{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T04:02:33Z","timestamp":1743480153215,"version":"3.40.3"},"reference-count":45,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>Percival S. Bailey (1892\u20131973) was a scholar, neuroscientist, neuropathologist, and neurosurgeon who made decisive contributions in the field of neuro-oncology. Far less known are his groundbreaking insights into understanding hypothalamic physiology through the study of craniopharyngiomas. As one of Harvey W. Cushing\u2019s most talented trainees, Bailey was instrumental in developing Cushing\u2019s project of a histologically based prognostic classification of brain tumors. He worked at Peter Bent Brigham Hospital on and off between 1919 and 1928, owing to frequent clashes with his mentor. A major cause of this long-term conflict was Bailey\u2019s 1921 experimental demonstration of the hypothalamic origin of diabetes insipidus and Fr\u00f6hlich\u2019s syndrome. This finding challenged Cushing\u2019s view that both alterations were due to pituitary gland insufficiency. In a seminal monograph written with John F. Fulton in 1929, both authors provided the first comprehensive account of the specific hypothalamic disturbances caused by tumors that originated within the infundibulum and third ventricle. The methodical study of Cushing\u2019s craniopharyngioma specimens allowed Bailey to recognize the close contact between these lesions and hypothalamic nuclei, a key concept that Bailey originally advanced for proper surgical planning. This article aims to credit Bailey for his pioneering definition of craniopharyngiomas as tumors with a true intrahypothalamic position.<\/jats:p>","DOI":"10.3171\/2019.3.jns183145","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T23:50:44Z","timestamp":1560556244000},"page":"197-209","source":"Crossref","is-referenced-by-count":3,"title":["Percival S. Bailey: eminent scholar of neurosciences who revealed the workings of the hypothalamus through clinicopathological research on craniopharyngiomas"],"prefix":"10.3171","volume":"133","author":[{"given":"Ruth","family":"Prieto","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Puerta de Hierro University Hospital; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M.","family":"Pascual","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, La Princesa University Hospital, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Arch Neurol Psychiatry","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1001\/archneurpsyc.1924.02190320031004","article-title":"Concerning the cerebellar symptoms produced by suprasellar tumours","volume":"11","author":"Bailey P","year":"1924","unstructured":"Bailey P: Concerning the cerebellar symptoms produced by suprasellar tumours. 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