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Secondarily, they explored demographic and clinical predictors of neuropsychological performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The neuropsychological functioning of 32 patients (median age at diagnosis 10.0 years) was prospectively assessed annually for up to 6 years after surgery (median days from surgery at baseline = 72). Tumor location was predominately supratentorial (65.6%). A combination of performance-based and parent-reported measures was used to assess intelligence, memory, executive functioning, and fine motor control in all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Binomial tests at the postoperative baseline revealed that the proportion of children falling below the average range (&lt; 16th percentile) was significantly higher than the rate expected among healthy peers on measures of verbal memory, processing speed, executive functioning, and fine motor control (p &lt; 0.05). Even so, linear mixed models indicated that neuropsychological functioning at the postoperative baseline did not significantly change over time for up to 6 years after surgery across all domains. A larger tumor size was associated with a slower reaction time (p &lt; 0.01). A supratentorial tumor location and history of seizures were associated with more parent-reported executive difficulties (p &lt; 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>While radiotherapy is a known risk factor for neuropsychological deficits in pediatric brain tumor patients, findings in this study indicate that children treated for low-grade glioma with surgery alone (without radiotherapy or chemotherapy) remain susceptible to difficulties with memory, executive functioning, and motor functioning that persist over time. Over half of the children in the study sample required school support services to address neuropsychological weaknesses. Although low-grade glioma is often conceptualized as a benign tumor, children treated for this lesion require ongoing monitoring and intervention to address neuropsychological weaknesses resulting from the tumor itself as well as the surgery.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2019.9.peds19357","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T22:01:34Z","timestamp":1580508094000},"page":"251-259","source":"Crossref","is-referenced-by-count":20,"title":["Neuropsychological functioning following surgery for pediatric low-grade glioma: a prospective longitudinal study"],"prefix":"10.3171","volume":"25","author":[{"given":"Andrew M.","family":"Heitzer","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Section of Psychology, Baylor College of Medicine;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Raghubar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Psychology, Baylor College of Medicine;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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