{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:43:12Z","timestamp":1792806192677,"version":"4.5.0"},"reference-count":42,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>\n                      This prospective case-control study was conducted to examine whether spherical deconvolution (SD) can unveil microstructural abnormalities in the corticospinal tract (CST) caused by\n                      <jats:italic>IDH<\/jats:italic>\n                      -mutant gliomas. To determine the significance of abnormal microstructure, the authors investigated the correlation between diffusion parameters and neurophysiological data collected with navigated transcranial magnetic stimulation (nTMS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Twenty participants (10 patients and 10 healthy controls) were recruited. Diffusion-weighted images were acquired on a 3-T MRI scanner using a cardiac-gated single-shot spin echo echo-planar imaging multiband sequence (TE 80 msec, TR 4000 msec) along 90 diffusion directions with a b-value of 2500 sec\/mm\n                      <jats:sup>2<\/jats:sup>\n                      (FOV 256 \u00d7 256 mm). Diffusion tensor imaging tractography and SD tractography were performed with deterministic tracking. The anterior portion of the ipsilateral superior peduncle and the precentral gyrus were used as regions of interest to delineate the CST. Diffusion indices were extracted and analyzed for significant differences between hemispheres in patients and between patient and control groups. A navigated brain stimulation system was used to deliver TMS pulses at hotspots at which motor evoked potentials (MEPs) for the abductor pollicis brevis, first digital interosseous, and abductor digiti minimi muscles are best elicited in patients and healthy controls. Functional measurements such as resting motor threshold (rMT), amplitude of MEPs, and latency of MEPs were noted. Significant differences between hemispheres in patients and between patients and controls were statistically analyzed. The Spearman rank correlation was used to investigate correlations between diffusion indices and functional measurements.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The hindrance modulated orientational anisotropy (HMOA), measured with SD tractography, is lower in the hemisphere ipsilateral to glioma (p = 0.028). The rMT in the hemisphere ipsilateral to a glioma is significantly greater than that in the contralateral hemisphere (p = 0.038). All measurements contralateral to the glioma, except for the mean amplitude of MEPs (p = 0.001), are similar to those of healthy controls. Mean diffusivity and axial diffusivity from SD tractography are positively correlated with rMT in the hemisphere ipsilateral to glioma (p = 0.02 and 0.006, respectively). The interhemispheric difference in HMOA and rMT is correlated in glioma patients (p = 0.007).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      SD tractography can demonstrate microstructural abnormality within the CST of patients with\n                      <jats:italic>IDH1<\/jats:italic>\n                      -mutant gliomas that correlates to the functional abnormality measured with nTMS.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2020.2.jns192994","type":"journal-article","created":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T03:36:53Z","timestamp":1588304213000},"page":"1368-1376","source":"Crossref","is-referenced-by-count":26,"title":["Altered corticospinal microstructure and motor cortex excitability in gliomas: an advanced tractography and transcranial magnetic stimulation study"],"prefix":"10.3171","volume":"134","author":[{"given":"Ayesha Sunil","family":"Mirchandani","sequence":"first","affiliation":[{"name":"Neuroimaging Department, King\u2019s College London;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Beyh","sequence":"additional","affiliation":[{"name":"Neuroimaging Department, King\u2019s College London;"},{"name":"NatBrainLab, Department of Forensics and Neurodevelopmental Sciences, King\u2019s College London; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Pedro","family":"Lavrador","sequence":"additional","affiliation":[{"name":"Neurosurgical Department, King\u2019s College London Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrietta","family":"Howells","sequence":"additional","affiliation":[{"name":"NatBrainLab, Department of Forensics and Neurodevelopmental Sciences, King\u2019s College London; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Dell\u2019Acqua","sequence":"additional","affiliation":[{"name":"NatBrainLab, Department of Forensics and Neurodevelopmental Sciences, King\u2019s College London; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Vergani","sequence":"additional","affiliation":[{"name":"Neurosurgical Department, King\u2019s College London Hospital, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Brain Mapping","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/978-3-7091-0723-2_20","article-title":"Preoperative diffusion tensor imaging (DTI): contribution to surgical planning and validation by intraoperative electrostimulation","author":"Bello\n \nL","year":"2011","unstructured":"Bello\n \nL\n\n, \n\nCastellano\n \nA\n\n, \n\nFava\n \nE\n\n, \n\n\n \nPreoperative diffusion tensor imaging (DTI): contribution to surgical planning and validation by intraoperative electrostimulation\n. 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