{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:24:17Z","timestamp":1794018257705,"version":"4.8.0"},"reference-count":32,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2]]},"abstract":"\n OBJECTIVE<\/jats:title>\n Stereotactic radiosurgery (SRS) is used for the management of residual or recurrent Cushing\u2019s disease (CD). Increasing experience and technological advancements of Gamma Knife radiosurgery (GKRS) systems can impact the outcomes of CD patients. The authors evaluated the association of their center\u2019s growing experience and the era in which GKRS was performed with treatment success and adverse events in patients with CD.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n The authors studied consecutive patients with CD treated with GKRS at the University of Virginia since installation of the first Gamma Knife system in March 1989 through August 2019. They compared endocrine remission and complication rates between patients treated before 2000 (early cohort) and those who were treated in 2000 and later (contemporary cohort).<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n One hundred thirty-four patients with CD underwent GKRS during the study period: 55 patients (41%) comprised the early cohort, and 79 patients (59%) comprised the contemporary cohort. The contemporary cohort, compared with the early cohort, had a significantly greater treatment volume, radiation prescription dose, maximal dose to the optic chiasm, and number of isocenters, and they more often had cavernous sinus involvement. Endocrine remission rates were higher in the contemporary cohort when compared with the early cohort (82% vs 66%, respectively; p = 0.01). In a Cox regression analysis adjusted for demographic, clinical, and SRS characteristics, the contemporary GKRS cohort had a higher probability of endocrine remission than the early cohort (HR 1.987, 95% CI 1.234\u20133.199; p = 0.005). The tumor control rate, incidence of cranial nerve neuropathy, and new anterior pituitary deficiency were similar between the two groups.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n Technological advancements over the years and growing center experience were important factors for improved endocrine remission rates in patients with CD. Technological aspects and results of contemporary Gamma Knife systems should be considered when counseling patients, planning treatment, and reporting treatment results. Studies exploring the learning curve for GKRS are warranted.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2019.12.jns192743","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T20:37:38Z","timestamp":1580503058000},"page":"547-554","source":"Crossref","is-referenced-by-count":16,"title":["Outcomes of Cushing\u2019s disease following Gamma Knife radiosurgery: effect of a center\u2019s growing experience and era of treatment"],"prefix":"10.3171","volume":"134","author":[{"given":"Adomas","family":"Bunevicius","sequence":"first","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrah","family":"Sheehan","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Lee Vance","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"},{"name":"Medicine, University of Virginia Health System, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Schlesinger","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason P.","family":"Sheehan","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neurosurg","first-page":"1491","article-title":"Clipping aneurysms improves outcomes for patients undergoing coiling","volume":"130","author":"Anderson IA","year":"2019","unstructured":"Anderson IA, Kailaya-Vasan A, Nelson RJ, Tolias CM: Clipping aneurysms improves outcomes for patients undergoing coiling. 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