{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:56:27Z","timestamp":1776272187691,"version":"3.50.1"},"reference-count":45,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>Cervical disc arthroplasty is a treatment option for symptomatic cervical disc disease. There is a paucity of literature on long-term safety outcomes, durability, and device-related failure rates. The M6-C artificial cervical disc is a device with titanium alloy endplates and a complex polymeric centerpiece. To date, trials have exhibited acceptable safety profiles.<\/jats:p><jats:p>This case series describes the presentation, management, and pathological findings of a delayed prevertebral periprosthetic mass anterior to the M6-C disc. Four patients at 3 different institutions underwent cervical disc replacement with the M6-C disc. Two to seven years postoperatively, they presented with dysphagia secondary to a compressive mass anterior to the disc. Case notes were reviewed to collect data on symptoms, management, and outcomes. The patients were systemically well and presented with progressive dysphagia. They had imaging findings of a mass anterior to the disc. They underwent a decompressive procedure, with 2 patients undergoing device removal and fusion. In 2 cases, a soft-tissue mass was seen intraoperatively, with frank pus. In 3 cases, <jats:italic>Propionibacterium acnes<\/jats:italic> was identified and antibiotic treatment given. Histopathology demonstrated mixed inflammatory infiltrates with foreign body\u2013type granulomas. Postoperatively, the dysphagia resolved.<\/jats:p><jats:p>The development of delayed dysphagia in a patient with an M6-C disc should prompt investigation to identify a mass lesion. To the authors\u2019 knowledge, this is the first report of delayed infection, or suspected delayed-type hypersensitivity reaction, following M6-C disc implantation. It is important for this to be added to the device safety concerns. Further prospective studies are needed to establish the incidence and the long-term safety and failure rates of the M6-C disc.<\/jats:p>","DOI":"10.3171\/2019.9.spine19900","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T22:55:11Z","timestamp":1576277711000},"page":"584-591","source":"Crossref","is-referenced-by-count":9,"title":["Delayed periprosthetic collection after cervical disc arthroplasty"],"prefix":"10.3171","volume":"32","author":[{"given":"Lauren","family":"Harris","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, United Kingdom; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Dyson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, United Kingdom; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Elliot","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, United Kingdom; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Peterson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, United Kingdom; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Ulbricht","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, United Kingdom; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Casey","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Eur Spine J","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1007\/s00586-013-2674-z","article-title":"Does nuclear tissue infected with bacteria following disc herniations lead to Modic changes in the adjacent vertebrae?","volume":"22","author":"Albert HB","year":"2013","unstructured":"Albert HB, Lambert P, Rollason J, Sorensen JS, Worthington T, Pedersen MB, : Does nuclear tissue infected with bacteria following disc herniations lead to Modic changes in the adjacent vertebrae? 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