{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T15:56:14Z","timestamp":1764258974654},"reference-count":11,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p>Central nervous system (CNS) candida infections are often associated with a poor prognosis. Typically, CNS candidiasis presents as meningitis or microabscesses. Here, the authors report a patient with a challenging presentation of a CNS <jats:italic>Candida<\/jats:italic> infection as a discrete, large cauda equina abscess. The patient initially presented with ventriculomegaly due to fourth ventricular outflow obstruction and a cauda equina mass. The patient was treated with a ventriculoperitoneal shunt and underwent a lumbar laminectomy for exploration of the lumbar lesion. An intradural abscess was encountered during surgery. Fungal wet mount revealed fungal elements and polymerase chain reaction confirmed the presence of <jats:italic>Candida albicans<\/jats:italic>. The patient did not have any known predisposition to fungal infections; therefore, the authors performed whole-exome sequencing using peripheral blood mononuclear cell DNA. They found heterozygous missense variants in the following genes: colony-stimulating factor 2 (<jats:italic>CSF2<\/jats:italic>) and Ras protein-specific guanine nucleotide-releasing factor 1 (<jats:italic>RASGRF1<\/jats:italic>)\u2014genes that have been specifically associated with protection from CNS candidiasis via caspase recruitment domain-containing protein 9 (CARD9) signaling, and phospholipase C gamma 2 (<jats:italic>PLCG2<\/jats:italic>)\u2014a lectin receptor involved in candidiasis. The authors\u2019 experience suggests that <jats:italic>C. albicans<\/jats:italic> can present as a cauda equina abscess. Hydrocephalus, a result of diffuse arachnoiditis, is a potential complication from intradural fungal abscesses.<\/jats:p>","DOI":"10.3171\/2019.6.spine19271","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T22:59:07Z","timestamp":1567205947000},"page":"890-893","source":"Crossref","is-referenced-by-count":4,"title":["Intradural cauda equina Candida abscess presenting with hydrocephalus: case report"],"prefix":"10.3171","volume":"31","author":[{"given":"Davis P.","family":"Argersinger","sequence":"first","affiliation":[{"name":"Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitaliy P.","family":"Natkha","sequence":"additional","affiliation":[{"name":"Department of Surgery, Texas Tech University Health Sciences Center, Lubbock, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Shepard","sequence":"additional","affiliation":[{"name":"Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland;"},{"name":"Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alissa A.","family":"Thomas","sequence":"additional","affiliation":[{"name":"University of Vermont Medical Center, Department of Neurological Sciences, Burlington, Vermont;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Oler","sequence":"additional","affiliation":[{"name":"Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter R.","family":"Williamson","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prashant","family":"Chittiboina","sequence":"additional","affiliation":[{"name":"Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland;"},{"name":"Neurosurgery Unit for Pituitary and Inheritable Disorders, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Heiss","sequence":"additional","affiliation":[{"name":"Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Immunol","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.4049\/jimmunol.1501512","article-title":"Local GM-CSF-dependent differentiation and activation of pulmonary dendritic cells and macrophages protect against progressive cryptococcal lung infection in mice","volume":"196","author":"Chen GH","year":"2016","unstructured":"Chen GH, Teitz-Tennenbaum S, Neal LM, Murdock BJ, Malachowski AN, Dils AJ, : Local GM-CSF-dependent differentiation and activation of pulmonary dendritic cells and macrophages protect against progressive cryptococcal lung infection in mice. 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