.9.spine18659","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T01:12:02Z","timestamp":1551229922000},"page":"323-331","source":"Crossref","is-referenced-by-count":41,"title":["Artificial disc replacement versus fusion in patients with cervical degenerative disc disease and radiculopathy: a randomized controlled trial with 5-year outcomes"],"prefix":"10.3171","volume":"30","author":[{"given":"Anna","family":"MacDowall","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences, Uppsala University, Uppsala;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno","family":"Canto Moreira","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience (CNS), K8, Karolinska Universitetssjukhuset Solna, Stockholm;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Uppsala University, Uppsala;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Skeppholm","sequence":"additional","affiliation":[{"name":"Department of Learning, Informatics, Management and Ethics (LIME), Medical Management Center, Health Economics and Health Evaluation Research Group, Karolinska Institutet, Stockholm;"},{"name":"Center for Spine Surgery in Stockholm, Sophiahemmets Sjukhus, Stockholm;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Lindhagen","sequence":"additional","affiliation":[{"name":"Uppsala Clinical Research Center, Uppsala University, Uppsala; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohan","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Uppsala University, Uppsala;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e5kan","family":"L\u00f6fgren","sequence":"additional","affiliation":[{"name":"Department of Neuro-Orthopaedic Center, Ryhov, J\u00f6nk\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Micha\u00eblsson","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Uppsala University, Uppsala;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claes","family":"Olerud","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Uppsala University, Uppsala;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Spine (Phila Pa 1976)","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1097\/00007632-199510001-00006","article-title":"Comparison between allograft plus demineralized bone matrix versus autograft in anterior cervical fusion. 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