{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T01:26:55Z","timestamp":1794014815500,"version":"4.8.0"},"reference-count":39,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Magnetic resonance imaging\u2013guided focused ultrasound (MRgFUS) is a novel and useful treatment for essential tremor (ET); however, the factors impacting treatment outcome are unknown. The authors conducted this study to determine the factors affecting the outcome of MRgFUS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>From May 2016 through August 2017, 15 patients with ET were admitted to Ohnishi Neurological Center and treated with MRgFUS. To determine the factors impacting treatment outcome, the authors retrospectively studied correlations between the Clinical Rating Scale for Tremor (CRST) improvement rate and age, disease duration, baseline CRST score, skull density ratio (SDR), skull volume, maximum delivered energy, or maximum temperature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The mean CRST score was 18.5 \u00b1 5.8 at baseline and 4.6 \u00b1 5.7 at 1 year. The rate of improvement in the CRST score was 80% \u00b1 22%. Younger age and lower baseline CRST score were correlated with a higher CRST improvement rate (p = 0.025 and 0.007, respectively). To obtain a CRST improvement rate \u2265 50%, a maximum temperature \u2265 55\u00b0C was necessary. There was no correlation between SDR and CRST improvement rate (p = 0.658). A lower SDR and higher skull volume required significantly higher maximum delivered energy (p = 0.014 and 0.016, respectively). A higher maximum temperature was associated with a significantly larger lesion volume (p = 0.026).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Younger age and lower baseline CRST score were favorable outcome factors. It is important to assess predictive factors when applying MRgFUS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2020.2.jns192814","type":"journal-article","created":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T03:36:53Z","timestamp":1588304213000},"page":"1618-1623","source":"Crossref","is-referenced-by-count":35,"title":["What factors impact the clinical outcome of magnetic resonance imaging\u2013guided focused ultrasound thalamotomy for essential tremor?"],"prefix":"10.3171","volume":"134","author":[{"given":"Kenji","family":"Fukutome","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Ohnishi Neurological Center, Akashi, Hyogo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Kuga","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Ohnishi Neurological Center, Akashi, Hyogo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Ohnishi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Ohnishi Neurological Center, Akashi, Hyogo;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiro","family":"Hirabayashi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Ohnishi Neurological Center, Akashi, Hyogo;"},{"name":"Department of Neurosurgery, National Hospital Organization Nara Medical Center, Nara;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Nakase","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Nara Medical University, Kashihara, Nara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"11","key":"b1","series-title":"Neurology","first-page":"S8","article-title":"Epidemiology and genetics of essential tremor","volume":"54","author":"Findley\n \nLJ","year":"2000","unstructured":"Findley\n \nLJ\n\n\n. \nEpidemiology and genetics of essential tremor\n. \nNeurology\n. \n2000\n;\n54\n(\n11\n)(\nsuppl 4\n):\nS8\n\u2013\nS13\n.\n10854346"},{"issue":"5","key":"b2","series-title":"Mov Disord","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1002\/mds.22838","article-title":"How common is the most common adult movement disorder? 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