{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T01:25:25Z","timestamp":1794014725709,"version":"4.8.0"},"reference-count":44,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Case reports and small patient series have suggested peripheral nerve field stimulation (PNFS) as a treatment for refractory trigeminal neuralgia attributed to multiple sclerosis (MS). Here, the authors aimed to assess the effects of this technique on long-term pain severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Data were prospectively collected on patients with refractory trigeminal neuralgia attributed to MS who underwent PNFS between July 2013 and August 2017 at the authors\u2019 neurosurgical department. Patients were evaluated before and after the first treatment as well as at follow-up at least twice a year. Patients underwent assessment of their pain severity using the Barrow Neurological Institute (BNI) Scale before treatment and at follow-up and were questioned about adverse events following cranial MRI performed after implantation of a permanent PNFS system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Eight patients (3 women) underwent PNFS trials and their median age was 61 years (IQR 73.75 \u2212 46.5 years). Seven patients proceeded to permanent implantation of the stimulation system. At a median follow-up of 33 months (IQR 42 \u2212 24 months), pain severity decreased from baseline to the last follow-up (BNI score decrease from V [IQR V \u2212 V] to III [IQR V \u2212 III], p = 0.054). Four patients experienced long-lasting benefit (at 48, 33, 24, and 15 months\u2019 follow-up, respectively), while in 3 patients the treatment eventually failed after an initially successful period. One patient had an infection, requiring system removal and subsequent reimplantation. No other complications occurred. No adverse events were noted in the patients undergoing MRI postimplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>This analysis indicates a possibly beneficial long-term effect of PNFS on refractory trigeminal neuralgia attributed to MS in some patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2019.12.jns192261","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T21:57:31Z","timestamp":1584741451000},"page":"1244-1250","source":"Crossref","is-referenced-by-count":5,"title":["Peripheral nerve field stimulation in medically refractory trigeminal neuralgia attributed to multiple sclerosis"],"prefix":"10.3171","volume":"134","author":[{"given":"Johann","family":"Klein","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University Hospital Carl Gustav Carus;"},{"name":"Dresden International 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