{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T07:03:20Z","timestamp":1783235000103,"version":"3.54.6"},"reference-count":82,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7]]},"abstract":"\n OBJECTIVE<\/jats:title>\n Although several studies have suggested that the incidence of intracranial aneurysms (IAs) is higher in smokers, the higher prevalence of subarachnoid hemorrhage (SAH) in smokers remains uncertain. It is unclear whether smoking additionally contributes to the formation of multiple aneurysms and the risk of rupture. The aim of this study was to determine whether smoking is associated with IA formation, multiplicity, or rupture.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n Patients from the prospective multicenter @neurIST database (n = 1410; 985 females [69.9%]) were reviewed for the presence of SAH, multiple aneurysms, and smoking status. The prevalence of smokers in the population of patients diagnosed with at least one IA was compared with that of smokers in the general population.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n The proportion of smokers was higher in patients with IAs (56.2%) than in the reference population (51.4%; p < 0.001). A significant association of smoking with the presence of an IA was found throughout group comparisons (p = 0.01). The presence of multiple IAs was also significantly associated with smoking (p = 0.003). A trend was found between duration of smoking and the presence of multiple IAs (p = 0.057). However, the proportion of smokers among patients suffering SAH was similar to that of smokers among patients diagnosed with unruptured IAs (p = 0.48).<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n Smoking is strongly associated with IA formation. Once an IA is present, however, smoking does not appear to increase the risk of rupture compared with IAs in the nonsmoking population. The trend toward an association between duration of smoking and the presence of multiple IAs stresses the need for counseling patients with IAs regarding lifestyle modification.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2019.4.focus19130","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T19:10:19Z","timestamp":1562353819000},"page":"E9","source":"Crossref","is-referenced-by-count":10,"title":["Association of single and multiple aneurysms with tobacco abuse: an @neurIST risk analysis"],"prefix":"10.3171","volume":"47","author":[{"given":"Bawarjan","family":"Schatlo","sequence":"first","affiliation":[{"name":"Department of Neurosurgery and Faculty of Medicine, and"},{"name":"Department of Neurosurgery, University Hospital G\u00f6ttingen, Georg-August University, G\u00f6ttingen;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver P.","family":"Gautschi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Faculty of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph M.","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Department of Computer Science, University of Applied Sciences and Arts Dortmund;"},{"name":"Institute for Medical Informatics, Biometry, and Epidemiology (IMIBE), University Hospital Essen, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ebeling","sequence":"additional","affiliation":[{"name":"Fraunhofer Institute for Scientific Computing and Algorithms (SCAI), Sankt Augustin;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"J\u00e4gersberg","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Faculty of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsolt","family":"Kulscar","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology and Faculty of Medicine, University Hospital Geneva, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor Mendes","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology and Faculty of Medicine, University Hospital Geneva, Switzerland;"},{"name":"Department of Medical Imaging, Toronto Western Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Schaller","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Faculty of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Bijlenga","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Faculty of Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Spine (Phila Pa 1976)","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1097\/01.BRS.0000061992.98108.A0","article-title":"The natural history of spondylolysis and spondylolisthesis: 45-year follow-up evaluation","volume":"28","author":"Beutler WJ","year":"2003","unstructured":"Beutler WJ, Fredrickson BE, Murtland A, Sweeney CA, Grant WD, Baker D: The natural history of spondylolysis and spondylolisthesis: 45-year follow-up evaluation. 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