{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T20:36:08Z","timestamp":1782506168218,"version":"3.54.5"},"reference-count":152,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7]]},"abstract":"\n OBJECTIVE<\/jats:title>\n Despite the prevalence and impact of intracranial aneurysms (IAs), the molecular basis of their pathogenesis remains largely unknown. Moreover, there is a dearth of clinically validated biomarkers to efficiently screen patients with IAs and prognosticate risk for rupture. The aim of this study was to survey the literature to systematically identify the spectrum of genetic aberrations that have been identified in IA formation and risk of rupture.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n A literature search was performed using the Medical Subject Headings (MeSH) system of databases including PubMed, EMBASE, and Google Scholar. Relevant studies that reported on genetic analyses of IAs, rupture risk, and long-term outcomes were included in the qualitative analysis.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n A total of 114 studies were reviewed and 65 were included in the qualitative synthesis. There are several well-established mendelian syndromes that confer risk to IAs, with variable frequency. Linkage analyses, genome-wide association studies, candidate gene studies, and exome sequencing identify several recurrent polymorphic variants at candidate loci, and genes associated with the risk of aneurysm formation and rupture, including\n ANRIL<\/jats:italic>\n (\n CDKN2B-AS1<\/jats:italic>\n , 9p21),\n ARGHEF17<\/jats:italic>\n (11q13),\n ELN<\/jats:italic>\n (7q11),\n SERPINA3<\/jats:italic>\n (14q32), and\n SOX17<\/jats:italic>\n (8q11). In addition, polymorphisms in\n eNOS\/NOS3<\/jats:italic>\n (7q36) may serve as predictive markers for outcomes following intracranial aneurysm rupture. Genetic aberrations identified to date converge on posited molecular mechanisms involved in vascular remodeling, with strong implications for an associated immune-mediated inflammatory response.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n Comprehensive studies of IA formation and rupture have identified candidate risk variants and loci; however, further genome-wide analyses are needed to identify high-confidence genetic aberrations. The literature supports a role for several risk loci in aneurysm formation and rupture with putative candidate genes. A thorough understanding of the genetic basis governing risk of IA development and the resultant aneurysmal subarachnoid hemorrhage may aid in screening, clinical management, and risk stratification of these patients, and it may also enable identification of putative mechanisms for future drug development.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2019.4.focus19204","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T19:10:15Z","timestamp":1562353815000},"page":"E10","source":"Crossref","is-referenced-by-count":32,"title":["Genetic basis of intracranial aneurysm formation and rupture: clinical implications in the postgenomic era"],"prefix":"10.3171","volume":"47","author":[{"given":"Nardin","family":"Samuel","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, University of Toronto; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Radovanovic","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, University of Toronto; and"},{"name":"Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Hum Mol Genet","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1093\/hmg\/ddl096","article-title":"A haplotype spanning two genes, ELN and LIMK1, decreases their transcripts and confers susceptibility to intracranial aneurysms","volume":"15","author":"Akagawa H","year":"2006","unstructured":"Akagawa H, Tajima A, Sakamoto Y, Krischek B, Yoneyama T, Kasuya H, : A haplotype spanning two genes, ELN and LIMK1, decreases their transcripts and confers susceptibility to intracranial aneurysms. Hum Mol Genet 15:1722\u20131734, 200610.1093\/hmg\/ddl09616611674"},{"key":"b2","series-title":"J Hum Genet","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/jhg.2010.82","article-title":"Genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms","volume":"55","author":"Akiyama K","year":"2010","unstructured":"Akiyama K, Narita A, Nakaoka H, Cui T, Takahashi T, Yasuno K, : Genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms. J Hum Genet 55:656\u2013661, 20102061376610.1038\/jhg.2010.82"},{"key":"b3","series-title":"Br J Neurosurg","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1080\/02688697.2018.1427213","article-title":"Association of functional MMP-2 gene variant with intracranial aneurysms: case-control genetic association study and meta-analysis","volume":"32","author":"Alg VS","year":"2018","unstructured":"Alg VS, Ke X, Grieve J, Bonner S, Walsh DC, Bulters D, : Association of functional MMP-2 gene variant with intracranial aneurysms: case-control genetic association study and meta-analysis. Br J Neurosurg 32:255\u2013259, 201810.1080\/02688697.2018.142721329334797"},{"key":"b4","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"2154","DOI":"10.1212\/WNL.0b013e318295d751","article-title":"Genetic risk factors for intracranial aneurysms: a meta-analysis in more than 116,000 individuals","volume":"80","author":"Alg VS","year":"2013","unstructured":"Alg VS, Sofat R, Houlden H, Werring DJ: Genetic risk factors for intracranial aneurysms: a meta-analysis in more than 116,000 individuals. Neurology 80:2154\u20132165, 201310.1212\/WNL.0b013e318295d75123733552"},{"key":"b5","series-title":"J Radiol Case Rep","first-page":"1","article-title":"Ruptured berry aneurysm as the initial presentation of polycystic kidney disease: a case report and review of literature","volume":"12","author":"AlNuaimi D","year":"2018","unstructured":"AlNuaimi D, AlKetbi R, AlFalahi A, AlBastaki U, Pierre-Jerome C: Ruptured berry aneurysm as the initial presentation of polycystic kidney disease: a case report and review of literature. J Radiol Case Rep 12:1\u20138, 201830651918"},{"key":"b6","series-title":"Sci Signal","doi-asserted-by":"publisher","first-page":"eaah6037","DOI":"10.1126\/scisignal.aah6037","article-title":"Prostaglandin E2-EP2-NF-\u03baB signaling in macrophages as a potential therapeutic target for intracranial aneurysms","volume":"10","author":"Aoki T","year":"2017","unstructured":"Aoki T, Fr\u020dsen J, Fukuda M, Bando K, Shioi G, Tsuji K, : Prostaglandin E2-EP2-NF-\u03baB signaling in macrophages as a potential therapeutic target for intracranial aneurysms. Sci Signal 10:eaah6037, 20172817428010.1126\/scisignal.aah6037"},{"key":"b7","series-title":"Circulation","doi-asserted-by":"publisher","first-page":"2830","DOI":"10.1161\/CIRCULATIONAHA.107.728303","article-title":"NF-\u03baB is a key mediator of cerebral aneurysm formation","volume":"116","author":"Aoki T","year":"2007","unstructured":"Aoki T, Kataoka H, Shimamura M, Nakagami H, Wakayama K, Moriwaki T, : NF-\u03baB is a key mediator of cerebral aneurysm formation. Circulation 116:2830\u20132840, 20071802553510.1161\/CIRCULATIONAHA.107.728303"},{"key":"b8","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3171\/2015.7.JNS154","article-title":"ADAMTS genes and the risk of cerebral aneurysm","volume":"125","author":"Arning A","year":"2016","unstructured":"Arning A, Jeibmann A, K\u00f6hnemann S, Brokinkel B, Ewelt C, Berger K, : ADAMTS genes and the risk of cerebral aneurysm. J Neurosurg 125:269\u2013274, 20162674548410.3171\/2015.7.JNS154"},{"key":"b9","series-title":"Cerebrovasc Dis","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1159\/000354161","article-title":"Gene expression profile of blood cells for the prediction of delayed cerebral ischemia after intracranial aneurysm rupture: a pilot study in humans","volume":"36","author":"Baumann A","year":"2013","unstructured":"Baumann A, Devaux Y, Audibert G, Zhang L, Bracard S, Colnat-Coulbois S, : Gene expression profile of blood cells for the prediction of delayed cerebral ischemia after intracranial aneurysm rupture: a pilot study in humans. Cerebrovasc Dis 36:236\u2013242, 20132413553610.1159\/000354161"},{"key":"b10","series-title":"Nat Genet","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1038\/ng.240","article-title":"Susceptibility loci for intracranial aneurysm in European and Japanese populations","volume":"40","author":"Bilguvar K","year":"2008","unstructured":"Bilguvar K, Yasuno K, Niemel\u00e4 M, Ruigrok YM, von Und Zu Fraunberg M, van Duijn CM, : Susceptibility loci for intracranial aneurysm in European and Japanese populations. Nat Genet 40:1472\u20131477, 200810.1038\/ng.24018997786"},{"key":"b11","series-title":"Clin Neurol Neurosurg","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.clineuro.2007.09.009","article-title":"Intracerebral haemorrhage as first manifestation of pseudoxanthoma elasticum","volume":"110","author":"Bock A","year":"2008","unstructured":"Bock A, Schwegler G: Intracerebral haemorrhage as first manifestation of pseudoxanthoma elasticum. Clin Neurol Neurosurg 110:262\u2013264, 20081796471210.1016\/j.clineuro.2007.09.009"},{"key":"b12","series-title":"AJNR Am J Neuroradiol","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.3174\/ajnr.A4762","article-title":"Neurovascular manifestations of hereditary hemorrhagic telangiectasia: a consecutive series of 376 patients during 15 years","volume":"37","author":"Brinjikji W","year":"2016","unstructured":"Brinjikji W, Iyer VN, Yamaki V, Lanzino G, Cloft HJ, Thielen KR, : Neurovascular manifestations of hereditary hemorrhagic telangiectasia: a consecutive series of 376 patients during 15 years. AJNR Am J Neuroradiol 37:1479\u20131486, 201610.3174\/ajnr.A476227012295"},{"key":"b13","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1161\/STROKEAHA.108.542571","article-title":"Greater rupture risk for familial as compared to sporadic unruptured intracranial aneurysms","volume":"40","author":"Broderick JP","unstructured":"Broderick JP, Brown RD Jr, Sauerbeck L, Hornung R, Huston J III, Woo D, : Greater rupture risk for familial as compared to sporadic unruptured intracranial aneurysms. Stroke 40:1952\u20131957, 200910.1161\/STROKEAHA.108.54257119228834"},{"key":"b14","series-title":"J Cereb Blood Flow Metab","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1038\/jcbfm.2012.84","article-title":"Biology of intracranial aneurysms: role of inflammation","volume":"32","author":"Chalouhi N","year":"2012","unstructured":"Chalouhi N, Ali MS, Jabbour PM, Tjoumakaris SI, Gonzalez LF, Rosenwasser RH, : Biology of intracranial aneurysms: role of inflammation. J Cereb Blood Flow Metab 32:1659\u20131676, 201210.1038\/jcbfm.2012.84"},{"key":"b15","series-title":"BMC Neurol","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/s12883-017-0986-z","article-title":"CDKN2BAS gene polymorphisms and the risk of intracranial aneurysm in the Chinese population","volume":"17","author":"Chen Y","year":"2017","unstructured":"Chen Y, Li G, Fan H, Guo S, Li R, Yin J, : CDKN2BAS gene polymorphisms and the risk of intracranial aneurysm in the Chinese population. BMC Neurol 17:214, 201710.1186\/s12883-017-0986-z29228923"},{"key":"b16","series-title":"Interv Neuroradiol","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1177\/159101990100700410","article-title":"Tuberous sclerosis complex with an unruptured intracranial aneurysm: manifestations of contiguous gene syndrome","volume":"7","author":"Chen YL","year":"2001","unstructured":"Chen YL, Luo CB, Hsu SW, Rodesch G, Lasjaunias P: Tuberous sclerosis complex with an unruptured intracranial aneurysm: manifestations of contiguous gene syndrome. Interv Neuroradiol 7:337\u2013341, 20012066336710.1177\/159101990100700410"},{"key":"b17","series-title":"Neurol India","doi-asserted-by":"publisher","first-page":"293","DOI":"10.4103\/0028-3886.115071","article-title":"The angiotensin converting enzyme insertion\/deletion polymorphism and intracranial aneurysm: a meta-analysis of case-control studies","volume":"61","author":"Chen Z","year":"2013","unstructured":"Chen Z, Ma J, Cen Y, Liu Y, You C: The angiotensin converting enzyme insertion\/deletion polymorphism and intracranial aneurysm: a meta-analysis of case-control studies. Neurol India 61:293\u2013299, 20132386015110.4103\/0028-3886.115071"},{"key":"b18","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1161\/hs1101.098329","article-title":"Lack of evidence for an association between neurofibromatosis type I and intracranial aneurysms: autopsy study and review of the literature","volume":"32","author":"Conway JE","year":"2001","unstructured":"Conway JE, Hutchins GM, Tamargo RJ: Lack of evidence for an association between neurofibromatosis type I and intracranial aneurysms: autopsy study and review of the literature. Stroke 32:2481\u20132485, 200110.1161\/hs1101.09832911692004"},{"key":"b19","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.1161\/STROKEAHA.112.656397","article-title":"Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk","volume":"43","author":"Foroud T","year":"2012","unstructured":"Foroud T, Koller DL, Lai D, Sauerbeck L, Anderson C, Ko N, : Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk. Stroke 43:2846\u20132852, 201210.1161\/STROKEAHA.112.65639722961961"},{"key":"b20","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"3194","DOI":"10.1161\/STROKEAHA.114.006096","article-title":"Genome-wide association study of intracranial aneurysm identifies a new association on chromosome 7","volume":"45","author":"Foroud T","year":"2014","unstructured":"Foroud T, Lai D, Koller D, Van\u2019t Hof F, Kurki MI, Anderson CS, : Genome-wide association study of intracranial aneurysm identifies a new association on chromosome 7. Stroke 45:3194\u20133199, 20142525618210.1161\/STROKEAHA.114.006096"},{"key":"b21","series-title":"Biol Res Nurs","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1177\/1099800408323221","article-title":"APOE genotype and functional outcome following aneurysmal subarachnoid hemorrhage","volume":"10","author":"Gallek MJ","year":"2009","unstructured":"Gallek MJ, Conley YP, Sherwood PR, Horowitz MB, Kassam A, Alexander SA: APOE genotype and functional outcome following aneurysmal subarachnoid hemorrhage. Biol Res Nurs 10:205\u2013212, 20091901766910.1177\/1099800408323221"},{"key":"b22","series-title":"Lancet Neurol","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S1474-4422(13)70263-1","article-title":"Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms: a pooled analysis of six prospective cohort studies","volume":"13","author":"Greving JP","year":"2014","unstructured":"Greving JP, Wermer MJ, Brown RD Jr, Morita A, Juvela S, Yonekura M, : Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms: a pooled analysis of six prospective cohort studies. Lancet Neurol 13:59\u201366, 20142429015910.1016\/S1474-4422(13)70263-1"},{"key":"b23","series-title":"J Am Soc Nephrol","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1681\/ASN.V84616","article-title":"Vascular expression of polycystin","volume":"8","author":"Griffin MD","year":"1997","unstructured":"Griffin MD, Torres VE, Grande JP, Kumar R: Vascular expression of polycystin. J Am Soc Nephrol 8:616\u2013626, 19971049579110.1681\/ASN.V84616"},{"key":"b24","series-title":"World Neurosurg","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.wneu.2017.02.062","article-title":"Endothelial nitric oxide synthase polymorphism is associated with delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage","volume":"101","author":"Hendrix P","year":"2017","unstructured":"Hendrix P, Foreman PM, Harrigan MR, Fisher WS III, Vyas NA, Lipsky RH, : Endothelial nitric oxide synthase polymorphism is associated with delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage. World Neurosurg 101:514\u2013519, 201710.1016\/j.wneu.2017.02.06228254540"},{"key":"b25","series-title":"World Neurosurg","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.wneu.2017.01.121","article-title":"Impact of high-mobility group box 1 polymorphism on delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage","volume":"101","author":"Hendrix P","year":"2017","unstructured":"Hendrix P, Foreman PM, Harrigan MR, Fisher WSR, Vyas NA, Lipsky RH, : Impact of high-mobility group box 1 polymorphism on delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. World Neurosurg 101:325\u2013330, 201710.1016\/j.wneu.2017.01.12128189859"},{"key":"b26","series-title":"World Neurosurg","doi-asserted-by":"publisher","first-page":"e666","DOI":"10.1016\/j.wneu.2018.07.019","article-title":"Role of apolipoprotein E genotypes in aneurysmal subarachnoid hemorrhage: susceptibility, complications, and prognosis","volume":"118","author":"Hu X","year":"2018","unstructured":"Hu X, Xie Z, Zan X, Ma L, Li H, You C, : Role of apolipoprotein E genotypes in aneurysmal subarachnoid hemorrhage: susceptibility, complications, and prognosis. World Neurosurg 118:e666\u2013e676, 201810.1016\/j.wneu.2018.07.01930010064"},{"key":"b27","series-title":"Nature","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/nature05159","article-title":"Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a","volume":"443","author":"Janzen V","year":"2006","unstructured":"Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM, : Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 443:421\u2013426, 200610.1038\/nature0515916957735"},{"key":"b28","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"989","DOI":"10.3171\/2008.11.JNS081266","article-title":"Apolipoprotein E genotype and outcome after aneurysmal subarachnoid hemorrhage","volume":"110","author":"Juvela S","year":"2009","unstructured":"Juvela S, Siironen J, Lappalainen J: Apolipoprotein E genotype and outcome after aneurysmal subarachnoid hemorrhage. J Neurosurg 110:989\u2013995, 200910.3171\/2008.11.JNS08126619199499"},{"key":"b29","series-title":"Emerg Radiol","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1007\/s10140-004-0357-0","article-title":"Autosomal dominant polycystic kidney disease presenting as subarachnoid hemorrhage","volume":"11","author":"Kanne JP","year":"2004","unstructured":"Kanne JP, Talner LB: Autosomal dominant polycystic kidney disease presenting as subarachnoid hemorrhage. Emerg Radiol 11:110\u2013112, 200410.1007\/s10140-004-0357-015801061"},{"issue":"5","key":"b30","series-title":"Neurosurg Focus","doi-asserted-by":"publisher","first-page":"E7","DOI":"10.3171\/foc.2004.17.5.7","article-title":"Update on genetic evidence for rupture-prone compared with rupture-resistant intracranial saccular aneurysms","volume":"17","author":"Khurana VG","year":"2004","unstructured":"Khurana VG, Meissner I, Meyer FB: Update on genetic evidence for rupture-prone compared with rupture-resistant intracranial saccular aneurysms. Neurosurg Focus 17(5):E7, 200410.3171\/foc.2004.17.5.715633984"},{"key":"b31","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"526","DOI":"10.3171\/jns.2005.102.3.0526","article-title":"The presence of tandem endothelial nitric oxide synthase gene polymorphisms identifying brain aneurysms more prone to rupture","volume":"102","author":"Khurana VG","year":"2005","unstructured":"Khurana VG, Meissner I, Sohni YR, Bamlet WR, McClelland RL, Cunningham JM, : The presence of tandem endothelial nitric oxide synthase gene polymorphisms identifying brain aneurysms more prone to rupture. J Neurosurg 102:526\u2013531, 20051579638910.3171\/jns.2005.102.3.0526"},{"key":"b32","series-title":"Cell","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.cell.2007.06.011","article-title":"Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells","volume":"130","author":"Kim I","year":"2007","unstructured":"Kim I, Saunders TL, Morrison SJ: Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell 130:470\u2013483, 20071765592210.1016\/j.cell.2007.06.011"},{"key":"b33","series-title":"AJNR Am J Neuroradiol","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.3174\/ajnr.A4718","article-title":"Prevalence of intracranial aneurysms in patients with connective tissue diseases: a retrospective study","volume":"37","author":"Kim ST","year":"2016","unstructured":"Kim ST, Brinjikji W, Kallmes DF: Prevalence of intracranial aneurysms in patients with connective tissue diseases: a retrospective study. AJNR Am J Neuroradiol 37:1422\u20131426, 201610.3174\/ajnr.A471826992822"},{"key":"b34","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1161\/STROKEAHA.116.012541","article-title":"RNA sequencing analysis of intracranial aneurysm walls reveals involvement of lysosomes and immunoglobulins in rupture","volume":"47","author":"Kleinloog R","year":"2016","unstructured":"Kleinloog R, Verweij BH, van der Vlies P, Deelen P, Swertz MA, de Muynck L, : RNA sequencing analysis of intracranial aneurysm walls reveals involvement of lysosomes and immunoglobulins in rupture. Stroke 47:1286\u20131293, 201610.1161\/STROKEAHA.116.01254127026628"},{"key":"b35","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"2458","DOI":"10.1161\/STROKEAHA.110.586420","article-title":"Genetic epidemiology of spontaneous subarachnoid hemorrhage: Nordic Twin Study","volume":"41","author":"Korja M","year":"2010","unstructured":"Korja M, Silventoinen K, McCarron P, Zdravkovic S, Skytthe A, Haapanen A, : Genetic epidemiology of spontaneous subarachnoid hemorrhage: Nordic Twin Study. Stroke 41:2458\u20132462, 201010.1161\/STROKEAHA.110.58642020847318"},{"key":"b36","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1136\/jnnp-2013-307276","article-title":"Evaluation of genetic risk loci for intracranial aneurysms in sporadic arteriovenous malformations of the brain","volume":"86","author":"Kremer PH","year":"2015","unstructured":"Kremer PH, Koeleman BP, Pawlikowska L, Weinsheimer S, Bendjilali N, Sidney S, : Evaluation of genetic risk loci for intracranial aneurysms in sporadic arteriovenous malformations of the brain. J Neurol Neurosurg Psychiatry 86:524\u2013529, 20152505376910.1136\/jnnp-2013-307276"},{"key":"b37","series-title":"Neuroscience","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.neuroscience.2010.05.002","article-title":"Association of the Jun dimerization protein 2 gene with intracranial aneurysms in Japanese and Korean cohorts as compared to a Dutch cohort","volume":"169","author":"Krischek B","year":"2010","unstructured":"Krischek B, Tajima A, Akagawa H, Narita A, Ruigrok Y, Rinkel G, : Association of the Jun dimerization protein 2 gene with intracranial aneurysms in Japanese and Korean cohorts as compared to a Dutch cohort. Neuroscience 169:339\u2013343, 20102045240510.1016\/j.neuroscience.2010.05.002"},{"key":"b38","series-title":"PLoS Genet","doi-asserted-by":"publisher","first-page":"e1004134","DOI":"10.1371\/journal.pgen.1004134","article-title":"High risk population isolate reveals low frequency variants predisposing to intracranial aneurysms","volume":"10","author":"Kurki MI","year":"2014","unstructured":"Kurki MI, Ga\u00e1l EI, Kettunen J, Lappalainen T, Menelaou A, Anttila V, : High risk population isolate reveals low frequency variants predisposing to intracranial aneurysms. PLoS Genet 10:e1004134, 20142449784410.1371\/journal.pgen.1004134"},{"key":"b39","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1161\/STROKEAHA.117.018557","article-title":"Intracranial aneurysm-associated single-nucleotide polymorphisms alter regulatory DNA in the human circle of Willis","volume":"49","author":"Laarman MD","year":"2018","unstructured":"Laarman MD, Vermunt MW, Kleinloog R, de Boer-Bergsma JJ, Brain Bank N, Rinkel GJE, : Intracranial aneurysm-associated single-nucleotide polymorphisms alter regulatory DNA in the human circle of Willis. Stroke 49:447\u2013453, 20182930197110.1161\/STROKEAHA.117.018557"},{"key":"b40","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1161\/hs0202.102326","article-title":"Apolipoprotein e genotype and outcome in aneurysmal subarachnoid hemorrhage","volume":"33","author":"Leung CH","year":"2002","unstructured":"Leung CH, Poon WS, Yu LM, Wong GK, Ng HK: Apolipoprotein e genotype and outcome in aneurysmal subarachnoid hemorrhage. Stroke 33:548\u2013552, 20021182366810.1161\/hs0202.102326"},{"key":"b41","series-title":"Proc Natl Acad Sci U S A","doi-asserted-by":"publisher","first-page":"15207","DOI":"10.1073\/pnas.0504501102","article-title":"Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity","volume":"102","author":"Leung TH","year":"2005","unstructured":"Leung TH, Ching YP, Yam JW, Wong CM, Yau TO, Jin DY, : Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity. Proc Natl Acad Sci U S A 102:15207\u201315212, 200510.1073\/pnas.050450110216217026"},{"key":"b42","series-title":"Metab Brain Dis","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1007\/s11011-015-9712-y","article-title":"Identification of two novel critical mutations in PCNT gene resulting in microcephalic osteodysplastic primordial dwarfism type II associated with multiple intracranial aneurysms","volume":"30","author":"Li FF","year":"2015","unstructured":"Li FF, Wang XD, Zhu MW, Lou ZH, Zhang Q, Zhu CY, : Identification of two novel critical mutations in PCNT gene resulting in microcephalic osteodysplastic primordial dwarfism type II associated with multiple intracranial aneurysms. Metab Brain Dis 30:1387\u20131394, 20152623188610.1007\/s11011-015-9712-y"},{"key":"b43","series-title":"Curr Neurovasc Res","doi-asserted-by":"publisher","first-page":"294","DOI":"10.2174\/1567202611666140912114450","article-title":"A variant in the endoglin gene is associated with the development of sporadic intracranial aneurysms","volume":"11","author":"Lin Y","year":"2014","unstructured":"Lin Y, Yu H, Song W, Zhang Y, Zhang C, Zhu Y, : A variant in the endoglin gene is associated with the development of sporadic intracranial aneurysms. Curr Neurovasc Res 11:294\u2013301, 201410.2174\/156720261166614091211445025219660"},{"key":"b44","series-title":"Nat Genet","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/ng1511","article-title":"A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2","volume":"37","author":"Loeys BL","year":"2005","unstructured":"Loeys BL, Chen J, Neptune ER, Judge DP, Podowski M, Holm T, : A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. Nat Genet 37:275\u2013281, 200510.1038\/ng1511"},{"key":"b45","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1056\/NEJMoa055695","article-title":"Aneurysm syndromes caused by mutations in the TGF-\u03b2 receptor","volume":"355","author":"Loeys BL","year":"2006","unstructured":"Loeys BL, Schwarze U, Holm T, Callewaert BL, Thomas GH, Pannu H, : Aneurysm syndromes caused by mutations in the TGF-\u03b2 receptor. N Engl J Med 355:788\u2013798, 200610.1056\/NEJMoa05569516928994"},{"key":"b46","series-title":"Nephrol Dial Transplant","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1093\/ndt\/12.9.1900","article-title":"A large TSC2 and PKD1 gene deletion is associated with renal and extrarenal signs of autosomal dominant polycystic kidney disease","volume":"12","author":"Longa L","year":"1997","unstructured":"Longa L, Scolari F, Brusco A, Carbonara C, Polidoro S, Valzorio B, : A large TSC2 and PKD1 gene deletion is associated with renal and extrarenal signs of autosomal dominant polycystic kidney disease. Nephrol Dial Transplant 12:1900\u20131907, 199710.1093\/ndt\/12.9.19009306341"},{"key":"b47","series-title":"J Hum Genet","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/jhg.2010.169","article-title":"Impact of LIMK1, MMP2 and TNF-\u03b1 variations for intracranial aneurysm in Japanese population","volume":"56","author":"Low SK","year":"2011","unstructured":"Low SK, Zembutsu H, Takahashi A, Kamatani N, Cha PC, Hosono N, : Impact of LIMK1, MMP2 and TNF-\u03b1 variations for intracranial aneurysm in Japanese population. J Hum Genet 56:211\u2013216, 201110.1038\/jhg.2010.16921228795"},{"key":"b48","series-title":"AJR Am J Roentgenol","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.2214\/ajr.136.5.1023","article-title":"Pseudoxanthoma elasticum with internal carotid artery aneurysm","volume":"136","author":"Munyer TP","year":"1981","unstructured":"Munyer TP, Margulis AR: Pseudoxanthoma elasticum with internal carotid artery aneurysm. AJR Am J Roentgenol 136:1023\u20131024, 1981678450510.2214\/ajr.136.5.1023"},{"key":"b49","series-title":"Nat Rev Genet","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/35056009","article-title":"Modifier genes in mice and humans","volume":"2","author":"Nadeau JH","year":"2001","unstructured":"Nadeau JH: Modifier genes in mice and humans. Nat Rev Genet 2:165\u2013174, 200110.1038\/3505600911256068"},{"key":"b50","series-title":"Neurol Neurochir Pol","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.pjnns.2017.08.007","article-title":"Natural history of intracranial aneurysms in autosomal dominant polycystic kidney disease","volume":"51","author":"Niemczyk M","year":"2017","unstructured":"Niemczyk M, Gradzik M, Fliszkiewicz M, Kulesza A, Go\u0142\u0119biowski M, P\u0105czek L: Natural history of intracranial aneurysms in autosomal dominant polycystic kidney disease. Neurol Neurochir Pol 51:476\u2013480, 20172884377010.1016\/j.pjnns.2017.08.007"},{"key":"b51","series-title":"Lancet Neurol","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/S1474-4422(09)70126-7","article-title":"Changes in case fatality of aneurysmal subarachnoid haemorrhage over time, according to age, sex, and region: a meta-analysis","volume":"8","author":"Nieuwkamp DJ","year":"2009","unstructured":"Nieuwkamp DJ, Setz LE, Algra A, Linn FH, de Rooij NK, Rinkel GJ: Changes in case fatality of aneurysmal subarachnoid haemorrhage over time, according to age, sex, and region: a meta-analysis. Lancet Neurol 8:635\u2013642, 20091950102210.1016\/S1474-4422(09)70126-7"},{"key":"b52","series-title":"Neurosurg Rev","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s10143-016-0761-4","article-title":"Relationship between endothelial nitric oxide synthase (eNOS) and natural history of intracranial aneurysms: meta-analysis","volume":"41","author":"Paschoal EHA","year":"2018","unstructured":"Paschoal EHA, Yamaki VN, Teixeira RKC, Paschoal Junior FM, Jong-A-Liem GS, Teixeira MJ, : Relationship between endothelial nitric oxide synthase (eNOS) and natural history of intracranial aneurysms: meta-analysis. Neurosurg Rev 41:87\u201394, 201810.1007\/s10143-016-0761-427339197"},{"key":"b53","series-title":"Int J Mol Sci","doi-asserted-by":"publisher","first-page":"E1245","DOI":"10.3390\/ijms19041245","article-title":"NF-\u03baB-mediated inflammation in the pathogenesis of intracranial aneurysm and subarachnoid hemorrhage. Does autophagy play a role?","volume":"19","author":"Pawlowska E","year":"2018","unstructured":"Pawlowska E, Szczepanska J, Wisniewski K, Tokarz P, Jask\u00f3lski DJ, Blasiak J: NF-\u03baB-mediated inflammation in the pathogenesis of intracranial aneurysm and subarachnoid hemorrhage. Does autophagy play a role? Int J Mol Sci 19:E1245, 20182967182810.3390\/ijms19041245"},{"key":"b54","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1161\/01.STR.29.1.251","article-title":"Prevalence and risk of rupture of intracranial aneurysms: a systematic review","volume":"29","author":"Rinkel GJ","year":"1998","unstructured":"Rinkel GJ, Djibuti M, Algra A, van Gijn J: Prevalence and risk of rupture of intracranial aneurysms: a systematic review. Stroke 29:251\u2013256, 199810.1161\/01.STR.29.1.2519445359"},{"key":"b55","series-title":"AJNR Am J Neuroradiol","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.3174\/ajnr.A1651","article-title":"Neuroradiologic manifestations of Loeys-Dietz syndrome type 1","volume":"30","author":"Rodrigues VJ","year":"2009","unstructured":"Rodrigues VJ, Elsayed S, Loeys BL, Dietz HC, Yousem DM: Neuroradiologic manifestations of Loeys-Dietz syndrome type 1. AJNR Am J Neuroradiol 30:1614\u20131619, 200910.3174\/ajnr.A165119556353"},{"key":"b56","series-title":"Curr Hypertens Rev","doi-asserted-by":"publisher","first-page":"37","DOI":"10.2174\/1573402111309010007","article-title":"The genetics of vascular complications in autosomal dominant polycystic kidney disease (ADPKD)","volume":"9","author":"Rossetti S","year":"2013","unstructured":"Rossetti S, Harris PC: The genetics of vascular complications in autosomal dominant polycystic kidney disease (ADPKD). Curr Hypertens Rev 9:37\u201343, 201310.2174\/157340211130901000723971643"},{"key":"b57","series-title":"Cardiovasc Pathol","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.carpath.2007.06.001","article-title":"A comparison of genetic chromosomal loci for intracranial, thoracic aortic, and abdominal aortic aneurysms in search of common genetic risk factors","volume":"17","author":"Ruigrok YM","year":"2008","unstructured":"Ruigrok YM, Elias R, Wijmenga C, Rinkel GJ: A comparison of genetic chromosomal loci for intracranial, thoracic aortic, and abdominal aortic aneurysms in search of common genetic risk factors. Cardiovasc Pathol 17:40\u201347, 200810.1016\/j.carpath.2007.06.00118160059"},{"key":"b58","series-title":"A review. Stroke","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1161\/01.STR.25.4.889","article-title":"Neurovascular manifestations of heritable connective tissue disorders","volume":"25","author":"Schievink WI","year":"1994","unstructured":"Schievink WI, Michels VV, Piepgras DG: Neurovascular manifestations of heritable connective tissue disorders. A review. Stroke 25:889\u2013903, 199410.1161\/01.STR.25.4.8898160237"},{"key":"b59","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1161\/STROKEAHA.108.532036","article-title":"Genomics of human intracranial aneurysm wall","volume":"40","author":"Shi C","year":"2009","unstructured":"Shi C, Awad IA, Jafari N, Lin S, Du P, Hage ZA, : Genomics of human intracranial aneurysm wall. Stroke 40:1252\u20131261, 20091922884510.1161\/STROKEAHA.108.532036"},{"key":"b60","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S0090-3019(03)00323-9","article-title":"Apolipoprotein E \u03b54 and the risk of unfavorable outcome after aneurysmal subarachnoid hemorrhage","volume":"60","author":"Tang J","year":"2003","unstructured":"Tang J, Zhao J, Zhao Y, Wang S, Chen B, Zeng W: Apolipoprotein E \u03b54 and the risk of unfavorable outcome after aneurysmal subarachnoid hemorrhage. Surg Neurol 60:391\u2013397, 200310.1016\/S0090-3019(03)00323-914572957"},{"key":"b61","series-title":"J Am Soc Nephrol","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1681\/ASN.V1211","article-title":"Vascular expression of polycystin-2","volume":"12","author":"Torres VE","year":"2001","unstructured":"Torres VE, Cai Y, Chen X, Wu GQ, Geng L, Cleghorn KA, : Vascular expression of polycystin-2. J Am Soc Nephrol 12:1\u20139, 20011113424410.1681\/ASN.V1211"},{"key":"b62","series-title":"Am J Hum Genet","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1086\/382285","article-title":"Intracranial aneurysms in Finnish families: confirmation of linkage and refinement of the interval to chromosome 19q13.3","volume":"74","author":"van der Voet M","year":"2004","unstructured":"van der Voet M, Olson JM, Kuivaniemi H, Dudek DM, Skunca M, Ronkainen A, : Intracranial aneurysms in Finnish families: confirmation of linkage and refinement of the interval to chromosome 19q13.3. Am J Hum Genet 74:564\u2013571, 200410.1086\/38228514872410"},{"key":"b63","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1161\/01.STR.0000128707.48644.7e","article-title":"Plasminogen activator inhibitor-1 4G allele in the 4G\/5G promoter polymorphism increases the occurrence of cerebral ischemia after aneurysmal subarachnoid hemorrhage","volume":"35","author":"Vergouwen MD","year":"2004","unstructured":"Vergouwen MD, Frijns CJ, Roos YB, Rinkel GJ, Baas F, Vermeulen M: Plasminogen activator inhibitor-1 4G allele in the 4G\/5G promoter polymorphism increases the occurrence of cerebral ischemia after aneurysmal subarachnoid hemorrhage. Stroke 35:1280\u20131283, 200410.1161\/01.STR.0000128707.48644.7e15105509"},{"key":"b64","series-title":"Nature","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/nature08801","article-title":"Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice","volume":"464","author":"Visel A","year":"2010","unstructured":"Visel A, Zhu Y, May D, Afzal V, Gong E, Attanasio C, : Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice. Nature 464:409\u2013412, 20102017373610.1038\/nature08801"},{"key":"b65","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"2670","DOI":"10.1161\/STROKEAHA.107.486225","article-title":"Association of kallikrein gene polymorphisms with intracranial aneurysms","volume":"38","author":"Weinsheimer S","year":"2007","unstructured":"Weinsheimer S, Goddard KA, Parrado AR, Lu Q, Sinha M, Lebedeva ER, : Association of kallikrein gene polymorphisms with intracranial aneurysms. Stroke 38:2670\u20132676, 20071776191910.1161\/STROKEAHA.107.486225"},{"key":"b66","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1161\/STROKEAHA.110.578740","article-title":"Screening for intracranial aneurysm in 355 patients with autosomal-dominant polycystic kidney disease","volume":"42","author":"Xu HW","year":"2011","unstructured":"Xu HW, Yu SQ, Mei CL, Li MH: Screening for intracranial aneurysm in 355 patients with autosomal-dominant polycystic kidney disease. Stroke 42:204\u2013206, 20112116413010.1161\/STROKEAHA.110.578740"},{"key":"b67","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1161\/STROKEAHA.114.007286","article-title":"Genetic study of intracranial aneurysms","volume":"46","author":"Yan J","year":"2015","unstructured":"Yan J, Hitomi T, Takenaka K, Kato M, Kobayashi H, Okuda H, : Genetic study of intracranial aneurysms. Stroke 46:620\u2013626, 201510.1161\/STROKEAHA.114.00728625649796"},{"key":"b68","series-title":"Circ Genom Precis Med","doi-asserted-by":"publisher","first-page":"e002099","DOI":"10.1161\/CIRCGEN.117.002099","article-title":"Rho guanine nucleotide exchange factor ARHGEF17 is a risk gene for intracranial aneurysms","volume":"11","author":"Yang X","year":"2018","unstructured":"Yang X, Li J, Fang Y, Zhang Z, Jin D, Chen X, : Rho guanine nucleotide exchange factor ARHGEF17 is a risk gene for intracranial aneurysms. Circ Genom Precis Med 11:e002099, 20182999722510.1161\/CIRCGEN.117.002099"},{"key":"b69","series-title":"Nat Genet","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/ng.563","article-title":"Genome-wide association study of intracranial aneurysm identifies three new risk loci","volume":"42","author":"Yasuno K","year":"2010","unstructured":"Yasuno K, Bilguvar K, Bijlenga P, Low SK, Krischek B, Auburger G, : Genome-wide association study of intracranial aneurysm identifies three new risk loci. Nat Genet 42:420\u2013425, 20102036413710.1038\/ng.563"},{"key":"b70","series-title":"J Hum Genet","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s10038-003-0030-6","article-title":"Association of positional and functional candidate genes FGF1, FBN2, and LOX on 5q31 with intracranial aneurysm","volume":"48","author":"Yoneyama T","year":"2003","unstructured":"Yoneyama T, Kasuya H, Onda H, Akagawa H, Jinnai N, Nakajima T, : Association of positional and functional candidate genes FGF1, FBN2, and LOX on 5q31 with intracranial aneurysm. J Hum Genet 48:309\u2013314, 20031275096310.1007\/s10038-003-0030-6"},{"key":"b71","series-title":"World Neurosurg","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.wneu.2017.04.064","article-title":"DNA methylation regulates gene expression in intracranial aneurysms","volume":"105","author":"Yu L","year":"2017","unstructured":"Yu L, Wang J, Wang S, Zhang D, Zhao Y, Wang R, : DNA methylation regulates gene expression in intracranial aneurysms. World Neurosurg 105:28\u201336, 20172843385110.1016\/j.wneu.2017.04.064"},{"key":"b72","series-title":"J Mol Neurosci","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s12031-018-1134-y","article-title":"Genetic risk factors for intracranial aneurysm in the Kazakh population","volume":"66","author":"Zholdybayeva EV","year":"2018","unstructured":"Zholdybayeva EV, Medetov YZ, Aitkulova AM, Makhambetov YT, Akshulakov SK, Kaliyev AB, : Genetic risk factors for intracranial aneurysm in the Kazakh population. J Mol Neurosci 66:135\u2013145, 201810.1007\/s12031-018-1134-y30121816"},{"key":"b73","series-title":"Am J Hum Genet","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1016\/j.ajhg.2016.09.001","article-title":"RNF213 is associated with intracranial aneurysms in the French-Canadian population","volume":"99","author":"Zhou S","year":"2016","unstructured":"Zhou S, Ambalavanan A, Rochefort D, Xie P, Bourassa CV, Hince P, : RNF213 is associated with intracranial aneurysms in the French-Canadian population. Am J Hum Genet 99:1072\u20131085, 201610.1016\/j.ajhg.2016.09.00127745834"},{"key":"b74","series-title":"Sci Rep","doi-asserted-by":"publisher","first-page":"4356","DOI":"10.1038\/s41598-018-21603-7","article-title":"Genome-wide association analysis identifies new candidate risk loci for familial intracranial aneurysm in the French-Canadian population","volume":"8","author":"Zhou S","year":"2018","unstructured":"Zhou S, Gan-Or Z, Ambalavanan A, Lai D, Xie P, Bourassa CV, : Genome-wide association analysis identifies new candidate risk loci for familial intracranial aneurysm in the French-Canadian population. Sci Rep 8:4356, 201810.1038\/s41598-018-21603-729531279"},{"key":"b75","series-title":"DNA Cell Biol","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1089\/dna.2016.3499","article-title":"DNA methylation of the PDGFD gene promoter increases the risk for intracranial aneurysms and brain arteriovenous malformations","volume":"36","author":"Zhou S","year":"2017","unstructured":"Zhou S, Gao X, Sun J, Lin Z, Huang Y: DNA methylation of the PDGFD gene promoter increases the risk for intracranial aneurysms and brain arteriovenous malformations. DNA Cell Biol 36:436\u2013442, 201710.1089\/dna.2016.349928346846"},{"key":"b76","series-title":"Am J Hum Genet","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.ajhg.2019.03.014","article-title":"Somatic PDGFRB activating variants in fusiform cerebral aneurysms","volume":"104","author":"Karasozen Y","year":"2019","unstructured":"Karasozen Y, Osbun JW, Parada CA, Busald T, Tatman P, Gonzalez-Cuyar LF, : Somatic PDGFRB activating variants in fusiform cerebral aneurysms. Am J Hum Genet 104:968\u2013976, 20193103101110.1016\/j.ajhg.2019.03.014"},{"key":"b1","series-title":"Hum Mol Genet","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1093\/hmg\/ddl096","article-title":"A haplotype spanning two genes, ELN and LIMK1, decreases their transcripts and confers susceptibility to intracranial aneurysms","volume":"15","author":"Akagawa H","year":"2006","unstructured":"Akagawa H, Tajima A, Sakamoto Y, Krischek B, Yoneyama T, Kasuya H, : A haplotype spanning two genes, ELN and LIMK1, decreases their transcripts and confers susceptibility to intracranial aneurysms. Hum Mol Genet 15:1722\u20131734, 200610.1093\/hmg\/ddl09616611674"},{"key":"b2","series-title":"J Hum Genet","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/jhg.2010.82","article-title":"Genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms","volume":"55","author":"Akiyama K","year":"2010","unstructured":"Akiyama K, Narita A, Nakaoka H, Cui T, Takahashi T, Yasuno K, : Genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms. J Hum Genet 55:656\u2013661, 20102061376610.1038\/jhg.2010.82"},{"key":"b3","series-title":"Br J Neurosurg","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1080\/02688697.2018.1427213","article-title":"Association of functional MMP-2 gene variant with intracranial aneurysms: case-control genetic association study and meta-analysis","volume":"32","author":"Alg VS","year":"2018","unstructured":"Alg VS, Ke X, Grieve J, Bonner S, Walsh DC, Bulters D, : Association of functional MMP-2 gene variant with intracranial aneurysms: case-control genetic association study and meta-analysis. Br J Neurosurg 32:255\u2013259, 201810.1080\/02688697.2018.142721329334797"},{"key":"b4","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"2154","DOI":"10.1212\/WNL.0b013e318295d751","article-title":"Genetic risk factors for intracranial aneurysms: a meta-analysis in more than 116,000 individuals","volume":"80","author":"Alg VS","year":"2013","unstructured":"Alg VS, Sofat R, Houlden H, Werring DJ: Genetic risk factors for intracranial aneurysms: a meta-analysis in more than 116,000 individuals. Neurology 80:2154\u20132165, 201310.1212\/WNL.0b013e318295d75123733552"},{"key":"b5","series-title":"J Radiol Case Rep","first-page":"1","article-title":"Ruptured berry aneurysm as the initial presentation of polycystic kidney disease: a case report and review of literature","volume":"12","author":"AlNuaimi D","year":"2018","unstructured":"AlNuaimi D, AlKetbi R, AlFalahi A, AlBastaki U, Pierre-Jerome C: Ruptured berry aneurysm as the initial presentation of polycystic kidney disease: a case report and review of literature. J Radiol Case Rep 12:1\u20138, 201830651918"},{"key":"b6","series-title":"Sci Signal","doi-asserted-by":"publisher","first-page":"eaah6037","DOI":"10.1126\/scisignal.aah6037","article-title":"Prostaglandin E2-EP2-NF-\u03baB signaling in macrophages as a potential therapeutic target for intracranial aneurysms","volume":"10","author":"Aoki T","year":"2017","unstructured":"Aoki T, Fr\u020dsen J, Fukuda M, Bando K, Shioi G, Tsuji K, : Prostaglandin E2-EP2-NF-\u03baB signaling in macrophages as a potential therapeutic target for intracranial aneurysms. Sci Signal 10:eaah6037, 20172817428010.1126\/scisignal.aah6037"},{"key":"b7","series-title":"Circulation","doi-asserted-by":"publisher","first-page":"2830","DOI":"10.1161\/CIRCULATIONAHA.107.728303","article-title":"NF-\u03baB is a key mediator of cerebral aneurysm formation","volume":"116","author":"Aoki T","year":"2007","unstructured":"Aoki T, Kataoka H, Shimamura M, Nakagami H, Wakayama K, Moriwaki T, : NF-\u03baB is a key mediator of cerebral aneurysm formation. Circulation 116:2830\u20132840, 20071802553510.1161\/CIRCULATIONAHA.107.728303"},{"key":"b8","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3171\/2015.7.JNS154","article-title":"ADAMTS genes and the risk of cerebral aneurysm","volume":"125","author":"Arning A","year":"2016","unstructured":"Arning A, Jeibmann A, K\u00f6hnemann S, Brokinkel B, Ewelt C, Berger K, : ADAMTS genes and the risk of cerebral aneurysm. J Neurosurg 125:269\u2013274, 20162674548410.3171\/2015.7.JNS154"},{"key":"b9","series-title":"Cerebrovasc Dis","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1159\/000354161","article-title":"Gene expression profile of blood cells for the prediction of delayed cerebral ischemia after intracranial aneurysm rupture: a pilot study in humans","volume":"36","author":"Baumann A","year":"2013","unstructured":"Baumann A, Devaux Y, Audibert G, Zhang L, Bracard S, Colnat-Coulbois S, : Gene expression profile of blood cells for the prediction of delayed cerebral ischemia after intracranial aneurysm rupture: a pilot study in humans. Cerebrovasc Dis 36:236\u2013242, 20132413553610.1159\/000354161"},{"key":"b10","series-title":"Nat Genet","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.1038\/ng.240","article-title":"Susceptibility loci for intracranial aneurysm in European and Japanese populations","volume":"40","author":"Bilguvar K","year":"2008","unstructured":"Bilguvar K, Yasuno K, Niemel\u00e4 M, Ruigrok YM, von Und Zu Fraunberg M, van Duijn CM, : Susceptibility loci for intracranial aneurysm in European and Japanese populations. Nat Genet 40:1472\u20131477, 200810.1038\/ng.24018997786"},{"key":"b11","series-title":"Clin Neurol Neurosurg","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.clineuro.2007.09.009","article-title":"Intracerebral haemorrhage as first manifestation of pseudoxanthoma elasticum","volume":"110","author":"Bock A","year":"2008","unstructured":"Bock A, Schwegler G: Intracerebral haemorrhage as first manifestation of pseudoxanthoma elasticum. Clin Neurol Neurosurg 110:262\u2013264, 20081796471210.1016\/j.clineuro.2007.09.009"},{"key":"b12","series-title":"AJNR Am J Neuroradiol","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.3174\/ajnr.A4762","article-title":"Neurovascular manifestations of hereditary hemorrhagic telangiectasia: a consecutive series of 376 patients during 15 years","volume":"37","author":"Brinjikji W","year":"2016","unstructured":"Brinjikji W, Iyer VN, Yamaki V, Lanzino G, Cloft HJ, Thielen KR, : Neurovascular manifestations of hereditary hemorrhagic telangiectasia: a consecutive series of 376 patients during 15 years. AJNR Am J Neuroradiol 37:1479\u20131486, 201610.3174\/ajnr.A476227012295"},{"key":"b13","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1161\/STROKEAHA.108.542571","article-title":"Greater rupture risk for familial as compared to sporadic unruptured intracranial aneurysms","volume":"40","author":"Broderick JP","unstructured":"Broderick JP, Brown RD Jr, Sauerbeck L, Hornung R, Huston J III, Woo D, : Greater rupture risk for familial as compared to sporadic unruptured intracranial aneurysms. Stroke 40:1952\u20131957, 200910.1161\/STROKEAHA.108.54257119228834"},{"key":"b14","series-title":"J Cereb Blood Flow Metab","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1038\/jcbfm.2012.84","article-title":"Biology of intracranial aneurysms: role of inflammation","volume":"32","author":"Chalouhi N","year":"2012","unstructured":"Chalouhi N, Ali MS, Jabbour PM, Tjoumakaris SI, Gonzalez LF, Rosenwasser RH, : Biology of intracranial aneurysms: role of inflammation. J Cereb Blood Flow Metab 32:1659\u20131676, 201210.1038\/jcbfm.2012.84"},{"key":"b15","series-title":"BMC Neurol","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/s12883-017-0986-z","article-title":"CDKN2BAS gene polymorphisms and the risk of intracranial aneurysm in the Chinese population","volume":"17","author":"Chen Y","year":"2017","unstructured":"Chen Y, Li G, Fan H, Guo S, Li R, Yin J, : CDKN2BAS gene polymorphisms and the risk of intracranial aneurysm in the Chinese population. BMC Neurol 17:214, 201710.1186\/s12883-017-0986-z29228923"},{"key":"b16","series-title":"Interv Neuroradiol","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1177\/159101990100700410","article-title":"Tuberous sclerosis complex with an unruptured intracranial aneurysm: manifestations of contiguous gene syndrome","volume":"7","author":"Chen YL","year":"2001","unstructured":"Chen YL, Luo CB, Hsu SW, Rodesch G, Lasjaunias P: Tuberous sclerosis complex with an unruptured intracranial aneurysm: manifestations of contiguous gene syndrome. Interv Neuroradiol 7:337\u2013341, 20012066336710.1177\/159101990100700410"},{"key":"b17","series-title":"Neurol India","doi-asserted-by":"publisher","first-page":"293","DOI":"10.4103\/0028-3886.115071","article-title":"The angiotensin converting enzyme insertion\/deletion polymorphism and intracranial aneurysm: a meta-analysis of case-control studies","volume":"61","author":"Chen Z","year":"2013","unstructured":"Chen Z, Ma J, Cen Y, Liu Y, You C: The angiotensin converting enzyme insertion\/deletion polymorphism and intracranial aneurysm: a meta-analysis of case-control studies. Neurol India 61:293\u2013299, 20132386015110.4103\/0028-3886.115071"},{"key":"b18","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1161\/hs1101.098329","article-title":"Lack of evidence for an association between neurofibromatosis type I and intracranial aneurysms: autopsy study and review of the literature","volume":"32","author":"Conway JE","year":"2001","unstructured":"Conway JE, Hutchins GM, Tamargo RJ: Lack of evidence for an association between neurofibromatosis type I and intracranial aneurysms: autopsy study and review of the literature. Stroke 32:2481\u20132485, 200110.1161\/hs1101.09832911692004"},{"key":"b19","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.1161\/STROKEAHA.112.656397","article-title":"Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk","volume":"43","author":"Foroud T","year":"2012","unstructured":"Foroud T, Koller DL, Lai D, Sauerbeck L, Anderson C, Ko N, : Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk. Stroke 43:2846\u20132852, 201210.1161\/STROKEAHA.112.65639722961961"},{"key":"b20","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"3194","DOI":"10.1161\/STROKEAHA.114.006096","article-title":"Genome-wide association study of intracranial aneurysm identifies a new association on chromosome 7","volume":"45","author":"Foroud T","year":"2014","unstructured":"Foroud T, Lai D, Koller D, Van\u2019t Hof F, Kurki MI, Anderson CS, : Genome-wide association study of intracranial aneurysm identifies a new association on chromosome 7. Stroke 45:3194\u20133199, 20142525618210.1161\/STROKEAHA.114.006096"},{"key":"b21","series-title":"Biol Res Nurs","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1177\/1099800408323221","article-title":"APOE genotype and functional outcome following aneurysmal subarachnoid hemorrhage","volume":"10","author":"Gallek MJ","year":"2009","unstructured":"Gallek MJ, Conley YP, Sherwood PR, Horowitz MB, Kassam A, Alexander SA: APOE genotype and functional outcome following aneurysmal subarachnoid hemorrhage. Biol Res Nurs 10:205\u2013212, 20091901766910.1177\/1099800408323221"},{"key":"b22","series-title":"Lancet Neurol","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S1474-4422(13)70263-1","article-title":"Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms: a pooled analysis of six prospective cohort studies","volume":"13","author":"Greving JP","year":"2014","unstructured":"Greving JP, Wermer MJ, Brown RD Jr, Morita A, Juvela S, Yonekura M, : Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms: a pooled analysis of six prospective cohort studies. Lancet Neurol 13:59\u201366, 20142429015910.1016\/S1474-4422(13)70263-1"},{"key":"b23","series-title":"J Am Soc Nephrol","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1681\/ASN.V84616","article-title":"Vascular expression of polycystin","volume":"8","author":"Griffin MD","year":"1997","unstructured":"Griffin MD, Torres VE, Grande JP, Kumar R: Vascular expression of polycystin. J Am Soc Nephrol 8:616\u2013626, 19971049579110.1681\/ASN.V84616"},{"key":"b24","series-title":"World Neurosurg","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.wneu.2017.02.062","article-title":"Endothelial nitric oxide synthase polymorphism is associated with delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage","volume":"101","author":"Hendrix P","year":"2017","unstructured":"Hendrix P, Foreman PM, Harrigan MR, Fisher WS III, Vyas NA, Lipsky RH, : Endothelial nitric oxide synthase polymorphism is associated with delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage. World Neurosurg 101:514\u2013519, 201710.1016\/j.wneu.2017.02.06228254540"},{"key":"b25","series-title":"World Neurosurg","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.wneu.2017.01.121","article-title":"Impact of high-mobility group box 1 polymorphism on delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage","volume":"101","author":"Hendrix P","year":"2017","unstructured":"Hendrix P, Foreman PM, Harrigan MR, Fisher WSR, Vyas NA, Lipsky RH, : Impact of high-mobility group box 1 polymorphism on delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. World Neurosurg 101:325\u2013330, 201710.1016\/j.wneu.2017.01.12128189859"},{"key":"b26","series-title":"World Neurosurg","doi-asserted-by":"publisher","first-page":"e666","DOI":"10.1016\/j.wneu.2018.07.019","article-title":"Role of apolipoprotein E genotypes in aneurysmal subarachnoid hemorrhage: susceptibility, complications, and prognosis","volume":"118","author":"Hu X","year":"2018","unstructured":"Hu X, Xie Z, Zan X, Ma L, Li H, You C, : Role of apolipoprotein E genotypes in aneurysmal subarachnoid hemorrhage: susceptibility, complications, and prognosis. World Neurosurg 118:e666\u2013e676, 201810.1016\/j.wneu.2018.07.01930010064"},{"key":"b27","series-title":"Nature","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/nature05159","article-title":"Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a","volume":"443","author":"Janzen V","year":"2006","unstructured":"Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM, : Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 443:421\u2013426, 200610.1038\/nature0515916957735"},{"key":"b28","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"989","DOI":"10.3171\/2008.11.JNS081266","article-title":"Apolipoprotein E genotype and outcome after aneurysmal subarachnoid hemorrhage","volume":"110","author":"Juvela S","year":"2009","unstructured":"Juvela S, Siironen J, Lappalainen J: Apolipoprotein E genotype and outcome after aneurysmal subarachnoid hemorrhage. J Neurosurg 110:989\u2013995, 200910.3171\/2008.11.JNS08126619199499"},{"key":"b29","series-title":"Emerg Radiol","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1007\/s10140-004-0357-0","article-title":"Autosomal dominant polycystic kidney disease presenting as subarachnoid hemorrhage","volume":"11","author":"Kanne JP","year":"2004","unstructured":"Kanne JP, Talner LB: Autosomal dominant polycystic kidney disease presenting as subarachnoid hemorrhage. Emerg Radiol 11:110\u2013112, 200410.1007\/s10140-004-0357-015801061"},{"issue":"5","key":"b30","series-title":"Neurosurg Focus","doi-asserted-by":"publisher","first-page":"E7","DOI":"10.3171\/foc.2004.17.5.7","article-title":"Update on genetic evidence for rupture-prone compared with rupture-resistant intracranial saccular aneurysms","volume":"17","author":"Khurana VG","year":"2004","unstructured":"Khurana VG, Meissner I, Meyer FB: Update on genetic evidence for rupture-prone compared with rupture-resistant intracranial saccular aneurysms. Neurosurg Focus 17(5):E7, 200410.3171\/foc.2004.17.5.715633984"},{"key":"b31","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"526","DOI":"10.3171\/jns.2005.102.3.0526","article-title":"The presence of tandem endothelial nitric oxide synthase gene polymorphisms identifying brain aneurysms more prone to rupture","volume":"102","author":"Khurana VG","year":"2005","unstructured":"Khurana VG, Meissner I, Sohni YR, Bamlet WR, McClelland RL, Cunningham JM, : The presence of tandem endothelial nitric oxide synthase gene polymorphisms identifying brain aneurysms more prone to rupture. J Neurosurg 102:526\u2013531, 20051579638910.3171\/jns.2005.102.3.0526"},{"key":"b32","series-title":"Cell","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.cell.2007.06.011","article-title":"Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells","volume":"130","author":"Kim I","year":"2007","unstructured":"Kim I, Saunders TL, Morrison SJ: Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell 130:470\u2013483, 20071765592210.1016\/j.cell.2007.06.011"},{"key":"b33","series-title":"AJNR Am J Neuroradiol","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.3174\/ajnr.A4718","article-title":"Prevalence of intracranial aneurysms in patients with connective tissue diseases: a retrospective study","volume":"37","author":"Kim ST","year":"2016","unstructured":"Kim ST, Brinjikji W, Kallmes DF: Prevalence of intracranial aneurysms in patients with connective tissue diseases: a retrospective study. AJNR Am J Neuroradiol 37:1422\u20131426, 201610.3174\/ajnr.A471826992822"},{"key":"b34","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1161\/STROKEAHA.116.012541","article-title":"RNA sequencing analysis of intracranial aneurysm walls reveals involvement of lysosomes and immunoglobulins in rupture","volume":"47","author":"Kleinloog R","year":"2016","unstructured":"Kleinloog R, Verweij BH, van der Vlies P, Deelen P, Swertz MA, de Muynck L, : RNA sequencing analysis of intracranial aneurysm walls reveals involvement of lysosomes and immunoglobulins in rupture. Stroke 47:1286\u20131293, 201610.1161\/STROKEAHA.116.01254127026628"},{"key":"b35","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"2458","DOI":"10.1161\/STROKEAHA.110.586420","article-title":"Genetic epidemiology of spontaneous subarachnoid hemorrhage: Nordic Twin Study","volume":"41","author":"Korja M","year":"2010","unstructured":"Korja M, Silventoinen K, McCarron P, Zdravkovic S, Skytthe A, Haapanen A, : Genetic epidemiology of spontaneous subarachnoid hemorrhage: Nordic Twin Study. Stroke 41:2458\u20132462, 201010.1161\/STROKEAHA.110.58642020847318"},{"key":"b36","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1136\/jnnp-2013-307276","article-title":"Evaluation of genetic risk loci for intracranial aneurysms in sporadic arteriovenous malformations of the brain","volume":"86","author":"Kremer PH","year":"2015","unstructured":"Kremer PH, Koeleman BP, Pawlikowska L, Weinsheimer S, Bendjilali N, Sidney S, : Evaluation of genetic risk loci for intracranial aneurysms in sporadic arteriovenous malformations of the brain. J Neurol Neurosurg Psychiatry 86:524\u2013529, 20152505376910.1136\/jnnp-2013-307276"},{"key":"b37","series-title":"Neuroscience","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.neuroscience.2010.05.002","article-title":"Association of the Jun dimerization protein 2 gene with intracranial aneurysms in Japanese and Korean cohorts as compared to a Dutch cohort","volume":"169","author":"Krischek B","year":"2010","unstructured":"Krischek B, Tajima A, Akagawa H, Narita A, Ruigrok Y, Rinkel G, : Association of the Jun dimerization protein 2 gene with intracranial aneurysms in Japanese and Korean cohorts as compared to a Dutch cohort. Neuroscience 169:339\u2013343, 20102045240510.1016\/j.neuroscience.2010.05.002"},{"key":"b38","series-title":"PLoS Genet","doi-asserted-by":"publisher","first-page":"e1004134","DOI":"10.1371\/journal.pgen.1004134","article-title":"High risk population isolate reveals low frequency variants predisposing to intracranial aneurysms","volume":"10","author":"Kurki MI","year":"2014","unstructured":"Kurki MI, Ga\u00e1l EI, Kettunen J, Lappalainen T, Menelaou A, Anttila V, : High risk population isolate reveals low frequency variants predisposing to intracranial aneurysms. PLoS Genet 10:e1004134, 20142449784410.1371\/journal.pgen.1004134"},{"key":"b39","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1161\/STROKEAHA.117.018557","article-title":"Intracranial aneurysm-associated single-nucleotide polymorphisms alter regulatory DNA in the human circle of Willis","volume":"49","author":"Laarman MD","year":"2018","unstructured":"Laarman MD, Vermunt MW, Kleinloog R, de Boer-Bergsma JJ, Brain Bank N, Rinkel GJE, : Intracranial aneurysm-associated single-nucleotide polymorphisms alter regulatory DNA in the human circle of Willis. Stroke 49:447\u2013453, 20182930197110.1161\/STROKEAHA.117.018557"},{"key":"b40","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1161\/hs0202.102326","article-title":"Apolipoprotein e genotype and outcome in aneurysmal subarachnoid hemorrhage","volume":"33","author":"Leung CH","year":"2002","unstructured":"Leung CH, Poon WS, Yu LM, Wong GK, Ng HK: Apolipoprotein e genotype and outcome in aneurysmal subarachnoid hemorrhage. Stroke 33:548\u2013552, 20021182366810.1161\/hs0202.102326"},{"key":"b41","series-title":"Proc Natl Acad Sci U S A","doi-asserted-by":"publisher","first-page":"15207","DOI":"10.1073\/pnas.0504501102","article-title":"Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity","volume":"102","author":"Leung TH","year":"2005","unstructured":"Leung TH, Ching YP, Yam JW, Wong CM, Yau TO, Jin DY, : Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity. Proc Natl Acad Sci U S A 102:15207\u201315212, 200510.1073\/pnas.050450110216217026"},{"key":"b42","series-title":"Metab Brain Dis","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1007\/s11011-015-9712-y","article-title":"Identification of two novel critical mutations in PCNT gene resulting in microcephalic osteodysplastic primordial dwarfism type II associated with multiple intracranial aneurysms","volume":"30","author":"Li FF","year":"2015","unstructured":"Li FF, Wang XD, Zhu MW, Lou ZH, Zhang Q, Zhu CY, : Identification of two novel critical mutations in PCNT gene resulting in microcephalic osteodysplastic primordial dwarfism type II associated with multiple intracranial aneurysms. Metab Brain Dis 30:1387\u20131394, 20152623188610.1007\/s11011-015-9712-y"},{"key":"b43","series-title":"Curr Neurovasc Res","doi-asserted-by":"publisher","first-page":"294","DOI":"10.2174\/1567202611666140912114450","article-title":"A variant in the endoglin gene is associated with the development of sporadic intracranial aneurysms","volume":"11","author":"Lin Y","year":"2014","unstructured":"Lin Y, Yu H, Song W, Zhang Y, Zhang C, Zhu Y, : A variant in the endoglin gene is associated with the development of sporadic intracranial aneurysms. Curr Neurovasc Res 11:294\u2013301, 201410.2174\/156720261166614091211445025219660"},{"key":"b44","series-title":"Nat Genet","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/ng1511","article-title":"A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2","volume":"37","author":"Loeys BL","year":"2005","unstructured":"Loeys BL, Chen J, Neptune ER, Judge DP, Podowski M, Holm T, : A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. Nat Genet 37:275\u2013281, 200510.1038\/ng1511"},{"key":"b45","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1056\/NEJMoa055695","article-title":"Aneurysm syndromes caused by mutations in the TGF-\u03b2 receptor","volume":"355","author":"Loeys BL","year":"2006","unstructured":"Loeys BL, Schwarze U, Holm T, Callewaert BL, Thomas GH, Pannu H, : Aneurysm syndromes caused by mutations in the TGF-\u03b2 receptor. N Engl J Med 355:788\u2013798, 200610.1056\/NEJMoa05569516928994"},{"key":"b46","series-title":"Nephrol Dial Transplant","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1093\/ndt\/12.9.1900","article-title":"A large TSC2 and PKD1 gene deletion is associated with renal and extrarenal signs of autosomal dominant polycystic kidney disease","volume":"12","author":"Longa L","year":"1997","unstructured":"Longa L, Scolari F, Brusco A, Carbonara C, Polidoro S, Valzorio B, : A large TSC2 and PKD1 gene deletion is associated with renal and extrarenal signs of autosomal dominant polycystic kidney disease. Nephrol Dial Transplant 12:1900\u20131907, 199710.1093\/ndt\/12.9.19009306341"},{"key":"b47","series-title":"J Hum Genet","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/jhg.2010.169","article-title":"Impact of LIMK1, MMP2 and TNF-\u03b1 variations for intracranial aneurysm in Japanese population","volume":"56","author":"Low SK","year":"2011","unstructured":"Low SK, Zembutsu H, Takahashi A, Kamatani N, Cha PC, Hosono N, : Impact of LIMK1, MMP2 and TNF-\u03b1 variations for intracranial aneurysm in Japanese population. J Hum Genet 56:211\u2013216, 201110.1038\/jhg.2010.16921228795"},{"key":"b48","series-title":"AJR Am J Roentgenol","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.2214\/ajr.136.5.1023","article-title":"Pseudoxanthoma elasticum with internal carotid artery aneurysm","volume":"136","author":"Munyer TP","year":"1981","unstructured":"Munyer TP, Margulis AR: Pseudoxanthoma elasticum with internal carotid artery aneurysm. AJR Am J Roentgenol 136:1023\u20131024, 1981678450510.2214\/ajr.136.5.1023"},{"key":"b49","series-title":"Nat Rev Genet","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/35056009","article-title":"Modifier genes in mice and humans","volume":"2","author":"Nadeau JH","year":"2001","unstructured":"Nadeau JH: Modifier genes in mice and humans. Nat Rev Genet 2:165\u2013174, 200110.1038\/3505600911256068"},{"key":"b50","series-title":"Neurol Neurochir Pol","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.pjnns.2017.08.007","article-title":"Natural history of intracranial aneurysms in autosomal dominant polycystic kidney disease","volume":"51","author":"Niemczyk M","year":"2017","unstructured":"Niemczyk M, Gradzik M, Fliszkiewicz M, Kulesza A, Go\u0142\u0119biowski M, P\u0105czek L: Natural history of intracranial aneurysms in autosomal dominant polycystic kidney disease. Neurol Neurochir Pol 51:476\u2013480, 20172884377010.1016\/j.pjnns.2017.08.007"},{"key":"b51","series-title":"Lancet Neurol","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/S1474-4422(09)70126-7","article-title":"Changes in case fatality of aneurysmal subarachnoid haemorrhage over time, according to age, sex, and region: a meta-analysis","volume":"8","author":"Nieuwkamp DJ","year":"2009","unstructured":"Nieuwkamp DJ, Setz LE, Algra A, Linn FH, de Rooij NK, Rinkel GJ: Changes in case fatality of aneurysmal subarachnoid haemorrhage over time, according to age, sex, and region: a meta-analysis. Lancet Neurol 8:635\u2013642, 20091950102210.1016\/S1474-4422(09)70126-7"},{"key":"b52","series-title":"Neurosurg Rev","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s10143-016-0761-4","article-title":"Relationship between endothelial nitric oxide synthase (eNOS) and natural history of intracranial aneurysms: meta-analysis","volume":"41","author":"Paschoal EHA","year":"2018","unstructured":"Paschoal EHA, Yamaki VN, Teixeira RKC, Paschoal Junior FM, Jong-A-Liem GS, Teixeira MJ, : Relationship between endothelial nitric oxide synthase (eNOS) and natural history of intracranial aneurysms: meta-analysis. Neurosurg Rev 41:87\u201394, 201810.1007\/s10143-016-0761-427339197"},{"key":"b53","series-title":"Int J Mol Sci","doi-asserted-by":"publisher","first-page":"E1245","DOI":"10.3390\/ijms19041245","article-title":"NF-\u03baB-mediated inflammation in the pathogenesis of intracranial aneurysm and subarachnoid hemorrhage. Does autophagy play a role?","volume":"19","author":"Pawlowska E","year":"2018","unstructured":"Pawlowska E, Szczepanska J, Wisniewski K, Tokarz P, Jask\u00f3lski DJ, Blasiak J: NF-\u03baB-mediated inflammation in the pathogenesis of intracranial aneurysm and subarachnoid hemorrhage. Does autophagy play a role? Int J Mol Sci 19:E1245, 20182967182810.3390\/ijms19041245"},{"key":"b54","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1161\/01.STR.29.1.251","article-title":"Prevalence and risk of rupture of intracranial aneurysms: a systematic review","volume":"29","author":"Rinkel GJ","year":"1998","unstructured":"Rinkel GJ, Djibuti M, Algra A, van Gijn J: Prevalence and risk of rupture of intracranial aneurysms: a systematic review. Stroke 29:251\u2013256, 199810.1161\/01.STR.29.1.2519445359"},{"key":"b55","series-title":"AJNR Am J Neuroradiol","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.3174\/ajnr.A1651","article-title":"Neuroradiologic manifestations of Loeys-Dietz syndrome type 1","volume":"30","author":"Rodrigues VJ","year":"2009","unstructured":"Rodrigues VJ, Elsayed S, Loeys BL, Dietz HC, Yousem DM: Neuroradiologic manifestations of Loeys-Dietz syndrome type 1. AJNR Am J Neuroradiol 30:1614\u20131619, 200910.3174\/ajnr.A165119556353"},{"key":"b56","series-title":"Curr Hypertens Rev","doi-asserted-by":"publisher","first-page":"37","DOI":"10.2174\/1573402111309010007","article-title":"The genetics of vascular complications in autosomal dominant polycystic kidney disease (ADPKD)","volume":"9","author":"Rossetti S","year":"2013","unstructured":"Rossetti S, Harris PC: The genetics of vascular complications in autosomal dominant polycystic kidney disease (ADPKD). Curr Hypertens Rev 9:37\u201343, 201310.2174\/157340211130901000723971643"},{"key":"b57","series-title":"Cardiovasc Pathol","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.carpath.2007.06.001","article-title":"A comparison of genetic chromosomal loci for intracranial, thoracic aortic, and abdominal aortic aneurysms in search of common genetic risk factors","volume":"17","author":"Ruigrok YM","year":"2008","unstructured":"Ruigrok YM, Elias R, Wijmenga C, Rinkel GJ: A comparison of genetic chromosomal loci for intracranial, thoracic aortic, and abdominal aortic aneurysms in search of common genetic risk factors. Cardiovasc Pathol 17:40\u201347, 200810.1016\/j.carpath.2007.06.00118160059"},{"key":"b58","series-title":"A review. Stroke","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1161\/01.STR.25.4.889","article-title":"Neurovascular manifestations of heritable connective tissue disorders","volume":"25","author":"Schievink WI","year":"1994","unstructured":"Schievink WI, Michels VV, Piepgras DG: Neurovascular manifestations of heritable connective tissue disorders. A review. Stroke 25:889\u2013903, 199410.1161\/01.STR.25.4.8898160237"},{"key":"b59","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1161\/STROKEAHA.108.532036","article-title":"Genomics of human intracranial aneurysm wall","volume":"40","author":"Shi C","year":"2009","unstructured":"Shi C, Awad IA, Jafari N, Lin S, Du P, Hage ZA, : Genomics of human intracranial aneurysm wall. Stroke 40:1252\u20131261, 20091922884510.1161\/STROKEAHA.108.532036"},{"key":"b60","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S0090-3019(03)00323-9","article-title":"Apolipoprotein E \u03b54 and the risk of unfavorable outcome after aneurysmal subarachnoid hemorrhage","volume":"60","author":"Tang J","year":"2003","unstructured":"Tang J, Zhao J, Zhao Y, Wang S, Chen B, Zeng W: Apolipoprotein E \u03b54 and the risk of unfavorable outcome after aneurysmal subarachnoid hemorrhage. Surg Neurol 60:391\u2013397, 200310.1016\/S0090-3019(03)00323-914572957"},{"key":"b61","series-title":"J Am Soc Nephrol","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1681\/ASN.V1211","article-title":"Vascular expression of polycystin-2","volume":"12","author":"Torres VE","year":"2001","unstructured":"Torres VE, Cai Y, Chen X, Wu GQ, Geng L, Cleghorn KA, : Vascular expression of polycystin-2. J Am Soc Nephrol 12:1\u20139, 20011113424410.1681\/ASN.V1211"},{"key":"b62","series-title":"Am J Hum Genet","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1086\/382285","article-title":"Intracranial aneurysms in Finnish families: confirmation of linkage and refinement of the interval to chromosome 19q13.3","volume":"74","author":"van der Voet M","year":"2004","unstructured":"van der Voet M, Olson JM, Kuivaniemi H, Dudek DM, Skunca M, Ronkainen A, : Intracranial aneurysms in Finnish families: confirmation of linkage and refinement of the interval to chromosome 19q13.3. Am J Hum Genet 74:564\u2013571, 200410.1086\/38228514872410"},{"key":"b63","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1161\/01.STR.0000128707.48644.7e","article-title":"Plasminogen activator inhibitor-1 4G allele in the 4G\/5G promoter polymorphism increases the occurrence of cerebral ischemia after aneurysmal subarachnoid hemorrhage","volume":"35","author":"Vergouwen MD","year":"2004","unstructured":"Vergouwen MD, Frijns CJ, Roos YB, Rinkel GJ, Baas F, Vermeulen M: Plasminogen activator inhibitor-1 4G allele in the 4G\/5G promoter polymorphism increases the occurrence of cerebral ischemia after aneurysmal subarachnoid hemorrhage. Stroke 35:1280\u20131283, 200410.1161\/01.STR.0000128707.48644.7e15105509"},{"key":"b64","series-title":"Nature","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1038\/nature08801","article-title":"Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice","volume":"464","author":"Visel A","year":"2010","unstructured":"Visel A, Zhu Y, May D, Afzal V, Gong E, Attanasio C, : Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice. Nature 464:409\u2013412, 20102017373610.1038\/nature08801"},{"key":"b65","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"2670","DOI":"10.1161\/STROKEAHA.107.486225","article-title":"Association of kallikrein gene polymorphisms with intracranial aneurysms","volume":"38","author":"Weinsheimer S","year":"2007","unstructured":"Weinsheimer S, Goddard KA, Parrado AR, Lu Q, Sinha M, Lebedeva ER, : Association of kallikrein gene polymorphisms with intracranial aneurysms. Stroke 38:2670\u20132676, 20071776191910.1161\/STROKEAHA.107.486225"},{"key":"b66","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1161\/STROKEAHA.110.578740","article-title":"Screening for intracranial aneurysm in 355 patients with autosomal-dominant polycystic kidney disease","volume":"42","author":"Xu HW","year":"2011","unstructured":"Xu HW, Yu SQ, Mei CL, Li MH: Screening for intracranial aneurysm in 355 patients with autosomal-dominant polycystic kidney disease. Stroke 42:204\u2013206, 20112116413010.1161\/STROKEAHA.110.578740"},{"key":"b67","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1161\/STROKEAHA.114.007286","article-title":"Genetic study of intracranial aneurysms","volume":"46","author":"Yan J","year":"2015","unstructured":"Yan J, Hitomi T, Takenaka K, Kato M, Kobayashi H, Okuda H, : Genetic study of intracranial aneurysms. Stroke 46:620\u2013626, 201510.1161\/STROKEAHA.114.00728625649796"},{"key":"b68","series-title":"Circ Genom Precis Med","doi-asserted-by":"publisher","first-page":"e002099","DOI":"10.1161\/CIRCGEN.117.002099","article-title":"Rho guanine nucleotide exchange factor ARHGEF17 is a risk gene for intracranial aneurysms","volume":"11","author":"Yang X","year":"2018","unstructured":"Yang X, Li J, Fang Y, Zhang Z, Jin D, Chen X, : Rho guanine nucleotide exchange factor ARHGEF17 is a risk gene for intracranial aneurysms. Circ Genom Precis Med 11:e002099, 20182999722510.1161\/CIRCGEN.117.002099"},{"key":"b69","series-title":"Nat Genet","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/ng.563","article-title":"Genome-wide association study of intracranial aneurysm identifies three new risk loci","volume":"42","author":"Yasuno K","year":"2010","unstructured":"Yasuno K, Bilguvar K, Bijlenga P, Low SK, Krischek B, Auburger G, : Genome-wide association study of intracranial aneurysm identifies three new risk loci. Nat Genet 42:420\u2013425, 20102036413710.1038\/ng.563"},{"key":"b70","series-title":"J Hum Genet","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s10038-003-0030-6","article-title":"Association of positional and functional candidate genes FGF1, FBN2, and LOX on 5q31 with intracranial aneurysm","volume":"48","author":"Yoneyama T","year":"2003","unstructured":"Yoneyama T, Kasuya H, Onda H, Akagawa H, Jinnai N, Nakajima T, : Association of positional and functional candidate genes FGF1, FBN2, and LOX on 5q31 with intracranial aneurysm. J Hum Genet 48:309\u2013314, 20031275096310.1007\/s10038-003-0030-6"},{"key":"b71","series-title":"World Neurosurg","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.wneu.2017.04.064","article-title":"DNA methylation regulates gene expression in intracranial aneurysms","volume":"105","author":"Yu L","year":"2017","unstructured":"Yu L, Wang J, Wang S, Zhang D, Zhao Y, Wang R, : DNA methylation regulates gene expression in intracranial aneurysms. World Neurosurg 105:28\u201336, 20172843385110.1016\/j.wneu.2017.04.064"},{"key":"b72","series-title":"J Mol Neurosci","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s12031-018-1134-y","article-title":"Genetic risk factors for intracranial aneurysm in the Kazakh population","volume":"66","author":"Zholdybayeva EV","year":"2018","unstructured":"Zholdybayeva EV, Medetov YZ, Aitkulova AM, Makhambetov YT, Akshulakov SK, Kaliyev AB, : Genetic risk factors for intracranial aneurysm in the Kazakh population. J Mol Neurosci 66:135\u2013145, 201810.1007\/s12031-018-1134-y30121816"},{"key":"b73","series-title":"Am J Hum Genet","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1016\/j.ajhg.2016.09.001","article-title":"RNF213 is associated with intracranial aneurysms in the French-Canadian population","volume":"99","author":"Zhou S","year":"2016","unstructured":"Zhou S, Ambalavanan A, Rochefort D, Xie P, Bourassa CV, Hince P, : RNF213 is associated with intracranial aneurysms in the French-Canadian population. Am J Hum Genet 99:1072\u20131085, 201610.1016\/j.ajhg.2016.09.00127745834"},{"key":"b74","series-title":"Sci Rep","doi-asserted-by":"publisher","first-page":"4356","DOI":"10.1038\/s41598-018-21603-7","article-title":"Genome-wide association analysis identifies new candidate risk loci for familial intracranial aneurysm in the French-Canadian population","volume":"8","author":"Zhou S","year":"2018","unstructured":"Zhou S, Gan-Or Z, Ambalavanan A, Lai D, Xie P, Bourassa CV, : Genome-wide association analysis identifies new candidate risk loci for familial intracranial aneurysm in the French-Canadian population. Sci Rep 8:4356, 201810.1038\/s41598-018-21603-729531279"},{"key":"b75","series-title":"DNA Cell Biol","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1089\/dna.2016.3499","article-title":"DNA methylation of the PDGFD gene promoter increases the risk for intracranial aneurysms and brain arteriovenous malformations","volume":"36","author":"Zhou S","year":"2017","unstructured":"Zhou S, Gao X, Sun J, Lin Z, Huang Y: DNA methylation of the PDGFD gene promoter increases the risk for intracranial aneurysms and brain arteriovenous malformations. DNA Cell Biol 36:436\u2013442, 201710.1089\/dna.2016.349928346846"},{"key":"b76","series-title":"Am J Hum Genet","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.ajhg.2019.03.014","article-title":"Somatic PDGFRB activating variants in fusiform cerebral aneurysms","volume":"104","author":"Karasozen Y","year":"2019","unstructured":"Karasozen Y, Osbun JW, Parada CA, Busald T, Tatman P, Gonzalez-Cuyar LF, : Somatic PDGFRB activating variants in fusiform cerebral aneurysms. Am J Hum Genet 104:968\u2013976, 20193103101110.1016\/j.ajhg.2019.03.014"}],"container-title":["Neurosurgical Focus"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/neurosurg-focus\/47\/1\/article-pE10.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/neurosurg-focus\/47\/1\/article-pE10.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/neurosurg-focus\/47\/1\/article-pE10.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T08:34:59Z","timestamp":1779525299000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/neurosurg-focus\/47\/1\/article-pE10.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":152,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/2019.4.focus19204","relation":{},"ISSN":["1092-0684"],"issn-type":[{"value":"1092-0684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7]]}}}