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The authors therefore hypothesized that cerebral venous volume would be increased in those children with sCS and intracranial hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>In a case series of 105 children with sCS, of whom 32 had intracranial hypertension, cerebral MRI techniques were used to quantify the volume of the superior sagittal sinus, straight sinus (StrS), and both transverse sinuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Linear regression showed that total cerebral venous volume increased by 580.8 mm<jats:sup>3<\/jats:sup> per cm increase in occipitofrontal head circumference (p &lt; 0.001). No significant difference was found between the intracranial hypertension group and the nonintracranial hypertension group (p = 0.470). Multivariate ANOVA showed increased StrS volume (as a proportion of total volume) in the intracranial hypertension group (8.5% vs 5.1% in the nonintracranial hypertension group, p &lt; 0.001). Multivariate logistic regression showed that a 100-mm<jats:sup>3<\/jats:sup> increase in StrS volume is associated with increased odds of having intracranial hypertension by 60% (OR 1.60, 95% CI 1.24\u20132.08).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Although intracranial hypertension was not associated with total cerebral venous volume increase, it was associated with an isolated increase in StrS volume. Hence, it is unlikely that general cerebral venous outflow obstruction is the mechanism of intracranial hypertension in sCS. Rather, these findings indicate either a central cerebral vulnerability to intracranial hypertension or a mechanism involving venous blood redistribution.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2019.12.peds19562","type":"journal-article","created":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T18:48:51Z","timestamp":1583434131000},"page":"506-513","source":"Crossref","is-referenced-by-count":6,"title":["Dural sinus volume in children with syndromic craniosynostosis and intracranial hypertension"],"prefix":"10.3171","volume":"25","author":[{"given":"Robbin","family":"de Goederen","sequence":"first","affiliation":[{"name":"Departments of Plastic and Reconstructive Surgery, and Hand Surgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris E.","family":"Cuperus","sequence":"additional","affiliation":[{"name":"Departments of Plastic and Reconstructive Surgery, and Hand Surgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Tasker","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Anesthesia (Pediatrics), Harvard Medical School and Boston Children\u2019s Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca K.","family":"den Ottelander","sequence":"additional","affiliation":[{"name":"Departments of Plastic and Reconstructive Surgery, and Hand Surgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein H. 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