{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:38:07Z","timestamp":1792809487605,"version":"4.5.0"},"reference-count":36,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>The authors compared survival and multiple comorbidities in children diagnosed with craniopharyngioma who underwent gross-total resection (GTR) versus subtotal resection (STR) with radiation therapy (RT), either intensity-modulated radiation therapy (IMRT) or proton beam therapy (PBT). The authors hypothesized that there are differences between multimodal treatment methods with respect to morbidity and progression-free survival (PFS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The medical records of children diagnosed with craniopharyngioma and treated surgically between February 1997 and December 2018 at Texas Children\u2019s Hospital were reviewed. Surgical treatment was stratified as GTR or STR + RT. RT was further stratified as PBT or IMRT; PBT was stratified as STR + PBT versus cyst decompression (CD) + PBT. The authors used Kaplan-Meier analysis to compare PFS and overall survival, and chi-square analysis to compare rates for hypopituitarism, vision loss, and hypothalamic obesity (HyOb).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Sixty-three children were included in the analysis; 49% were female. The mean age was 8.16 years (95% CI 7.08\u20139.27). Twelve of 14 children in the IMRT cohort underwent CD. The 5-year PFS rates were as follows: 73% for GTR (n = 31), 54% for IMRT (n = 14), 100% for STR + PBT (n = 7), and 77% for CD + PBT (n = 11; p = 0.202). The overall survival rates were similar in all groups. Rates of hypopituitarism (96% GTR vs 75% IMRT vs 100% STR + PBT, 50% CD + PBT; p = 0.023) and diabetes insipidus (DI) (90% GTR vs 61% IMRT vs 85% STR + PBT, 20% CD + PBT; p = 0.004) were significantly higher in the GTR group. There was no significant difference in the HyOb or vision loss at the end of study follow-up among the different groups. Within the PBT group, 2 patients presented a progressive vasculopathy with subsequent strokes. One patient experienced a PBT-induced tumor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>GTR and CD + PBT presented similar rates of 5-year PFS. Hypopituitarism and DI rates were higher with GTR, but the rate of HyOb was similar among different treatment modalities. PBT may reduce the burden of hypopituitarism and DI, although radiation carries a risk of potential serious complications, including progressive vasculopathy and secondary malignancy. Further prospective study comparing neurocognitive outcomes is necessary.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2020.11.peds20803","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T03:12:05Z","timestamp":1623381125000},"page":"152-159","source":"Crossref","is-referenced-by-count":23,"title":["Comparison of multimodal surgical and radiation treatment methods for pediatric craniopharyngioma: long-term analysis of progression-free survival and morbidity"],"prefix":"10.3171","volume":"28","author":[{"given":"Vijay M.","family":"Ravindra","sequence":"first","affiliation":[{"name":"Division of Pediatric Neurosurgery, Texas Children\u2019s Hospital, Department of Neurosurgery, Baylor College of Medicine, Houston;"},{"name":"Department of Neurosurgery, Naval Medical Center San Diego; and"},{"name":"Division of Pediatric Neurosurgery, University of California, San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Fatih","family":"Okcu","sequence":"additional","affiliation":[{"name":"Texas Children\u2019s Cancer Center, Department of Pediatrics, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Ruggieri","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, Texas Children\u2019s Hospital, Department of Neurosurgery, Baylor College of Medicine, Houston;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S.","family":"Frank","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Texas Medical Branch, Galveston;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold C.","family":"Paulino","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Texas Children\u2019s Hospital, Houston;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"McGovern","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Texas Children\u2019s Hospital, Houston;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent E.","family":"Horne","sequence":"additional","affiliation":[{"name":"Section of Pediatric Diabetes and Endocrinology, Department of Pediatrics, Texas Children\u2019s Hospital, Baylor College of Medicine, Houston, Texas;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Dauser","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, Texas Children\u2019s Hospital, Department of Neurosurgery, Baylor College of Medicine, Houston;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Whitehead","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, Texas Children\u2019s Hospital, Department of Neurosurgery, Baylor College of Medicine, Houston;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Aldave","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, Texas Children\u2019s Hospital, Department of Neurosurgery, Baylor College of Medicine, Houston;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"2","key":"b1","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s00381-012-1926-2","article-title":"A systematic review of the results of surgery and radiotherapy on tumor control for pediatric craniopharyngioma","volume":"29","author":"Clark AJ","year":"2013","unstructured":"Clark AJ, Cage TA, Aranda D, . A systematic review of the results of surgery and radiotherapy on tumor control for pediatric craniopharyngioma. Childs Nerv Syst. 2013;29(2):231\u2013238.2308993310.1007\/s00381-012-1926-2"},{"issue":"11","key":"b2","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1007\/s00381-013-2153-1","article-title":"Suprasellar pediatric craniopharyngioma resection via endonasal endoscopic approach","volume":"29","author":"Ali ZS","year":"2013","unstructured":"Ali ZS, Lang SS, Kamat AR, . Suprasellar pediatric craniopharyngioma resection via endonasal endoscopic approach. Childs Nerv Syst. 2013;29(11):2065\u20132070.10.1007\/s00381-013-2153-123702738"},{"issue":"4","key":"b3","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"547","DOI":"10.3171\/jns.1998.89.4.0547","article-title":"The descriptive epidemiology of craniopharyngioma","volume":"89","author":"Bunin GR","year":"1998","unstructured":"Bunin GR, Surawicz TS, Witman PA, . The descriptive epidemiology of craniopharyngioma. J Neurosurg. 1998;89(4):547\u2013551.976104710.3171\/jns.1998.89.4.0547"},{"issue":"6","key":"b4","series-title":"Neuro Oncol","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1093\/neuonc\/not026","article-title":"Trends in treatment and outcomes of pediatric craniopharyngioma, 1975-2011","volume":"15","author":"Cohen M","year":"2013","unstructured":"Cohen M, Bartels U, Branson H, . Trends in treatment and outcomes of pediatric craniopharyngioma, 1975-2011. Neuro Oncol. 2013;15(6):767\u2013774.2348668910.1093\/neuonc\/not026"},{"issue":"8-9","key":"b5","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1007\/s00381-005-1186-5","article-title":"Long-term results of the surgical treatment of craniopharyngioma: the experience at the Policlinico Gemelli, Catholic University, Rome","volume":"21","author":"Caldarelli M","year":"2005","unstructured":"Caldarelli M, Massimi L, Tamburrini G, . Long-term results of the surgical treatment of craniopharyngioma: the experience at the Policlinico Gemelli, Catholic University, Rome. Childs Nerv Syst. 2005;21(8-9):747\u2013757.10.1007\/s00381-005-1186-5"},{"issue":"1","key":"b6","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3171\/jns.1996.85.1.0073","article-title":"Management of childhood craniopharyngioma: can the morbidity of radical surgery be predicted?","volume":"85","author":"De Vile CJ","year":"1996","unstructured":"De Vile CJ, Grant DB, Kendall BE, . Management of childhood craniopharyngioma: can the morbidity of radical surgery be predicted?. J Neurosurg. 1996;85(1):73\u201381.10.3171\/jns.1996.85.1.00738683285"},{"issue":"1","key":"b7","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3171\/jns.1992.76.1.0047","article-title":"Aggressive surgical management of craniopharyngiomas in children","volume":"76","author":"Hoffman HJ","year":"1992","unstructured":"Hoffman HJ, De Silva M, Humphreys RP, . Aggressive surgical management of craniopharyngiomas in children. J Neurosurg. 1992;76(1):47\u201352.10.3171\/jns.1992.76.1.00471727168"},{"issue":"4","key":"b8","series-title":"Dev Med Child Neurol","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1111\/j.1469-8749.2004.tb00476.x","article-title":"Outcome of craniopharyngioma in children: long-term complications and quality of life","volume":"46","author":"Poretti A","year":"2004","unstructured":"Poretti A, Grotzer MA, Ribi K, . Outcome of craniopharyngioma in children: long-term complications and quality of life. Dev Med Child Neurol. 2004;46(4):220\u2013229.10.1111\/j.1469-8749.2004.tb00476.x15077699"},{"issue":"1","key":"b9","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3171\/jns.2002.97.1.0003","article-title":"Craniopharyngioma in adults and children: a study of 122 surgical cases","volume":"97","author":"Van Effenterre R","year":"2002","unstructured":"Van Effenterre R, Boch AL. Craniopharyngioma in adults and children: a study of 122 surgical cases. J Neurosurg. 2002;97(1):3\u201311.1213492910.3171\/jns.2002.97.1.0003"},{"issue":"1","key":"b10","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3171\/2009.7.PEDS09215","article-title":"Efficacy and safety of radical resection of primary and recurrent craniopharyngiomas in 86 children","volume":"5","author":"Elliott RE","year":"2010","unstructured":"Elliott RE, Hsieh K, Hochm T, . Efficacy and safety of radical resection of primary and recurrent craniopharyngiomas in 86 children. J Neurosurg Pediatr. 2010;5(1):30\u201348.10.3171\/2009.7.PEDS0921520043735"},{"issue":"3","key":"b11","series-title":"Int J Radiat Oncol Biol Phys","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/S0360-3016(02)02799-2","article-title":"Craniopharyngioma: the St. Jude Children\u2019s Research Hospital experience 1984-2001","volume":"53","author":"Merchant TE","year":"2002","unstructured":"Merchant TE, Kiehna EN, Sanford RA, . Craniopharyngioma: the St. Jude Children\u2019s Research Hospital experience 1984-2001. Int J Radiat Oncol Biol Phys. 2002;53(3):533\u2013542.1206259410.1016\/S0360-3016(02)02799-2"},{"issue":"2","key":"b12","series-title":"Int J Radiat Oncol Biol Phys","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.ijrobp.2010.11.027","article-title":"Dosimetric comparison of three-dimensional conformal proton radiotherapy, intensity-modulated proton therapy, and intensity-modulated radiotherapy for treatment of pediatric craniopharyngiomas","volume":"82","author":"Boehling NS","year":"2012","unstructured":"Boehling NS, Grosshans DR, Bluett JB, . Dosimetric comparison of three-dimensional conformal proton radiotherapy, intensity-modulated proton therapy, and intensity-modulated radiotherapy for treatment of pediatric craniopharyngiomas. Int J Radiat Oncol Biol Phys. 2012;82(2):643\u2013652.2127711110.1016\/j.ijrobp.2010.11.027"},{"issue":"2","key":"b13","series-title":"Int J Radiat Oncol Biol Phys","doi-asserted-by":"publisher","first-page":"e281","DOI":"10.1016\/j.ijrobp.2011.01.005","article-title":"On the benefits and risks of proton therapy in pediatric craniopharyngioma","volume":"82","author":"Beltran C","year":"2012","unstructured":"Beltran C, Roca M, Merchant TE. On the benefits and risks of proton therapy in pediatric craniopharyngioma. Int J Radiat Oncol Biol Phys. 2012;82(2):e281\u2013e287.2157020910.1016\/j.ijrobp.2011.01.005"},{"issue":"1","key":"b14","series-title":"Pediatr Blood Cancer","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1002\/pbc.21530","article-title":"Proton versus photon radiotherapy for common pediatric brain tumors: comparison of models of dose characteristics and their relationship to cognitive function","volume":"51","author":"Merchant TE","year":"2008","unstructured":"Merchant TE, Hua CH, Shukla H, . Proton versus photon radiotherapy for common pediatric brain tumors: comparison of models of dose characteristics and their relationship to cognitive function. Pediatr Blood Cancer. 2008;51(1):110\u2013117.1830627410.1002\/pbc.21530"},{"issue":"4","key":"b15","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"293","DOI":"10.3171\/2012.7.PEDS11436","article-title":"Treatment-related morbidity and the management of pediatric craniopharyngioma: a systematic review","volume":"10","author":"Clark AJ","year":"2012","unstructured":"Clark AJ, Cage TA, Aranda D, . Treatment-related morbidity and the management of pediatric craniopharyngioma: a systematic review. J Neurosurg Pediatr. 2012;10(4):293\u2013301.10.3171\/2012.7.PEDS1143622920295"},{"issue":"4","key":"b16","series-title":"Neurosurg Focus","doi-asserted-by":"publisher","first-page":"E10","DOI":"10.3171\/2010.1.FOCUS09297","article-title":"Radiation therapy for pediatric craniopharyngioma","volume":"28","author":"Kiehna EN","year":"2010","unstructured":"Kiehna EN, Merchant TE. Radiation therapy for pediatric craniopharyngioma. Neurosurg Focus. 2010;28(4):E10.2036735410.3171\/2010.1.FOCUS09297"},{"issue":"4","key":"b17","series-title":"Horm Res","first-page":"193","article-title":"Childhood craniopharyngioma. Recent advances in diagnosis, treatment and follow-up","volume":"69","author":"Muller HL","year":"2008","unstructured":"Muller HL. Childhood craniopharyngioma. Recent advances in diagnosis, treatment and follow-up. Horm Res. 2008;69(4):193\u2013202.18204266"},{"issue":"11","key":"b18","series-title":"AJNR Am J Neuroradiol","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.3174\/ajnr.A5361","article-title":"Topographic diagnosis of craniopharyngiomas: the accuracy of MRI findings observed on conventional T1 and T2 images","volume":"38","author":"Prieto R","year":"2017","unstructured":"Prieto R, Pascual JM, Barrios L. Topographic diagnosis of craniopharyngiomas: the accuracy of MRI findings observed on conventional T1 and T2 images. AJNR Am J Neuroradiol. 2017;38(11):2073\u20132080.2893562510.3174\/ajnr.A5361"},{"key":"b19","article-title":"Centers for Disease Control and Prevention. Individual growth charts","unstructured":"Centers for Disease Control and Prevention. Individual growth charts. Accessed January 6, 2021. https:\/\/www.cdc.gov\/growthcharts\/charts.htm"},{"issue":"246","key":"b20","series-title":"Vital Health Stat 11","first-page":"1","article-title":"2000 CDC growth charts for the United States: methods and development","author":"Kuczmarski RJ","year":"2002","unstructured":"Kuczmarski RJ, Ogden CL, Guo SS, . 2000 CDC growth charts for the United States: methods and development. Vital Health Stat 11 2002;(246):1\u2013190.12043359"},{"key":"b21","series-title":"Front Endocrinol (Lausanne)","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3389\/fendo.2011.00060","article-title":"Hypothalamic obesity after craniopharyngioma: mechanisms, diagnosis, and treatment","volume":"2","author":"Lustig RH","year":"2011","unstructured":"Lustig RH. Hypothalamic obesity after craniopharyngioma: mechanisms, diagnosis, and treatment. Front Endocrinol (Lausanne). 2011;2:60.10.3389\/fendo.2011.00060"},{"issue":"8-9","key":"b22","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1007\/s00381-005-1209-2","article-title":"Craniopharyngioma: the pendulum of surgical management","volume":"21","author":"Sainte-Rose C","year":"2005","unstructured":"Sainte-Rose C, Puget S, Wray A, . Craniopharyngioma: the pendulum of surgical management. Childs Nerv Syst. 2005;21(8-9):691\u2013695.10.1007\/s00381-005-1209-216078079"},{"issue":"2","key":"b23","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"178","DOI":"10.3171\/2013.11.PEDS1320","article-title":"Comparative effectiveness of treatment options for pediatric craniopharyngiomas","volume":"13","author":"Ali ZS","year":"2014","unstructured":"Ali ZS, Bailey RL, Daniels LB, . Comparative effectiveness of treatment options for pediatric craniopharyngiomas. J Neurosurg Pediatr. 2014;13(2):178\u2013188.2431365910.3171\/2013.11.PEDS1320"},{"issue":"2","key":"b24","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s00381-019-04294-x","article-title":"Sixty years single institutional experience with pediatric craniopharyngioma: between the past and the future","volume":"36","author":"Fouda MA","year":"2020","unstructured":"Fouda MA, Scott RM, Marcus KJ, . Sixty years single institutional experience with pediatric craniopharyngioma: between the past and the future. Childs Nerv Syst. 2020;36(2):291\u2013296.10.1007\/s00381-019-04294-x31292757"},{"issue":"3","key":"b25","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"242","DOI":"10.3171\/2019.10.PEDS19147","article-title":"Craniopharyngioma in children: trends from a third consecutive single-center cohort study","volume":"25","author":"Marcus HJ","year":"2020","unstructured":"Marcus HJ, Rasul FT, Hussein Z, . Craniopharyngioma in children: trends from a third consecutive single-center cohort study. J Neurosurg Pediatr. 2020;25(3):242\u2013250.10.3171\/2019.10.PEDS19147"},{"issue":"2","key":"b26","series-title":"Int J Radiat Oncol Biol Phys","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.ijrobp.2014.05.051","article-title":"Proton beam therapy versus conformal photon radiation therapy for childhood craniopharyngioma: multi-institutional analysis of outcomes, cyst dynamics, and toxicity","volume":"90","author":"Bishop AJ","year":"2014","unstructured":"Bishop AJ, Greenfield B, Mahajan A, . Proton beam therapy versus conformal photon radiation therapy for childhood craniopharyngioma: multi-institutional analysis of outcomes, cyst dynamics, and toxicity. Int J Radiat Oncol Biol Phys. 2014;90(2):354\u2013361.10.1016\/j.ijrobp.2014.05.05125052561"},{"issue":"3","key":"b27","series-title":"Brain Inj","doi-asserted-by":"publisher","first-page":"270","DOI":"10.3109\/02699052.2011.648709","article-title":"Quality-of-life, mood and executive functioning after childhood craniopharyngioma treated with surgery and proton beam therapy","volume":"26","author":"Laffond C","year":"2012","unstructured":"Laffond C, Dellatolas G, Alapetite C, . Quality-of-life, mood and executive functioning after childhood craniopharyngioma treated with surgery and proton beam therapy. Brain Inj. 2012;26(3):270\u2013281.10.3109\/02699052.2011.64870922372414"},{"issue":"3","key":"b28","series-title":"Int J Radiat Oncol Biol Phys","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.ijrobp.2008.05.010","article-title":"Surveillance of craniopharyngioma cyst growth in children treated with proton radiotherapy","volume":"73","author":"Winkfield KM","year":"2009","unstructured":"Winkfield KM, Linsenmeier C, Yock TI, . Surveillance of craniopharyngioma cyst growth in children treated with proton radiotherapy. Int J Radiat Oncol Biol Phys. 2009;73(3):716\u2013721.1867608910.1016\/j.ijrobp.2008.05.010"},{"key":"b29","series-title":"J Surg Res","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jss.2018.01.029","article-title":"Comparing survival outcomes of gross total resection and subtotal resection with radiotherapy for craniopharyngioma: a meta-analysis","volume":"226","author":"Wang G","year":"2018","unstructured":"Wang G, Zhang X, Feng M, Guo F. Comparing survival outcomes of gross total resection and subtotal resection with radiotherapy for craniopharyngioma: a meta-analysis. J Surg Res. 2018;226:131\u2013139.10.1016\/j.jss.2018.01.02929661278"},{"issue":"1","key":"b30","series-title":"J Neurol Surg B Skull Base","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1055\/s-0037-1621738","article-title":"Pediatric craniopharyngiomas: a primer for the skull base surgeon","volume":"79","author":"Graffeo CS","year":"2018","unstructured":"Graffeo CS, Perry A, Link MJ, Daniels DJ. Pediatric craniopharyngiomas: a primer for the skull base surgeon. J Neurol Surg B Skull Base. 2018;79(1):65\u201380.10.1055\/s-0037-162173829404243"},{"issue":"5","key":"b31","series-title":"Int J Radiat Oncol Biol Phys","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1016\/j.ijrobp.2005.09.034","article-title":"Combined proton and photon irradiation for craniopharyngioma: long-term results of the early cohort of patients treated at Harvard Cyclotron Laboratory and Massachusetts General Hospital","volume":"64","author":"Fitzek MM","year":"2006","unstructured":"Fitzek MM, Linggood RM, Adams J, Munzenrider JE. Combined proton and photon irradiation for craniopharyngioma: long-term results of the early cohort of patients treated at Harvard Cyclotron Laboratory and Massachusetts General Hospital. Int J Radiat Oncol Biol Phys. 2006;64(5):1348\u20131354.1658049410.1016\/j.ijrobp.2005.09.034"},{"issue":"5","key":"b32","series-title":"Int J Radiat Oncol Biol Phys","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/j.ijrobp.2012.10.031","article-title":"Longitudinal investigation of adaptive functioning following conformal irradiation for pediatric craniopharyngioma and low-grade glioma","volume":"85","author":"Netson KL","year":"2013","unstructured":"Netson KL, Conklin HM, Wu S, . Longitudinal investigation of adaptive functioning following conformal irradiation for pediatric craniopharyngioma and low-grade glioma. Int J Radiat Oncol Biol Phys. 2013;85(5):1301\u20131306.10.1016\/j.ijrobp.2012.10.03123245284"},{"issue":"6","key":"b33","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1210\/jc.2012-3928","article-title":"Childhood craniopharyngioma: hypothalamus-sparing surgery decreases the risk of obesity","volume":"98","author":"Elowe-Gruau E","year":"2013","unstructured":"Elowe-Gruau E, Beltrand J, Brauner R, . Childhood craniopharyngioma: hypothalamus-sparing surgery decreases the risk of obesity. J Clin Endocrinol Metab. 2013;98(6):2376\u20132382.10.1210\/jc.2012-392823633208"},{"issue":"7","key":"b34","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1210\/jc.2011-0174","article-title":"Consequences of craniopharyngioma surgery in children","volume":"96","author":"M\u00fcller HL","year":"2011","unstructured":"M\u00fcller HL. Consequences of craniopharyngioma surgery in children. J Clin Endocrinol Metab. 2011;96(7):1981\u20131991.10.1210\/jc.2011-017421508127"},{"issue":"1","key":"b35","series-title":"Int J Radiat Oncol Biol Phys","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S0360-3016(02)02888-2","article-title":"Preirradiation endocrinopathies in pediatric brain tumor patients determined by dynamic tests of endocrine function","volume":"54","author":"Merchant TE","year":"2002","unstructured":"Merchant TE, Williams T, Smith JM, . Preirradiation endocrinopathies in pediatric brain tumor patients determined by dynamic tests of endocrine function. Int J Radiat Oncol Biol Phys. 2002;54(1):45\u201350.1218297310.1016\/S0360-3016(02)02888-2"},{"issue":"7","key":"b36","series-title":"Pediatr Blood Cancer","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1002\/pbc.22884","article-title":"Long-term clinical outcomes following treatment of childhood craniopharyngioma","volume":"56","author":"Winkfield KM","year":"2011","unstructured":"Winkfield KM, Tsai HK, Yao X, . Long-term clinical outcomes following treatment of childhood craniopharyngioma. Pediatr Blood Cancer. 2011;56(7):1120\u20131126.10.1002\/pbc.2288421488157"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/28\/2\/article-p152.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/28\/2\/article-p152.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/28\/2\/article-p152.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:54:16Z","timestamp":1792806856000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/28\/2\/article-p152.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":36,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3171\/2020.11.peds20803","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8]]}}}