{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:41:26Z","timestamp":1792806086613,"version":"4.5.0"},"reference-count":20,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,1]]},"abstract":"<jats:p>Dysgeusia, or distorted taste, has recently been acknowledged as a complication of thalamic ablation or thalamic deep brain stimulation as a treatment of tremor. In a unique patient, left-sided MR-guided focused ultrasound thalamotomy improved right-sided essential tremor but also induced severe dysgeusia. Although dysgeusia persisted and caused substantial weight loss, tremor slowly relapsed. Therefore, 19 months after the first procedure, the patient underwent a second focused ultrasound thalamotomy procedure, which again improved tremor but also completely resolved the dysgeusia.<\/jats:p>\n                  <jats:p>On the basis of normative and patient-specific whole-brain tractography, the authors determined the relationship between the thalamotomy lesions and the medial border of the medial lemniscus\u2014a surrogate for the solitariothalamic gustatory fibers\u2014after the first and second focused ultrasound thalamotomy procedures. Both tractography methods suggested partial and complete disruption of the solitariothalamic gustatory fibers after the first and second thalamotomy procedures, respectively.<\/jats:p>\n                  <jats:p>The tractography findings in this unique patient demonstrate that incomplete and complete disruption of a neural pathway can induce and resolve symptoms, respectively, and serve as the rationale for ablative procedures for neurological and psychiatric disorders.<\/jats:p>","DOI":"10.3171\/2020.11.jns202882","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T03:06:47Z","timestamp":1641524807000},"page":"215-220","source":"Crossref","is-referenced-by-count":8,"title":["Dysgeusia induced and resolved by focused ultrasound thalamotomy: case report"],"prefix":"10.3171","volume":"136","author":[{"given":"Philippe","family":"De Vloo","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, Toronto Western Hospital\u2014University Health Network,"},{"name":"Department of Neurosurgery, University Hospitals Leuven, KU Leuven, Vlaams-Brabant, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Boutet","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, Toronto Western Hospital\u2014University Health Network,"},{"name":"Joint Department of Medical Imaging, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin J. 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Safra Program in Parkinson\u2019s Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, and Division of Neurology, University of Toronto, Ontario, Canada; and"},{"name":"Center for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement","family":"Hamani","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres M","family":"Lozano","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, Toronto Western Hospital\u2014University Health Network,"},{"name":"Krembil Research Institute, Toronto, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"9034","key":"r1","series-title":"Lancet","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1016\/S0140-6736(05)64449-2","article-title":"Dysgeusia (\"cognate, dis-gusting\")","volume":"348","author":"Lawrence C","year":"1996","unstructured":"Lawrence C. 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