{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:03:34Z","timestamp":1783080214322,"version":"3.54.6"},"reference-count":26,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>At failure of endoscopic third ventriculostomy (ETV) with choroid plexus cauterization (CPC), the ETV ostomy may be found to be closed or open. Failure with a closed ostomy may indicate a population that could benefit from evolving techniques to keep the ostomy open and may be candidates for repeat ETV, whereas failure with an open ostomy may be due to persistently abnormal CSF dynamics. This study seeks to identify clinical and radiographic predictors of ostomy status at the time of ETV\/CPC failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors conducted a multicenter, retrospective cohort study on all pediatric patients with hydrocephalus who failed initial ETV\/CPC treatment between January 2013 and October 2016. Failure was defined as the need for repeat ETV or ventriculoperitoneal (VP) shunt placement. Clinical and radiographic data were collected, and ETV ostomy status was determined endoscopically at the subsequent hydrocephalus procedure. Statistical analysis included the Mann-Whitney U-test, Wilcoxon rank-sum test, t-test, and Pearson chi-square test where appropriate, as well as multivariate logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Of 72 ETV\/CPC failures, 28 patients (39%) had open-ostomy failure and 44 (61%) had closed-ostomy failure. Patients with open-ostomy failure were older (median 5.1 weeks corrected age for gestation [interquartile range (IQR) 0.9\u201315.9 weeks]) than patients with closed-ostomy failure (median 0.2 weeks [IQR \u22121.3 to 4.5 weeks]), a significant difference by univariate and multivariate regression. Etiologies of hydrocephalus included intraventricular hemorrhage of prematurity (32%), myelomeningocele (29%), congenital communicating (11%), aqueductal stenosis (11%), cyst\/tumor (4%), and other causes (12%). A wider baseline third ventricle was associated with open-ostomy failure (median 15.0 mm [IQR 10.3\u201318.5 mm]) compared to closed-ostomy failure (median 11.7 mm [IQR 8.9\u201316.5 mm], p = 0.048). Finally, at the time of failure, patients with closed-ostomy failure had enlargement of their ventricles (frontal and occipital horn ratio [FOHR], failure vs baseline, median 0.06 [IQR 0.00\u20130.11]), while patients with open-ostomy failure had no change in ventricle size (median 0.01 [IQR \u22120.04 to 0.05], p = 0.018). Previous CSF temporizing procedures, intraoperative bleeding, and time to failure were not associated with ostomy status at ETV\/CPC failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Older corrected age for gestation, larger baseline third ventricle width, and no change in FOHR were associated with open-ostomy ETV\/CPC failure. Future studies are warranted to further define and confirm features that may be predictive of ostomy status at the time of ETV\/CPC failure.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2019.2.peds18743","type":"journal-article","created":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T13:08:26Z","timestamp":1555679306000},"page":"41-46","source":"Crossref","is-referenced-by-count":10,"title":["Predictors of endoscopic third ventriculostomy ostomy status in patients who experience failure of endoscopic third ventriculostomy with choroid plexus cauterization"],"prefix":"10.3171","volume":"24","author":[{"given":"Andrew T.","family":"Hale","sequence":"first","affiliation":[{"name":"Surgical Outcomes Center for Kids, Monroe Carell Jr. Children\u2019s Hospital at Vanderbilt, Nashville;"},{"name":"Medical Scientist Training Program, Vanderbilt University School of Medicine, Nashville, Tennessee;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda N.","family":"Stanton","sequence":"additional","affiliation":[{"name":"Surgical Outcomes Center for Kids, Monroe Carell Jr. Children\u2019s Hospital at Vanderbilt, Nashville;"},{"name":"Virginia Commonwealth University School of Medicine, Richmond, Virginia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Surgical Outcomes Center for Kids, Monroe Carell Jr. Children\u2019s Hospital at Vanderbilt, Nashville;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faizal","family":"Haji","sequence":"additional","affiliation":[{"name":"Divsion of Pediatric Neurosurgery, Department of Neurosurgery, University of Alabama at Birmingham, Alabama;"},{"name":"Department of Neurosurgery, Queens University, Kingston, Ontario, Canada; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Gannon","sequence":"additional","affiliation":[{"name":"Surgical Outcomes Center for Kids, Monroe Carell Jr. Children\u2019s Hospital at Vanderbilt, Nashville;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Arynchyna","sequence":"additional","affiliation":[{"name":"Divsion of Pediatric Neurosurgery, Department of Neurosurgery, University of Alabama at Birmingham, Alabama;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Wellons","sequence":"additional","affiliation":[{"name":"Surgical Outcomes Center for Kids, Monroe Carell Jr. Children\u2019s Hospital at Vanderbilt, Nashville;"},{"name":"Division of Pediatric Neurosurgery, Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon G.","family":"Rocque","sequence":"additional","affiliation":[{"name":"Divsion of Pediatric Neurosurgery, Department of Neurosurgery, University of Alabama at Birmingham, Alabama;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Naftel","sequence":"additional","affiliation":[{"name":"Surgical Outcomes Center for Kids, Monroe Carell Jr. Children\u2019s Hospital at Vanderbilt, Nashville;"},{"name":"Division of Pediatric Neurosurgery, Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Clin Neurol Neurosurg","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.clineuro.2016.11.006","article-title":"Simplest radiological measurement related to clinical success in endoscopic third ventriculostomy","volume":"152","author":"B\u00f6rcek AO","year":"2017","unstructured":"B\u00f6rcek AO, U\u00e7ar M, Karaaslan B: Simplest radiological measurement related to clinical success in endoscopic third ventriculostomy. 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