{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T13:21:39Z","timestamp":1793020899949,"version":"4.5.0"},"reference-count":50,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>The most common functioning pituitary adenoma is prolactinoma. Patients with medically refractory or residual\/recurrent tumors that are not amenable to resection can be treated with stereotactic radiosurgery (SRS). The aim of this multicenter study was to evaluate the role of SRS for treating prolactinomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>This retrospective study included prolactinomas treated with SRS between 1997 and 2016 at ten institutions. Patients\u2019 clinical and treatment parameters were investigated. Patients were considered to be in endocrine remission when they had a normal level of prolactin (PRL) without requiring dopamine agonist medications. Endocrine control was defined as endocrine remission or a controlled PRL level \u2264 30 ng\/ml with dopamine agonist therapy. Other outcomes were evaluated including new-onset hormone deficiency, tumor recurrence, and new neurological complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The study cohort comprised 289 patients. The endocrine remission rates were 28%, 41%, and 54% at 3, 5, and 8 years after SRS, respectively. Following SRS, 25% of patients (72\/289) had new hormone deficiency. Sixty-three percent of the patients (127\/201) with available data attained endocrine control. Three percent of patients (9\/269) had a new visual complication after SRS. Five percent of the patients (13\/285) were recorded as having tumor progression. A pretreatment PRL level \u2264 270 ng\/ml was a predictor of endocrine remission (p = 0.005, adjusted HR 0.487). An increasing margin dose resulted in better endocrine control after SRS (p = 0.033, adjusted OR 1.087).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>In patients with medically refractory prolactinomas or a residual\/recurrent prolactinoma, SRS affords remarkable therapeutic effects in endocrine remission, endocrine control, and tumor control. New-onset hypopituitarism is the most common adverse event.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2019.4.jns183443","type":"journal-article","created":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T00:09:09Z","timestamp":1566000549000},"page":"717-726","source":"Crossref","is-referenced-by-count":20,"title":["The benefit and risk of stereotactic radiosurgery for prolactinomas: an international multicenter cohort study"],"prefix":"10.3171","volume":"133","author":[{"given":"Yi-Chieh","family":"Hung","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia;"},{"name":"Departments of Neurosurgery and Surgery, Chi-Mei Medical Center, Tainan;"},{"name":"Department of Recreation and Healthcare Management, Chia Nan University of Pharmacy and Science, Tainan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Chia","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei;"},{"name":"School of Medicine, National Yang-Ming University, Taipei, Taiwan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huai-che","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasser","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn N.","family":"Kearns","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Nabeel","sequence":"additional","affiliation":[{"name":"Gamma Knife Center Cairo, Nasser Institute Hospital, Cairo;"},{"name":"Department of Neurosurgery, Benha University, Qalubya, Egypt;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Abdel Karim","sequence":"additional","affiliation":[{"name":"Gamma Knife Center Cairo, Nasser Institute Hospital, Cairo;"},{"name":"Clinical Oncology, Ain Shams University, Cairo; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem M.","family":"Emad Eldin","sequence":"additional","affiliation":[{"name":"Gamma Knife Center Cairo, Nasser Institute Hospital, Cairo;"},{"name":"Department of Radiation Oncology, National Cancer Institute, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr M. 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