{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:41:10Z","timestamp":1792806070992,"version":"4.5.0"},"reference-count":14,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3]]},"abstract":"\n OBJECTIVE<\/jats:title>\n Thyroid-stimulating hormone (TSH)\u2013secreting pituitary adenoma (TSHoma) is a rare type of pituitary adenoma; thus, little is known about TSHomas. The purpose of this study was to analyze clinical characteristics and therapeutic outcomes of TSHomas based on a single-center experience. The authors also searched for reliable preoperative and early postoperative factors that could predict long-term endocrinological remission.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n The clinical, radiological, and pathological characteristics and surgical and endocrinological outcomes of 31 consecutive cases of TSHomas that were surgically treated between 2005 and 2017 were reviewed retrospectively. Preoperative factors were evaluated for their ability to predict long-term remission by comparing remission and nonremission groups. TSH and free thyroxine levels were measured at 2, 6, 12, 18, and 24 hours after surgery to determine whether they could predict long-term remission.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Gross-total removal of tumor was achieved in 28 patients (90.3%), and 26 patients (83.9%) achieved endocrinological remission by surgery alone based on long-term endocrinological follow-up (median 50 months, range 32\u201381 months). The majority of the tumors were solid (21\/31, 67.7%), and en bloc resection was possible in 16 patients (51.6%). Larger tumor size and tumor invasion into cavernous sinus and sphenoid sinus were strong predictors of lower rates of endocrinological remission. Immediate postoperative TSH level at 12 hours after surgery was the strongest predictor, with a 0.62 \u03bcIU\/mL cutoff. Postoperative complications included CSF rhinorrhea in one patient and epistaxis in another patient, who underwent additional surgical treatment for the complications.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n Tumor size and extent are major prognostic factors for both extent of resection and endocrinological remission. The consistency of TSHomas was more likely to be solid, which makes extracapsular dissection more feasible. Long-term remission of TSHomas could be predicted even during the early postoperative period.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2020.1.jns192787","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T21:57:31Z","timestamp":1584741451000},"page":"794-800","source":"Crossref","is-referenced-by-count":15,"title":["Immediate postoperative measurement of thyroid-stimulating hormone as an early predictor of remission in thyroid-stimulating hormone\u2013secreting pituitary adenomas"],"prefix":"10.3171","volume":"134","author":[{"given":"Soo Heon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Yonsei University College of Medicine, Seoul;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol Ryong","family":"Ku","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul;"},{"name":"Pituitary Tumor Center, Severance Hospital, Seoul;"},{"name":"Yonsei Endocrine Research Institute, Yonsei University College of Medicine, Seoul; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minkyun","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yonsei University College of Medicine, Seoul;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihwan","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yonsei University College of Medicine, Seoul;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woohyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yonsei University College of Medicine, Seoul;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Ho","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yonsei University College of Medicine, Seoul;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Hyung","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yonsei University College of Medicine, Seoul;"},{"name":"Pituitary Tumor Center, Severance Hospital, Seoul;"},{"name":"Yonsei Endocrine Research Institute, Yonsei University College of Medicine, Seoul; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daham","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul;"},{"name":"Pituitary Tumor Center, Severance Hospital, Seoul;"},{"name":"Yonsei Endocrine Research Institute, Yonsei University College of Medicine, Seoul; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jig","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Seoul;"},{"name":"Pituitary Tumor Center, Severance Hospital, Seoul;"},{"name":"Yonsei Endocrine Research Institute, Yonsei University College of Medicine, Seoul; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Ho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yonsei University College of Medicine, Seoul;"},{"name":"Department of Neurosurgery, Ewha Woman\u2019s University College of Medicine, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eui Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yonsei University College of Medicine, Seoul;"},{"name":"Pituitary Tumor Center, Severance Hospital, Seoul;"},{"name":"Yonsei Endocrine Research Institute, Yonsei University College of Medicine, Seoul; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"6","key":"b1","series-title":"Endocr Rev","first-page":"610","article-title":"Thyrotropin-secreting pituitary tumors","volume":"17","author":"Beck-Peccoz P","year":"1996","unstructured":"Beck-Peccoz P, Brucker-Davis F, Persani L, Thyrotropin-secreting pituitary tumors. 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