{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T09:05:50Z","timestamp":1779527150997,"version":"3.53.1"},"reference-count":28,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"\n OBJECTIVE<\/jats:title>\n Intraoperative MRI with Gd-based contrast agent (GBCA) improves the extent of resection of contrast-enhancing brain tumors. Signal changes of CSF due to perioperative GBCA leakage in the subarachnoid space have been reported. However, although GBCA potentially exhibits neurotoxic effects, so far no associated complications have been described. In this case series, the authors report a single-center cohort of patients with subarachnoid GBCA extravasation after intraoperative MRI and discuss potential neurotoxic complications and potential ways of avoiding them.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n All patients with CSF signal increase on unenhanced T1-weighted and FLAIR images on postoperative MRI, who had previously undergone tumor resection with use of intraoperative MRI, were retrospectively included and compared with a control cohort. The control group was matched in age, tumor characteristics, and extent of resection; comparisons were made regarding postoperative seizures and ICU stay. A subgroup with initially diagnosed malignant glioma was additionally analyzed for potential delay of initiation of adjuvant treatment and overall survival.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Seven patients with postoperative GBCA accumulation in the subarachnoid space were identified; 5 presented with focal seizures and altered mental status postoperatively. Poor patient condition led to extended ICU stay and prolonged delay of the initiation of adjuvant treatment in patients with newly diagnosed malignant glioma. Overall survival was reduced compared to the matched control group.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n The results suggest that there might be a risk of neurotoxic complications if GBCA that is intravenously applied during neurosurgery leaks into the subarachnoid space. Patients with highly vascularized tumors with intraoperative bleeding seem to be especially at risk for GBCA accumulation and neurotoxic complications. Therefore, awareness of the potential risk of complicating GBCA leakage is mandatory in the application of intraoperative GBCA.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2020.10.focus20402","type":"journal-article","created":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T11:31:25Z","timestamp":1609500685000},"page":"E12","source":"Crossref","is-referenced-by-count":9,"title":["Neurotoxicity of subarachnoid Gd-based contrast agent accumulation: a potential complication of intraoperative MRI?"],"prefix":"10.3171","volume":"50","author":[{"given":"Monika","family":"Lauer","sequence":"first","affiliation":[{"name":"Institute of Neuroradiology, University Hospital Frankfurt, Goethe University, Frankfurt am Main;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Lauer","sequence":"additional","affiliation":[{"name":"Institute of Neuroradiology, University Hospital Frankfurt, Goethe University, Frankfurt am Main;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se-Jong","family":"You","sequence":"additional","affiliation":[{"name":"Institute of Neuroradiology, University Hospital Frankfurt, Goethe University, Frankfurt am Main;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Kluge","sequence":"additional","affiliation":[{"name":"Institute of Neuroradiology, University Hospital Frankfurt, Goethe University, Frankfurt am Main;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Hattingen","sequence":"additional","affiliation":[{"name":"Institute of Neuroradiology, University Hospital Frankfurt, Goethe University, Frankfurt am Main;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick N.","family":"Harter","sequence":"additional","affiliation":[{"name":"Edinger Institute (Institute of Neurology), Goethe University, Frankfurt am Main;"},{"name":"German Cancer Research Center (DKFZ) Heidelberg, and German Cancer Consortium (DKTK) Frankfurt\/Mainz;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Senft","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Frankfurt, Goethe University, Frankfurt am Main; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlies","family":"Wagner","sequence":"additional","affiliation":[{"name":"Institute of Neuroradiology, University Hospital Frankfurt, Goethe University, Frankfurt am Main;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Voss","sequence":"additional","affiliation":[{"name":"Dr. Senckenberg Institute of Neurooncology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"11","key":"b1","series-title":"Lancet Oncol","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/S1470-2045(11)70196-6","article-title":"Intraoperative MRI guidance and extent of resection in glioma surgery: a randomised, controlled trial","volume":"12","author":"Senft C","year":"2011","unstructured":"Senft C, Bink A, Franz K, Intraoperative MRI guidance and extent of resection in glioma surgery: a randomised, controlled trial. 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