{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T09:16:14Z","timestamp":1778318174869,"version":"3.51.4"},"reference-count":50,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6]]},"abstract":"\n OBJECTIVE<\/jats:title>\n The purpose of this study was to analyze the clinical and biochemical outcome of consecutive patients with acromegaly after microscopic transsphenoidal surgery (MTS) at a single center over an 8-year period.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n A retrospective analysis of patients with acromegaly treated via MTS between 2008 and 2015 at the authors\u2019 center was performed. The mean follow-up was 29 months (range 1\u2013120 months). Parameters investigated included tumor size, pre- and postoperative insulin-like growth factor\u2013I, growth hormone levels, pretreatment, perioperative complications, and clinical outcome.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n A total of 280 patients with acromegaly were treated surgically at the authors\u2019 center over the abovementioned time frame and were included in analyses. For 231 of these patients, complete follow-up data were available for evaluation. One hundred eighty-eight patients (81%) showed remission initially according to current criteria. So far, 23 of these patients relapsed in the further course, so that on follow-up 165 patients (71%) demonstrated full remission by surgery alone. Most patients in whom remission after surgery failed were treated with somatostatin receptor ligands and\/or dopamine agonists as second-line treatment. The main postoperative complications included transient hyponatremia and diabetes insipidus (13\/280; 4.6%). CSF leakage only occurred in 2 cases (2\/280; 0.7%). No surgery-related death occurred.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n The data underline the effectiveness of MTS in acromegaly. Many patients with recurrent disease or incomplete tumor resection can be successfully managed pharmacologically.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2020.3.focus2061","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T08:21:59Z","timestamp":1591172519000},"page":"E9","source":"Crossref","is-referenced-by-count":6,"title":["Real-life analysis of 280 patients with surgically treated acromegaly: a single-center experience from 2008 to 2015"],"prefix":"10.3171","volume":"48","author":[{"given":"Roman","family":"Rotermund","sequence":"first","affiliation":[{"name":"Department of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius M.","family":"Mader","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Till","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Friedrich-Ebert-Krankenhaus, Neumuenster; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob","family":"Matschke","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Aberle","sequence":"additional","affiliation":[{"name":"IIIrd Department of Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara","family":"Krajewski","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Clinic Schleswig-Holstein, Campus L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Flitsch","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir-Hossein","family":"Rahvar","sequence":"additional","affiliation":[{"name":"IIIrd Department of Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.3171\/2017.12.JNS172318","article-title":"Complications associated with microscopic and endoscopic transsphenoidal pituitary surgery: experience of 1153 consecutive cases treated at a single tertiary care pituitary center","volume":"130","author":"Agam MS","year":"2019","unstructured":"Agam MS, Wedemeyer MA, Wrobel B, Weiss MH, Carmichael JD, Zada G: Complications associated with microscopic and endoscopic transsphenoidal pituitary surgery: experience of 1153 consecutive cases treated at a single tertiary care pituitary center. 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