{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:38:24Z","timestamp":1788406704094,"version":"build-2803163510"},"reference-count":30,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4]]},"abstract":"\n OBJECTIVE<\/jats:title>\n In comparison with the general population, children with syndromic craniosynostosis (sCS) have abnormal cerebral venous anatomy and are more likely to develop intracranial hypertension. To date, little is known about the postnatal development change in cerebral blood flow (CBF) in sCS. The aim of this study was to determine CBF in patients with sCS, and compare findings with control subjects.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n A prospective cohort study of patients with sCS using MRI and arterial spin labeling (ASL) determined regional CBF patterns in comparison with a convenience sample of control subjects with identical MRI\/ASL assessments in whom the imaging showed no cerebral\/neurological pathology. Patients with SCS and control subjects were stratified into four age categories and compared using CBF measurements from four brain lobes, the cerebellum, supratentorial cortex, and white matter. In a subgroup of patients with sCS the authors also compared longitudinal pre- to postoperative CBF changes.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Seventy-six patients with sCS (35 female [46.1%] and 41 male [53.9%]), with a mean age of 4.5 years (range 0.2\u201319.2 years), were compared with 86 control subjects (38 female [44.2%] and 48 male [55.8%]), with a mean age of 6.4 years (range 0.1\u201317.8 years). Untreated sCS patients < 1 year old had lower CBF than control subjects. In older age categories, CBF normalized to values observed in controls. Graphical analyses of CBF by age showed that the normally expected peak in CBF during childhood, noted at 4 years of age in control subjects, occurred at 5\u20136 years of age in patients with sCS. Patients with longitudinal pre- to postoperative CBF measurements showed significant increases in CBF after surgery.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n Untreated patients with sCS < 1 year old have lower CBF than control subjects. Following vault expansion, and with age, CBF in these patients normalizes to that of control subjects, but the usual physiological peak in CBF in childhood occurs later than expected.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2019.10.peds19150","type":"journal-article","created":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T17:04:08Z","timestamp":1581095048000},"page":"340-350","source":"Crossref","is-referenced-by-count":13,"title":["Cerebral blood flow in children with syndromic craniosynostosis: cohort arterial spin labeling studies"],"prefix":"10.3171","volume":"25","author":[{"given":"Priya N.","family":"Doerga","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery and Hand Surgery, Dutch Craniofacial Center,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten H.","family":"Lequin","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Medical Center Utrecht, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein H. G.","family":"Dremmen","sequence":"additional","affiliation":[{"name":"Department of Radiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca K.","family":"den Ottelander","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery and Hand Surgery, Dutch Craniofacial Center,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katya A. L.","family":"Mauff","sequence":"additional","affiliation":[{"name":"Department of Biostatistics,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias W.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Radiology and Radiological Science, Section of Pediatric Neuroradiology, Division of Pediatric Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland;"},{"name":"Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, Switzerland;"},{"name":"Department of Diagnostic Imaging, Division of Neuroradiology, The Hospital for Sick Children, Toronto, ON, Canada; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan A.","family":"Hernandez-Tamames","sequence":"additional","affiliation":[{"name":"Department of Radiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"Versnel","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery and Hand Surgery, Dutch Craniofacial Center,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen F. M.","family":"Joosten","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Lise C.","family":"van Veelen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sophia Children\u2019s Hospital, Erasmus MC, University Medical Center Rotterdam;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Tasker","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Anesthesiology (Pediatrics), Harvard Medical School and Boston Children\u2019s Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene M. J.","family":"Mathijssen","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery and Hand Surgery, Dutch Craniofacial Center,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Magn Reson Med","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1002\/mrm.25197","article-title":"Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia","volume":"73","author":"Alsop DC","year":"2015","unstructured":"Alsop DC, Detre JA, Golay X, G\u00fcnther M, Hendrikse J, Hernandez-Garcia L, : Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. Magn Reson Med 73:102\u2013116, 201510.1002\/mrm.25197"},{"key":"b2","series-title":"Br J Radiol","doi-asserted-by":"publisher","first-page":"20160495","DOI":"10.1259\/bjr.20160495","article-title":"A qualitative comparison of arterial spin labelling and dynamic susceptibility contrast MRI in 52 children with a range of neurological conditions","volume":"90","author":"Armitage PA","year":"2017","unstructured":"Armitage PA, Skipper N, Connolly DJ, Griffiths PD: A qualitative comparison of arterial spin labelling and dynamic susceptibility contrast MRI in 52 children with a range of neurological conditions. Br J Radiol 90:20160495, 201710.1259\/bjr.2016049527858468"},{"key":"b3","series-title":"Plast Reconstr Surg","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1097\/00006534-200207000-00002","article-title":"Postoperative mental and morphological outcome for nonsyndromic brachycephaly","volume":"110","author":"Arnaud E","year":"2002","unstructured":"Arnaud E, Meneses P, Lajeunie E, Thorne JA, Marchac D, Renier D: Postoperative mental and morphological outcome for nonsyndromic brachycephaly. Plast Reconstr Surg 110:6\u201313, 200210.1097\/00006534-200207000-0000212087222"},{"key":"b4","series-title":"Biomed Res Int","doi-asserted-by":"publisher","first-page":"172646","DOI":"10.1155\/2014\/172646","article-title":"Role of 99mTc-ECD SPECT in the management of children with craniosynostosis","volume":"2014","author":"Barik M","year":"2014","unstructured":"Barik M, Bajpai M, Das RR, Malhotra A, Panda SS, Sahoo MK, : Role of 99mTc-ECD SPECT in the management of children with craniosynostosis. Biomed Res Int 2014:172646, 201410.1155\/2014\/17264624987670"},{"key":"b5","series-title":"J Craniofac Surg","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1097\/00001665-200411000-00026","article-title":"Visual loss in syndromic craniosynostosis with papilledema but without other symptoms of intracranial hypertension","volume":"15","author":"Bartels MC","year":"2004","unstructured":"Bartels MC, Vaandrager JM, de Jong TH, Simonsz HJ: Visual loss in syndromic craniosynostosis with papilledema but without other symptoms of intracranial hypertension. J Craniofac Surg 15:1019\u20131024, 200410.1097\/00001665-200411000-0002615547395"},{"key":"b6","series-title":"Eur J Radiol","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.ejrad.2018.02.003","article-title":"Measurement of pediatric regional cerebral blood flow from 6 months to 15 years of age in a clinical population","volume":"101","author":"Carsin-Vu A","year":"2018","unstructured":"Carsin-Vu A, Corouge I, Commowick O, Bouzill\u00e9 G, Barillot C, Ferr\u00e9 JC, : Measurement of pediatric regional cerebral blood flow from 6 months to 15 years of age in a clinical population. Eur J Radiol 101:38\u201344, 201810.1016\/j.ejrad.2018.02.003"},{"key":"b7","series-title":"J Craniomaxillofac Surg","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1016\/j.jcms.2016.07.007","article-title":"Increase of prevalence of craniosynostosis","volume":"44","author":"Cornelissen M","year":"2016","unstructured":"Cornelissen M, Ottelander Bd, Rizopoulos D, van der Hulst R, Mink van der Molen A, van der Horst C, : Increase of prevalence of craniosynostosis. J Craniomaxillofac Surg 44:1273\u20131279, 201610.1016\/j.jcms.2016.07.00727499511"},{"key":"b8","series-title":"J Craniofac Surg","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1097\/00001665-199901000-00008","article-title":"Positron emission tomography studies confirm the need for early surgical intervention in patients with single-suture craniosynostosis","volume":"10","author":"David LR","year":"1999","unstructured":"David LR, Genecov DG, Camastra AA, Wilson JA, Argenta LC: Positron emission tomography studies confirm the need for early surgical intervention in patients with single-suture craniosynostosis. J Craniofac Surg 10:38\u201342, 199910.1097\/00001665-199901000-0000810388424"},{"key":"b9","series-title":"J Craniofac Surg","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1097\/00001665-199605000-00003","article-title":"Cerebral perfusion defects secondary to simple craniosynostosis","volume":"7","author":"David LR","year":"1996","unstructured":"David LR, Wilson JA, Watson NE, Argenta LC: Cerebral perfusion defects secondary to simple craniosynostosis. J Craniofac Surg 7:177\u2013185, 1996908688210.1097\/00001665-199605000-00003"},{"key":"b10","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s00381-011-1614-7","article-title":"Brain and ventricular volume in patients with syndromic and complex craniosynostosis","volume":"28","author":"de Jong T","year":"2012","unstructured":"de Jong T, Rijken BF, Lequin MH, van Veelen ML, Mathijssen IM: Brain and ventricular volume in patients with syndromic and complex craniosynostosis. Childs Nerv Syst 28:137\u2013140, 20122201196410.1007\/s00381-011-1614-7"},{"key":"b11","series-title":"J Craniomaxillofac Surg","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.jcms.2014.11.023","article-title":"Venous hypertension in syndromic and complex craniosynostosis: the abnormal anatomy of the jugular foramen and collaterals","volume":"43","author":"Florisson JM","year":"2015","unstructured":"Florisson JM, Barmpalios G, Lequin M, van Veelen ML, Bannink N, Hayward RD, : Venous hypertension in syndromic and complex craniosynostosis: the abnormal anatomy of the jugular foramen and collaterals. J Craniomaxillofac Surg 43:312\u2013318, 201510.1016\/j.jcms.2014.11.02325604402"},{"key":"b12","series-title":"Neuroradiology","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1007\/s00234-015-1571-z","article-title":"A neuroradiologist\u2019s guide to arterial spin labeling MRI in clinical practice","volume":"57","author":"Grade M","year":"2015","unstructured":"Grade M, Hernandez Tamames JA, Pizzini FB, Achten E, Golay X, Smits M: A neuroradiologist\u2019s guide to arterial spin labeling MRI in clinical practice. Neuroradiology 57:1181\u20131202, 20152635120110.1007\/s00234-015-1571-z"},{"key":"b13","series-title":"Radiology","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1148\/radiol.2016150789","article-title":"Arterial spin labeling perfusion of the brain: emerging clinical applications","volume":"281","author":"Haller S","year":"2016","unstructured":"Haller S, Zaharchuk G, Thomas DL, Lovblad KO, Barkhof F, Golay X: Arterial spin labeling perfusion of the brain: emerging clinical applications. Radiology 281:337\u2013356, 20162775593810.1148\/radiol.2016150789"},{"key":"b14","series-title":"Radiographics","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1148\/rg.282075066","article-title":"Hypoxic-ischemic brain injury: imaging findings from birth to adulthood","volume":"28","author":"Huang BY","year":"2008","unstructured":"Huang BY, Castillo M: Hypoxic-ischemic brain injury: imaging findings from birth to adulthood. Radiographics 28:417\u2013439, 617, 20081834944910.1148\/rg.282075066"},{"key":"b15","series-title":"Eur J Hum Genet","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/ejhg.2010.235","article-title":"Craniosynostosis","volume":"19","author":"Johnson D","year":"2011","unstructured":"Johnson D, Wilkie AO: Craniosynostosis. Eur J Hum Genet 19:369\u2013376, 20112124874510.1038\/ejhg.2010.235"},{"key":"b16","series-title":"AJNR Am J Neuroradiol","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.3174\/ajnr.A4366","article-title":"Correlation of asymmetry indices measured by arterial spin-labeling MR imaging and SPECT in patients with crossed cerebellar diaschisis","volume":"36","author":"Kang KM","year":"2015","unstructured":"Kang KM, Sohn CH, Kim BS, Kim YI, Choi SH, Yun TJ, : Correlation of asymmetry indices measured by arterial spin-labeling MR imaging and SPECT in patients with crossed cerebellar diaschisis. AJNR Am J Neuroradiol 36:1662\u20131668, 201510.3174\/ajnr.A436626228883"},{"key":"b17","series-title":"Pediatrics","doi-asserted-by":"publisher","first-page":"e1608","DOI":"10.1542\/peds.2013-3077","article-title":"Intellectual, behavioral, and emotional functioning in children with syndromic craniosynostosis","volume":"133","author":"Maliepaard M","year":"2014","unstructured":"Maliepaard M, Mathijssen IM, Oosterlaan J, Okkerse JM: Intellectual, behavioral, and emotional functioning in children with syndromic craniosynostosis. Pediatrics 133:e1608\u2013e1615, 201410.1542\/peds.2013-307724864183"},{"key":"b18","series-title":"J Craniofac Surg","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1097\/scs.0b013e31802d4c6c","article-title":"Benchmarking for craniosynostosis","volume":"18","author":"Mathijssen IM","year":"2007","unstructured":"Mathijssen IM, Arnaud E: Benchmarking for craniosynostosis. J Craniofac Surg 18:436\u2013442, 20071741429810.1097\/scs.0b013e31802d4c6c"},{"key":"b19","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1007\/s003810050344","article-title":"Venous intracranial haemodynamics in children undergoing operative treatment for the repair of craniosynostosis. A prospective study using transcranial colour-coded duplex sonography","volume":"15","author":"Mursch K","year":"1999","unstructured":"Mursch K, Enk T, Christen HJ, Markakis E, Behnke-Mursch J: Venous intracranial haemodynamics in children undergoing operative treatment for the repair of craniosynostosis. A prospective study using transcranial colour-coded duplex sonography. Childs Nerv Syst 15:110\u2013118, 199910.1007\/s00381005034410230667"},{"key":"b20","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s003810000320","article-title":"Management of craniosynostoses","volume":"16","author":"Renier D","year":"2000","unstructured":"Renier D, Lajeunie E, Arnaud E, Marchac D: Management of craniosynostoses. Childs Nerv Syst 16:645\u2013658, 20001115171410.1007\/s003810000320"},{"key":"b21","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"370","DOI":"10.3171\/jns.1982.57.3.0370","article-title":"Intracranial pressure in craniostenosis","volume":"57","author":"Renier D","year":"1982","unstructured":"Renier D, Sainte-Rose C, Marchac D, Hirsch JF: Intracranial pressure in craniostenosis. J Neurosurg 57:370\u2013377, 198210.3171\/jns.1982.57.3.03707097333"},{"key":"b22","series-title":"AJNR Am J Neuroradiol","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.3174\/ajnr.A4301","article-title":"Diffusion tensor imaging and fiber tractography in children with craniosynostosis syndromes","volume":"36","author":"Rijken BF","year":"2015","unstructured":"Rijken BF, Leemans A, Lucas Y, van Montfort K, Mathijssen IM, Lequin MH: Diffusion tensor imaging and fiber tractography in children with craniosynostosis syndromes. AJNR Am J Neuroradiol 36:1558\u20131564, 201510.3174\/ajnr.A430125953762"},{"key":"b23","series-title":"Kaku Igaku","first-page":"1411","article-title":"[Study by I-123-IMP-SPECT before and after surgery for craniosynostosis.]","volume":"27","author":"Satoh M","year":"1990","unstructured":"Satoh M, Ishikawa N, Enomoto T, Takeda T, Yoshizawa T, Nose T: [Study by I-123-IMP-SPECT before and after surgery for craniosynostosis.] Kaku Igaku 27:1411\u20131418, 1990 (Japanese)2290212"},{"key":"b24","series-title":"J Nucl Med","first-page":"394","article-title":"Technetium-99m-HMPAO SPECT cerebral blood flow study in children with craniosynostosis","volume":"36","author":"Sen A","year":"1995","unstructured":"Sen A, Dougal P, Padhy AK, Bhattacharya A, Kumar R, Bal C, : Technetium-99m-HMPAO SPECT cerebral blood flow study in children with craniosynostosis. J Nucl Med 36:394\u2013398, 19957884500"},{"key":"b25","series-title":"Indian J Dermatol","doi-asserted-by":"publisher","first-page":"505","DOI":"10.4103\/0019-5154.190118","article-title":"Methodology series module 5: sampling strategies","volume":"61","author":"Setia MS","year":"2016","unstructured":"Setia MS: Methodology series module 5: sampling strategies. Indian J Dermatol 61:505\u2013509, 201610.4103\/0019-5154.19011827688438"},{"key":"b26","series-title":"Eur J Neurol","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1111\/ene.12826","article-title":"Accuracy of arterial spin labeling magnetic resonance imaging (MRI) perfusion in detecting the epileptogenic zone in patients with drug-resistant neocortical epilepsy: comparison with electrophysiological data, structural MRI, SISCOM and FDG-PET","volume":"23","author":"Sierra-Marcos A","year":"2016","unstructured":"Sierra-Marcos A, Carre\u00f1o M, Setoain X, L\u00f3pez-Rueda A, Aparicio J, Donaire A, : Accuracy of arterial spin labeling magnetic resonance imaging (MRI) perfusion in detecting the epileptogenic zone in patients with drug-resistant neocortical epilepsy: comparison with electrophysiological data, structural MRI, SISCOM and FDG-PET. Eur J Neurol 23:160\u2013167, 20162634655510.1111\/ene.12826"},{"key":"b27","series-title":"Plast Reconstr Surg","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1097\/PRS.0000000000001434","article-title":"Algorithm for the management of intracranial hypertension in children with syndromic craniosynostosis","volume":"136","author":"Spruijt B","year":"2015","unstructured":"Spruijt B, Joosten KF, Driessen C, Rizopoulos D, Naus NC, van der Schroeff MP, : Algorithm for the management of intracranial hypertension in children with syndromic craniosynostosis. Plast Reconstr Surg 136:331\u2013340, 201510.1097\/PRS.000000000000143425909300"},{"key":"b28","series-title":"AJNR Am J Neuroradiol","first-page":"917","article-title":"Developmental changes of cerebral blood flow and oxygen metabolism in children","volume":"20","author":"Takahashi T","year":"1999","unstructured":"Takahashi T, Shirane R, Sato S, Yoshimoto T: Developmental changes of cerebral blood flow and oxygen metabolism in children. AJNR Am J Neuroradiol 20:917\u2013922, 199910369366"},{"key":"b29","series-title":"Dev Cell","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.devcel.2017.07.027","article-title":"Cerebral vein malformations result from loss of Twist1 expression and BMP signaling from skull progenitor cells and dura","volume":"42","author":"Tischfield MA","year":"2017","unstructured":"Tischfield MA, Robson CD, Gilette NM, Chim SM, Sofela FA, DeLisle MM, : Cerebral vein malformations result from loss of Twist1 expression and BMP signaling from skull progenitor cells and dura. Dev Cell 42:445\u2013461.e5, 201710.1016\/j.devcel.2017.07.02728844842"},{"key":"b30","series-title":"J Craniofac Surg","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1097\/SCS.0b013e3181cfa7bf","article-title":"Preoperative and postoperative transcranial Doppler sonographic evaluations of the cerebral hemodynamics of craniostenosis","volume":"21","author":"Wang B","year":"2010","unstructured":"Wang B, Cheng Z, Mu X, Fan B, Guo Z: Preoperative and postoperative transcranial Doppler sonographic evaluations of the cerebral hemodynamics of craniostenosis. J Craniofac Surg 21:432\u2013435, 201010.1097\/SCS.0b013e3181cfa7bf20216458"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/25\/4\/article-p340.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/25\/4\/article-p340.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/25\/4\/article-p340.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T15:57:41Z","timestamp":1681574261000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/25\/4\/article-p340.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":30,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3171\/2019.10.peds19150","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]}}}