{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:26:39Z","timestamp":1794018399089,"version":"4.8.0"},"reference-count":40,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7]]},"abstract":"\n OBJECTIVE<\/jats:title>\n Congenital intracranial cysts account for a significant portion of intracranial lesions in the pediatric population. The efficiency of surgical treatment in a pediatric cohort with intracranial arachnoid cysts (ACs) at different locations regarding clinical symptoms and mass effect was evaluated.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n A retrospective study of all children who underwent surgical treatment of an intracranial AC during an 11-year period (2007\u20132018) was performed. Demographics, clinical symptoms, and radiological cyst size pre- and postoperatively, as well as the reoperation rate and possible treatment complications, were analyzed.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n A total of 116 intracranial cysts at 8 different anatomical locations were surgically treated in 113 children (median age 5 years and 10 months) predominantly by endoscopic technique (84%). The complication rate was 3%, and the reoperation rate was 16%. Preoperative cyst enlargement was significantly more common in infants (p < 0.0001), as was the need for reoperation (p = 0.023). After a median radiological follow-up of 26 months, > 50% reduction of cyst volume was seen in 53 cysts (46%), and 47 cysts (40%) showed a 10%\u201350% reduction. Acute clinical symptoms improved: nausea and vomiting, accelerated head growth, and headaches improved at 100%, 92% and 89%, respectively. However, chronic symptoms responded less favorably after a median clinical follow-up of 26 months.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n The strategy of predominantly endoscopic treatment with navigation planning is efficient to alleviate clinical symptoms and to significantly reduce the mass effect of pediatric intracranial cysts at different anatomical locations. The subgroup of infants requires close pre- and postoperative monitoring.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2020.10.peds20839","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T03:10:01Z","timestamp":1619752201000},"page":"102-112","source":"Crossref","is-referenced-by-count":17,"title":["Surgical management of intracranial arachnoid cysts in pediatric patients: radiological and clinical outcome"],"prefix":"10.3171","volume":"28","author":[{"given":"Matthias","family":"Schulz","sequence":"first","affiliation":[{"name":"Pediatric Neurosurgery, Campus Virchow Klinikum, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasin","family":"Oezkan","sequence":"additional","affiliation":[{"name":"Pediatric Neurosurgery, Campus Virchow Klinikum, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Schaumann","sequence":"additional","affiliation":[{"name":"Pediatric Neurosurgery, Campus Virchow Klinikum, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Sieg","sequence":"additional","affiliation":[{"name":"QUEST Center for Transforming Biomedical Research, Berlin Institute of Health, Berlin, Institute of Biometry and Clinical Epidemiology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Tietze","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Campus Virchow Klinikum, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich-Wilhelm","family":"Thomale","sequence":"additional","affiliation":[{"name":"Pediatric Neurosurgery, Campus Virchow Klinikum, Charit\u00e9-Universit\u00e4tsmedizin Berlin, corporate member of Freie Universit\u00e4t Berlin, Humboldt-Universit\u00e4t zu Berlin, and Berlin Institute of Health, Berlin;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"4","key":"r1","series-title":"J Neurol","first-page":"689","article-title":"Prevalence and symptoms of intracranial arachnoid cysts: a population-based study","volume":"263","author":"Rabiei K","year":"2016","unstructured":"Rabiei K, Jaraj D, Marlow T, . 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Clinical and radiological outcomes following surgical treatment for intra-cranial arachnoid cysts. Clin Neurol Neurosurg. 2019;177:42\u201346."},{"issue":"3","key":"r6","series-title":"Neurosurgery","first-page":"824","article-title":"Endoscopic treatment of arachnoid cysts: a detailed account of surgical techniques and results","volume":"67","author":"Oertel JM","year":"2010","unstructured":"Oertel JM, Wagner W, Mondorf Y, . Endoscopic treatment of arachnoid cysts: a detailed account of surgical techniques and results. Neurosurgery. 2010;67(3):824\u2013836."},{"issue":"5)(suppl","key":"r7","series-title":"J Neurosurg","first-page":"385","article-title":"A population-based study of intracranial arachnoid cysts: clinical and neuroimaging outcomes following surgical cyst decompression in children","volume":"105","author":"Helland CA","year":"2006","unstructured":"Helland CA, Wester K. 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