{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T16:33:25Z","timestamp":1774715605237,"version":"3.50.1"},"reference-count":32,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Reduced intracranial volume (ICV) and raised intracranial pressure (ICP) are assumed to be principal pathophysiological mechanisms in childhood craniosynostosis. This study examined the association between ICV and ICP and whether ICV can be used to estimate the ICP.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The authors analyzed ICV and ICP measurements from children with craniosynostosis without concurrent hydrocephalus and from age-matched individuals without craniosynostosis who underwent diagnostic ICP measurement.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The study included 19 children with craniosynostosis (mean age 2.2 \u00b1 1.9 years) and 12 reference individuals without craniosynostosis (mean age 2.5 \u00b1 1.6 years). There was no difference in ICV between the patient and reference cohorts. Both mean ICP (17.1 \u00b1 5.6 mm Hg) and mean wave amplitude (5.9 \u00b1 2.6 mm Hg) were higher in the patient cohort. The results disclosed no significant association between ICV and ICP values in the patient or reference cohorts, and no association was seen between change in ICV and ICP values after cranial vault expansion surgery (CVES) in 5 children in whom ICV and ICP were measured before and after CVES.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In this cohort of children with craniosynostosis, there was no significant association between ICV and ICP values prior to CVES and no significant association between change in ICV and ICP values after CVES in a subset of patients. Therefore, ICV could not reliably estimate the ICP values. The authors suggest that intracranial hypertension in childhood craniosynostosis may not be caused by reduced ICV alone but rather by a distorted relationship between ICV and the volume of intracranial content (brain tissue, CSF, and blood).<\/jats:p><\/jats:sec>","DOI":"10.3171\/2019.2.peds18767","type":"journal-article","created":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T13:08:26Z","timestamp":1555679306000},"page":"66-74","source":"Crossref","is-referenced-by-count":17,"title":["Intracranial volume versus static and pulsatile intracranial pressure values in children with craniosynostosis"],"prefix":"10.3171","volume":"24","author":[{"given":"Erlend Aamb\u00f8","family":"Langvatn","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Oslo University Hospital\u2013Rikshospitalet, Oslo, Norway; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radek","family":"Fri\u010d","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Oslo University Hospital\u2013Rikshospitalet, Oslo, Norway; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernt J.","family":"Due-T\u00f8nnessen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Oslo University Hospital\u2013Rikshospitalet, Oslo, Norway; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per Kristian","family":"Eide","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Oslo University Hospital\u2013Rikshospitalet, Oslo, Norway; and"},{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Clin Neurosci","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.jocn.2006.07.001","article-title":"Intracranial volume measurement of sagittal craniosynostosis","volume":"14","author":"Anderson PJ","year":"2007","unstructured":"Anderson PJ, Netherway DJ, McGlaughlin K, David DJ: Intracranial volume measurement of sagittal craniosynostosis. J Clin Neurosci 14:455\u2013458, 20071728939110.1016\/j.jocn.2006.07.001"},{"issue":"5","key":"b2","series-title":"Neurosurg Focus","doi-asserted-by":"publisher","first-page":"E6","DOI":"10.3171\/2015.2.FOCUS14853","article-title":"Intracranial hypertension after surgical correction for craniosynostosis: a systematic review","volume":"38","author":"Christian EA","year":"2015","unstructured":"Christian EA, Imahiyerobo TA, Nallapa S, Urata M, McComb JG, Krieger MD: Intracranial hypertension after surgical correction for craniosynostosis: a systematic review. Neurosurg Focus 38(5):E6, 201510.3171\/2015.2.FOCUS1485325929968"},{"key":"b3","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.3171\/2015.11.JNS151529","article-title":"The correlation between pulsatile intracranial pressure and indices of intracranial pressure-volume reserve capacity: results from ventricular infusion testing","volume":"125","author":"Eide PK","year":"2016","unstructured":"Eide PK: The correlation between pulsatile intracranial pressure and indices of intracranial pressure-volume reserve capacity: results from ventricular infusion testing. J Neurosurg 125:1493\u20131503, 201610.3171\/2015.11.JNS15152926918478"},{"key":"b4","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1159\/000108790","article-title":"Is intracranial pressure waveform analysis useful in the management of pediatric neurosurgical patients?","volume":"43","author":"Eide PK","year":"2007","unstructured":"Eide PK, Egge A, Due-T\u00f8nnessen BJ, Helseth E: Is intracranial pressure waveform analysis useful in the management of pediatric neurosurgical patients? Pediatr Neurosurg 43:472\u2013481, 20071799203510.1159\/000108790"},{"key":"b5","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1159\/000066311","article-title":"Assessment of continuous intracranial pressure recordings in childhood craniosynostosis","volume":"37","author":"Eide PK","year":"2002","unstructured":"Eide PK, Helseth E, Due-T\u00f8nnessen B, Lundar T: Assessment of continuous intracranial pressure recordings in childhood craniosynostosis. Pediatr Neurosurg 37:310\u2013320, 20021242204610.1159\/000066311"},{"key":"b6","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1159\/000050421","article-title":"Changes in intracranial pressure after calvarial expansion surgery in children with slit ventricle syndrome","volume":"35","author":"Eide PK","year":"2001","unstructured":"Eide PK, Helseth E, Due-T\u00f8nnessen B, Lundar T: Changes in intracranial pressure after calvarial expansion surgery in children with slit ventricle syndrome. Pediatr Neurosurg 35:195\u2013204, 200110.1159\/00005042111694797"},{"key":"b7","series-title":"Clin Neurol Neurosurg","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.clineuro.2010.10.008","article-title":"Static and pulsatile intracranial pressure in idiopathic intracranial hypertension","volume":"113","author":"Eide PK","year":"2011","unstructured":"Eide PK, Kerty E: Static and pulsatile intracranial pressure in idiopathic intracranial hypertension. Clin Neurol Neurosurg 113:123\u2013128, 201110.1016\/j.clineuro.2010.10.00821075509"},{"key":"b8","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1227\/01.NEU.0000363408.69856.B8","article-title":"Diagnostic intracranial pressure monitoring and surgical management in idiopathic normal pressure hydrocephalus: a 6-year review of 214 patients","volume":"66","author":"Eide PK","year":"2010","unstructured":"Eide PK, Sorteberg W: Diagnostic intracranial pressure monitoring and surgical management in idiopathic normal pressure hydrocephalus: a 6-year review of 214 patients. Neurosurgery 66:80\u201391, 201010.1227\/01.NEU.0000363408.69856.B820023540"},{"key":"b9","series-title":"Br J Plast Surg","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/0007-1226(92)90013-N","article-title":"Relationship between intracranial pressure and intracranial volume in craniosynostosis","volume":"45","author":"Fok H","year":"1992","unstructured":"Fok H, Jones BM, Gault DG, Andar U, Hayward R: Relationship between intracranial pressure and intracranial volume in craniosynostosis. Br J Plast Surg 45:394\u2013397, 1992163829610.1016\/0007-1226(92)90013-N"},{"key":"b10","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.3171\/2016.4.JNS152862","article-title":"Comparative observational study on the clinical presentation, intracranial volume measurements, and intracranial pressure scores in patients with either Chiari malformation Type I or idiopathic intracranial hypertension","volume":"126","author":"Fri\u010d R","year":"2017","unstructured":"Fri\u010d R, Eide PK: Comparative observational study on the clinical presentation, intracranial volume measurements, and intracranial pressure scores in patients with either Chiari malformation Type I or idiopathic intracranial hypertension. J Neurosurg 126:1312\u20131322, 201710.3171\/2016.4.JNS152862"},{"key":"b11","series-title":"Plast Reconstr Surg","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1097\/00006534-199209000-00003","article-title":"Intracranial pressure and intracranial volume in children with craniosynostosis","volume":"90","author":"Gault DT","year":"1992","unstructured":"Gault DT, Renier D, Marchac D, Jones BM: Intracranial pressure and intracranial volume in children with craniosynostosis. Plast Reconstr Surg 90:377\u2013381, 199210.1097\/00006534-199209000-000031513883"},{"issue":"1 Suppl","key":"b12","series-title":"J Neurosurg","first-page":"16","article-title":"How low can you go? Intracranial pressure, cerebral perfusion pressure, and respiratory obstruction in children with complex craniosynostosis","volume":"102","author":"Hayward R","year":"2005","unstructured":"Hayward R, Gonsalez S: How low can you go? Intracranial pressure, cerebral perfusion pressure, and respiratory obstruction in children with complex craniosynostosis. J Neurosurg 102 (1 Suppl):16\u201322, 2005"},{"key":"b13","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1007\/s00381-007-0436-0","article-title":"The intracranial pressure of the patients with mild form of craniosynostosis","volume":"23","author":"Inagaki T","year":"2007","unstructured":"Inagaki T, Kyutoku S, Seno T, Kawaguchi T, Yamahara T, Oshige H, : The intracranial pressure of the patients with mild form of craniosynostosis. Childs Nerv Syst 23:1455\u20131459, 200710.1007\/s00381-007-0436-0"},{"key":"b14","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"475","DOI":"10.3171\/2018.5.PEDS1876","article-title":"Intraoperative intracranial pressure monitoring in the pediatric craniosynostosis population","volume":"22","author":"Judy BF","year":"2018","unstructured":"Judy BF, Swanson JW, Yang W, Storm PB, Bartlett SP, Taylor JA, : Intraoperative intracranial pressure monitoring in the pediatric craniosynostosis population. J Neurosurg Pediatr 22:475\u2013480, 20183007445010.3171\/2018.5.PEDS1876"},{"key":"b15","series-title":"Plast Reconstr Surg","article-title":"Intracranial volumes in a large series of healthy children","volume":"124","author":"Kamdar MR","year":"2072\u20132075","unstructured":"Kamdar MR, Gomez RA, Ascherman JA: Intracranial volumes in a large series of healthy children. Plast Reconstr Surg 124:2072\u20132075, 2009"},{"key":"b16","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"207","DOI":"10.3171\/2016.1.PEDS15569","article-title":"Effect of molding helmets on intracranial pressure and head shape in nonsurgically treated sagittal craniosynostosis patients","volume":"18","author":"Marupudi NI","year":"2016","unstructured":"Marupudi NI, Sood S, Rozzelle A, Ham SD: Effect of molding helmets on intracranial pressure and head shape in nonsurgically treated sagittal craniosynostosis patients. J Neurosurg Pediatr 18:207\u2013212, 201610.3171\/2016.1.PEDS1556927058454"},{"key":"b17","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"498","DOI":"10.3171\/2017.3.PEDS17118","article-title":"Raised intracranial pressure and cognitive delay in craniosynostosis","volume":"20","author":"Mathijssen I","year":"2017","unstructured":"Mathijssen I, de Goederen R, Versnel SL, Joosten KFM, van Veelen MC, Tasker RC: Raised intracranial pressure and cognitive delay in craniosynostosis. J Neurosurg Pediatr 20:498\u2013502, 2017 (Letter)10.3171\/2017.3.PEDS1711828820338"},{"key":"b18","series-title":"J Craniofac Surg","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1097\/SCS.0000000000002016","article-title":"Guideline for care of patients with the diagnoses of craniosynostosis: working group on craniosynostosis","volume":"26","author":"Mathijssen IM","year":"2015","unstructured":"Mathijssen IM: Guideline for care of patients with the diagnoses of craniosynostosis: working group on craniosynostosis. J Craniofac Surg 26:1735\u20131807, 201510.1097\/SCS.0000000000002016"},{"issue":"2 Suppl","key":"b19","series-title":"J Neurosurg","first-page":"137","article-title":"Intracranial volume in patients with nonsyndromal craniosynostosis","volume":"103","author":"Netherway DJ","year":"2005","unstructured":"Netherway DJ, Abbott AH, Anderson PJ, David DJ: Intracranial volume in patients with nonsyndromal craniosynostosis. J Neurosurg 103 (2 Suppl):137\u2013141, 200516370279"},{"key":"b20","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1159\/000121038","article-title":"Incidence of increased intracranial pressure after early surgical treatment of syndromic craniosynostosis","volume":"24","author":"Pollack IF","year":"1996","unstructured":"Pollack IF, Losken HW, Biglan AW: Incidence of increased intracranial pressure after early surgical treatment of syndromic craniosynostosis. Pediatr Neurosurg 24:202\u2013209, 1996887316210.1159\/000121038"},{"key":"b21","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"370","DOI":"10.3171\/jns.1982.57.3.0370","article-title":"Intracranial pressure in craniostenosis","volume":"57","author":"Renier D","year":"1982","unstructured":"Renier D, Sainte-Rose C, Marchac D, Hirsch JF: Intracranial pressure in craniostenosis. J Neurosurg 57:370\u2013377, 198210.3171\/jns.1982.57.3.03707097333"},{"key":"b22","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3171\/2011.4.PEDS1160","article-title":"Treatment for delayed presentation of sagittal synostosis: challenges pertaining to occult intracranial hypertension","volume":"8","author":"Seruya M","year":"2011","unstructured":"Seruya M, Oh AK, Boyajian MJ, Posnick JC, Keating RF: Treatment for delayed presentation of sagittal synostosis: challenges pertaining to occult intracranial hypertension. J Neurosurg Pediatr 8:40\u201348, 20112172188810.3171\/2011.4.PEDS1160"},{"key":"b23","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"617","DOI":"10.3171\/jns.1999.91.4.0617","article-title":"Intracranial volume change in craniosynostosis","volume":"91","author":"Sgouros S","year":"1999","unstructured":"Sgouros S, Hockley AD, Goldin JH, Wake MJ, Natarajan K: Intracranial volume change in craniosynostosis. J Neurosurg 91:617\u2013625, 19991050738410.3171\/jns.1999.91.4.0617"},{"key":"b24","series-title":"Vom Bau des menschlichen K\u00f6rpers","author":"S\u00f6mmerring ST","year":"1839","unstructured":"S\u00f6mmerring ST: Vom Bau des menschlichen K\u00f6rpers. Lepizig: Bischoff, Henle u. a., 1839"},{"key":"b25","series-title":"Plast Reconstr Surg","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1097\/PRS.0000000000001434","article-title":"Algorithm for the management of intracranial hypertension in children with syndromic craniosynostosis","volume":"136","author":"Spruijt B","year":"2015","unstructured":"Spruijt B, Joosten KF, Driessen C, Rizopoulos D, Naus NC, van der Schroeff MP, : Algorithm for the management of intracranial hypertension in children with syndromic craniosynostosis. Plast Reconstr Surg 136:331\u2013340, 201510.1097\/PRS.000000000000143425909300"},{"key":"b26","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1007\/s00381-004-1117-x","article-title":"Intracranial pressure monitoring in children with single suture and complex craniosynostosis: a review","volume":"21","author":"Tamburrini G","year":"2005","unstructured":"Tamburrini G, Caldarelli M, Massimi L, Santini P, Di Rocco C: Intracranial pressure monitoring in children with single suture and complex craniosynostosis: a review. Childs Nerv Syst 21:913\u2013921, 20051587102710.1007\/s00381-004-1117-x"},{"key":"b27","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"350","DOI":"10.3171\/2014.11.PEDS1426","article-title":"The incidence of raised intracranial pressure in nonsyndromic sagittal craniosynostosis following primary surgery","volume":"15","author":"Thomas GP","year":"2015","unstructured":"Thomas GP, Johnson D, Byren JC, Judge AD, Jayamohan J, Magdum SA, : The incidence of raised intracranial pressure in nonsyndromic sagittal craniosynostosis following primary surgery. J Neurosurg Pediatr 15:350\u2013360, 201510.3171\/2014.11.PEDS142625559921"},{"key":"b28","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/BF00301758","article-title":"Subdural intracranial pressure monitoring in craniosynostosis: its role in surgical management","volume":"11","author":"Thompson DN","year":"1995","unstructured":"Thompson DN, Harkness W, Jones B, Gonsalez S, Andar U, Hayward R: Subdural intracranial pressure monitoring in craniosynostosis: its role in surgical management. Childs Nerv Syst 11:269\u2013275, 199510.1007\/BF003017587648567"},{"key":"b29","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1159\/000120907","article-title":"Intracranial pressure in single-suture craniosynostosis","volume":"22","author":"Thompson DN","year":"1995","unstructured":"Thompson DN, Malcolm GP, Jones BM, Harkness WJ, Hayward RD: Intracranial pressure in single-suture craniosynostosis. Pediatr Neurosurg 22:235\u2013240, 199510.1159\/0001209077547454"},{"key":"b30","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1097\/00006123-199602000-00009","article-title":"The effectiveness of papilledema as an indicator of raised intracranial pressure in children with craniosynostosis","volume":"38","author":"Tuite GF","year":"1996","unstructured":"Tuite GF, Chong WK, Evanson J, Narita A, Taylor D, Harkness WF, : The effectiveness of papilledema as an indicator of raised intracranial pressure in children with craniosynostosis. Neurosurgery 38:272\u2013278, 1996886905410.1097\/00006123-199602000-00009"},{"key":"b31","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"674","DOI":"10.3171\/2014.8.PEDS1425","article-title":"The preoperative incidence of raised intracranial pressure in nonsyndromic sagittal craniosynostosis is underestimated in the literature","volume":"14","author":"Wall SA","year":"2014","unstructured":"Wall SA, Thomas GP, Johnson D, Byren JC, Jayamohan J, Magdum SA, : The preoperative incidence of raised intracranial pressure in nonsyndromic sagittal craniosynostosis is underestimated in the literature. J Neurosurg Pediatr 14:674\u2013681, 20142525960210.3171\/2014.8.PEDS1425"},{"key":"b32","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1007\/s00381-013-2049-0","article-title":"Intraoperative pre- and post-craniofacial reconstruction intracranial pressure (ICP) monitoring in children with craniosynostosis","volume":"29","author":"Yokote A","year":"2013","unstructured":"Yokote A, Aihara Y, Eguchi S, Okada Y: Intraoperative pre- and post-craniofacial reconstruction intracranial pressure (ICP) monitoring in children with craniosynostosis. Childs Nerv Syst 29:1363\u20131367, 201310.1007\/s00381-013-2049-023400867"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/24\/1\/article-p66.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/24\/1\/article-p66.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/24\/1\/article-p66.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T12:52:14Z","timestamp":1681563134000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/24\/1\/article-p66.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":32,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/2019.2.peds18767","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7]]}}}