{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:16:03Z","timestamp":1778318163886,"version":"3.51.4"},"reference-count":90,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Surgery for frontal lobe epilepsy remains a challenge because of the variable seizure outcomes after surgery. Disconnective procedures are increasingly applied to isolate the epileptogenic focus and avoid complications related to extensive brain resection. Previously, the authors described the anterior quadrant disconnection procedure to treat large frontal lobe lesions extending up to but not involving the primary motor cortex. In this article, they describe a surgical technique for unilateral disconnection of the prefrontal cortex, while providing an accurate description of the surgical and functional anatomy of this disconnective procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The authors report the surgical treatment of a 5-month-old boy who presented with refractory epilepsy due to extensive cortical dysplasia of the left prefrontal lobe. In addition, with the aim of both describing the subcortical intrinsic anatomy and illustrating the different connections between the prefrontal lobe and the rest of the brain, the authors dissected six human cadaveric brain hemispheres. These dissections were performed from lateral to medial and from medial to lateral to reveal the various tracts sectioned during the three different steps in the surgery, namely the intrafrontal disconnection, anterior callosotomy, and frontobasal disconnection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The first step of the dissection involves cutting the U-fibers. During the anterior intrafrontal disconnection, the superior longitudinal fasciculus in the depth of the middle frontal gyrus, the uncinate fasciculus, and the inferior frontooccipital fasciculus in the depth of the inferior frontal gyrus at the level of the anterior insular point are visualized and sectioned, followed by sectioning of the anterior limb of the internal capsule. Once the frontal horn is reached, the anterior callosotomy can be performed to disconnect the genu and the rostrum of the corpus callosum. The intrafrontal disconnection is deepened toward the falx, and at the medial surface, the cingulum is sectioned. The frontobasal disconnection involves cutting the anterior limb of the anterior commissure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>This technique allows selective isolation of the epileptogenic focus located in the prefrontal lobe to avoid secondary propagation. Understanding the surface and white matter fiber anatomy is essential to safely perform the procedure and obtain a favorable seizure outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2020.1.focus19938","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T19:35:29Z","timestamp":1585942529000},"page":"E10","source":"Crossref","is-referenced-by-count":5,"title":["Unilateral prefrontal lobotomy for epilepsy: technique and surgical anatomy"],"prefix":"10.3171","volume":"48","author":[{"given":"Giulia","family":"Cossu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University Hospital of Lausanne;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Gonz\u00e1lez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hospital General Universitario de Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etienne","family":"Pralong","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital of Lausanne;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Kalser","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Neuro-Pediatrics, University Hospital of Lausanne, Switzerland; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Messerer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital of Lausanne;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy Thomas","family":"Daniel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital of Lausanne;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Neuroimage","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.neuroimage.2006.10.047","article-title":"White matter development during late adolescence in healthy males: a cross-sectional diffusion tensor imaging study","volume":"35","author":"Ashtari M","year":"2007","unstructured":"Ashtari M, Cervellione KL, Hasan KM, Wu J, McIlree C, Kester H, : White matter development during late adolescence in healthy males: a cross-sectional diffusion tensor imaging study. 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