{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:02:44Z","timestamp":1787025764403,"version":"build-2736575974"},"reference-count":39,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>\n                      The lack of a continuous, noninvasive modality for monitoring intracranial pressure (ICP) is a major obstacle in the care of pediatric patients with hydrocephalus who are at risk for intracranial hypertension. Intracranial hypertension can lead to cerebral ischemia and brain tissue hypoxia. In this study, the authors evaluated the use of near-infrared spectroscopy (NIRS) to measure regional cerebral oxygen saturation (rSO\n                      <jats:sub>2<\/jats:sub>\n                      ) in symptomatic pediatric patients with hydrocephalus concerning for elevated ICP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      The authors evaluated the NIRS rSO\n                      <jats:sub>2<\/jats:sub>\n                      trends in pediatric patients presenting with acute hydrocephalus and clinical symptoms of intracranial hypertension. NIRS rSO\n                      <jats:sub>2<\/jats:sub>\n                      values were recorded hourly before and after neurosurgical intervention. To test for significance between preoperative and postoperative values, the authors constructed a linear regression model with the rSO\n                      <jats:sub>2<\/jats:sub>\n                      values as the outcome and pre- and postsurgery cohorts as the independent variable, adjusted for age and sex, and used the generalized estimating equation method to account for within-subject correlation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Twenty-two pediatric patients underwent NIRS rSO\n                      <jats:sub>2<\/jats:sub>\n                      monitoring before and after CSF diversion surgery. The mean durations of NIRS rSO\n                      <jats:sub>2<\/jats:sub>\n                      recording pre- and postoperatively were 13.95 and 26.82 hours, respectively. The mean pre- and postoperative rSO\n                      <jats:sub>2<\/jats:sub>\n                      values were 73.84% and 80.65%, respectively, and the adjusted mean difference estimated from the regression model was 5.98% (adjusted p &lt; 0.0001), suggestive of improved cerebral oxygenation after definitive neurosurgical CSF diversion treatment. Postoperatively, all patients returned to baseline neurological status with no clinical symptoms of elevated ICP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Cerebral oxygenation trends measured by NIRS in symptomatic pediatric hydrocephalus patients with intracranial hypertension generally improve after CSF diversion surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2019.9.peds19457","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T17:01:34Z","timestamp":1580490094000},"page":"235-241","source":"Crossref","is-referenced-by-count":8,"title":["Perioperative near-infrared spectroscopy cerebral oxygen saturation in symptomatic pediatric hydrocephalus patients at risk for intracranial hypertension"],"prefix":"10.3171","volume":"25","author":[{"given":"Shih-Shan","family":"Lang","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Children\u2019s Hospital of Philadelphia;"},{"name":"Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania;"},{"name":"Center for Data Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omaditya","family":"Khanna","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Thomas Jefferson University Hospital;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie J.","family":"Atkin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, Children\u2019s Hospital of Philadelphia;"},{"name":"Department of Anesthesia, Perelman School of Medicine, University of Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy E.","family":"Palma","sequence":"additional","affiliation":[{"name":"Center for Data Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine, Children\u2019s Hospital of Philadelphia;"},{"name":"Department of Anesthesia, Perelman School of Medicine, University of Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip B.","family":"Storm","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children\u2019s Hospital of Philadelphia;"},{"name":"Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania;"},{"name":"Center for Data Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory G.","family":"Heuer","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children\u2019s Hospital of Philadelphia;"},{"name":"Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania;"},{"name":"Center for Data Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children\u2019s Hospital of Philadelphia;"},{"name":"Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania;"},{"name":"Center for Data Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela J.","family":"Waanders","sequence":"additional","affiliation":[{"name":"Center for Data Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia;"},{"name":"Division of Hematology, Oncology, and Stem Cell Transplant, Ann & Robert H. 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