{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:40:45Z","timestamp":1792201245432,"version":"4.4.0"},"reference-count":30,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Previous studies have demonstrated the importance of intracranial elastance; however, methodological difficulties have limited widespread clinical use. Measuring elastance may offer potential benefit in helping to identify patients at risk for untoward intracranial pressure (ICP) elevation from small rises in intracranial volume. The authors sought to develop an easily used method that accounts for the changing ICP that occurs over a cardiac cycle and to assess this method in a large-animal model over a broad range of ICPs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The authors used their previously described cardiac-gated intracranial balloon pump and swine model of cerebral edema. In the present experiment they measured elastance at 4 points along the cardiac cycle\u2014early systole, peak systole, mid-diastole, and end diastole\u2014by using rapid balloon inflation to 1 ml over an ICP range of 10\u201330 mm Hg.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The authors studied 7 swine with increasing cerebral edema. Intracranial elastance rose progressively with increasing ICP. Peak-systolic and end-diastolic elastance demonstrated the most consistent rise in elastance as ICP increased. Cardiac-gated elastance measurements had markedly lower variance within swine compared with non\u2013cardiac-gated measures. The slope of the ICP\u2013elastance curve differed between swine. At ICP between 20 and 25 mm Hg, elastance varied between 8.7 and 15.8 mm Hg\/ml, indicating that ICP alone cannot accurately predict intracranial elastance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Measuring intracranial elastance in a cardiac-gated manner is feasible and may offer an improved precision of measure. The authors\u2019 preliminary data suggest that because elastance values may vary at similar ICP levels, ICP alone may not necessarily best reflect the state of intracranial volume reserve capacity. Paired ICP\u2013elastance measurements may offer benefit as an adjunct \u201cearly warning monitor\u201d alerting to the risk of untoward ICP elevation in brain-injured patients that is induced by small increases in intracranial volume.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2020.3.jns193262","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T22:04:53Z","timestamp":1591394693000},"page":"1650-1657","source":"Crossref","is-referenced-by-count":7,"title":["Cardiac-gated intracranial elastance in a swine model of raised intracranial pressure: a novel method to assess intracranial pressure\u2013volume dynamics"],"prefix":"10.3171","volume":"134","author":[{"given":"Omer","family":"Doron","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Hadassah-Hebrew University Medical Center, Jerusalem;"},{"name":"Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Barnea","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nino","family":"Stocchetti","sequence":"additional","affiliation":[{"name":"Department of Physiopathology and Transplantation, Milan University and Neuro ICU Fondazione IRCCS C\u00e0 Granda Ospedale Maggiore Policlinico, Milan, Italy; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Or","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erez","family":"Nossek","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, New York University Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hadassah-Hebrew University Medical Center, Jerusalem;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Trans Med Chir Soc Edinb","first-page":"84","article-title":"An account of the appearance observed in the dissection of two or three individuals presumed to have perished in the storm of the third and whose bodies were discovered in the vicinity of Leith on the morning of the fourth November 1821, with some reflections on the pathology of the brain","volume":"I","author":"Kellie\n \nG","year":"1824","unstructured":"Kellie\n \nG\n\n\n. \nAn account of the appearance observed in the dissection of two or three individuals presumed to have perished in the storm of the third and whose bodies were discovered in the vicinity of Leith on the morning of the fourth November 1821, with some reflections on the pathology of the brain\n. \nTrans Med Chir Soc Edinb\n. \n1824\n;\nI\n:\n84\n\u2013\n169\n."},{"key":"b2","series-title":"Observations on the Structure and Function of the Nervous System","author":"Monro\n \nA","year":"1783","unstructured":"Monro\n \nA\n\n\n. \nObservations on the Structure and Function of the Nervous System\n. \nCreech & Johnston\n; \n1783\n."},{"key":"b3","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1212\/WNL.15.7.622","article-title":"Cerebral vasomotor paralysis produced by intracranial hypertension","volume":"15","author":"Langfitt\n \nTW","year":"1965","unstructured":"Langfitt\n \nTW\n\n, \n\nWeinstein\n \nJD\n\n, \n\nKassell\n \nNF\n\n\n. \nCerebral vasomotor paralysis produced by intracranial hypertension\n. \nNeurology\n. \n1965\n;\n15\n:\n622\n\u2013\n641\n.\n10.1212\/WNL.15.7.62214306322"},{"issue":"5","key":"b4","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"523","DOI":"10.3171\/jns.1975.43.5.0523","article-title":"Compartmental analysis of compliance and outflow resistance of the cerebrospinal fluid system","volume":"43","author":"Marmarou\n \nA","year":"1975","unstructured":"Marmarou\n \nA\n\n, \n\nShulman\n \nK\n\n, \n\nLaMorgese\n \nJ\n\n\n. \nCompartmental analysis of compliance and outflow resistance of the cerebrospinal fluid system\n. \nJ Neurosurg\n. \n1975\n;\n43\n(\n5\n):\n523\n\u2013\n534\n.\n118138410.3171\/jns.1975.43.5.0523"},{"issue":"3","key":"b5","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"332","DOI":"10.3171\/jns.1978.48.3.0332","article-title":"A nonlinear analysis of the cerebrospinal fluid system and intracranial pressure dynamics","volume":"48","author":"Marmarou\n \nA","year":"1978","unstructured":"Marmarou\n \nA\n\n, \n\nShulman\n \nK\n\n, \n\nRosende\n \nRM\n\n\n. \nA nonlinear analysis of the cerebrospinal fluid system and intracranial pressure dynamics\n. \nJ Neurosurg\n. \n1978\n;\n48\n(\n3\n):\n332\n\u2013\n344\n.\n10.3171\/jns.1978.48.3.0332632857"},{"issue":"4","key":"b6","series-title":"Arch Neurol","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1001\/archneur.1973.00490220073011","article-title":"Induced changes of cerebrospinal fluid volume. Effects during continuous monitoring of ventricular fluid pressure","volume":"28","author":"Miller\n \nJD","year":"1973","unstructured":"Miller\n \nJD\n\n, \n\nGaribi\n \nJ\n\n, \n\nPickard\n \nJD\n\n\n. \nInduced changes of cerebrospinal fluid volume. Effects during continuous monitoring of ventricular fluid pressure\n. \nArch Neurol\n. \n1973\n;\n28\n(\n4\n):\n265\n\u2013\n269\n.\n468843210.1001\/archneur.1973.00490220073011"},{"key":"b7","series-title":"Intracranial Pressure","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1007\/978-3-642-65486-2_46","article-title":"Intracranial volume\/pressure relationships during continuous monitoring of ventricular fluid pressure","author":"Miller\n \nJD","year":"1972","unstructured":"Miller\n \nJD\n\n, \n\nGaribi\n \nJ\n\n\n. \nIntracranial volume\/pressure relationships during continuous monitoring of ventricular fluid pressure\n. In: \n\n\nBrock\n \nM\n\n, \n\nDietz\n \nH\n\n\n, eds. \nIntracranial Pressure\n. \nSpringer\n; \n1972\n:\n270\n\u2013\n274\n.\n10.1007\/978-3-642-65486-2_46"},{"key":"b8","series-title":"Clin Neurosurg","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1093\/neurosurgery\/22.CN_suppl_1.76","article-title":"Volume and pressure in the craniospinal axis","volume":"22","author":"Miller\n \nJD","year":"1975","unstructured":"Miller\n \nJD\n\n\n. \nVolume and pressure in the craniospinal axis\n. \nClin Neurosurg\n. \n1975\n;\n22\n:\n76\n\u2013\n105\n.\n10.1093\/neurosurgery\/22.CN_suppl_1.761102210"},{"issue":"3","key":"b9","series-title":"Injury","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0020-1383(74)80021-5","article-title":"Intracranial volume pressure studies in patients with head injury","volume":"5","author":"Miller\n \nJD","year":"1974","unstructured":"Miller\n \nJD\n\n, \n\nPickard\n \nJD\n\n\n. \nIntracranial volume pressure studies in patients with head injury\n. \nInjury\n. \n1974\n;\n5\n(\n3\n):\n265\n\u2013\n268\n.\n482789910.1016\/S0020-1383(74)80021-5"},{"issue":"1-2","key":"b10","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF01774379","article-title":"The influence of the decompressive operation on the intracranial pressure and the pressure-volume relation in patients with severe head injuries","volume":"45","author":"Hase\n \nU","year":"1978","unstructured":"Hase\n \nU\n\n, \n\nReulen\n \nHJ\n\n, \n\nMeinig\n \nG\n\n, \n\nSch\u00fcrmann\n \nK\n\n\n. \nThe influence of the decompressive operation on the intracranial pressure and the pressure-volume relation in patients with severe head injuries\n. \nActa Neurochir (Wien)\n. \n1978\n;\n45\n(\n1-2\n):\n1\n\u2013\n13\n.\n10.1007\/BF01774379742427"},{"issue":"1","key":"b11","series-title":"Surg Neurol","first-page":"47","article-title":"CSF pressure-volume dynamics in neurosurgical patients: a preliminary evaluation in six patients","volume":"9","author":"Sullivan\n \nHG","year":"1978","unstructured":"Sullivan\n \nHG\n\n, \n\nMiller\n \nJD\n\n, \n\nGriffith\n \nRL\n \nIII\n\n, \n\nBecker\n \nDP\n\n\n. \nCSF pressure-volume dynamics in neurosurgical patients: a preliminary evaluation in six patients\n. \nSurg Neurol\n. \n1978\n;\n9\n(\n1\n):\n47\n\u2013\n54\n.\n622681"},{"issue":"3","key":"b12","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1002\/ana.410050304","article-title":"Bolous versus steady-state infusion for determination of CSF outflow resistance","volume":"5","author":"Sullivan\n \nHG","year":"1979","unstructured":"Sullivan\n \nHG\n\n, \n\nMiller\n \nJD\n\n, \n\nGriffith\n \nRL\n \nIII\n\n, \n\n\n \nBolous versus steady-state infusion for determination of CSF outflow resistance\n. \nAnn Neurol\n. \n1979\n;\n5\n(\n3\n):\n228\n\u2013\n238\n.\n44375510.1002\/ana.410050304"},{"key":"b13","series-title":"Annu Rev Biomed Eng","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1146\/annurev-bioeng-060418-052257","article-title":"Intracranial pressure and intracranial elastance monitoring in neurocritical care","volume":"21","author":"Heldt\n \nT","year":"2019","unstructured":"Heldt\n \nT\n\n, \n\nZoerle\n \nT\n\n, \n\nTeichmann\n \nD\n\n, \n\nStocchetti\n \nN\n\n\n. \nIntracranial pressure and intracranial elastance monitoring in neurocritical care\n. \nAnnu Rev Biomed Eng\n. \n2019\n;\n21\n:\n523\n\u2013\n549\n.\n10.1146\/annurev-bioeng-060418-05225731167100"},{"key":"b14","series-title":"J Clin Neurosci","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.jocn.2018.10.051","article-title":"A swine model of intracellular cerebral edema \u2013 cerebral physiology and intracranial compliance","volume":"58","author":"Ramirez de Noriega\n \nF","year":"2018","unstructured":"Ramirez de Noriega\n \nF\n\n, \n\nManley\n \nGT\n\n, \n\nMoscovici\n \nS\n\n, \n\n\n \nA swine model of intracellular cerebral edema \u2013 cerebral physiology and intracranial compliance\n. \nJ Clin Neurosci\n. \n2018\n;\n58\n:\n192\n\u2013\n199\n.\n10.1016\/j.jocn.2018.10.05130454689"},{"issue":"5","key":"b15","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.3171\/2019.1.JNS182864","article-title":"Cerebral blood flow augmentation using a cardiac-gated intracranial pulsating balloon pump in a swine model of elevated ICP","volume":"132","author":"Doron\n \nO","year":"2020","unstructured":"Doron\n \nO\n\n, \n\nOr\n \nT\n\n, \n\nBattino\n \nL\n\n, \n\n\n \nCerebral blood flow augmentation using a cardiac-gated intracranial pulsating balloon pump in a swine model of elevated ICP\n. \nJ Neurosurg\n. \n2020\n;\n132\n(\n5\n):\n1606\n\u2013\n1615\n.\n10.3171\/2019.1.JNS182864"},{"issue":"10","key":"b16","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1136\/jnnp.37.10.1093","article-title":"Intracranial volume\u2013pressure relationships during experimental brain compression in primates. 1. Pressure responses to changes in ventricular volume","volume":"37","author":"Leech\n \nP","year":"1974","unstructured":"Leech\n \nP\n\n, \n\nMiller\n \nJD\n\n\n. \nIntracranial volume\u2013pressure relationships during experimental brain compression in primates. 1. Pressure responses to changes in ventricular volume\n. \nJ Neurol Neurosurg Psychiatry\n. \n1974\n;\n37\n(\n10\n):\n1093\n\u2013\n1098\n.\n444380310.1136\/jnnp.37.10.1093"},{"issue":"1-2","key":"b17","series-title":"Minerva Anestesiol","first-page":"1","article-title":"Clinical use of cerebral elastance and intracranial dynamics measurements. Article in Italian","volume":"59","author":"Stocchetti\n \nN","year":"1993","unstructured":"Stocchetti\n \nN\n\n, \n\nMattioli\n \nC\n\n, \n\nMainini\n \nP\n\n, \n\n\n \nClinical use of cerebral elastance and intracranial dynamics measurements. Article in Italian\n. \nMinerva Anestesiol\n. \n1993\n;\n59\n(\n1-2\n):\n1\n\u2013\n9\n.\n8474666"},{"key":"b18","series-title":"Acta Neurochir Suppl","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/3-211-32318-X_64","article-title":"Preliminary report on Spiegelberg pre and post-operative monitoring of severe head-injured patients who received decompressive craniectomy","volume":"95","author":"Abdullah\n \nJ","year":"2005","unstructured":"Abdullah\n \nJ\n\n, \n\nZamzuri\n \nI\n\n, \n\nAwang\n \nS\n\n, \n\n\n \nPreliminary report on Spiegelberg pre and post-operative monitoring of severe head-injured patients who received decompressive craniectomy\n. \nActa Neurochir Suppl\n. \n2005\n;\n95\n:\n311\n\u2013\n314\n.\n10.1007\/3-211-32318-X_6416463872"},{"issue":"6","key":"b19","series-title":"Br J Neurosurg","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1080\/02688699943097","article-title":"A comparative study of the Spiegelberg compliance device with a manual volume-injection method: a clinical evaluation in patients with hydrocephalus","volume":"13","author":"Piper\n \nI","year":"1999","unstructured":"Piper\n \nI\n\n, \n\nSpiegelberg\n \nA\n\n, \n\nWhittle\n \nI\n\n, \n\n\n \nA comparative study of the Spiegelberg compliance device with a manual volume-injection method: a clinical evaluation in patients with hydrocephalus\n. \nBr J Neurosurg\n. \n1999\n;\n13\n(\n6\n):\n581\n\u2013\n586\n.\n1071572710.1080\/02688699943097"},{"key":"b20","series-title":"Acta Neurochir Suppl","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/3-211-32318-X_59","article-title":"Assessment of different data representations and averaging methods on the Spiegelberg compliance device","volume":"95","author":"Yau\n \nYH","year":"2005","unstructured":"Yau\n \nYH\n\n, \n\nPiper\n \nIR\n\n, \n\nContant\n \nC\n\n, \n\n\n \nAssessment of different data representations and averaging methods on the Spiegelberg compliance device\n. \nActa Neurochir Suppl\n. \n2005\n;\n95\n:\n289\n\u2013\n292\n.\n10.1007\/3-211-32318-X_5916463867"},{"issue":"3","key":"b21","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1227\/00006123-198703000-00006","article-title":"Intracranial compliance is time-dependent","volume":"20","author":"Anile\n \nC","year":"1987","unstructured":"Anile\n \nC\n\n, \n\nPortnoy\n \nHD\n\n, \n\nBranch\n \nC\n\n\n. \nIntracranial compliance is time-dependent\n. \nNeurosurgery\n. \n1987\n;\n20\n(\n3\n):\n389\n\u2013\n395\n.\n357461510.1227\/00006123-198703000-00006"},{"issue":"suppl 1","key":"b22","series-title":"J Neurotrauma","doi-asserted-by":"publisher","first-page":"S55","DOI":"10.1089\/neu.2007.9988","article-title":"Guidelines for the management of severe traumatic brain injury. VIII. Intracranial pressure thresholds","volume":"24","author":"Bratton\n \nSL","year":"2007","unstructured":"Bratton\n \nSL\n\n, \n\nChestnut\n \nRM\n\n, \n\nGhajar\n \nJ\n\n, \n\n\n \nGuidelines for the management of severe traumatic brain injury. VIII. Intracranial pressure thresholds\n. \nJ Neurotrauma\n. \n2007\n;\n24\n(\nsuppl 1\n):\nS55\n\u2013\nS58\n. \nPublished correction appears in J Neurotrauma. 2008;25(3):276\u2013278\n.\n1751154610.1089\/neu.2007.9988"},{"issue":"1","key":"b23","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1227\/NEU.0000000000001432","article-title":"Guidelines for the Management of Severe Traumatic Brain Injury, Fourth Edition","volume":"80","author":"Carney\n \nN","year":"2017","unstructured":"Carney\n \nN\n\n, \n\nTotten\n \nAM\n\n, \n\nO\u2019Reilly\n \nC\n\n, \n\n\n \nGuidelines for the Management of Severe Traumatic Brain Injury, Fourth Edition\n. \nNeurosurgery\n. \n2017\n;\n80\n(\n1\n):\n6\n\u2013\n15\n.\n2765400010.1227\/NEU.0000000000001432"},{"issue":"12","key":"b24","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1056\/NEJMoa1605215","article-title":"Trial of decompressive craniectomy for traumatic intracranial hypertension","volume":"375","author":"Hutchinson\n \nPJ","year":"2016","unstructured":"Hutchinson\n \nPJ\n\n, \n\nKolias\n \nAG\n\n, \n\nTimofeev\n \nIS\n\n, \n\n\n \nTrial of decompressive craniectomy for traumatic intracranial hypertension\n. \nN Engl J Med\n. \n2016\n;\n375\n(\n12\n):\n1119\n\u2013\n1130\n.\n2760250710.1056\/NEJMoa1605215"},{"issue":"4","key":"b25","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"893","DOI":"10.3171\/2014.1.JNS131292","article-title":"Patient-specific thresholds of intracranial pressure in severe traumatic brain injury","volume":"120","author":"Lazaridis\n \nC","year":"2014","unstructured":"Lazaridis\n \nC\n\n, \n\nDeSantis\n \nSM\n\n, \n\nSmielewski\n \nP\n\n, \n\n\n \nPatient-specific thresholds of intracranial pressure in severe traumatic brain injury\n. \nJ Neurosurg\n. \n2014\n;\n120\n(\n4\n):\n893\n\u2013\n900\n.\n10.3171\/2014.1.JNS13129224506248"},{"issue":"1","key":"b26","series-title":"Neurocrit Care","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s12028-012-9780-3","article-title":"Intracranial pressure dose and outcome in traumatic brain injury","volume":"18","author":"Sheth\n \nKN","year":"2013","unstructured":"Sheth\n \nKN\n\n, \n\nStein\n \nDM\n\n, \n\nAarabi\n \nB\n\n, \n\n\n \nIntracranial pressure dose and outcome in traumatic brain injury\n. \nNeurocrit Care\n. \n2013\n;\n18\n(\n1\n):\n26\n\u2013\n32\n.\n2305508710.1007\/s12028-012-9780-3"},{"issue":"4","key":"b27","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"678","DOI":"10.3171\/JNS\/2008\/109\/10\/0678","article-title":"Relationship of \u201cdose\u201d of intracranial hypertension to outcome in severe traumatic brain injury","volume":"109","author":"Vik\n \nA","year":"2008","unstructured":"Vik\n \nA\n\n, \n\nNag\n \nT\n\n, \n\nFredriksli\n \nOA\n\n, \n\n\n \nRelationship of \u201cdose\u201d of intracranial hypertension to outcome in severe traumatic brain injury\n. \nJ Neurosurg\n. \n2008\n;\n109\n(\n4\n):\n678\n\u2013\n684\n.\n10.3171\/JNS\/2008\/109\/10\/067818826355"},{"issue":"suppl 2","key":"b28","series-title":"Neurocrit Care","doi-asserted-by":"publisher","first-page":"S64","DOI":"10.1007\/s12028-014-0048-y","article-title":"Intracranial pressure monitoring: fundamental considerations and rationale for monitoring","volume":"21","author":"Chesnut\n \nR","year":"2014","unstructured":"Chesnut\n \nR\n\n, \n\nVidetta\n \nW\n\n, \n\nVespa\n \nP\n\n, \n\nLe Roux\n \nP\n\n\n. \nIntracranial pressure monitoring: fundamental considerations and rationale for monitoring\n. \nNeurocrit Care\n. \n2014\n;\n21\n(\nsuppl 2\n):\nS64\n\u2013\nS84\n.\n2520868010.1007\/s12028-014-0048-y"},{"key":"b29","series-title":"Ann N Y Acad Sci","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/nyas.12483","article-title":"A conceptual approach to managing severe traumatic brain injury in a time of uncertainty","volume":"1345","author":"Chesnut\n \nRM","year":"2015","unstructured":"Chesnut\n \nRM\n\n\n. \nA conceptual approach to managing severe traumatic brain injury in a time of uncertainty\n. \nAnn N Y Acad Sci\n. \n2015\n;\n1345\n:\n99\n\u2013\n107\n.\n10.1111\/nyas.12483"},{"issue":"11","key":"b30","series-title":"Experientia","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1007\/BF01918814","article-title":"Experimental hydrocephalus following mechanical increment of intraventricular pulse pressure","volume":"33","author":"Di Rocco\n \nC","year":"1977","unstructured":"Di Rocco\n \nC\n\n, \n\nPettorossi\n \nVE\n\n, \n\nCaldarelli\n \nM\n\n, \n\n\n \nExperimental hydrocephalus following mechanical increment of intraventricular pulse pressure\n. \nExperientia\n. \n1977\n;\n33\n(\n11\n):\n1470\n\u2013\n1472\n.\n92371310.1007\/BF01918814"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/134\/5\/article-p1650.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/134\/5\/article-p1650.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/134\/5\/article-p1650.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:49:02Z","timestamp":1792198142000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/134\/5\/article-p1650.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":30,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/2020.3.jns193262","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5]]}}}