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Patients\u2019 medical histories were reviewed, and the catheters and\/or tissues were subjected to conventional histological and immunohistochemical evaluations. In addition, 3 cases were subjected to electron microscopic examination including elemental analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The majority of symptomatic obstructions were associated with distal slit catheters (17 slit, 3 open-end, and 2 unknown type). Among the autopsy cases, deaths were attributed to shunt failure in 2 cases of slit catheter obstruction, 1 case of open-end catheter obstruction, and 1 case of catheter withdrawal from the peritoneal cavity. The early tissue response consisted of a predominantly T lymphocyte accumulation with phagocytosis of graphite particles by macrophages. This is associated with proliferation of fibroblasts, mesothelial cells, and blood vessels, which can grow through the slits and occlude the catheter lumen. As the inflammation subsides after approximately 1 year, the tissue plug becomes collagenized and calcified.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>This study, supported by experimental literature in other organ systems, indicates that graphite used to coat the slit openings of distal catheters from ventriculoperitoneal shunts likely predisposes to obstruction. Neurosurgeons and manufacturers should consider the potential negative consequences of this shunt design. The authors concur with previous recommendations that slit-valve distal catheters should not be used for ventriculoperitoneal shunting unless they can be proven safe and efficacious in a controlled trial.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2019.6.jns191082","type":"journal-article","created":{"date-parts":[[2019,9,28]],"date-time":"2019-09-28T05:57:52Z","timestamp":1569650272000},"page":"1495-1502","source":"Crossref","is-referenced-by-count":3,"title":["Inflammation and obstruction of distal catheter slits in ventriculoperitoneal shunts: likely role of graphite"],"prefix":"10.3171","volume":"133","author":[{"given":"Marc R.","family":"Del Bigio","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Manitoba;"},{"name":"Children\u2019s Hospital Research Institute of Manitoba;"},{"name":"SharedHealth Manitoba;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder K.","family":"Sidhu","sequence":"additional","affiliation":[{"name":"Manitoba Institute for Materials, University of Manitoba;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin J.","family":"Kazina","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery, University of Manitoba and Health Sciences Centre; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demitre","family":"Serletis","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery, University of Manitoba and Health Sciences Centre; and"},{"name":"Manitoba Neurosurgery Laboratory, Children\u2019s Hospital Research Institute of Manitoba, Winnipeg, Mannitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1227\/NEU.0000000000000196","article-title":"Ventriculoperitoneal shunt 30-day failure rate: a retrospective international cohort study","volume":"74","author":"Al-Tamimi YZ","year":"2014","unstructured":"Al-Tamimi YZ, Sinha P, Chumas PD, Crimmins D, Drake J, Kestle J, : Ventriculoperitoneal shunt 30-day failure rate: a retrospective international cohort study. 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