{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:22:26Z","timestamp":1780572146409,"version":"3.54.1"},"reference-count":60,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9]]},"abstract":"\n OBJECTIVE<\/jats:title>\n In this study the authors compared the anterior lumbar interbody fusion (ALIF) and posterior transforaminal lumbar interbody fusion (TLIF) techniques in a homogeneous group of patients affected by single-level L5\u2013S1 degenerative disc disease (DDD) and postdiscectomy syndrome (PDS). The purpose of the study was to analyze perioperative, functional, and radiological data between the two techniques.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n A retrospective analysis of patient data was performed between 2015 and 2018. Patients were clustered into two homogeneous groups (group 1 = ALIF, group 2 = TLIF) according to surgical procedure. A statistical analysis of clinical perioperative and radiological findings was performed to compare the two groups. A senior musculoskeletal radiologist retrospectively revised all radiological images.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Seventy-two patients were comparable in terms of demographic features and surgical diagnosis and included in the study, involving 32 (44.4%) male and 40 (55.6%) female patients with an average age of 47.7 years. The mean follow-up duration was 49.7 months. Thirty-six patients (50%) were clustered in group 1, including 31 (86%) with DDD and 5 (14%) with PDS. Thirty-six patients (50%) were clustered in group 2, including 28 (78%) with DDD and 8 (22%) with PDS. A significant reduction in surgical time (107.4 vs 181.1 minutes) and blood loss (188.9 vs 387.1 ml) in group 1 (p < 0.0001) was observed. No significant differences in complications and reoperation rates between the two groups (p = 0.561) was observed. A significant improvement in functional outcome was observed in both groups (p < 0.001), but no significant difference between the two groups was found at the last follow-up. In group 1, a faster median time of return to work (2.4 vs 3.2 months) was recorded. A significant improvement in L5\u2013S1 postoperative lordosis restoration was registered in the ALIF group (9.0 vs 5.0, p = 0.023).<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n According to these results, interbody fusion is effective in the surgical management of discogenic pain. Even if clinical benefits were achieved earlier in the ALIF group (better scores and faster return to work), both procedures improved functional outcomes at last follow-up. The ALIF group showed significant reduction of blood loss, shorter surgical time, and better segmental lordosis restoration when compared to the TLIF group. No significant differences in postoperative complications were observed between the groups. Based on these results, the ALIF technique enhances radiological outcome improvement in spinopelvic parameters when compared to TLIF in the management of adult patients with L5\u2013S1 DDD.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2020.6.focus20374","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T06:32:03Z","timestamp":1598941923000},"page":"E2","source":"Crossref","is-referenced-by-count":30,"title":["Functional and radiological outcome of anterior retroperitoneal versus posterior transforaminal interbody fusion in the management of single-level lumbar degenerative disease"],"prefix":"10.3171","volume":"49","author":[{"given":"Roberto","family":"Bassani","sequence":"first","affiliation":[{"name":"IRCCS Istituto Ortopedico Galeazzi, Milan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Morselli","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Ortopedico Galeazzi, Milan;"},{"name":"Department of Human Neuroscience, \u201cSapienza\u201d University, Rome; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amos M.","family":"Querenghi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Ortopedico Galeazzi, Milan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Nuara","sequence":"additional","affiliation":[{"name":"Residency Program in Orthopedics and Traumatology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca Maria","family":"Sconfienza","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Ortopedico Galeazzi, Milan;"},{"name":"Department of Biomedical Sciences for Health, University of Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe M.","family":"Peretti","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Ortopedico Galeazzi, Milan;"},{"name":"Department of Biomedical Sciences for Health, University of Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"4","key":"b1","series-title":"Clin Spine Surg","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1097\/BSD.0000000000000356","article-title":"L5\/S1 fusion rates in degenerative spine surgery: a systematic review comparing ALIF, TLIF, and axial interbody arthrodesis","volume":"29","author":"Schroeder GD","year":"2016","unstructured":"Schroeder GD, Kepler CK, Millhouse PW, L5\/S1 fusion rates in degenerative spine surgery: a systematic review comparing ALIF, TLIF, and axial interbody arthrodesis. 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